Calculate similarity between ontological terms and sets of ontological terms based on term information content and assess statistical significance of similarity in the context of a collection of terms sets - Greene et al. 2017 <doi:10.1093/bioinformatics/btw763>.

Representations, conversions and display of orientation SO(3) data. See the orientlib help topic for details.

This package provides an interface to OpenCL, allowing R to leverage computing power of GPUs and other HPC accelerator devices.

Maximum homogeneity clustering algorithm for one-dimensional data described in W. D. Fisher (1958) <doi:10.1080/01621459.1958.10501479> via dynamic programming.

Solves penalized least squares problems for big tall data using the orthogonalizing EM algorithm of Xiong et al. (2016) <doi:10.1080/00401706.2015.1054436>. The main fitting function is oem() and the functions cv.oem() and xval.oem() are for cross validation, the latter being an accelerated cross validation function for linear models. The big.oem() function allows for out of memory fitting. A description of the underlying methods and code interface is described in Huling and Chien (2022) <doi:10.18637/jss.v104.i06>.

Machine learning estimator specifically optimized for predictive modeling of ordered non-numeric outcomes. ocf provides forest-based estimation of the conditional choice probabilities and the covariatesâ marginal effects. Under an "honesty" condition, the estimates are consistent and asymptotically normal and standard errors can be obtained by leveraging the weight-based representation of the random forest predictions. Please reference the use as Di Francesco (2025) <doi:10.1080/07474938.2024.2429596>.

Designed for performing impact analysis of opinions in a digital text document (DTD). The package allows a user to assess the extent to which a theme or subject within a document impacts the overall opinion expressed in the document. The package can be applied to a wide range of opinion-based DTD, including commentaries on social media platforms (such as Facebook', Twitter and Youtube'), online products reviews, and so on. The utility of opitools was originally demonstrated in Adepeju and Jimoh (2021) <doi:10.31235/osf.io/c32qh> in the assessment of COVID-19 impacts on neighbourhood policing using Twitter data. Further examples can be found in the vignette of the package.

Provide methods for estimating optimal treatment regimes in survival contexts with Kaplan-Meier-like estimators when no unmeasured confounding assumption is satisfied (Jiang, R., Lu, W., Song, R., and Davidian, M. (2017) <doi:10.1111/rssb.12201>) and when no unmeasured confounding assumption fails to hold and a binary instrument is available (Xia, J., Zhan, Z., Zhang, J. (2022) <arXiv:2210.05538>).

This package implements the orthogonal reparameterization approach recommended by Lancaster (2002) to estimate dynamic panel models with fixed effects (and optionally: panel specific intercepts). The approach uses a likelihood-based estimator and produces estimates that are asymptotically unbiased as N goes to infinity, with a T as low as 2.

It provides functions to generate a correlation matrix from a genetic dataset and to use this matrix to predict the phenotype of an individual by using the phenotypes of the remaining individuals through kriging. Kriging is a geostatistical method for optimal prediction or best unbiased linear prediction. It consists of predicting the value of a variable at an unobserved location as a weighted sum of the variable at observed locations. Intuitively, it works as a reverse linear regression: instead of computing correlation (univariate regression coefficients are simply scaled correlation) between a dependent variable Y and independent variables X, it uses known correlation between X and Y to predict Y.

This package provides functions for the design process of survey sampling, with specific tools for multi-wave and multi-phase designs. Perform optimum allocation using Neyman (1934) <doi:10.2307/2342192> or Wright (2012) <doi:10.1080/00031305.2012.733679> allocation, split strata based on quantiles or values of known variables, randomly select samples from strata, allocate sampling waves iteratively, and organize a complex survey design. Also includes a Shiny application for observing the effects of different strata splits. A paper on this package was published in the Journal of Statistical Software <doi:10.18637/jss.v114.i10>.

This package provides functions to do O2PLS-DA analysis for multiple omics data integration. The algorithm came from "O2-PLS, a two-block (X±Y) latent variable regression (LVR) method with an integral OSC filter" which published by Johan Trygg and Svante Wold at 2003 <doi:10.1002/cem.775>. O2PLS is a bidirectional multivariate regression method that aims to separate the covariance between two data sets (it was recently extended to multiple data sets) (Löfstedt and Trygg, 2011 <doi:10.1002/cem.1388>; Löfstedt et al., 2012 <doi:10.1016/j.aca.2013.06.026>) from the systematic sources of variance being specific for each data set separately.

This package provides a building block for optimization algorithms based on a simplex. The optimsimplex package may be used in the following optimization methods: the simplex method of Spendley et al. (1962) <doi:10.1080/00401706.1962.10490033>, the method of Nelder and Mead (1965) <doi:10.1093/comjnl/7.4.308>, Box's algorithm for constrained optimization (1965) <doi:10.1093/comjnl/8.1.42>, the multi-dimensional search by Torczon (1989) <https://www.cs.wm.edu/~va/research/thesis.pdf>, etc...

