Worms Reloaded is a turn-based and returns to its original 2D gameplay for the first time on PC since Worms World Party in 2001. There are both single-player and multiplayer modes available with up to four players online or local hotspot.

Players take turns controlling their team of worms with the ultimate goal of taking out the opposing team(s). The player must act within a time limit before the turn ends.

Framework for visualising tables of counts, proportions and probabilities. The framework is called product plots, alluding to the computation of area as a product of height and width, and the statistical concept of generating a joint distribution from the product of conditional and marginal distributions. The framework, with extensions, is sufficient to encompass over 20 visualisations previously described in fields of statistical graphics and infovis, including bar charts, mosaic plots, treemaps, equal area plots and fluctuation diagrams.

peakCombiner, a fully R based, user-friendly, transparent, and customizable tool that allows even novice R users to create a high-quality consensus peak list. The modularity of its functions allows an easy way to optimize input and output data. A broad range of accepted input data formats can be used to create a consensus peak set that can be exported to a file or used as the starting point for most downstream peak analyses.

This package implements a new method ClussCluster descried in Ge Jiang and Jun Li, "Simultaneous Detection of Clusters and Cluster-Specific Genes in High-throughput Transcriptome Data" (Unpublished). Simultaneously perform clustering analysis and signature gene selection on high-dimensional transcriptome data sets. To do so, ClussCluster incorporates a Lasso-type regularization penalty term to the objective function of K- means so that cell-type-specific signature genes can be identified while clustering the cells.

This package provides tools for analysing inflation dynamics. Computes weighted contributions of price index components, core inflation measures (trimmed mean, weighted median, exclusion-based) following Bryan and Cecchetti (1994) <doi:10.1016/0304-3932(94)90030-2>, inflation persistence via sum-of-AR-coefficients, diffusion indices, Phillips curve estimation, breakeven inflation, and trend inflation using the Beveridge-Nelson decomposition and Hodrick-Prescott filter. All functions are pure computation and work with price data from any source.

Interfaces R with LSD simulation models. Reads object-oriented data in results files (.res[.gz]) produced by LSD and creates appropriate multi-dimensional arrays in R'. Supports multiple core parallel threads of multi-file data reading for increased performance. Also provides functions to extract basic information and statistics from data files. LSD (Laboratory for Simulation Development) is free software developed by Marco Valente and Marcelo C. Pereira (documentation and downloads available at <https://www.labsimdev.org/>).

Bootstrap routines for nested linear mixed effects models fit using either lme4 or nlme'. The provided bootstrap() function implements the parametric, residual, cases, random effect block (REB), and wild bootstrap procedures. An overview of these procedures can be found in Van der Leeden et al. (2008) <doi: 10.1007/978-0-387-73186-5_11>, Carpenter, Goldstein & Rasbash (2003) <doi: 10.1111/1467-9876.00415>, and Chambers & Chandra (2013) <doi: 10.1080/10618600.2012.681216>.

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.

Compiles and displays the available data sets regarding the Italian school system, with a focus on the infrastructural aspects. Input datasets are downloaded from the web, with the aim of updating everything to real time. The functions are divided in four main modules, namely Get', to scrape raw data from the web Util', various utilities needed to process raw data Group', to aggregate data at the municipality or province level Map', to visualize the output datasets.

This package provides utility functions for validation and quality control of clinical trial datasets and outputs across SDTM', ADaM and TFL workflows. The package supports dataset loading, metadata inspection, frequency and summary calculations, table-ready aggregations, and compare-style dataset review similar to SAS PROC COMPARE'. Functions are designed to support reproducible execution, transparent review, and independent verification of statistical programming results. Dataset comparisons may leverage arsenal <https://cran.r-project.org/package=arsenal>.

This package provides a unified framework for unit root and stationarity testing including quantile ADF tests (Koenker and Xiao, 2004) <doi:10.1198/016214504000001114>, GARCH-based unit root tests with endogenous structural breaks (Narayan and Liu, 2015) <doi:10.1016/j.eneco.2014.11.021>, and comprehensive Dickey-Fuller, Phillips-Perron, KPSS, ERS/DF-GLS, Zivot-Andrews, and Kobayashi-McAleer tests with an Elder-Kennedy decision strategy (Elder and Kennedy, 2001) <doi:10.1080/00220480109595179>.

This package performs a sensitivity analysis using weighted rank tests in observational studies with I blocks of size J; see Rosenbaum (2024) <doi:10.1080/01621459.2023.2221402>. The package can perform adaptive inference in block designs; see Rosenbaum (2012) <doi:10.1093/biomet/ass032>. The package can increase design sensitivity using the conditioning tactic in Rosenbaum (2025) <doi:10.1093/jrsssb/qkaf007>. The main functions are wgtRank(), wgtRankCI(), wgtRanktt() and wgtRankC().

