Estimation equations are from a variety of sources and associated error estimation.

Policy evaluation using generalized Qini curves: Evaluate data-driven treatment targeting rules for one or more treatment arms over different budget constraints in experimental or observational settings under unconfoundedness.

Age-specific mortality rates are estimated and projected using the Kannisto, Lee-Carter and related methods as described in Sevcikova et al. (2016) <doi:10.1007/978-3-319-26603-9_15>.

Given a set of models for which a measure of model (mis)fit and model complexity is provided, CHull(), developed by Ceulemans and Kiers (2006) <doi:10.1348/000711005X64817>, determines the models that are located on the boundary of the convex hull and selects an optimal model by means of the scree test values.

This package provides methods for quantifying the information gain contributed by individual modalities in multimodal regression models. Information gain is measured using Expected Relative Entropy (ERE) or pseudo-R² metrics, with corresponding p-values and confidence intervals. Currently supports linear and logistic regression models with plans for extension to additional Generalized Linear Models and Cox proportional hazard model.

This package provides a general framework for computing powers of matrices. A key feature is the capability for users to write callback functions, called after each iteration, thus enabling customization for specific applications. Diverse types of matrix classes/matrix multiplication are accommodated. If the multiplication type computes in parallel, then the package computation is also parallel.

This package performs the MRFA approach proposed by Sung et al. (2020) <doi:10.1080/01621459.2019.1595630> to fit and predict nonlinear regression problems, particularly for large-scale and high-dimensional problems. The application includes deterministic or stochastic computer experiments, spatial datasets, and so on.

This package provides functions for testing randomness for a univariate time series with arbitrary distribution (discrete, continuous, mixture of both types) and for testing independence between random variables with arbitrary distributions. The test statistics are based on the multilinear empirical copula and multipliers are used to compute P-values. The test of independence between random variables appeared in Genest, Nešlehová, Rémillard & Murphy (2019) and the test of randomness appeared in Nasri (2022).

The tools for MicroRNA Set Enrichment Analysis can identify risk pathways(or prior gene sets) regulated by microRNA set in the context of microRNA expression data. (1) This package constructs a correlation profile of microRNA and pathways by the hypergeometric statistic test. The gene sets of pathways derived from the three public databases (Kyoto Encyclopedia of Genes and Genomes ('KEGG'); Reactome'; Biocarta') and the target gene sets of microRNA are provided by four databases('TarBaseV6.0'; mir2Disease'; miRecords'; miRTarBase';). (2) This package can quantify the change of correlation between microRNA for each pathway(or prior gene set) based on a microRNA expression data with cases and controls. (3) This package uses the weighted Kolmogorov-Smirnov statistic to calculate an enrichment score (ES) of a microRNA set that co-regulate to a pathway , which reflects the degree to which a given pathway is associated with the specific phenotype. (4) This package can provide the visualization of the results.

Includes functions for conducting univariate and multivariate meta-analysis. This includes the estimation of the asymptotic variance-covariance matrix of effect sizes. For more details see Becker (1992) <doi:10.2307/1165128>, Cooper, Hedges, and Valentine (2019) <doi:10.7758/9781610448864>, and Schmid, Stijnen, and White (2020) <doi:10.1201/9781315119403>.

This package provides official spatial boundary datasets for Malawi at multiple administrative levels: country (level 0), regions (level 1), districts (level 2), and traditional authorities (level 3). Also includes Lake Malawi boundary data. Boundary data are the Common Operational Datasets (COD-AB) sourced from the National Statistics Office of Malawi and distributed via the OCHA Humanitarian Data Exchange (HDX), version 02 <https://data.humdata.org/dataset/cod-ab-mwi>. Intended for use with the mwmap package or any spatial analysis workflow requiring Malawi administrative boundaries.

This package implements parametric modal Autoregressive Integrated Moving Average (ARIMA) models utilizing the Skewed Distribution (SKD) family. Current distributions supported are the Skew-Normal, Skewed Student-t, and Skewed Laplace. The conditional mode is parameterized and optimized via maximum likelihood using analytical gradients. Includes comprehensive residual diagnostics, robustness options (heavy tails, asymmetry), robust parametric bootstrap prediction intervals, and classical asymptotic inference via the Fisher Information matrix. Methods are described in Galarza, C.E., Lachos, V.H., Cabral, C.R.B., & Castro, L.M. (2017) <doi:10.1002/sta4.140>.

