This package provides a comprehensive toolkit for clinical Human Leukocyte Antigen (HLA) informatics, built on tidyverse <https://tidyverse.tidyverse.org/> principles and making use of genotype list string (GL string, Mack et al. (2023) <doi:10.1111/tan.15126>) for storing and computing HLA genotype data. Specific functionalities include: coercion of HLA data in tabular format to and from GL string; calculation of matching and mismatching in all directions, with multiple output formats; automatic formatting of HLA data for searching within a GL string; truncation of molecular HLA data to a specific number of fields; and reading HLA genotypes in HML files and extracting the GL string.

This package provides tools to decompose differences in cohort health expectancy (HE) by age and cause using longitudinal data. The package implements a novel longitudinal attribution method based on a semiparametric additive hazards model with time-dependent covariates, specifically designed to address interval censoring and semi-competing risks via a copula framework. The resulting age-cause-specific contributions to disability prevalence and death probability can be used to quantify and decompose differences in cohort HE between groups. The package supports stepwise replacement decomposition algorithms and is applicable to cohort-based health disparity research across diverse populations. Related methods include Sun et al. (2023) <doi:10.1177/09622802221133552>.

This package provides a software package to perform Wombling, or boundary analysis, using the nimble Bayesian hierarchical modeling environment. Wombling is used widely to track regions of rapid change within the spatial reference domain. Specific functions in the package implement Gaussian process models for point-referenced spatial data followed by predictive inference on rates of change over curves using line integrals. We demonstrate model based Bayesian inference using posterior distributions featuring simple analytic forms while offering uncertainty quantification over curves. For more details on wombling please see, Banerjee and Gelfand (2006) <doi:10.1198/016214506000000041> and Halder, Banerjee and Dey (2024) <doi:10.1080/01621459.2023.2177166>.

This package provides a collection of functions to perform the Application Programming Interface (API) calls associated with the Walk Score website (www.walkscore.com) within the R environment. These functions can be used to query the Walk Score and Transit Score database for a wide variety of information using R scripts. This package includes the simple Walk Score and Transit Score API calls, which return the scores associated with an input location, as well as calls which return some data used to calculate the scores. These functions are especially useful for mass data collection and gathering Walk Score and Transit Score values for large lists of locations.

This package provides functions for revealing what happens when effect size estimates from previous studies are taken into account when evaluating each new dataset in a study sequence. The analyses can be conducted for cumulative meta-analyses and for Bayesian data analyses. The package contains sample data for a wide selection of research topics. Jointly considering previous findings along with new data is more likely to result in correct conclusions than does the traditional practice of not incorporating previous findings, which often results in a back and forth ping-pong of conclusions when evaluating a sequence of studies. O'Connor & Ermacora (2021, <doi:10.1037/cbs0000259>).

Tightens an observational block design into a smaller design with either smaller or fewer blocks while controlling for covariates. The method uses fine balance, optimal subset matching (Rosenbaum, 2012 <doi:10.1198/jcgs.2011.09219>) and two-criteria matching (Zhang et al 2023 <doi:10.1080/01621459.2021.1981337>). The main function is tighten(). The suggested rrelaxiv package for solving minimum cost flow problems: (i) derives from Bertsekas and Tseng (1988) <doi:10.1007/BF02288322>, (ii) is not available on CRAN due to its academic license, (iii) may be downloaded from GitHub at <https://github.com/josherrickson/rrelaxiv/>, (iv) is not essential to use the package.

This package provides a method for comparing the results of two binary diagnostic tests using paired data. Users can rapidly perform descriptive and inferential statistics in a single function call. Options permit users to select which parameters they are interested in comparing and methods for correction for multiple comparisons. Confidence intervals are calculated using the methods with the best coverage. Hypothesis tests use the methods with the best asymptotic performance. A summary of the methods is available in Roldán-Nofuentes (2020) <doi:10.1186/s12874-020-00988-y>. This package is targeted at clinical researchers who want to rapidly and effectively compare results from binary diagnostic tests.

Temporally autocorrelated populations are correlated in their vital rates (growth, death, etc.) from year to year. It is very common for populations, whether they be bacteria, plants, or humans, to be temporally autocorrelated. This poses a challenge for stochastic population modeling, because a temporally correlated population will behave differently from an uncorrelated one. This package provides tools for simulating populations with white noise (no temporal autocorrelation), red noise (positive temporal autocorrelation), and blue noise (negative temporal autocorrelation). The algebraic formulation for autocorrelated noise comes from Ruokolainen et al. (2009) <doi:10.1016/j.tree.2009.04.009>. Models for unstructured populations and for structured populations (matrix models) are available.

Spatial data are generally auto-correlated, meaning that if two units selected are close to each other, then it is likely that they share the same properties. For this reason, when sampling in the population it is often needed that the sample is well spread over space. A new method to draw a sample from a population with spatial coordinates is proposed. This method is called wave (Weakly Associated Vectors) sampling. It uses the less correlated vector to a spatial weights matrix to update the inclusion probabilities vector into a sample. For more details see Raphaël Jauslin and Yves Tillé (2019) <doi:10.1007/s13253-020-00407-1>.

