This package implements the MEC-TX (MEchanistic Clustering - Treatment eXposure) framework for encoding, clustering, and survival analysis of real-world oncology treatment timelines. Provides functions for normalising medication records, computing treatment intervals, performing k-means clustering in PCA space, assigning line-of-therapy labels, and comparing survival outcomes across treatment groups. Designed for use with registry-based cohorts such as the ORIEN AVATAR dataset. Methods follow the digital-twin framework described in Dhrubo and Spakowicz (2026) <https://github.com/spakowiczlab/mec-tx>. treatment timelines using the MEC-TX digital-twin framework.

Generalization of Shapiro-Wilk test for multivariate variables.

Maximum a posteriori (MAP) estimation for topic models (i.e., Latent Dirichlet Allocation) in text analysis, as described in Taddy (2012) On estimation and selection for topic models'. Previous versions of this code were included as part of the textir package. If you want to take advantage of openmp parallelization, uncomment the relevant flags in src/MAKEVARS before compiling.

This package provides a computationally efficient solution for generating optimal experimental designs in Accelerated Life Testing (ALT). Leveraging a Particle Swarm Optimization (PSO)-based hybrid algorithm, the package identifies optimal test plans that minimize estimation variance under specified failure models and stress profiles. For more detailed, see Lee et al. (2025), Optimal Robust Strategies for Accelerated Life Tests and Fatigue Testing of Polymer Composite Materials <doi:10.1214/25-AOAS2075>, and Hoang (2025), Model-Robust Minimax Design of Accelerated Life Tests via PSO-based Hybrid Algorithm, Master Thesis, Unpublished.

An interface to build machine learning models for classification and regression problems. mikropml implements the ML pipeline described by TopçuoÄ lu et al. (2020) <doi:10.1128/mBio.00434-20> with reasonable default options for data preprocessing, hyperparameter tuning, cross-validation, testing, model evaluation, and interpretation steps. See the website <https://www.schlosslab.org/mikropml/> for more information, documentation, and examples.

This package provides tools for the integration, visualisation, and modelling of spatial epidemiological data using the method described in Azeez, A., & Noel, C. (2025). Predictive Modelling and Spatial Distribution of Pancreatic Cancer in Africa Using Machine Learning-Based Spatial Model <doi:10.5281/zenodo.16529986> and <doi:10.5281/zenodo.16529016>. It facilitates the analysis of geographic health data by combining modern spatial mapping tools with advanced machine learning (ML) algorithms. mlspatial enables users to import and pre-process shapefile and associated demographic or disease incidence data, generate richly annotated thematic maps, and apply predictive models, including Random Forest, XGBoost', and Support Vector Regression, to identify spatial patterns and risk factors. It is suited for spatial epidemiologists, public health researchers, and GIS analysts aiming to uncover hidden geographic patterns in health-related outcomes and inform evidence-based interventions.

An extensible expectation-maximization (EM) framework for finite mixtures of quantile regressions (clusterwise / mixture-of-experts quantile regression). A single EM substrate with an engine/extension contract carries a family of capabilities: the core free-weight mixture of Wu and Yao (2016) <doi:10.1016/j.csda.2014.04.014> -- a fast asymmetric-Laplace path and the nonparametric kernel-density EM with components constrained to have their tau-quantile equal to zero (Hall and Presnell 1999 device); expectile and M-quantile component-loss families (Newey and Powell 1987; Breckling and Chambers 1988); component-specific penalized variable selection (SCAD / adaptive-LASSO, the quantile analogue of Khalili and Chen 2007); and joint multi-quantile estimation with a shared latent classification and non-crossing component curves. Provides classification-aware standard errors (sparsity and stochastic-EM multiple imputation), multi-start estimation, component-count selection, and prediction. The companion package mixqrgate adds location-varying gating.

Routines to perform estimation and inference under the multivariate t-distribution <doi:10.1007/s10182-022-00468-2>. Currently, the following methodologies are implemented: multivariate mean and covariance estimation, hypothesis testing about equicorrelation and homogeneity of variances, the Wilson-Hilferty transformation, QQ-plots with envelopes and random variate generation.

Providing the kubernetes-like class ManagedCloudProvider as a child class of the CloudProvider class in the DockerParallel package. The class is able to manage the cloud instance made by the non-kubernetes cloud service. For creating a provider for the non-kubernetes cloud service, the developer needs to define a reference class inherited from ManagedCloudProvider and define the method for the generics runDockerWorkerContainers(), getDockerWorkerStatus() and killDockerWorkerContainers(). For more information, please see the vignette in this package and <https://CRAN.R-project.org/package=DockerParallel>.