This package provides a simple way to memoize function results to improve performance by eliminating unnecessary computation or data retrieval activities.

Persistent interface to Macaulay2 <https://www.macaulay2.com> and front-end tools facilitating its use in the R ecosystem. For details see Kahle et. al. (2020) <doi:10.18637/jss.v093.i09>.

The Molecular Signatures Database ('MSigDB') is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis <doi:10.1016/j.cels.2015.12.004>. The msig package provides you with powerful, easy-to-use and flexible query functions for the MsigDB database. There are 2 query modes in the msig package: online query and local query. Both queries contain 2 steps: gene set name and gene. The online search is divided into 2 modes: registered search and non-registered browse. For registered search, email that you registered should be provided. Local queries can be made from local database, which can be updated by msig_update() function.

Companion package of Carrion-i-Silvestre & Sansó (2026): "Testing for Constant Unconditional Variance in Heavy-Tailed Time Series". It implements the Modified Iterative Cumulative Sum of Squares Algorithm, which is an extension of the Iterative Cumulative Sum of Squares (ICSS) Algorithm of Inclan and Tiao (1994), and it checks for changes in the unconditional variance of a time series controlling for the tail index of the underlying distribution. The fourth order moment is estimated non-parametrically to avoid the size problems when the innovations are non-Gaussian (see, Sansó et al., 2004). Critical values and p-values are generated using a Generalized Extreme Value distribution approach. References Carrion-i-Silvestre J.J & Sansó A (2026) <doi:10.1080/03610918.2026.2615207>. Inclan C & Tiao G.C (1994) <doi:10.1080/01621459.1994.10476824>, Sansó A & Aragó V & Carrion-i-Silvestre J.L (2004) <https://dspace.uib.es/xmlui/bitstream/handle/11201/152078/524035.pdf>.

The monotone package contains a fast up-and-down-blocks implementation for the pool-adjacent-violators algorithm for simple linear ordered monotone regression, including two spin-off functions for unimodal and bivariate monotone regression (see <doi:10.18637/jss.v102.c01>).

Convert Markdown ('.md') or R Markdown ('.Rmd') texts, R scripts, directory structures, and other hierarchical structured documents into mind map widgets or Freemind codes or Mermaid mind map codes, and vice versa. Freemind mind map ('.mm') files can be opened by or imported to common mind map software such as Freemind (<https://freemind.sourceforge.io/wiki/index.php/Main_Page>). Mermaid mind map codes (<https://mermaid.js.org/>) can be directly embedded in documents.

Reads, plots, and manipulates large taxonomic data sets, like those generated from modern high-throughput sequencing, such as metabarcoding (i.e. amplification metagenomics, 16S metagenomics, etc). It provides a tree-based visualization called "heat trees" used to depict statistics for every taxon in a taxonomy using color and size. It also provides various functions to do common tasks in microbiome bioinformatics on data in the taxmap format defined by the taxa package. The metacoder package is described in the publication by Foster et al. (2017) <doi:10.1371/journal.pcbi.1005404>.

Computes regression deletion diagnostics for multivariate linear models and provides some associated diagnostic plots. The diagnostic measures include hat-values (leverages), generalized Cook's distance, and generalized squared studentized residuals. Several types of plots to detect influential observations are provided.

Permutation tests for variance components for 2-level, 3-level and 4-level data with univariate or multivariate responses.

This package provides functions and examples based on the m-out-of-n bootstrap suggested by Politis, D.N. and Romano, J.P. (1994) <doi:10.1214/aos/1176325770>. Additionally there are functions to estimate the scaling factor tau and the subsampling size m. For a detailed description and a full list of references, see Dalitz, C. and Lögler, F. (2025) <doi:10.32614/RJ-2025-031>.

Auto-downloads Parquet data from the MTGJSON CDN and exposes the full Magic: The Gathering dataset through R6-based query interfaces backed by DuckDB'.

Simultaneous multiple outcomes prediction based on revised stacking algorithms, which enables the integration of information from predictions of individual models. An implementation of methodologies proposed in our paper: Li Xing, Mary L Lesperance, Xuekui Zhang. (2019) Bioinformatics, "Simultaneous prediction of multiple outcomes using revised stacking algorithms" <doi:10.1093/bioinformatics/btz531>.