Interactions between different biological entities are crucial for the function of biological systems. In such networks, nodes represent biological elements, such as genes, proteins and microbes, and their interactions can be defined by edges, which can be either binary or weighted. The dysregulation of these networks can be associated with different clinical conditions such as diseases and response to treatments. However, such variations often occur locally and do not concern the whole network. To capture local variations of such networks, we propose multiplex network differential analysis (MNDA). MNDA allows to quantify the variations in the local neighborhood of each node (e.g. gene) between the two given clinical states, and to test for statistical significance of such variation. Yousefi et al. (2023) <doi:10.1101/2023.01.22.525058>.

Allows the user to convert PDF tables to formats more amenable to analysis ('.csv', .xml', or .xlsx') by wrapping the PDFTables API. In order to use the package, the user needs to sign up for an API account on the PDFTables website (<https://pdftables.com/pdf-to-excel-api>). The package works by taking a PDF file as input, uploading it to PDFTables, and returning a file with the extracted data.

This package provides a set of tools to implement the non-parametric bounds and Bayesian methods for assessing post-treatment bias developed in Blackwell, Brown, Hill, Imai, and Yamamoto (2025) <doi:10.1017/pan.2025.3>.

Tailoring the optimal biomarker(s) for disease screening or diagnosis based on subjects individual characteristics.

Support functions, data sets, and vignettes for the psych package. Contains several of the biggest data sets for the psych package as well as four vignettes. A few helper functions for file manipulation are included as well. For more information, see the <https://personality-project.org/r/> web page.

This package implements the primePCA algorithm, developed and analysed in Zhu, Z., Wang, T. and Samworth, R. J. (2019) High-dimensional principal component analysis with heterogeneous missingness. <arXiv:1906.12125>.

Allows users to find a piecewise linear regression approximation to a given continuous univariate function within a specified error tolerance. Methods based on Warwicker and Rebennack (2025) "Efficient continuous piecewise linear regression for linearising univariate non-linear functions" <doi:10.1080/24725854.2023.2299809>.

Parallelized version of the "segment" function from Bioconductor package "DNAcopy", utilizing multi-core computation on host CPU.

Calculates the pooled mean group (PMG) estimator for dynamic panel data models, as described by Pesaran, Shin and Smith (1999) <doi:10.1080/01621459.1999.10474156>.

This package provides profile likelihoods for a parameter of interest in commonly used statistical models. The models include linear models, generalized linear models, proportional odds models, linear mixed-effects models, and linear models for longitudinal responses fitted by generalized least squares. The package also provides plots for normalized profile likelihoods as well as the maximum profile likelihood estimates and the kth likelihood support intervals.

This package provides a Shiny application for calculating phytosanitary inspection plans based on risks. It generates a diagram of pallets in a lot, highlights the units to be sampled, and documents them based on the selected sampling method (simple random or systematic sampling).

Perform sample size, power calculation and subsequent analysis for Immuno-oncology (IO) trials composed of responders and non-responders.

Using Electronic Health Record (EHR) is difficult because most of the time the true characteristic of the patient is not available. Instead we can retrieve the International Classification of Disease code related to the disease of interest or we can count the occurrence of the Unified Medical Language System. None of them is the true phenotype which needs chart review to identify. However chart review is time consuming and costly. PheVis is an algorithm which is phenotyping (i.e identify a characteristic) at the visit level in an unsupervised fashion. It can be used for chronic or acute diseases. An example of how to use PheVis is available in the vignette. Basically there are two functions that are to be used: `train_phevis()` which trains the algorithm and `test_phevis()` which get the predicted probabilities. The detailed method is described in preprint by Ferté et al. (2020) <doi:10.1101/2020.06.15.20131458>.

This package implements Procrustes cross-validation method for Principal Component Analysis, Principal Component Regression and Partial Least Squares regression models. S. Kucheryavskiy (2023) <doi:10.1016/j.aca.2023.341096>.

This package provides functions and example data to teach and increase the reproducibility of the methods and code underlying the Propensity to Cycle Tool (PCT), a research project and web application hosted at <https://www.pct.bike/>. For an academic paper on the methods, see Lovelace et al (2017) <doi:10.5198/jtlu.2016.862>.

