This package provides a set of Study Data Tabulation Model (SDTM) datasets from the Clinical Data Interchange Standards Consortium (CDISC) pilot project used for testing and developing Analysis Data Model (ADaM) datasets inside the pharmaverse family of packages. SDTM dataset specifications are described in the CDISC SDTM implementation guide, accessible by creating a free account on <https://www.cdisc.org/>.

Function to read PX-Web data into R via API. The example code reads data from the three national statistical institutes, Statistics Norway, Statistics Sweden and Statistics Finland.

Considering the singly imputed synthetic data generated via plug-in sampling under the multivariate normal model, draws inference procedures including the generalized variance, the sphericity test, the test for independence between two subsets of variables, and the test for the regression of one set of variables on the other. For more details see Klein et al. (2021) <doi:10.1007/s13571-019-00215-9>.

An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as Monolix', NONMEM', and nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with Monolix', pmxNODE interfaces with MonolixSuite via the lixoftConnectors package. The lixoftConnectors package is distributed with MonolixSuite (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.

Particle swarm optimization - a basic variant.

Compute standard Non-Compartmental Analysis (NCA) parameters for typical pharmacokinetic analyses and summarize them.

Data files and documentation for PEDiatric vALidation oF vAriableS in TBI (PEDALFAST). The data was used in "Functional Status Scale in Children With Traumatic Brain Injury: A Prospective Cohort Study" by Bennett, Dixon, et al (2016) <doi:10.1097/PCC.0000000000000934>.

This package provides data set and function for exploration of Multiple Indicator Cluster Survey (MICS) 2014 Household questionnaire data for Punjab, Pakistan (<http://www.mics.unicef.org/surveys>).

This package provides tools to interact with the Pangaea Database (<https://www.pangaea.de>), including functions for searching for data, fetching datasets by dataset ID', and working with the Pangaea OAI-PMH service.

This package provides functions for the construction of Petri Nets. Petri Nets can be replayed by firing enabled transitions. Silent transitions will be hidden by the execution handler. Also includes functionalities for the visualization of Petri Nets and export of Petri Nets to PNML (Petri Net Markup Language) files.

Receiver Operating Characteristic (ROC) analysis is performed assuming samples are from the Power Lindley distribution. Specificity, sensitivity, area under the curve and ROC curve are provided.

This package provides a dataset of Pokemon information in both English and Brazilian Portuguese. The dataset contains 949 rows and 22 columns, including information such as the Pokemon's name, ID, height, weight, stats, type, and more.

Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).

Extracts features from amplification curve data of quantitative Polymerase Chain Reactions (qPCR) according to Pabinger et al. 2014 <doi:10.1016/j.bdq.2014.08.002> for machine learning purposes. Helper functions prepare the amplification curve data for processing as functional data (e.g., Hausdorff distance) or enable the plotting of amplification curve classes (negative, ambiguous, positive). The hookreg() and hookregNL() functions of Burdukiewicz et al. (2018) <doi:10.1016/j.bdq.2018.08.001> can be used to predict amplification curves with an hook effect-like curvature. The pcrfit_single() function can be used to extract features from an amplification curve.

Bayesian dynamic borrowing is an approach to incorporating external data to supplement a randomized, controlled trial analysis in which external data are incorporated in a dynamic way (e.g., based on similarity of outcomes); see Viele 2013 <doi:10.1002/pst.1589> for an overview. This package implements the hierarchical commensurate prior approach to dynamic borrowing as described in Hobbes 2011 <doi:10.1111/j.1541-0420.2011.01564.x>. There are three main functionalities. First, psborrow2 provides a user-friendly interface for applying dynamic borrowing on the study results handles the Markov Chain Monte Carlo sampling on behalf of the user. Second, psborrow2 provides a simulation framework to compare different borrowing parameters (e.g. full borrowing, no borrowing, dynamic borrowing) and other trial and borrowing characteristics (e.g. sample size, covariates) in a unified way. Third, psborrow2 provides a set of functions to generate data for simulation studies, and also allows the user to specify their own data generation process. This package is designed to use the sampling functions from cmdstanr which can be installed from <https://stan-dev.r-universe.dev>.

This package implements projection pursuit forest algorithm for supervised classification.

The Penn World Table 8.x provides information on relative levels of income, output, inputs, and productivity for 167 countries between 1950 and 2011.

Simulates pooled sequencing data under a variety of conditions. Also allows for the evaluation of the average absolute difference between allele frequencies computed from genotypes and those computed from pooled data. Carvalho et al., (2022) <doi:10.1101/2023.01.20.524733>.

Inference and visualize gene regulatory network based on single-cell RNA sequencing pseudo-time information.

Eco-phylogenetic and community phylogenetic analyses. Keeps community ecological and phylogenetic data matched up and comparable using comparative.comm objects. Wrappers for common community phylogenetic indices ('pez.shape', pez.evenness', pez.dispersion', and pez.dissimilarity metrics). Implementation of Cavender-Bares (2004) correlation of phylogenetic and ecological matrices ('fingerprint.regression'). Phylogenetic Generalised Linear Mixed Models (PGLMMs; pglmm') following Ives & Helmus (2011) and Rafferty & Ives (2013). Simulation of null assemblages, traits, and phylogenies ('scape', sim.meta.comm').

Functional claims reserving methods based on aggregated chain-ladder data, also known as a run-off triangle, implemented in three nonparametric algorithms (PARALLAX, REACT, and MACRAME) proposed in Maciak, Mizera, and Pešta (2022) <doi:10.1017/asb.2022.4>. Additional methods including permutation bootstrap for completed run-off triangles are also provided.

Inspects provenance collected by the rdt or rdtLite packages, or other tools providing compatible PROV JSON output created by the execution of a script, and find differences between two provenance collections. Factors under examination included the hardware and software used to execute the script, versions of attached libraries, use of global variables, modified inputs and outputs, and changes in main and sourced scripts. Based on detected changes, provExplainR can be used to study how these factors affect the behavior of the script and generate a promising diagnosis of the causes of different script results. More information about rdtLite and associated tools is available at <https://github.com/End-to-end-provenance/> and Barbara Lerner, Emery Boose, and Luis Perez (2018), Using Introspection to Collect Provenance in R, Informatics, <doi:10.3390/informatics5010012>.

The calculation of p-variation of the finite sample data. This package is a realisation of the procedure described in Butkus, V. & Norvaisa, R. Lith Math J (2018). <doi: 10.1007/s10986-018-9414-3> The formal definitions and reference into literature are given in vignette.

Uses provenance collected by rdtLite package or comparable tool to display information about input files, output files, and exchanged files for a single R script or a series of R scripts.