Bayesian estimation of inverse variance weighted (IVW), Burgess et al. (2013) <doi:10.1002/gepi.21758>, and MR-Egger, Bowden et al. (2015) <doi:10.1093/ije/dyv080>, summary data models for Mendelian randomization analyses.

Fits mixed Poisson regression models (Poisson-Inverse Gaussian or Negative-Binomial) on data sets with response variables being count data. The models can have varying precision parameter, where a linear regression structure (through a link function) is assumed to hold on the precision parameter. The Expectation-Maximization algorithm for both these models (Poisson Inverse Gaussian and Negative Binomial) is an important contribution of this package. Another important feature of this package is the set of functions to perform global and local influence analysis. See Barreto-Souza and Simas (2016) <doi:10.1007/s11222-015-9601-6> for further details.

DNA methylation is an epigenetic modification involved in genomic stability, gene regulation, development and disease. DNA methylation occurs mainly through the addition of a methyl group to cytosines, for example to cytosines in a CpG dinucleotide context (CpG stands for a cytosine followed by a guanine). Tissue-specific methylation patterns lead to genomic regions with different characteristic methylation levels. E.g. in vertebrates CpG islands (regions with high CpG content) that are associated to promoter regions of expressed genes tend to be unmethylated. MethEvolSIM is a model-based simulation software for the generation and modification of cytosine methylation patterns along a given tree, which can be a genealogy of cells within an organism, a coalescent tree of DNA sequences sampled from a population, or a species tree. The simulations are based on an extension of the model of Grosser & Metzler (2020) <doi:10.1186/s12859-020-3438-5> and allows for changes of the methylation states at single cytosine positions as well as simultaneous changes of methylation frequencies in genomic structures like CpG islands.

This package implements a methodology for the design and analysis of dose-response studies that combines aspects of multiple comparison procedures and modeling approaches (Bretz, Pinheiro and Branson, 2005, Biometrics 61, 738-748, <doi: 10.1111/j.1541-0420.2005.00344.x>). The package provides tools for the analysis of dose finding trials as well as a variety of tools necessary to plan a trial to be conducted with the MCP-Mod methodology. Please note: The MCPMod package will not be further developed, all future development of the MCP-Mod methodology will be done in the DoseFinding R-package.

This package implements Meta Fuzzy Functions (MFFs) for regression Tak and Ucan (2026) <doi:10.1016/j.asoc.2026.114592> by aggregating predictions from multiple base learners using membership weights learned in the prediction space of validation set. The package supports fuzzy and crisp meta-ensemble structures via Fuzzy C-Means (FCM) Tak (2018) <doi:10.1016/j.asoc.2018.08.009>, Possibilistic FCM (PFCM) Tak (2021) <doi:10.1016/j.ins.2021.01.024>, Gustafsonâ Kessel (GK) clustering, and k-means, and provides a workflow to (i) generate validation/test prediction matrices from common regression learners (linear and penalized regression via glmnet', random forests, gradient boosting with xgboost and lightgbm'), (ii) fit cluster-wise meta fuzzy functions and compute membership-based weights, (iii) tune clustering-related hyperparameters (number of clusters/functions, fuzziness exponent, possibilistic regularization) via grid search on validation loss, and (iv) predict on new/test prediction matrices and evaluate performance using standard regression metrics (MAE, RMSE, MAPE, SMAPE, MSE, MedAE). This enables flexible, interpretable ensemble regression where different base models contribute to different meta components according to learned memberships.

Procedures to fit species distributions models from occurrence records and environmental variables, using glmnet for model fitting. Model structure is the same as for the Maxent Java package, version 3.4.0, with the same feature types and regularization options. See the Maxent website <http://biodiversityinformatics.amnh.org/open_source/maxent> for more details.

Builds matched nulls for cluster-count claims: synthetic twins of a dataset that preserve every marginal distribution and the full correlation matrix while containing no cluster structure by construction. A reported number of clusters or "types" can then be tested against what the data's own margins and covariance already produce, using any clustering pipeline. A t-copula option adds tail dependence to the null, so that an apparent excess of clusters can be checked against a heavier-tailed alternative before it is read as evidence of types. Implements the matched-null procedure of Meng (2026) "Types Without Taxa" <doi:10.17605/OSF.IO/2EKCG>.

This package provides a novel framework to estimate mixed models via gradient boosting. The implemented functions are based on the mboost and lme4 packages, and the family range is therefore determined by lme4'. A correction mechanism for cluster-constant covariates is implemented, as well as estimation of the covariance of random effects. These methods are described in the accompanying publication; see <doi:10.1007/s11222-025-10612-y> for details.

