An implementation for estimating Effective control to 50% of growth inhibition (EC50) for multi isolates and stratified datasets. It implements functions from the drc package in a way that is displayed a tidy data.frame as output. Info about the drc package is available in Ritz C, Baty F, Streibig JC, Gerhard D (2015) <doi:10.1371/journal.pone.0146021>.

This package provides tools for competing risks trials that allow simultaneous inference on recovery and mortality endpoints. Provides data preparation helpers, standard cumulative incidence estimators (restricted mean time gained/lost), and severity weighted extensions that integrate longitudinal ordinal outcomes to summarise treatment benefit. Methods follow Wen, Hu, and Wang (2023) Biometrics 79(3):1635-1645 <doi:10.1111/biom.13752>.

Datasets from the WallOmics project. Contains phenomics, metabolomics, proteomics and transcriptomics data collected from two organs of five ecotypes of the model plant Arabidopsis thaliana exposed to two temperature growth conditions. Exploratory and integrative analyses of these data are presented in Durufle et al (2020) <doi:10.1093/bib/bbaa166> and Durufle et al (2020) <doi:10.3390/cells9102249>.

This package implements exact and approximate methods for nearest neighbor detection, in a framework that allows them to be easily switched within Bioconductor packages or workflows. The exact algorithm is implemented using pre-clustering with the k-means algorithm. Functions are also provided to search for all neighbors within a given distance. Parallelization is achieved for all methods using the BiocParallel framework.

Implementation of Bayesian models for spatial and spatio-temporal interpolation of circular data using Gaussian Wrapped and Gaussian Projected distributions. We developed the methods described in Jona Lasinio G. et al. (2012) <doi: 10.1214/12-aoas576>, Wang F. et al. (2014) <doi: 10.1080/01621459.2014.934454> and Mastrantonio G. et al. (2016) <doi: 10.1007/s11749-015-0458-y>.

Implement the methods proposed by Ahmad & Dey (2007) <doi:10.1016/j.datak.2007.03.016> in calculating the dissimilarity matrix at the presence of mixed attributes. This Package includes functions to discretize quantitative variables, calculate conditional probability for each pair of attribute values, distance between every pair of attribute values, significance of attributes, calculate dissimilarity between each pair of objects.

LecÈ iile prof/cls trebuie completate cu un câmp "ora", astfel ca oricare douÄ lecÈ ii prof/cls/ora sÄ nu se suprapunÄ Ã®ntr-o aceeaÈ i orÄ . The prof/cls lessons must be completed with a "hour" field ('ora), so that any two prof/cls/ora lessons do not overlap in the same hour. <https://vlad.bazon.net/>.

This package provides a finite-population significance test of the sharp causal null hypothesis that treatment exposure X has no effect on final outcome Y, within the principal stratum of Compliers. A generalized likelihood ratio test statistic is used, and the resulting p-value is exact. Currently, it is assumed that there are only Compliers and Never Takers in the population.

Sensitivity analysis for tests, confidence intervals and estimates in matched observational studies with one or more controls using weighted or unweighted Huber-Maritz M-tests (including the permutational t-test). The method is from Rosenbaum (2014) Weighted M-statistics with superior design sensitivity in matched observational studies with multiple controls JASA, 109(507), 1145-1158 <doi:10.1080/01621459.2013.879261>.

This package provides a lightweight and focused text annotation tool built with shiny'. Provides an interactive graphical user interface for coding text documents, managing code hierarchies, creating memos, and analyzing coding patterns. Features include code co-occurrence analysis, visualization of coding patterns, comparison of multiple coding sets, and export capabilities. Supports collaborative qualitative research through standardized annotation formats and analysis tools.

EASY-ROUTES is yet another routes handling system on top of Hunchentoot. It's just glue code for Restas routing subsystem (CL-ROUTES).

It supports:

• dispatch based on HTTP method

• arguments extraction from the url path

• decorators

• URL generation from route names

This package provides EASY-ROUTES, EASY-ROUTES+DJULA and EASY-ROUTES+ERRORS systems.