This package provides a tool for optimizing scales of effect when modeling ecological processes in space. Specifically, the scale parameter of a distance-weighted kernel distribution is identified for all environmental layers included in the model. Includes functions to assist in model selection, model evaluation, efficient transformation of raster surfaces using fast Fourier transformation, and projecting models. For more details see Peterman (2026) <doi:10.1007/s10980-025-02267-x>.

This package provides a macro language for R programs, which provides a macro facility similar to SAS®'. This package contains basic macro capabilities like defining macro variables, executing conditional logic, and defining macro functions.

This is the core package offering a portal to the many packages universe. It includes functions to help researchers access, work across, and maintain ensembles of datasets on global governance called datacubes.

We implement a surrogate modeling algorithm to guide simulation-based sample size planning. The method is described in detail in our paper (Zimmer & Debelak (2023) <doi:10.1037/met0000611>). It supports multiple study design parameters and optimization with respect to a cost function. It can find optimal designs that correspond to a desired statistical power or that fulfill a cost constraint. We also provide a tutorial paper (Zimmer et al. (2023) <doi:10.3758/s13428-023-02269-0>).

This package provides tools for estimating multivariate probit models, calculating conditional and unconditional expectations, and calculating marginal effects on conditional and unconditional expectations.

This package implements a high dimensional mediation analysis algorithm using Local False Discovery Rates. The methodology is described in Roy and Zhang (2024) <doi:10.48550/arXiv.2402.13933>.

This package provides a simple and trustworthy methodology for the analysis of misreported continuous time series using either a frequentist (bootstrap-based EM algorithm) or a Bayesian (MCMC via JAGS) approach. The frequentist method is described in Morina et al. (2021) <doi:10.1038/s41598-021-02620-5>. The Bayesian extension fits the same ARMA model with misreporting structure using a full posterior distribution, providing credible intervals and DIC for model comparison, as described in Morina et al. (2024) <doi:10.1101/2024.02.26.24303373>.

Inference of Multiscale graphical models with neighborhood selection approach. The method is based on solving a convex optimization problem combining a Lasso and fused-group Lasso penalties. This allows to infer simultaneously a conditional independence graph and a clustering partition. The optimization is based on the Continuation with Nesterov smoothing in a Shrinkage-Thresholding Algorithm solver (Hadj-Selem et al. 2018) <doi:10.1109/TMI.2018.2829802> implemented in python.

Functions, data sets and examples for the book: Yves Croissant (2025) "Microeconometrics with R", Chapman and Hall/CRC The R Series <doi:10.1201/9781003100263>. The package includes a set of estimators for models used in microeconometrics, especially for count data and limited dependent variables. Test functions include score test, Hausman test, Vuong test, Sargan test and conditional moment test. A small subset of the data set used in the book is also included.

Create animated biplots that enables dynamic visualisation of temporal or sequential changes in multivariate data by animating a single biplot across the levels of a time variable. It builds on objects from the biplotEZ package, Lubbe S, le Roux N, Nienkemper-Swanepoel J, Ganey R, Buys R, Adams Z, Manefeldt P (2024) <doi:10.32614/CRAN.package.biplotEZ>, allowing users to create animated biplots that reveal how both samples and variables evolve over time.

This package performs key functions for MCMC analysis using minimal code - visualizes, manipulates, and summarizes MCMC output. Functions support simple and straightforward subsetting of model parameters within the calls, and produce presentable and publication-ready output. MCMC output may be derived from Bayesian model output fit with Stan, NIMBLE, JAGS, and other software.

In many agricultural, engineering, industrial, post-harvest and processing experiments, the number of factor level changes and hence the total number of changes is of serious concern as such experiments may consists of hard-to-change factors where it is physically very difficult to change levels of some factors or sometime such experiments may require normalization time to obtain adequate operating condition. For this reason, run orders that offer the minimum number of factor level changes and at the same time minimize the possible influence of systematic trend effects on the experimentation have been sought. Factorial designs with minimum changes in factors level may be preferred for such situations as these minimally changed run orders will minimize the cost of the experiments. For method details see, Bhowmik, A.,Varghese, E., Jaggi, S. and Varghese, C. (2017)<doi:10.1080/03610926.2016.1152490>.This package used to construct all possible minimally changed factorial run orders for different experimental set ups along with different statistical criteria to measure the performance of these designs. It consist of the function minFactDesign().

Generate multivariate discrete data with generalized Poisson, negative binomial and binomial marginal distributions using user-specified distribution parameters and a target correlation matrix. The method is described in Cheng and Demirtas (2026) <doi:10.48550/arXiv.2602.07707>.

Efficient finite difference method for valuing European and American multi-asset options.

Generate central composite designs (CCD)with full as well as fractional factorial points (half replicate) and Box Behnken designs (BBD) with minimally changed run sequence.