CrispRVariants provides tools for analysing the results of a CRISPR-Cas9 mutagenesis sequencing experiment, or other sequencing experiments where variants within a given region are of interest. These tools allow users to localize variant allele combinations with respect to any genomic location (e.g. the Cas9 cut site), plot allele combinations and calculate mutation rates with flexible filtering of unrelated variants.

This Package utilizes a generalized linear model(GLM) of the negative binomial family to characterize count data and allows for multi-factor design. NanoStrongDiff incorporate size factors, calculated from positive controls and housekeeping controls, and background level, obtained from negative controls, in the model framework so that all the normalization information provided by NanoString nCounter Analyzer is fully utilized.

This data package contains timecourse gene expression data sets. The first dataset, from Shoemaker et al, consists of microarray samples from lung tissue of mice exposed to different influenzy strains from 14 timepoints. The two other datasets are leaf and root samples from sorghum crops exposed to pre- and post-flowering drought stress and a control condition, sampled across the plants lifetime.

This package provides functions that compute the lattice-based density and regression estimators for two-dimensional regions with irregular boundaries and holes. The density estimation technique is described in Barry and McIntyre (2011) <doi:10.1016/j.ecolmodel.2011.02.016>, while the non-parametric regression technique is described in McIntyre and Barry (2018) <doi:10.1080/10618600.2017.1375935>.

Hybridization probes for target sequences can be made based on melting temperature value calculated by R package TmCalculator <https://CRAN.R-project.org/package=TmCalculator> and methods extended from Beliveau, B. J.,(2018) <doi:10.1073/pnas.1714530115>, and those hybridization probes can be used to capture specific target regions in fluorescence in situ hybridization and next generation sequence experiments.

Obtener listado de datos, acceder y extender series del Portal de Datos de Hacienda.Las proyecciones se realizan con forecast', Hyndman RJ, Khandakar Y (2008) <doi:10.18637/jss.v027.i03>. Search, download and forecast time-series from the Ministry of Economy of Argentina. Forecasts are built with the forecast package, Hyndman RJ, Khandakar Y (2008) <doi:10.18637/jss.v027.i03>.

Offers a TableContainer() function to create tables enriched with row, column, and table annotations. This package is similar to SummarizedExperiment in Bioconductor <doi:10.18129/B9.bioc.SummarizedExperiment>, but designed to work independently of Bioconductor, it ensures annotations are automatically updated when the table is subset. Additionally, it includes format_tbl() methods for enhanced table formatting and display.

The Readline library provides a set of functions for use by applications that allow users to edit command lines as they are typed in. Both Emacs and vi editing modes are available. The Readline library includes additional functions to maintain a list of previously-entered command lines, to recall and perhaps reedit those lines, and perform csh-like history expansion on previous commands.

This package provides a feasible framework for mutation analysis and reverse transcription polymerase chain reaction (RT-PCR) assay evaluation of COVID-19, including mutation profile visualization, statistics and mutation ratio of each assay. The mutation ratio is conducive to evaluating the coverage of RT-PCR assays in large-sized samples. Mercatelli, D. and Giorgi, F. M. (2020) <doi:10.20944/preprints202004.0529.v1>.

Implementation of a procedure---Domingue (2012) <https://eric.ed.gov/?id=ED548657>, Domingue (2014) <doi:10.1007/s11336-013-9342-4>; see also Karabatsos (2001) <https://psycnet.apa.org/record/2002-01665-005> and Kyngdon (2011) <doi:10.1348/2044-8317.002004>---to test the single and double cancellation axioms of conjoint measure in data that is dichotomously coded and measured with error.

This is the core package that provides both the user API and developer API to deploy the parallel cluster on the cloud using the container service. The user can call clusterPreset() to define the cloud service provider and container and makeDockerCluster() to create the cluster. The developer should see "developer's cookbook" on how to define the cloud provider and container.

Defines a collection of functions to compute average power and sample size for studies that use the false discovery rate as the final measure of statistical significance. A three-rectangle approximation method of a p-value histogram is proposed to derive a formula to compute the statistical power for analyses that involve the FDR. The methodology paper of this package is under review.

Creating a great user interface for your Shiny apps can be a hassle, especially if you want to work purely in R and don't want to use, for instance HTML templates. This package adds support for a powerful UI library Fomantic UI - <https://fomantic-ui.com/> (before Semantic). It also supports universal UI input binding that works with various DOM elements.

