Framework for the Item Response Theory analysis of dichotomous and ordinal polytomous outcomes under the assumption of within-item multidimensionality and discreteness of the latent traits. The fitting algorithms allow for missing responses and for different item parametrizations and are based on the Expectation-Maximization paradigm. Individual covariates affecting the class weights may be included in the new version together with possibility of constraints on all model parameters.

Adaptive smoothing functions for estimating the blood oxygenation level dependent (BOLD) effect by using functional Magnetic Resonance Imaging (fMRI) data, based on adaptive Gauss Markov random fields, for real as well as simulated data. The implemented models make use of efficient Markov Chain Monte Carlo methods. Implemented methods are based on the research developed by A. Brezger, L. Fahrmeir, A. Hennerfeind (2007) <https://www.jstor.org/stable/4626770>.

An interface to Azure CosmosDB': <https://azure.microsoft.com/en-us/services/cosmos-db/>. On the admin side, AzureCosmosR provides functionality to create and manage Cosmos DB instances in Microsoft's Azure cloud. On the client side, it provides an interface to the Cosmos DB SQL API, letting the user store and query documents and attachments in Cosmos DB'. Part of the AzureR family of packages.

Formalizes spatial support at scale for ecological and geographical analysis. Given points and support polygons, classifies points as "core" (inside original support) or "halo" (inside scaled support but outside original), pruning all others. The default scale produces equal core and halo areas - a geometrically derived choice requiring no tuning. An optional mask enforces hard boundaries such as coastlines. Political borders are treated as soft boundaries with no ecological meaning.

Cancer RADAR is a project which aim is to develop an infrastructure that allows quantifying the risk of cancer by migration background across Europe. This package contains a set of functions cancer registries partners should use to reshape 5 year-age group cancer incidence data into a set of summary statistics (see Boyle & Parkin (1991, ISBN:978-92-832-1195-2)) in lines with Cancer RADAR data protections rules.

Graphically display the (causal) effect of a continuous variable on a time-to-event outcome using multiple different types of plots based on g-computation. Those functions include, among others, survival area plots, survival contour plots, survival quantile plots and 3D surface plots. Due to the use of g-computation, all plot allow confounder-adjustment naturally. For details, see Robin Denz, Nina Timmesfeld (2023) <doi:10.1097/EDE.0000000000001630>.

Compare C-statistics (concordance statistics) between two survival models, using either bootstrap resampling (Harrell's C) or Uno's C with perturbation-resampling (from the survC1 package). Returns confidence intervals and a p-value for the difference in C-statistics. Useful for evaluating and comparing predictive performance of survival models. Methods implemented for Uno's C are described in Uno et al. (2011) <doi:10.1002/sim.4154>.

This package provides a function toolkit to facilitate reproducible RNA-Seq Differential Gene Expression (DGE) analysis (Law (2015) <doi:10.12688/f1000research.9005.3>). The tools include both analysis work-flow and utility functions: mapping/unit conversion, count normalization, accounting for unknown covariates, and more. This is a complement/cohort to the DGEobj package that provides a flexible container to manage and annotate Differential Gene Expression analysis results.

This package provides access to low-level operating system mechanisms for performing atomic operations on shared data structures. Mutexes provide shared and exclusive locks. Semaphores act as counters. Message queues move text strings from one process to another. All these interprocess communication (IPC) tools can optionally block with or without a timeout. Implemented using the cross-platform boost C++ library <https://www.boost.org/doc/libs/release/libs/interprocess/>.

Rcpp implementation of the multivariate Kalman filter for state space models that can handle missing values and exogenous data in the observation and state equations. There is also a function to handle time varying parameters. Kim, Chang-Jin and Charles R. Nelson (1999) "State-Space Models with Regime Switching: Classical and Gibbs-Sampling Approaches with Applications" <doi:10.7551/mitpress/6444.001.0001><http://econ.korea.ac.kr/~cjkim/>.

This package provides a unified set of helper functions to access datasets from the New Orleans Open Data platform <https://data.nola.gov/>. Functions return results as tidy tibbles and support optional filtering, sorting, and row limits via the Socrata API. The package provides a consistent interface for discovering and downloading datasets from the San Francisco Open Data Portal using human-readable dataset keys or official Socrata dataset identifiers.

Obtain information on peak flow data from the National River Flow Archive (NRFA) in the United Kingdom, either from the Peak Flow Dataset files <https://nrfa.ceh.ac.uk/data/peak-flow-dataset> once these have been downloaded to the user's computer or using the NRFA's API. These files are in a format suitable for direct use in the WINFAP software, hence the name of the package.