This package provides functions which can be used to support the Multicriteria Decision Analysis (MCDA) process involving multiple criteria, by PROMETHEE (Preference Ranking Organization METHod for Enrichment of Evaluations).

Estimate complex Structural Equation Models (SEMs) by fitting Partial Least Squares Structural Equation Modeling (PLS-SEM) and Partial Least Squares consistent Structural Equation Modeling (PLSc-SEM) specifications that handle categorical data, non-linear relations, and multilevel structures. The implementation follows Lohmöller (1989) for the classic PLS-SEM algorithm, Dijkstra and Henseler (2015) for consistent PLSc-SEM, Dijkstra et al., (2014) for nonlinear PLSc-SEM, and Schuberth, Henseler, Dijkstra (2018) for ordinal PLS-SEM and PLSc-SEM. Additional extensions are under development. The MC-OrdPLSc algorithm, used to handle ordinal interaction models is detailed in Slupphaug et al., (2026). References: Lohmöller, J.-B. (1989, ISBN:9783790803002). "Latent Variable Path Modeling with Partial Least Squares." Dijkstra, T. K., & Henseler, J. (2015). <doi:10.1016/j.jmva.2015.06.002>. "Consistent partial least squares path modeling." Dijkstra, T. K., & Schermelleh-Engel, K. (2014). <doi:10.1016/j.csda.2014.07.008>. "Consistent partial least squares for nonlinear structural equation models." Schuberth, F., Henseler, J., & Dijkstra, T. K. (2018). <doi:10.1007/s11135-018-0767-9>. "Partial least squares path modeling using ordinal categorical indicators." Slupphaug, K. Mehmetoglu, M. & Mittner, M. (2026). <doi:10.31234/osf.io/fwzj6_v1>. "Consistent Estimates from Biased Estimators: Monte-Carlo Consistent Partial Least Squares for Latent Interaction Models with Ordinal Indicators.".

This package provides a set of functions to efficiently recognize and clean the continuous dorsal pattern of a female brown anole lizard (Anolis sagrei) traced from ImageJ', an open platform for scientific image analysis (see <https://imagej.net> for more information), and extract common features such as the pattern sinuosity indices, coefficient of variation, and max-min width.

Colour palettes for data, based on some well known public data sets. Includes helper functions to map absolute values to known palettes, and capture the work of image colour mapping as raster data sets.

This package provides functions to simulate point prevalence studies (PPSs) of healthcare-associated infections (HAIs) and to convert prevalence to incidence in steady state setups. Companion package to the preprint Willrich et al., From prevalence to incidence - a new approach in the hospital setting; <doi:10.1101/554725> , where methods are explained in detail.

This tool computes the probability of detection (POD) curve and the limit of detection (LOD), i.e. the number of copies of the target DNA sequence required to ensure a 95 % probability of detection (LOD95). Other quantiles of the LOD can be specified. This is a reimplementation of the mathematical-statistical modelling of the validation of qualitative polymerase chain reaction (PCR) methods within a single laboratory as provided by the commercial tool PROLab <http://quodata.de/>. The modelling itself has been described by Uhlig et al. (2015) <doi:10.1007/s00769-015-1112-9>.

Given a project schedule and associated costs, this package calculates the earned value to date. It is an implementation of Project Management Body of Knowledge (PMBOK) methodologies (reference Project Management Institute. (2021). A guide to the Project Management Body of Knowledge (PMBOK guide) (7th ed.). Project Management Institute, Newtown Square, PA, ISBN 9781628256673 (pdf)).

Runs generalized and multinominal logistic (GLM and MLM) models, as well as random forest (RF), Bagging (BAG), and Boosting (BOOST). This package prints out to predictive outcomes easy for the selected data and data splits.

Supports analysis of aerobiological data. Available features include determination of pollen season limits, replacement of outliers (Kasprzyk and Walanus (2014) <doi:10.1007/s10453-014-9332-8>), calculation of growing degree days (Baskerville and Emin (1969) <doi:10.2307/1933912>), and determination of the base temperature for growing degree days (Yang et al. (1995) <doi:10.1016/0168-1923(94)02185-M).