Draw syntenic relationships between genome assemblies. There are 3 functions which take a tab delimited file containing alignment data for syntenic blocks between genomes to produce either a linear alignment plot, an evolution highway style plot, or a painted ideogram representing syntenic relationships. There is also a function to convert alignment data in the DESCHRAMBLER/inferCAR format to the required data structure.

Unit testing is a solid component of automated CI/CD pipelines. tinytest - a lightweight, zero-dependency alternative to testthat was developed. To be able to integrate tinytests results into common CI/CD systems the test results from tinytest need to be caputred and converted to JUnit XML format. tinytest2JUnit enables this conversion while staying also lightweight and only have tinytest as its dependency.

romanisim is a Galsim-based simulator of imaging data from the WFI on the Nancy Grace Roman Space Telescope (pronounced roman-eye-sim, stylized Roman I-Sim). It uses Galsim to render astronomical scenes, WebbPSF to model the point spread function, and CRDS to access the calibration information needed to produce realistic WFI images.

Stores expression profiling data from experiments compatible with the multiWGCNA R package. This includes human postmortem microarray data from patients and controls (GSE28521), astrocyte Ribotag RNA-seq data from EAE and wildtype mice (GSE100329), and mouse RNA-seq data from tau pathology (rTg4510) and wildtype control mice (GSE125957). These data can be accessed using the ExperimentHub workflow (see multiWGCNA vignettes).

Collection of Visium spatial gene expression datasets by 10X Genomics, formatted into objects of class SpatialExperiment. Data cover various organisms and tissues, and include: single- and multi-section experiments, as well as single sections subjected to both whole transcriptome and targeted panel analysis. Datasets may be used for testing of and as examples in packages, for tutorials and workflow demonstrations, or similar purposes.

Tool to find where a function has its lowest value(minimum). The functions can be any dimensions. Recommended use is with eps=10^-10, but can be run with 10^-20, although this depends on the function. Two more methods are in this package, simple gradient method (Gradmod) and Powell method (Powell). These are not recommended for use, their purpose are purely for comparison.

Cases are matched to controls in an efficient, optimal and computationally flexible way. It uses the idea of sub-sampling in the level of the case, by creating pseudo-observations of controls. The user can select between replacement and without replacement, the number of controls, and several covariates to match upon. See Mamouris (2021) <doi:10.1186/s12874-021-01256-3> for an overview.

Implement Bayesian multilevel modelling for compositional data. Compute multilevel compositional data and perform log-ratio transforms at between and within-person levels, fit Bayesian multilevel models for compositional predictors and outcomes, and run post-hoc analyses such as isotemporal substitution models. References: Le, Stanford, Dumuid, and Wiley (2025) <doi:10.1037/met0000750>, Le, Dumuid, Stanford, and Wiley (2025) <doi:10.1080/00273171.2025.2565598>.

Facilitates querying data from the â Facebook Marketing API', particularly for social science research <https://developers.facebook.com/docs/marketing-apis/>. Data from the Facebook Marketing API has been used for a variety of social science applications, such as for poverty estimation (Marty and Duhaut (2024) <doi:10.1038/s41598-023-49564-6>), disease surveillance (Araujo et al. (2017) <doi:10.48550/arXiv.1705.04045>), and measuring migration (Alexander, Polimis, and Zagheni (2020) <doi:10.1007/s11113-020-09599-3>). The package facilitates querying the number of Facebook daily/monthly active users for multiple location types (e.g., from around a specific coordinate to an administrative region) and for a number of attribute types (e.g., interests, behaviors, education level, etc). The package supports making complex queries within one API call and making multiple API calls across different locations and/or parameters.

Ceteris Paribus Profiles (What-If Plots) are designed to present model responses around selected points in a feature space. For example around a single prediction for an interesting observation. Plots are designed to work in a model-agnostic fashion, they are working for any predictive Machine Learning model and allow for model comparisons. Ceteris Paribus Plots supplement the Break Down Plots from breakDown package.

This package provides functions of five estimation method for ED50 (50 percent effective dose) are provided, and they are respectively Dixon-Mood method (1948) <doi:10.2307/2280071>, Choi's original turning point method (1990) <doi:10.2307/2531453> and it's modified version given by us, as well as logistic regression and isotonic regression. Besides, the package also supports comparison between two estimation results.