Generates synthetic Our Future Health cohort datasets for method development, including participant, questionnaire, clinic measurements, outpatient, inpatient, emergency, mortality, primary care medication, and geography outputs. Supports reproducible generation with configurable cohort size and user-defined International Classification of Diseases, Tenth Revision (ICD-10), Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4), and British National Formulary (BNF) code pools.

It makes an objective Bayesian analysis of the spatial regression model using both the normal (NSR) and student-T (TSR) distributions. The functions provided give prior and posterior objective densities and allow default Bayesian estimation of the model regression parameters. Details can be found in Ordonez et al. (2020) <arXiv:2004.04341>.

This package provides a function to detect and trim outliers in Gaussian mixture model-based clustering using methods described in Clark and McNicholas (2024) <doi:10.1007/s00357-024-09473-3>.

This package provides a comprehensive set of helpers that streamline data transmission and processing, making it effortless to interact with the OpenAI API.

Extracts covariates from Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) domains using an R-only pipeline. Supports configurable temporal windows, domain-specific covariates for drug exposure, drug era (including Anatomical Therapeutic Chemical (ATC) groupings), condition occurrence, condition era, concept sets and cohorts. Methods are based on the Observational Health Data Sciences and Informatics (OHDSI) framework described in Hripcsak et al. (2015) <doi:10.1038/sdata.2015.35> and "The Book of OHDSI" OHDSI (2019, ISBN:978-1-7923-0589-8).

Conversion between the most common odds types for sports betting. Hong Kong odds, US odds, Decimal odds, Indonesian odds, Malaysian odds, and raw Probability are covered in this package.

Distance based bipartite matching using minimum cost flow, oriented to matching of treatment and control groups in observational studies ('Hansen and Klopfer 2006 <doi:10.1198/106186006X137047>). Routines are provided to generate distances from generalised linear models (propensity score matching), formulas giving variables on which to limit matched distances, stratified or exact matching directives, or calipers, alone or in combination.

This ONEST software implements the method of assessing the pathologist agreement in reading PD-L1 assays (Reisenbichler et al. (2020 <doi:10.1038/s41379-020-0544-x>)), to determine the minimum number of evaluators needed to estimate agreement involving a large number of raters. Input to the program should be binary(1/0) pathology data, where â 0â may stand for negative and â 1â for positive. Additional examples were given using the data from Rimm et al. (2017 <doi:10.1001/jamaoncol.2017.0013>).

This package provides routines for finding an Optimal System of Distinct Representatives (OSDR), as defined by D.Gale (1968) <doi:10.1016/S0021-9800(68)80039-0>.

Shiny Application to visualize Olympic Data. From 1896 to 2016. Even Winter Olympics events are included. Data is from Kaggle at <https://www.kaggle.com/heesoo37/120-years-of-olympic-history-athletes-and-results>.

This package provides a penalized regression framework that can simultaneously estimate the optimal treatment strategy and identify important variables. Appropriate for either censored or uncensored continuous response.

This package provides utilities for processing of Oxy-Bisulfite microarray data (e.g. via the Illumina Infinium platform, <http://www.illumina.com>) with tandem arrays, one using conventional bisulfite conversion, the other using oxy-bisulfite conversion.

Implementation of the Open Perimetry Interface (OPI) for simulating and controlling visual field machines using R. The OPI is a standard for interfacing with visual field testing machines (perimeters) first started as an open source project with support of Haag-Streit in 2010. It specifies basic functions that allow many visual field tests to be constructed. As of February 2022 it is fully implemented on the Haag-Streit Octopus 900 and CrewT ImoVifa ('Topcon Tempo') with partial implementations on the Centervue Compass, Kowa AP 7000 and Android phones. It also has a cousin: the R package visualFields', which has tools for analysing and manipulating visual field data.

Get operating characteristics of one-arm clinical trial designs for time-to-event endpoint through simulation and perform analysis with time-to-event data.

Intended to create standard human-in-the-loop validity tests for typical automated content analysis such as topic modeling and dictionary-based methods. This package offers a standard workflow with functions to prepare, administer and evaluate a human-in-the-loop validity test. This package provides functions for validating topic models using word intrusion, topic intrusion (Chang et al. 2009, <https://papers.nips.cc/paper/3700-reading-tea-leaves-how-humans-interpret-topic-models>) and word set intrusion (Ying et al. 2021) <doi:10.1017/pan.2021.33> tests. This package also provides functions for generating gold-standard data which are useful for validating dictionary-based methods. The default settings of all generated tests match those suggested in Chang et al. (2009) and Song et al. (2020) <doi:10.1080/10584609.2020.1723752>.