An implementation of representation-dependent gene level operations for genetic algorithms with genes representing permutations: Initialization of genes, mutation, and crossover. The crossover operation provided is position-based crossover (Syswerda, G., Chap. 21 in Davis, L. (1991, ISBN:0-442-00173-8). For mutation, several variants are included: Order-based mutation (Syswerda, G., Chap. 21 in Davis, L. (1991, ISBN:0-442-00173-8), randomized Lin-Kernighan heuristics (Croes, G. A. (1958) <doi:10.1287/opre.6.6.791> and Lin, S. and Kernighan. B. W. (1973) <doi:10.1287/opre.21.2.498>), and randomized greedy operators. A random mix operator for mutation selects a mutation variant randomly.

iClusterPlus is developed for integrative clustering analysis of multi-type genomic data and is an enhanced version of iCluster proposed and developed by Shen, Olshen and Ladanyi (2009). Multi-type genomic data arise from the experiments where biological samples (e.g. tumor samples) are analyzed by multiple techniques, for instance, array comparative genomic hybridization (aCGH), gene expression microarray, RNA-seq and DNA-seq, and so on. In the iClusterPlus model, binary observations such as somatic mutation are modeled as Binomial processes; categorical observations such as copy number states are realizations of Multinomial random variables; counts are modeled as Poisson random processes; and continuous measures are modeled by Gaussian distributions.

This package provides Python-based extensions to enhance data analytics workflows, particularly for tasks involving data preprocessing and predictive modeling. Includes tools for data sampling, transformation, feature selection, balancing strategies (e.g., SMOTE), and model construction. These capabilities leverage Python libraries via the reticulate interface, enabling seamless integration with a broader machine learning ecosystem. Supports instance selection and hybrid workflows that combine R and Python functionalities for flexible and reproducible analytical pipelines. The architecture is inspired by the Experiment Lines approach, which promotes modularity, extensibility, and interoperability across tools. More information on Experiment Lines is available in Ogasawara et al. (2009) <doi:10.1007/978-3-642-02279-1_20>.

There is a long tradition of studying the flux of carbon from the biosphere to the atmosphere by following a particular cohort of litter (wood, leaves, roots, or other organic material) through time. The resulting data are mass remaining and time. A variety of functional forms may be used to fit the resulting data. Some work better empirically. Some are better connected to a process-based understanding. Some have a small number of free parameters; others have more. This package matches decomposition data to a family of these curves using likelihood--based fitting. This package is based on published research by Cornwell & Weedon (2013) <doi:10.1111/2041-210X.12138>.

Mitteroecker & Gunz (2009) <doi:10.1007/s11692-009-9055-x> describe how geometric morphometric methods allow researchers to quantify the size and shape of physical biological structures. We provide tools to extend geometric morphometric principles to the study of non-physical structures, hormone profiles, as outlined in Ehrlich et al (2021) <doi:10.1002/ajpa.24514>. Easily transform daily measures into multivariate landmark-based data. Includes custom functions to apply multivariate methods for data exploration as well as hypothesis testing. Also includes shiny web app to streamline data exploration. Developed to study menstrual cycle hormones but functions have been generalized and should be applicable to any biomarker over any time period.

This package performs demographic, bifurcation and evolutionary analysis of physiologically structured population models, which is a class of models that consistently translates continuous-time models of individual life history to the population level. A model of individual life history has to be implemented specifying the individual-level functions that determine the life history, such as development and mortality rates and fecundity. M.A. Kirkilionis, O. Diekmann, B. Lisser, M. Nool, B. Sommeijer & A.M. de Roos (2001) <doi:10.1142/S0218202501001264>. O.Diekmann, M.Gyllenberg & J.A.J.Metz (2003) <doi:10.1016/S0040-5809(02)00058-8>. A.M. de Roos (2008) <doi:10.1111/j.1461-0248.2007.01121.x>.

Aimed at applying the Harvest classification tree algorithm, modified algorithm of classic classification tree.The harvested tree has advantage of deleting redundant rules in trees, leading to a simplify and more efficient tree model.It was firstly used in drug discovery field, but it also performs well in other kinds of data, especially when the region of a class is disconnected. This package also improves the basic harvest classification tree algorithm by extending the field of data of algorithm to both continuous and categorical variables. To learn more about the harvest classification tree algorithm, you can go to http://www.stat.ubc.ca/Research/TechReports/techreports/220.pdf for more information.