This package provides a fast parallelized alternative to R's native dist function to calculate distance matrices for continuous, binary, and multi-dimensional input matrices, which supports a broad variety of predefined distance functions from other R packages, as well as user- defined functions written in C++. For ease of use, the parDist function extends the signature of the dist function and uses the same parameter naming conventions as distance methods of existing R packages.

This package makes it possible on most UNIX platforms to contact your own DNS implementation in your test environment. It requires socket_wrapper to be able to contact the server. Alternatively, the wrapper is able to fake DNS queries and return valid responses to your application. It provides the following features:

• Redirects name queries to the nameservers specified in your resolv.conf.

• Can fake DNS queries using a simple formatted DNS hosts file.

Programming neuroscience specific Clinical Data Standards Interchange Consortium (CDISC) compliant Analysis Data Model (ADaM) datasets in R'. ADaM datasets are a mandatory part of any New Drug or Biologics License Application submitted to the United States Food and Drug Administration (FDA). Analysis derivations are implemented in accordance with the "Analysis Data Model Implementation Guide" (CDISC Analysis Data Model Team, 2021, <https://www.cdisc.org/standards/foundational/adam>). This package extends the admiral package.

These dataset contains daily quality air measurements in Spain over a period of 18 years (from 2001 to 2018). The measurements refer to several pollutants. These data are openly published by the Government of Spain. The datasets were originally spread over a number of files and formats. Here, the same information is contained in simple dataframe for convenience of researches, journalists or general public. See the Spanish Government website <http://www.miteco.gob.es/> for more information.

This package provides tools for the analysis of questionnaire and survey data in epidemiological and One Health research. The package supports data preparation, reliability assessment, exploratory factor analysis, Kaiser-Meyer-Olkin assessment, parallel analysis, visualization, reporting, and export of results using a consistent analysis workflow. The methods are based on established approaches to psychometric and multivariate analysis; see Kaiser (1974) <doi:10.1007/BF02291575>, Horn (1965) <doi:10.1007/BF02289447>, and Tabachnick and Fidell (2019, ISBN:9780134790541).

Computes the Road Tolerance Index (RTI) and the Human Footprint Tolerance Index (HFTI) for species occurrence data. It automates data cleaning and integrates spatial data (roads and human footprint) to produce reproducible tolerance metrics for biodiversity and conservation research. The HFTI calculation is based on the global human footprint dataset by Mu et al. (2022) <doi:10.1038/s41597-022-01284-8>. This package is part of a PhD thesis focused on amphibian ecology in Brazil.

Binding to the C++ implementation of the flexible polyline encoding by HERE <https://github.com/heremaps/flexible-polyline>. The flexible polyline encoding is a lossy compressed representation of a list of coordinate pairs or coordinate triples. The encoding is achieved by: (1) Reducing the decimal digits of each value; (2) encoding only the offset from the previous point; (3) using variable length for each coordinate delta; and (4) using 64 URL-safe characters to display the result.

This package provides transparent, reproducible, and auditable tools for validating, preparing, encoding, summarising, comparing, modelling, and diagnosing ordered categorical sequence data. Supports explicit preprocessing policies, contiguous motifs and bounded subsequences, consensus and group comparisons, edit and transition distances, clustering and stability diagnostics, transition networks, higher-order models, categorical, mixture, multichannel, and covariate hidden Markov models, longitudinal panel workflows, time-varying models, design-aware inference, analysis contracts and provenance audits, and guarded adapters to specialist sequence-analysis packages.

The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.

Facilitates the calculation of 40 different insulin sensitivity indices based on fasting, oral glucose tolerance test (OGTT), lipid (adipose), tracer (palmitate and glycerol rate), and DXA (fat mass) measurement values. Enables easy and accurate assessment of insulin sensitivity, critical for understanding and managing metabolic disorders like diabetes and obesity. Indices calculated are described in Gastaldelli (2022) <doi:10.1002/oby.23503>, Suleman (2024) <doi:10.1210/clinem/dgae275>, and Lorenzo (2010) <doi:10.1210/jc.2010-1144>.

This package implements Bayesian hierarchical models for estimating antibody kinetic parameters from longitudinal serological data. Fits two-phase within-host models capturing antibody rise, peak, and decay following pathogen infection, using JAGS for posterior inference. Designed as the upstream companion to the serocalculator package for end-to-end seroepidemiological analysis. Methods are described in Teunis and colleagues (2016) <doi:10.1016/j.epidem.2016.04.001> and Teunis and van Eijkeren (2020) <doi:10.1002/sim.8578>.

This package supports the computation of an F-test for the association between expression values and clinical entities. In many cases a two way layout with gene and a dichotomous group as factors will be considered. However, adjustment for other covariates and the analysis of arbitrary clinical variables, interactions, gene co-expression, time series data and so on is also possible. The test is carried out by comparison of corresponding linear models via the extra sum of squares principle.