Data used in compiling the Handbook of UK Urban Tree Allometric Equations and Size Characteristics (Fennel 2024). The data include measurements of height, crown radius and diameter at breast height (DBH) for UK urban trees. For more details see Fennell (2024) Handbook of UK Urban Tree Allometric Equations and Size Characteristics (Version 1.4). <doi:10.13140/RG.2.2.28745.04961>.

This package performs robust cluster analysis allowing for outliers and noise that cannot be fitted by any cluster. The data are modelled by a mixture of Gaussian distributions and a noise component, which is an improper uniform distribution covering the whole Euclidean space. Parameters are estimated by (pseudo) maximum likelihood. This is fitted by a EM-type algorithm. See Coretto and Hennig (2016) <doi:10.1080/01621459.2015.1100996>, and Coretto and Hennig (2017) <https://jmlr.org/papers/v18/16-382.html>.

This package provides functions to design and simulate optimal two-stage randomized controlled trials (RCTs) with ordered categorical outcomes, supporting rank-based tests and group-sequential decision rules. Methods build on classical and modern rank tests and two-stage/Group-Sequential designs, e.g., Park (2025) <doi: 10.1371/journal.pone.0318211>. Please see the package reference manual and vignettes for details.

Fast, optimal, and reproducible clustering algorithms for circular, periodic, or framed data. The algorithms introduced here are based on a core algorithm for optimal framed clustering the authors have developed (Debnath & Song 2021) <doi:10.1109/TCBB.2021.3077573>. The runtime of these algorithms is O(K N log^2 N), where K is the number of clusters and N is the number of circular data points. On a desktop computer using a single processor core, millions of data points can be grouped into a few clusters within seconds. One can apply the algorithms to characterize events along circular DNA molecules, circular RNA molecules, and circular genomes of bacteria, chloroplast, and mitochondria. One can also cluster climate data along any given longitude or latitude. Periodic data clustering can be formulated as circular clustering. The algorithms offer a general high-performance solution to circular, periodic, or framed data clustering.

Allows you to easily execute expensive compute operations only once, and save the resulting object to disk.

Exemplifying analysis of large-scale protein data from the Olink platform', primarily relative protein expression data that has been exported from Olink NPX Software', as well as QUANT data from Olink'. QUANT data is log-transformed. Materials focus on reading data, demonstrating data wrangling and quality control analysis, performing statistical analysis and generating figures to visualize the results of the statistical analysis. The goal of this package is to guide users extract biological insights from large-scale protein data run on the Olink platform'. More information on Olink data can be found at <https://olink.com/>.

This package provides functions to calculate the out-of-bag learning curve for random forests for any measure that is available in the mlr package. Supported random forest packages are randomForest and ranger and trained models of these packages with the train function of mlr'. The main function is OOBCurve() that calculates the out-of-bag curve depending on the number of trees. With the OOBCurvePars() function out-of-bag curves can also be calculated for mtry', sample.fraction and min.node.size for the ranger package.

We proposes a framework that provides real time support for early detection of anomalous series within a large collection of streaming time series data. By definition, anomalies are rare in comparison to a system's typical behaviour. We define an anomaly as an observation that is very unlikely given the forecast distribution. The algorithm first forecasts a boundary for the system's typical behaviour using a representative sample of the typical behaviour of the system. An approach based on extreme value theory is used for this boundary prediction process. Then a sliding window is used to test for anomalous series within the newly arrived collection of series. Feature based representation of time series is used as the input to the model. To cope with concept drift, the forecast boundary for the system's typical behaviour is updated periodically. More details regarding the algorithm can be found in Talagala, P. D., Hyndman, R. J., Smith-Miles, K., et al. (2019) <doi:10.1080/10618600.2019.1617160>.

Anomaly detection in dynamic, temporal networks. The package oddnet uses a feature-based method to identify anomalies. First, it computes many features for each network. Then it models the features using time series methods. Using time series residuals it detects anomalies. This way, the temporal dependencies are accounted for when identifying anomalies (Kandanaarachchi, Hyndman 2022) <arXiv:2210.07407>.