This package provides a minimal, light-weight set of tools for producing nice looking maps in R, with support for map projections. See Brown (2016) <doi:10.32614/RJ-2016-005>.

We provide detailed functions for univariate Mixed Tempered Stable distribution.

This package provides methods for detecting signals related to (adverse event, medical product e.g. drugs, vaccines) pairs, a data generation function for simulating pharmacovigilance datasets, and various utility functions. For more details please see Liu A., Mukhopadhyay R., and Markatou M. <doi:10.48550/arXiv.2410.01168>.

To perform main effect matrix factor model (MEFM) estimation for a given matrix time series as described in Lam and Cen (2024) <doi:10.48550/arXiv.2406.00128>. Estimation of traditional matrix factor models is also supported. Supplementary functions for testing MEFM over factor models are included.

Quantify exposure-outcome causal effects with adjustment for multiple biases. The functions can simultaneously adjust for any combination of uncontrolled confounding, exposure/outcome misclassification, and selection bias. The underlying method generalizes the combination of inverse probability of selection weighting with predictive value weighting. Simultaneous multi-bias analysis can be used to enhance the validity and transparency of real-world evidence obtained from observational, longitudinal studies. Based on the work from Paul Brendel, Aracelis Torres, and Onyebuchi Arah (2023) <doi:10.1093/ije/dyad001>.

This package provides a variety of functions useful for data analysis, selection, manipulation, and graphics.

This package provides tools for likelihood-based inference in one-dimensional stochastic differential equations with mixed effects using expectationâ maximization (EM) algorithms. The package supports Wiener and Ornsteinâ Uhlenbeck diffusion processes with user-specified drift functions, allowing flexible parametric forms including polynomial, exponential, and trigonometric structures. Estimation is performed via Markov chain Monte Carlo EM.

Concise and interpretable summaries for machine learning models and learners of the mlr3 ecosystem. The package takes inspiration from the summary function for (generalized) linear models but extends it to non-parametric machine learning models, based on generalization performance, model complexity, feature importances and effects, and fairness metrics.

In the omics data association studies, it is common to conduct the p-value corrections to control the false significance. Beyond the P-value corrections, E-value is recently studied to facilitate multiple testing correction based on V. Vovk and R. Wang (2021) <doi:10.1214/20-AOS2020>. This package provides E-value calculation for DNA methylation data and RNA-seq data. Currently, five data formats are supported: DNA methylation levels using DMR detection tools (BiSeq, DMRfinder, MethylKit, Metilene and other DNA methylation tools) and RNA-seq data. The relevant references are listed below: Katja Hebestreit and Hans-Ulrich Klein (2022) <doi:10.18129/B9.bioc.BiSeq>; Altuna Akalin et.al (2012) <doi:10.18129/B9.bioc.methylKit>.

This package provides a novel framework to estimate mixed models via gradient boosting. The implemented functions are based on the mboost and lme4 packages, and the family range is therefore determined by lme4'. A correction mechanism for cluster-constant covariates is implemented, as well as estimation of the covariance of random effects. These methods are described in the accompanying publication; see <doi:10.1007/s11222-025-10612-y> for details.

Regression methods for the meta-SDT model. The package implements methods for cognitive experiments of metacognition as described in Kristensen, S. B., Sandberg, K., & Bibby, B. M. (2020). Regression methods for metacognitive sensitivity. Journal of Mathematical Psychology, 94. <doi:10.1016/j.jmp.2019.102297>.

You can use the set of wrappers for analytical schemata to reduce the effort in writing machine-readable data. The set of all-in-one wrappers will cover widely used functions from data analysis packages.

Multidimensional projection techniques are used to create two dimensional representations of multidimensional data sets.

This package provides a higher-level interface to continuous-time Markov multi-state models for panel (interval-censored) data. Seven canonical clinical process structures are supplied with structurally valid generator matrices, so that transition matrices and starting values need not be constructed by hand. Panel data can be simulated from exact trajectories under regular or irregular observation schedules, with optional exactly observed absorption times and optional Weibull holding times for assessing the Markov assumption. A single fitting call validates the input against the assumed structure and returns the estimated generator with confidence intervals, mean sojourn times, transition probability matrices and observed transition counts, together with the optimiser's convergence code. A Monte Carlo driver reports Monte Carlo standard errors alongside bias, root mean squared error and interval coverage. Likelihood evaluation is delegated to msm (Jackson, 2011, <doi:10.18637/jss.v038.i08>); the panel-data likelihood is that of Kalbfleisch and Lawless (1985) <doi:10.1080/01621459.1985.10478195>.

This package provides functions of marginal mean and quantile regression models are used to analyze environmental exposure and biomonitoring data with repeated measurements and non-detects (i.e., values below the limit of detection (LOD)), as well as longitudinal exposure data that include non-detects and time-dependent covariates. For more details see Chen IC, Bertke SJ, Curwin BD (2021) <doi:10.1038/s41370-021-00345-1>, Chen IC, Bertke SJ, Estill CF (2024) <doi:10.1038/s41370-024-00640-7>, Chen IC, Bertke SJ, Dahm MM (2024) <doi:10.1093/annweh/wxae068>, and Chen IC (2025) <doi:10.1038/s41370-025-00752-8>.