Set of tools for descriptive analysis of metaproteomics data generated from high-throughput mass spectrometry instruments. These tools allow to cluster peptides and proteins abundance, expressed as spectral counts, and to manipulate them in groups of metaproteins. This information can be represented using multiple visualization functions to portray the global metaproteome landscape and to differentiate samples or conditions, in terms of abundance of metaproteins, taxonomic levels and/or functional annotation. The provided tools allow to implement flexible analytical pipelines that can be easily applied to studies interested in metaproteomics analysis.

Colour palettes and helper functions for visualising Mycobacterium tuberculosis genomic and epidemiological data with ggplot2 and ggtree'. The package provides predefined palettes, scale functions, tree/cladogram helpers, and convenient preview tools to ensure consistent branding in pathogen-omics visualisations. The palettes were developed as part of the mycolorsTB project <https://github.com/PathoGenOmics-Lab/mycolorsTB>.

This package provides a set of tools to facilitate data sonification and handle the musicXML format <https://usermanuals.musicxml.com/MusicXML/Content/XS-MusicXML.htm>. Several classes are defined for basic musical objects such as note pitch, note duration, note, measure and score. Moreover, sonification utilities functions are provided, e.g. to map data into musical attributes such as pitch, loudness or duration. A typical sonification workflow hence looks like: get data; map them to musical attributes; create and write the musicXML score, which can then be further processed using specialized music software (e.g. MuseScore', GuitarPro', etc.). Examples can be found in the blog <https://globxblog.github.io/>, the presentation by Renard and Le Bescond (2022, <https://hal.science/hal-03710340v1>) or the poster by Renard et al. (2023, <https://hal.inrae.fr/hal-04388845v1>).

Interface to the Google Maps APIs: (1) routing directions based on the Directions API, returned as sf objects, either as single feature per alternative route, or a single feature per segment per alternative route; (2) travel distance or time matrices based on the Distance Matrix API; (3) geocoded locations based on the Geocode API, returned as sf objects, either points or bounds; (4) map images using the Maps Static API, returned as stars objects.

This package performs the execution of the main procedures of multiple comparisons in the literature, Scott-Knott (1974) <http://www.jstor.org/stable/2529204>, Batista (2016) <http://repositorio.ufla.br/jspui/handle/1/11466>, including graphic representations and export to different extensions of its results. An additional part of the package is the presence of the performance evaluation of the tests (Type I error per experiment and the power). This will assist the user in making the decision for the chosen test.

Local linear estimation of psychometric functions. Provides functions for nonparametric estimation of a psychometric function and for estimation of a derived threshold and slope, and their standard deviations and confidence intervals.For more details see Zychaluk and Foster (2009) <doi:10.3758/APP.71.6.1414> and Foster and Zychaluk (2007) <doi:10.1109/MSP.2007.4286564>.

Simulate, manage, visualize, and analyze spatially and temporally explicit datasets of mating potential. Implements methods to calculate synchrony, proximity, and compatibility.Synchrony calculations are based on methods described in Augspurger (1983) <doi:10.2307/2387650>, Kempenaers (1993) <doi:10.2307/3676415>, Ison et al. (2014) <doi:10.3732/ajb.1300065>, and variations on these, as described.

Use standard genomics file format (BED) and a table of orthologs to illustrate synteny conservation at the genome-wide scale. Significantly conserved linkage groups are identified as described in Simakov et al. (2020) <doi:10.1038/s41559-020-1156-z> and displayed on an Oxford Grid (Edwards (1991) <doi:10.1111/j.1469-1809.1991.tb00394.x>) or a chord diagram as in Simakov et al. (2022) <doi:10.1126/sciadv.abi5884>. The package provides a function that uses a network-based greedy algorithm to find communities (Clauset et al. (2004) <doi:10.1103/PhysRevE.70.066111>) and so automatically order the chromosomes on the plot to improve interpretability.

