This package implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Sample size calculations in causal inference with observational data are increasingly desired. This package is a tool to calculate sample size under prespecified power with minimal summary quantities needed.

Set of functions that implement the PoDBAY method, described in the publication A method to estimate probability of disease and vaccine efficacy from clinical trial immunogenicity data by Julie Dudasova, Regina Laube, Chandni Valiathan, Matthew C. Wiener, Ferdous Gheyas, Pavel Fiser, Justina Ivanauskaite, Frank Liu and Jeffrey R. Sachs (NPJ Vaccines, 2021), <doi:10.1038/s41541-021-00377-6>.

This package provides tools to show and draw image pixels using HTML widgets and Shiny applications. It can be used to visualize the MNIST dataset for handwritten digit recognition or to create new image recognition datasets.

This package provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.

R package to query and get data out of a Pumilio sound archive system (http://ljvillanueva.github.io/pumilio/).

This provides utilities for creating classed error and warning conditions based on where the error originated.

Kernel density estimation with global bandwidth selection via "plug-in".

Load the Just Another Gibbs Sampling (JAGS) module pexm'. The module provides the tools to work with the Piecewise Exponential (PE) distribution in a Bayesian model with the corresponding Markov Chain Monte Carlo algorithm (Gibbs Sampling) implemented via JAGS. Details about the module implementation can be found in Mayrink et al. (2021) <doi:10.18637/jss.v100.i08>.

For a data matrix with m rows and n columns (m>=n), the power method is used to compute, simultaneously, the eigendecomposition of a square symmetric matrix. This result is used to obtain the singular value decomposition (SVD) and the principal component analysis (PCA) results. Compared to the classical SVD method, the first r singular values can be computed.

The function pointdensity returns a density count and the temporal average for every point in the original list. The dataframe returned includes four columns: lat, lon, count, and date_avg. The "lat" column is the original latitude data; the "lon" column is the original longitude data; the "count" is the density count of the number of points within a radius of radius*grid_size (the neighborhood); and the date_avg column includes the average date of each point in the neighborhood.

Read and write GraphPad Prism .pzfx files in R.

An implementation of prediction intervals for overdispersed count data, for overdispersed binomial data and for linear random effects models.

This is an implementation of model-based trees with global model parameters (PALM trees). The PALM tree algorithm is an extension to the MOB algorithm (implemented in the partykit package), where some parameters are fixed across all groups. Details about the method can be found in Seibold, Hothorn, Zeileis (2016) <arXiv:1612.07498>. The package offers coef(), logLik(), plot(), and predict() functions for PALM trees.

Automatic estimation of number of principal components in PCA with PEnalized SEmi-integrated Likelihood (PESEL). See Piotr Sobczyk, Malgorzata Bogdan, Julie Josse "Bayesian dimensionality reduction with PCA using penalized semi-integrated likelihood" (2017) <doi:10.1080/10618600.2017.1340302>.

This package provides functions to prepare rankings data and fit the Plackett-Luce model jointly attributed to Plackett (1975) <doi:10.2307/2346567> and Luce (1959, ISBN:0486441369). The standard Plackett-Luce model is generalized to accommodate ties of any order in the ranking. Partial rankings, in which only a subset of items are ranked in each ranking, are also accommodated in the implementation. Disconnected/weakly connected networks implied by the rankings may be handled by adding pseudo-rankings with a hypothetical item. Optionally, a multivariate normal prior may be set on the log-worth parameters and ranker reliabilities may be incorporated as proposed by Raman and Joachims (2014) <doi:10.1145/2623330.2623654>. Maximum a posteriori estimation is used when priors are set. Methods are provided to estimate standard errors or quasi-standard errors for inference as well as to fit Plackett-Luce trees. See the package website or vignette for further details.

Shiny app to interactively visualize hierarchical clustering with prototypes. For details on hierarchical clustering with prototypes, see Bien and Tibshirani (2011) <doi:10.1198/jasa.2011.tm10183>. This package currently launches the application.

The algorithm combines the most predictive variable, such as count of the main International Classification of Diseases (ICD) codes, and other Electronic Health Record (EHR) features (e.g. health utilization and processed clinical note data), to obtain a score for accurate risk prediction and disease classification. In particular, it normalizes the surrogate to resemble gaussian mixture and leverages the remaining features through random corruption denoising. Background and details about the method can be found at Yu et al. (2018) <doi:10.1093/jamia/ocx111>.

Makes it easy to build panel data in wide format from Panel Survey of Income Dynamics (PSID) delivered raw data. Downloads data directly from the PSID server using the SAScii package. psidR takes care of merging data from each wave onto a cross-period index file, so that individuals can be followed over time. The user must specify which years they are interested in, and the PSID variable names (e.g. ER21003) for each year (they differ in each year). The package offers helper functions to retrieve variable names from different waves. There are different panel data designs and sample subsetting criteria implemented ("SRC", "SEO", "immigrant" and "latino" samples). More information about the PSID can be obtained at <https://simba.isr.umich.edu/data/data.aspx>.

Deterministic Pena-Yohai initial estimator for robust S estimators of regression. The procedure is described in detail in Pena, D., & Yohai, V. (1999) <doi:10.2307/2670164>.

Consider a linear predictive regression setting with a potentially large set of candidate predictors. This work is concerned with detecting the presence of out of sample predictability based on out of sample mean squared error comparisons given in Gonzalo and Pitarakis (2023) <doi:10.1016/j.ijforecast.2023.10.005>.

Estimates power, minimum detectable effect size (MDES) and sample size requirements. The context is multilevel randomized experiments with multiple outcomes. The estimation takes into account the use of multiple testing procedures. Development of this package was supported by a grant from the Institute of Education Sciences (R305D170030). For a full package description, including a detailed technical appendix, see <doi:10.18637/jss.v108.i06>.

Perform sample size, power calculation and subsequent analysis for Immuno-oncology (IO) trials composed of responders and non-responders.

Carrying out inferences about any linear combination of proportions and the ratio of two proportions.