Online PCA for multivariate and functional data using perturbation methods, low-rank incremental methods, and stochastic optimization methods.

This package provides a function for fitting various penalized Bayesian cumulative link ordinal response models when the number of parameters exceeds the sample size. These models have been described in Zhang and Archer (2021) <doi:10.1186/s12859-021-04432-w>.

This package provides a method for the quantitative prediction using omics data. This package provides functions to construct the quantitative prediction model using omics data.

Plot malaria parasite genetic data on two or more episodes. Compute per-person posterior probabilities that each Plasmodium vivax (Pv) recurrence is a recrudescence, relapse, or reinfection (3Rs) using per-person P. vivax genetic data on two or more episodes and a statistical model described in Taylor, Foo and White (2022) <doi:10.1101/2022.11.23.22282669>. Plot per-recurrence posterior probabilities.

Deterministic Pena-Yohai initial estimator for robust S estimators of regression. The procedure is described in detail in Pena, D., & Yohai, V. (1999) <doi:10.2307/2670164>.

Calculates the periodogram of a time series, maximum-likelihood fits an Ornstein-Uhlenbeck state space (OUSS) null model and evaluates the statistical significance of periodogram peaks against the OUSS null hypothesis. The OUSS is a parsimonious model for stochastically fluctuating variables with linear stabilizing forces, subject to uncorrelated measurement errors. Contrary to the classical white noise null model for detecting cyclicity, the OUSS model can account for temporal correlations typically occurring in ecological and geological time series. Citation: Louca, Stilianos and Doebeli, Michael (2015) <doi:10.1890/14-0126.1>.

Allows the user to perform ANOVA tests (in a strict sense: continuous and normally-distributed Y variable and 1 or more factorial/categorical X variable(s)), with the possibility to specify the type of sum of squares (1, 2 or 3), the types of variables (Fixed or Random) and their relationships (crossed or nested) with the sole function of the package (FullyParamANOVA()). The resulting outputs are the same as in SAS software. A dataset (Butterfly) to test the function is also joined.

This package performs partial principal component analysis of a large sparse matrix. The matrix may be stored as a list of matrices to be concatenated (implicitly) horizontally. Useful application includes cases where the number of total nonzero entries exceed the capacity of 32 bit integers (e.g., with large Single Nucleotide Polymorphism data).

Includes tools to calculate statistical power, minimum detectable effect size (MDES), MDES difference (MDESD), and minimum required sample size for various multilevel randomized experiments (MRE) with continuous outcomes. Accomodates 14 types of MRE designs to detect main treatment effect, seven types of MRE designs to detect moderated treatment effect (2-1-1, 2-1-2, 2-2-1, 2-2-2, 3-3-1, 3-3-2, and 3-3-3 designs; <total.lev> - <trt.lev> - <mod.lev>), five types of MRE designs to detect mediated treatment effects (2-1-1, 2-2-1, 3-1-1, 3-2-1, and 3-3-1 designs; <trt.lev> - <med.lev> - <out.lev>), four types of partially nested (PN) design to detect main treatment effect, and three types of PN designs to detect mediated treatment effects (2/1, 3/1, 3/2; <trt.arm.lev> / <ctrl.arm.lev>). See PowerUp! Excel series at <https://www.causalevaluation.org/>.

This package provides tools for transforming, a posteriori time-scaling, and modifying phylogenies containing extinct (i.e. fossil) lineages. In particular, most users are interested in the functions timePaleoPhy, bin_timePaleoPhy, cal3TimePaleoPhy and bin_cal3TimePaleoPhy, which date cladograms of fossil taxa using stratigraphic data. This package also contains a large number of likelihood functions for estimating sampling and diversification rates from different types of data available from the fossil record (e.g. range data, occurrence data, etc). paleotree users can also simulate diversification and sampling in the fossil record using the function simFossilRecord, which is a detailed simulator for branching birth-death-sampling processes composed of discrete taxonomic units arranged in ancestor-descendant relationships. Users can use simFossilRecord to simulate diversification in incompletely sampled fossil records, under various models of morphological differentiation (i.e. the various patterns by which morphotaxa originate from one another), and with time-dependent, longevity-dependent and/or diversity-dependent rates of diversification, extinction and sampling. Additional functions allow users to translate simulated ancestor-descendant data from simFossilRecord into standard time-scaled phylogenies or unscaled cladograms that reflect the relationships among taxon units.

This package provides randomization using permutation for applications. To provide a Quality Control (QC) check, QC samples can be randomized within strata. A second function allows for the ability to â switchâ samples to meet set requirements and perform a certain amount of minimization on these switches. The functions are flexible for users by specifying strata size and number of QC samples per strata. The randomization meets the following requirements â ¢ QC sample requirements: QC samples not adjacent, QC samples from same mother must follow certain patterns. â ¢ Matched sample sets must be within a single strata, and next to each other.