This package discovers meso-scale chromatin remodelling from 3C data. 3C data is local in nature. It givens interaction counts between restriction enzyme digestion fragments and a preferred viewpoint region. By binning this data and using permutation testing, this package can test whether there are statistically significant changes in the interaction counts between the data from two cell types or two treatments.

Use optimal equal-HR method to determine two optimal cutpoints of a continuous predictor that has a U-shaped relationship with survival outcomes based on Cox regression model. The optimal equal-HR method estimates two optimal cut-points that have approximately the same log hazard value based on Cox regression model and divides individuals into different groups according to their HR values.

Computes a single scalar metric for diurnal cortisol cycle analysis, the Cortisol Sine Score (CSS). The score is calculated as the sum over time points of concentration multiplied by sin(2 * pi * time / 24), giving positive weights to morning time points and negative weights to evening ones. The method is model-free, robust, and suitable for regression, classification, clustering, and biomarker research.

This package provides a basic, clear implementation of tree-based gradient boosting designed to illustrate the core operation of boosting models. Tuning parameters (such as stochastic subsampling, modified learning rate, or regularization) are not implemented. The only adjustable parameter is the number of training rounds. If you are looking for a high performance boosting implementation with tuning parameters, consider the xgboost package.

Provide functionality to manage, clean and match highfrequency trades and quotes data, calculate various liquidity measures, estimate and forecast volatility, detect price jumps and investigate microstructure noise and intraday periodicity. A detailed vignette can be found in the open-access paper "Analyzing Intraday Financial Data in R: The highfrequency Package" by Boudt, Kleen, and Sjoerup (2022, <doi:10.18637/jss.v104.i08>).

This package provides a collection of datasets containing a variety of in vitro toxicokinetic measurements including -- but not limited to -- chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The datasets provided by the package were processed and analyzed with the companion invitroTKstats package.

Spontaneous adverse event reports have a high potential for detecting adverse drug reactions. However, due to their dimension, the analysis of such databases requires statistical methods. We propose to use a logistic regression whose sparsity is viewed as a model selection challenge. Since the model space is huge, a Metropolis-Hastings algorithm carries out the model selection by maximizing the BIC criterion.

The Nordklim dataset 1.0 is a unique and useful achievement for climate analysis. It includes observations of twelve different climate elements from more than 100 stations in the Nordic region, in time span over 100 years. The project contractors were NORDKLIM/NORDMET on behalf of the National meteorological services in Denmark (DMI), Finland (FMI), Iceland (VI), Norway (DNMI) and Sweden (SMHI).

This package performs survival analysis for one-way layout. The package includes the generalized test for survival ANOVA (Tsui and Weerahandi (1989) <doi:10.2307/2289949> and (Weerahandi, 2004; ISBN:978-0471470175)). It also performs pairwise comparisons and graphical approaches. Moreover, it assesses the weibullness of data in each group via test. The package computes mean and confidence interval under Weibull distribution.

The Readline library provides a set of functions for use by applications that allow users to edit command lines as they are typed in. Both Emacs and vi editing modes are available. The Readline library includes additional functions to maintain a list of previously-entered command lines, to recall and perhaps reedit those lines, and perform csh-like history expansion on previous commands.

This package provides vectorised functions for computing p-values of various common discrete statistical tests, as described e.g. in Agresti (2002) <doi:10.1002/0471249688>, including their distributions. Exact and approximate computation methods are provided. For exact p-values, several procedures of determining two-sided p-values are included, which are outlined in more detail in Hirji (2006) <doi:10.1201/9781420036190>.

When evaluating the results of a genome-wide association study (GWAS), it is important to perform a quality control to ensure that the results are valid, complete, correctly formatted, and, in case of meta-analysis, consistent with other studies that have applied the same analysis. This package was developed to facilitate and streamline this process and provide the user with a comprehensive report.

This package provides a simple and the early stage package for matrix profile based on the paper of Chin-Chia Michael Yeh, Yan Zhu, Liudmila Ulanova, Nurjahan Begum, Yifei Ding, Hoang Anh Dau, Diego Furtado Silva, Abdullah Mueen, and Eamonn Keogh (2016) <DOI:10.1109/ICDM.2016.0179>. This package calculates all-pairs-similarity for a given window size for time series data.