We developed EasyCellType which can automatically examine the input marker lists obtained from existing software such as Seurat over the cell markerdatabases. Two quantification approaches to annotate cell types are provided: Gene set enrichment analysis (GSEA) and a modified versio of Fisher's exact test. The function presents annotation recommendations in graphical outcomes: bar plots for each cluster showing candidate cell types, as well as a dot plot summarizing the top 5 significant annotations for each cluster.

Example software for the analysis of data from designed experiments, especially agricultural crop experiments. The basics of the analysis of designed experiments are discussed using real examples from agricultural field trials. A range of statistical methods using a range of R statistical packages are exemplified . The experimental data is made available as separate data sets for each example and the R analysis code is made available as example code. The example code can be readily extended, as required.

An implementation of Bayesian survival models with graph-structured selection priors for sparse identification of omics features predictive of survival (Madjar et al., 2021 <doi:10.1186/s12859-021-04483-z>) and its extension to use a fixed graph via a Markov Random Field (MRF) prior for capturing known structure of omics features, e.g. disease-specific pathways from the Kyoto Encyclopedia of Genes and Genomes database (Hermansen et al., 2025 <doi:10.48550/arXiv.2503.13078>).

Calculate agrometeorological variables for crops including growing degree days (McMaster, GS & Wilhelm, WW (1997) <doi:10.1016/S0168-1923(97)00027-0>), cumulative rainfall, number of stress days and cumulative or mean radiation and evaporation. Convert dates to day of year and vice versa. Also, download curated and interpolated Australian weather data from the Queensland Government DES longpaddock website <https://www.longpaddock.qld.gov.au/>. This data is freely available under the Creative Commons 4.0 licence.

Extends daltoolbox with Python-backed components for deep learning, scikit-learn classification, and time-series forecasting through reticulate'. The package provides objects that follow the daltoolbox architecture while delegating model creation, fitting, encoding, and prediction to Python libraries such as torch and scikit-learn'. In the package name, dp stands for Deep Python'. The overall workflow is inspired by the Experiment Lines approach described in Ogasawara et al. (2009) <doi:10.1007/978-3-642-02279-1_20>.

The penalized and non-penalized Minorize-Maximization (MM) method for frailty models to fit the clustered data, multi-event data and recurrent data. Least absolute shrinkage and selection operator (LASSO), minimax concave penalty (MCP) and smoothly clipped absolute deviation (SCAD) penalized functions are implemented. All the methods are computationally efficient. These general methods are proposed based on the following papers, Huang, Xu and Zhou (2022) <doi:10.3390/math10040538>, Huang, Xu and Zhou (2023) <doi:10.1177/09622802221133554>.

This package provides a comprehensive set of datasets and tools for causal inference research. The package includes data from clinical trials, cancer studies, epidemiological surveys, environmental exposures, and health-related observational studies. Designed to facilitate causal analysis, risk assessment, and advanced statistical modeling, it leverages datasets from packages such as causalOT', survival', causalPAF', evident', melt', and sanon'. The package is inspired by the foundational work of Pearl (2009) <doi:10.1017/CBO9780511803161> on causal inference frameworks.

Integrates fairness auditing and bias mitigation methods for the mlr3 ecosystem. This includes fairness metrics, reporting tools, visualizations and bias mitigation techniques such as "Reweighing" described in Kamiran, Calders (2012) <doi:10.1007/s10115-011-0463-8> and "Equalized Odds" described in Hardt et al. (2016) <https://papers.nips.cc/paper/2016/file/9d2682367c3935defcb1f9e247a97c0d-Paper.pdf>. Integration with mlr3 allows for auditing of ML models as well as convenient joint tuning of machine learning algorithms and debiasing methods.

Estimates cohort-by-time average treatment effects under staggered treatment adoption by the generalized method of moments. Three weighting schemes are provided, corresponding to a pooled stationary covariance, a cohort-specific stationary covariance, and an unrestricted within-cohort covariance. Optional adjustment for baseline covariates by outcome regression, and a serial-correlation robust over-identification test of parallel trends and no anticipation, are also supported. The methods are described in Arora and Bijani (2026) <doi:10.2139/ssrn.6558759>.

Analysing data from evaluations of educational interventions using a randomised controlled trial design. Various analytical tools to perform sensitivity analysis using different methods are supported (e.g. frequentist models with bootstrapping and permutations options, Bayesian models). The included commands can be used for simple randomised trials, cluster randomised trials and multisite trials. The methods can also be used more widely beyond education trials. This package can be used to evaluate other intervention designs using Frequentist and Bayesian multilevel models.

Core C++ engine for glmbayes': envelope-based iid linear and generalized linear model samplers, prior-family routing, and optional OpenCL acceleration. Sampling for supported non-conjugate models uses accept-reject methods based on likelihood subgradients as in Nygren and Nygren (2006) <doi:10.1198/016214506000000357>. Intended as a developer backend for the glmbayes formula interface; end users should use glmbayes for modelling with interfaces analogous to lm and glm'. Mixed-model engines are planned for a future release.

This package implements marker-based estimation of heritability when observations on genetically identical replicates are available. These can be either observations on individual plants or plot-level data in a field trial. Heritability can then be estimated using a mixed model for the individual plant or plot data. For comparison, also mixed-model based estimation using genotypic means and estimation of repeatability with ANOVA are implemented. For illustration the package contains several datasets for the model species Arabidopsis thaliana.