This package implements methods for multiple canonical correlation analysis (CCA) for more than two data blocks, with a focus on multivariate repeated measures and functional data. The package provides two approaches: (i) multiple kernel CCA, which embeds each data block into a reproducing kernel Hilbert space to capture nonlinear dependencies, and (ii) multiple functional CCA, which represents repeated measurements as smooth functions and performs analysis in a Hilbert space framework. Both approaches are formulated via covariance operators and solved as generalized eigenvalue problems with regularization to ensure numerical stability. The methods allow estimation of canonical variables, generalized canonical correlations, and low-dimensional representations for exploratory analysis and visualization of dependence structures across multiple feature sets. The implementation follows the framework developed in Górecki, KrzyÅ ko, Gnettner and Kokoszka (2025) <doi:10.48550/arXiv.2510.04457>.

This package provides functions to access drug regulatory data from public RESTful APIs including the FDA Open API and the Health Canada Drug Product Database API', retrieving real-time or historical information on drug approvals, adverse events, recalls, and product details. Additionally, the package includes a curated collection of open datasets focused on drugs, pharmaceuticals, treatments, and clinical studies. These datasets cover diverse topics such as treatment dosages, pharmacological studies, placebo effects, drug reactions, misuses of pain relievers, and vaccine effectiveness. The package supports reproducible research and teaching in pharmacology, medicine, and healthcare by integrating reliable international APIs and structured datasets from public, academic, and government sources. For more information on the APIs, see: FDA API <https://open.fda.gov/apis/> and Health Canada API <https://health-products.canada.ca/api/documentation/dpd-documentation-en.html>.

This package provides a framework for multiple imputation for proteomics is proposed by Marie Chion, Christine Carapito and Frederic Bertrand (2021) <doi:10.1371/journal.pcbi.1010420>. It is dedicated to dealing with multiple imputation for proteomics.

This package contains functions for performing Mokken scale analysis on test and questionnaire data. It includes an automated item selection algorithm, and various checks of model assumptions.

This package provides a suite of mixed-integer linear programming (MILP) model builders and solversâ including Gurobi', HiGHS', Symphony', GNU Linear Programming Kit (GLPK)', and lpSolve'â for automated test assembly (ATA) in multistage testing (MST). Offers filtering of decision variables through itemâ module eligibility and the application of explicit bounds to simplify the MILP model and accelerate the optimization process. Supports bottom up, top down, and hybrid assembly strategies; enemy-item and enemy-stimulus exclusions; stimulus all in/all out or partial selection; anchor item/stimulus specification; and item exposure control. Accommodates both single-objective and multi-objective optimization ('weighted sum', maximin', capped maximin', minimax', and goal programming'). Enables simultaneous assembly of multiple panels with item and stimulus content balancing and exposure control. Provides analytical evaluation of assembled MST performance within seconds. Includes tools for diagnosing infeasible optimization models by systematically identifying sources of infeasibility and reformulating models with slack variables to restore feasibility.Methods implemented in this package build on established work in optimal test assembly (van der Linden, 2005 <doi:10.1007/0-387-29054-0>), item-set constrained test assembly (van der Linden, 2000 <doi:10.1177/01466210022031697>), hybrid assembly (Xiong, 2018 <doi:10.1177/0146621618762739>), recursion-based analytic methods (Lim et al., 2021 <doi:10.1111/jedm.12276>), and classification evaluation (Rudner, 2000 <doi:10.7275/an9m-2035>; Rudner, 2005 <doi:10.7275/56a5-6b14>).

This package implements Multi-Group Sparse Discriminant Analysis proposal of I.Gaynanova, J.Booth and M.Wells (2016), Simultaneous sparse estimation of canonical vectors in the p>>N setting, JASA <doi:10.1080/01621459.2015.1034318>.

Supply functions for the creation and handling of missing data as well as tools to evaluate missing data methods. Nearly all possibilities of generating missing data discussed by Santos et al. (2019) <doi:10.1109/ACCESS.2019.2891360> and some additional are implemented. Functions are supplied to compare parameter estimates and imputed values to true values to evaluate missing data methods. Evaluations of these types are done, for example, by Cetin-Berber et al. (2019) <doi:10.1177/0013164418805532> and Kim et al. (2005) <doi:10.1093/bioinformatics/bth499>.

This package provides a number of functions to facilitate the handling and production of reports using time series data. The package was developed to be understandable for beginners, so some functions aim to transform processes that would be complex into functions with a few lines. The main advantage of using the metools package is the ease of producing reports and working with time series using a few lines of code, so the code is clean and easy to understand/maintain. Learn more about the metools at <https://metoolsr.wordpress.com>.

It contains six common multi-category classification accuracy evaluation measures. All of these measures could be found in Li and Ming (2019) <doi:10.1002/sim.8103>. Specifically, Hypervolume Under Manifold (HUM), described in Li and Fine (2008) <doi:10.1093/biostatistics/kxm050>. Correct Classification Percentage (CCP), Integrated Discrimination Improvement (IDI), Net Reclassification Improvement (NRI), R-Squared Value (RSQ), described in Li, Jiang and Fine (2013) <doi:10.1093/biostatistics/kxs047>. Polytomous Discrimination Index (PDI), described in Van Calster et al. (2012) <doi:10.1007/s10654-012-9733-3>. Li et al. (2018) <doi:10.1177/0962280217692830>. PDI with variance estimation using Dover et al. (2021) <doi:10.1002/sim.9187>. We described all these above measures and our mcca package in Li, Gao and D'Agostino (2019) <doi:10.1002/sim.8103>.