This package provides a comprehensive framework for analyzing agricultural nutrient balances across multiple spatial scales (county, HUC8', HUC2') with integration of wastewater treatment plant ('WWTP') effluent loads for both nitrogen and phosphorus. Supports classification of spatial units as nutrient sources, sinks, or balanced areas based on agricultural surplus and deficit calculations. Includes visualization tools, spatial transition probability analysis, and nutrient flow network mapping. Built-in datasets include agricultural nutrient balance data from the Nutrient Use Geographic Information System ('NuGIS'; The Fertilizer Institute and Plant Nutrition Canada, 1987-2016) <https://nugis.tfi.org/tabular_data/> and U.S. Environmental Protection Agency ('EPA') wastewater discharge data from the ECHO Discharge Monitoring Report ('DMR') Loading Tool (2007-2016) <https://echo.epa.gov/trends/loading-tool/water-pollution-search>. Data are downloaded on demand from the Open Science Framework ('OSF') repository to minimize package size while maintaining full functionality. The integrated manureshed framework methodology is described in Akanbi et al. (2025) <doi:10.1016/j.resconrec.2025.108697>. Designed for nutrient management planning, environmental analysis, and circular economy research at watershed/administrative to national scales. This material is based upon financial support by the National Science Foundation, EEC Division of Engineering Education and Centers, NSF Engineering Research Center for Advancing Sustainable and Distributed Fertilizer Production (CASFER), NSF 20-553 Gen-4 Engineering Research Centers award 2133576. We thank Dr. Robert D. Sabo (U.S. Environmental Protection Agency) for his valuable contributions to the conceptual development and review of this work. We acknowledge Dr. Sheri Spiegal (U.S. Department of Agricultureâ Agricultural Research Service) for foundational contributions to the manureshed classification framework (Spiegal et al. 2020) <doi:10.1016/j.agsy.2020.102813>.

Useful functions to analyze proteomic workflows including number of identifications, data completeness, missed cleavages, quantitative and retention time precision etc. Various software outputs are supported such as ProteomeDiscoverer', Spectronaut', DIA-NN and MaxQuant'.

An interactive document on the topic of multidimensional scaling and principal component analysis using rmarkdown and shiny packages. Runtime examples are provided in the package function as well as at <https://kartikeyabolar.shinyapps.io/MDS_PCAShiny/>.

This package implements Multivariate Quantile-on-Quantile Regression (m-QQR) of Sinha, Ghosh, Hussain, Nguyen and Das (2023) <doi:10.1016/j.eneco.2023.107021>, extending the bivariate Quantile-on-Quantile regression of Sim and Zhou (2015) <doi:10.1016/j.jbankfin.2015.01.013> to include exogenous moderators and controls with optional interaction terms. For each pair of quantile levels (theta of the response and tau of the regressor) the package fits a locally-weighted quantile regression of y on the principal regressor x, a lagged dependent variable, moderators Z and the x*Z interaction terms, using Gaussian kernel weights on the empirical cumulative distribution function (CDF) distance. Bootstrap standard errors and Koenker-Machado pseudo R-squared are reported. Visualisations include MATLAB'-style Parula and Jet 3D surfaces, heatmaps and contour plots through plotly'.

Companion package of Carrion-i-Silvestre & Sansó (2026): "Testing for Constant Unconditional Variance in Heavy-Tailed Time Series". It implements the Modified Iterative Cumulative Sum of Squares Algorithm, which is an extension of the Iterative Cumulative Sum of Squares (ICSS) Algorithm of Inclan and Tiao (1994), and it checks for changes in the unconditional variance of a time series controlling for the tail index of the underlying distribution. The fourth order moment is estimated non-parametrically to avoid the size problems when the innovations are non-Gaussian (see, Sansó et al., 2004). Critical values and p-values are generated using a Generalized Extreme Value distribution approach. References Carrion-i-Silvestre J.J & Sansó A (2026) <doi:10.1080/03610918.2026.2615207>. Inclan C & Tiao G.C (1994) <doi:10.1080/01621459.1994.10476824>, Sansó A & Aragó V & Carrion-i-Silvestre J.L (2004) <https://dspace.uib.es/xmlui/bitstream/handle/11201/152078/524035.pdf>.

Multimodal mediation analysis is an emerging problem in microbiome data analysis. Multimedia make advanced mediation analysis techniques easy to use, ensuring that all statistical components are transparent and adaptable to specific problem contexts. The package provides a uniform interface to direct and indirect effect estimation, synthetic null hypothesis testing, bootstrap confidence interval construction, and sensitivity analysis. More details are available in Jiang et al. (2024) "multimedia: Multimodal Mediation Analysis of Microbiome Data" <doi:10.1101/2024.03.27.587024>.

Can detect relatively weak spatial genetic patterns by using Moran's Eigenvector Maps (MEM) to extract only the spatial component of genetic variation. Has applications in landscape genetics where the movement and dispersal of organisms are studied using neutral genetic variation.

This package provides a comprehensive range of facilities to perform umbrella reviews with stratification of the evidence in R. The package accomplishes this aim by building on three core functions that: (i) automatically perform all required calculations in an umbrella review (including but not limited to meta-analyses), (ii) stratify evidence according to various classification criteria, and (iii) generate a visual representation of the results. Note that if you are not familiar with R, the core features of this package are available from a web browser (<https://www.metaumbrella.org/>).