Use stem analysis data to reconstructing tree growth and carbon accumulation. Users can independently or in combination perform a number of standard tasks for any tree species. (i) Age class determination. (ii) The cumulative growth, mean annual increment, and current annual increment of diameter at breast height (DBH) with bark, tree height, and stem volume with bark are estimated. (iii) Tree biomass and carbon storage estimation from volume and allometric models are calculated. (iv) Height-diameter relationship is fitted with nonlinear models, if diameter at breast height (DBH) or tree height are available, which can be used to retrieve tree height and diameter at breast height (DBH). <https://github.com/forestscientist/StemAnalysis>.

This package provides functions for identification and transportation of causal effects. Provides a conditional causal effect identification algorithm (IDC) by Shpitser, I. and Pearl, J. (2006) <http://ftp.cs.ucla.edu/pub/stat_ser/r329-uai.pdf>, an algorithm for transportability from multiple domains with limited experiments by Bareinboim, E. and Pearl, J. (2014) <http://ftp.cs.ucla.edu/pub/stat_ser/r443.pdf>, and a selection bias recovery algorithm by Bareinboim, E. and Tian, J. (2015) <http://ftp.cs.ucla.edu/pub/stat_ser/r445.pdf>. All of the previously mentioned algorithms are based on a causal effect identification algorithm by Tian , J. (2002) <http://ftp.cs.ucla.edu/pub/stat_ser/r309.pdf>.

For a given graph containing vertices, edges, and a signal associated with the vertices, the PathwaySpace package performs a convolution operation, which involves a weighted combination of neighboring vertices and their associated signals. The package then uses a decay function to project these signals, creating geodesic paths on a 2D-image space. PathwaySpace could have various applications, such as visualizing and analyzing network data in a graphical format that highlights the relationships and signal strengths between vertices. It can be particularly useful for understanding the influence of signals through complex networks. By combining graph theory, signal processing, and visualization, the PathwaySpace package provides a novel way of representing and analyzing graph data.

Multivariate data analysis is the simultaneous observation of more than one characteristic. In contrast to the analysis of univariate data, in this approach not only a single variable or the relation between two variables can be investigated, but the relations between many attributes can be considered. For the statistical analysis of chemical data one has to take into account the special structure of this type of data. This package contains about 30 functions, mostly for regression, classification and model evaluation and includes some data sets used in the R help examples. It was designed as a R companion to the book "Introduction to Multivariate Statistical Analysis in Chemometrics" written by K. Varmuza and P. Filzmoser (2009).

This package provides functions to calculate weights, estimates of changes and corresponding variance estimates for panel data with non-response. Partially overlapping samples are handled. Initially, weights are calculated by linear calibration. By default, the survey package is used for this purpose. It is also possible to use ReGenesees, which can be installed from <https://github.com/DiegoZardetto/ReGenesees>. Variances of linear combinations (changes and averages) and ratios are calculated from a covariance matrix based on residuals according to the calibration model. The methodology was presented at the conference, The Use of R in Official Statistics, and is described in Langsrud (2016) <http://www.revistadestatistica.ro/wp-content/uploads/2016/06/RRS2_2016_A021.pdf>.

This package provides tools for crop breeding analysis including Genetic Coefficient of Variation (GCV), Phenotypic Coefficient of Variation (PCV), heritability, genetic advance calculations, stability analysis using the Eberhart-Russell model, two-way ANOVA for genotype-environment interactions, and Additive Main Effects and Multiplicative Interaction (AMMI) analysis. These tools are developed for crop breeding research and stability evaluation under various environmental conditions. The methods are based on established statistical and biometrical principles. Refer to Eberhart and Russell (1966) <doi:10.2135/cropsci1966.0011183X000600010011x> for stability parameters, Fisher (1935) "The Design of Experiments" <ISBN:9780198522294>, Falconer (1996) "Introduction to Quantitative Genetics" <ISBN:9780582243026>, and Singh and Chaudhary (1985) "Biometrical Methods in Quantitative Genetic Analysis" <ISBN:9788122433764> for foundational methodologies.

This package provides functions to perform comparative causal mediation analysis to compare the mediation effects of different treatments via a common mediator. Results contain the estimates and confidence intervals for the two comparative causal mediation analysis estimands, as well as the ATE and ACME for each treatment. Functions provided in the package will automatically assess the comparative causal mediation analysis scope conditions (i.e. for each comparative causal mediation estimand, a numerator and denominator that are both estimated with the desired statistical significance and of the same sign). Results will be returned for each comparative causal mediation estimand only if scope conditions are met for it. See details in Bansak(2020)<doi:10.1017/pan.2019.31>.

Create a skeleton shiny application with create_template() that is reproducible, can be saved and meets academic standards for attribution. Forked from wallace'. Code is split into modules that are loaded and linked together automatically and each call one function. Guidance pages explain modules to users and flexible logging informs them of any errors. Options enable asynchronous operations, viewing of source code, interactive maps and data tables. Use to create complex analytical applications, following best practices in open science and software development. Includes functions for automating repetitive development tasks and an example application at run_shinyscholar() that requires install.packages("shinyscholar", dependencies = TRUE). A guide to developing applications can be found on the package website.