This package provides a suite of functions for conducting and interpreting analysis of statistical interaction in regression models that was formerly part of the jtools package. Functionality includes visualization of two- and three-way interactions among continuous and/or categorical variables as well as calculation of "simple slopes" and Johnson-Neyman intervals (see e.g., Bauer & Curran, 2005 <doi:10.1207/s15327906mbr4003_5>). These capabilities are implemented for generalized linear models in addition to the standard linear regression context.

The package compiles functions for calculating prices of American put options with Least Squares Monte Carlo method. The option types are plain vanilla American put, Asian American put, and Quanto American put. The pricing algorithms include variance reduction techniques such as Antithetic Variates and Control Variates. Additional functions are given to derive "price surfaces" at different volatilities and strikes, create 3-D plots, quickly generate Geometric Brownian motion, and calculate prices of European options with Black & Scholes analytical solution.

Analysis and visualisation of synchrony, interaction, and joint movements from audio and video movement data of a group of music performers. The demo is data described in Clayton, Leante, and Tarsitani (2021) <doi:10.17605/OSF.IO/KS325>, while example analyses can be found in Clayton, Jakubowski, and Eerola (2019) <doi:10.1177/1029864919844809>. Additionally, wavelet analysis techniques have been applied to examine movement-related musical interactions, as shown in Eerola et al. (2018) <doi:10.1098/rsos.171520>.

This package provides functions for computing fit indices for evaluating the path component of latent variable structural equation models. Available fit indices include RMSEA-P and NSCI-P originally presented and evaluated by Williams and O'Boyle (2011) <doi:10.1177/1094428110391472> and demonstrated by O'Boyle and Williams (2011) <doi:10.1037/a0020539> and Williams, O'Boyle, & Yu (2020) <doi:10.1177/1094428117736137>. Also included are fit indices described by Hancock and Mueller (2011) <doi:10.1177/0013164410384856>.

This package provides methods for generating .dat files for use with the AMPL software using spatial data, particularly rasters. It includes support for various spatial data formats and different problem types. By automating the process of generating AMPL datasets, this package can help streamline optimization workflows and make it easier to solve complex optimization problems. The methods implemented in this package are described in detail in a publication by Fourer et al. (<doi:10.1287/mnsc.36.5.519>).

This package implements panel cointegration tests allowing for structural breaks and cross-section dependence following the methodology of Banerjee and Carrion-i-Silvestre (2015) <doi:10.1002/jae.2348>. The package provides iterative factor-break estimation, individual ADF tests on defactored residuals, standardized panel test statistics, and the Bai and Ng (2004) <doi:10.1111/j.1468-0262.2004.00528.x> MQ test for identifying common stochastic trends. Supports five model specifications with varying deterministic components and break structures.

The package includes functions to retrieve the sequences around the peak, obtain enriched Gene Ontology (GO) terms, find the nearest gene, exon, miRNA or custom features such as most conserved elements and other transcription factor binding sites supplied by users. Starting 2.0.5, new functions have been added for finding the peaks with bi-directional promoters with summary statistics (peaksNearBDP), for summarizing the occurrence of motifs in peaks (summarizePatternInPeaks) and for adding other IDs to annotated peaks or enrichedGO (addGeneIDs).

Wrapping an array-like object (typically an on-disk object) in a DelayedArray object allows one to perform common array operations on it without loading the object in memory. In order to reduce memory usage and optimize performance, operations on the object are either delayed or executed using a block processing mechanism. Note that this also works on in-memory array-like objects like DataFrame objects (typically with Rle columns), Matrix objects, and ordinary arrays and data frames.

This package provides a method that allows for the use of a collection of non-matched normal tissue samples. Our approach uses a non-parametric bootstrap subsampling of the available reference samples to estimate the distribution of read counts from targeted sequencing. As inspired by random forest, this is combined with a procedure that subsamples the amplicons associated with each of the targeted genes. The obtained information allows us to reliably classify the copy number aberrations on the gene level.

This package creates pre- and post- intervention scattergrams based on audiometric data. These scattergrams are formatted for publication in Otology & Neurotology and other otolaryngology journals. For more details and instructions on how to use this package, please reference Pan and Oghalai (2026) <doi: 10.1097/MAO.0000000000004693>. For further history on the development of scattergrams for reporting audiometric results in clinical trials, please see Gurgel et al (2012) <doi:10.1177/0194599812458401>, Oghalai and Jackler (2016) <doi:10.1177/0194599816638314>.

This package implements the Bayesian unit root test for Panel Autoregressive (PAR) time series models developed by Kumar et al. (2016) <https://hdl.handle.net/10419/179393>. The package evaluates the unit root hypothesis (difference stationarity versus trend stationarity) in panel data using the Posterior Odds Ratio (POR). It accommodates PAR models with linear time trend as well as linear time trend with augmentation terms of arbitrary order. Full posterior probabilities, Bayes factors, and individual panel estimates are computed automatically.

Estimates and evaluates the intraspecific competition coefficient associated with the edge (border) effect in agricultural field trials, using the Besag-Kempton autoregressive model and a least-squares estimator following Darghan, Rivera, Gonzalez and Castellanos (2022) <doi:10.47280/RevFacAgron(LUZ).v39.n1.18>. Provides field-layout generation, spatial weight matrices, a formula interface for arbitrary two-way designs, a simulation-based decision procedure for presence or absence of the edge effect, Moran's I diagnostics, and a shiny application.