This package provides a mutation analysis tool that discovers cancer driver genes with frequent mutations in protein signalling sites such as post-translational modifications (phosphorylation, ubiquitination, etc). The Poisson generalized linear regression model identifies genes where cancer mutations in signalling sites are more frequent than expected from the sequence of the entire gene. Integration of mutations with signalling information helps find new driver genes and propose candidate mechanisms to known drivers.

Racket is a general-purpose programming language in the Scheme family, with a large set of libraries and a compiler based on Chez Scheme. Racket is also a platform for language-oriented programming, from small domain-specific languages to complete language implementations.

The ``minimal Racket'' distribution includes just enough of Racket for you to use raco pkg to install more. Bundled packages, such as the DrRacket IDE, are not included.

Calculates the optimal price of assets (such as airline flight seats, hotel room bookings) whose value becomes zero after a fixed ``expiry date''. Assumes potential customers arrive (possibly in groups) according to a known inhomogeneous Poisson process. Also assumes a known time-varying elasticity of demand (price sensitivity) function. Uses elementary techniques based on ordinary differential equations. Uses the package deSolve to effect the solution of these differential equations.

This package provides a runtime for the Tree-sitter parsing library <https://tree-sitter.github.io/tree-sitter/> that mirrors the API of the treesitter package, so it can serve as a drop-in replacement. Parses source code into concrete syntax trees and updates them incrementally as the source changes. Grammars are supplied by separate packages such as treesitter.r', so the runtime itself depends on nothing beyond base R.

Colour vision models, colour spaces and colour thresholds. Provides flexibility to build user-defined colour vision models for n number of photoreceptor types. Includes Vorobyev & Osorio (1998) Receptor Noise Limited models <doi:10.1098/rspb.1998.0302>, Chittka (1992) colour hexagon <doi:10.1007/BF00199331>, and Endler & Mielke (2005) model <doi:10.1111/j.1095-8312.2005.00540.x>. Models have been extended to accept any number of photoreceptor types.

Base DataSHIELD functions for the client side. DataSHIELD is a software package which allows you to do non-disclosive federated analysis on sensitive data. DataSHIELD analytic functions have been designed to only share non disclosive summary statistics, with built in automated output checking based on statistical disclosure control. With data sites setting the threshold values for the automated output checks. For more details, see citation('dsBaseClient').

Estimation, model selection and goodness-of-fit of (1) factor copula models for mixed continuous and discrete data in Kadhem and Nikoloulopoulos (2021) <doi:10.1111/bmsp.12231>; (2) bi-factor and second-order copula models for item response data in Kadhem and Nikoloulopoulos (2023) <doi:10.1007/s11336-022-09894-2>; (3) factor tree copula models for item response data in Kadhem and Nikoloulopoulos (2022) <arXiv:2201.00339>.

Hybrid Markov chain Monte Carlo (MCMC) for sampling from multimodal target distributions when derivatives are unavailable. A Gaussian process approximation is used to emulate derivatives, enabling efficient exploration with parallel tempering. The method is described in Fielding, Nott and Liong (2011) <doi:10.1198/TECH.2010.09195>. The research was carried out as part of the Singapore-Delft Water Alliance Multi-Objective Multi-Reservoir Management programme (R-264-001-272).

Manage optional data for your package. The data can be hosted anywhere, and you have to give a Uniform Resource Locator (URL) for each file. File integrity checks are supported. This is useful for package authors who need to ship more than the 5 Megabyte of data currently allowed by the the Comprehensive R Archive Network (CRAN). Download functions are supposed to be called by users in interactive sessions only.

This started out as a package for file and string manipulation. Since then, the fs and strex packages emerged, offering functionality previously given by this package. Those packages have hence almost pushed filesstrings into extinction. However, it still has a small number of unique, handy file manipulation functions which can be seen in the vignette. One example is a function to remove spaces from all file names in a directory.

The package includes some statistical outlier detection methods for epimutations detection in DNA methylation data. The methods included in the package are MANOVA, Multivariate linear models, isolation forest, robust mahalanobis distance, quantile and beta. The methods compare a case sample with a suspected disease against a reference panel (composed of healthy individuals) to identify epimutations in the given case sample. It also contains functions to annotate and visualize the identified epimutations.

scBubbletree is a quantitative method for the visual exploration of scRNA-seq data, preserving key biological properties such as local and global cell distances and cell density distributions across samples. It effectively resolves overplotting and enables the visualization of diverse cell attributes from multiomic single-cell experiments. Additionally, scBubbletree is user-friendly and integrates seamlessly with popular scRNA-seq analysis tools, facilitating comprehensive and intuitive data interpretation.