Estimation of two-state (survival) models and irreversible illness- death models with possibly interval-censored, left-truncated and right-censored data. Proportional intensities regression models can be specified to allow for covariates effects separately for each transition. We use either a parametric approach with Weibull baseline intensities or a semi-parametric approach with M-splines approximation of baseline intensities in order to obtain smooth estimates of the hazard functions. Parameter estimates are obtained by maximum likelihood in the parametric approach and by penalized maximum likelihood in the semi-parametric approach.

This package provides an integrated workflow for UK Biobank Research Analysis Platform (RAP) hosted and RAP-generated analysis tables. The package supports RAP phenotype extraction planning, predefined variable sets and disease definitions, standardized baseline preprocessing, multi-source endpoint ascertainment, prevalent and incident case classification, survival-ready cohort construction, regression, multiple imputation, propensity score analysis, mediation analysis, subgroup and sensitivity analyses, machine learning, proteomics enrichment and protein-protein interaction analysis, and publication-oriented visualization. The package workflow is described in He et al. (2026) <doi:10.64898/2026.06.19.26356057>.

OpenFabrics Interfaces (OFI) is a framework focused on exporting fabric communication services to applications. OFI is best described as a collection of libraries and applications used to export fabric services. The key components of OFI are: application interfaces, provider libraries, kernel services, daemons, and test applications.

Libfabric is a core component of OFI. It is the library that defines and exports the user-space API of OFI, and is typically the only software that applications deal with directly. It works in conjunction with provider libraries, which are often integrated directly into libfabric.

Estimates and plots effect estimates from models with all possible combinations of a list of variables. It can be used for assessing treatment effects in clinical trials or risk factors in bio-medical and epidemiological research. Like Stata command confall (Wang Z (2007) <doi:10.1177/1536867X0700700203> ), allestimates calculates and stores all effect estimates, and plots them against p values or Akaike information criterion (AIC) values. It currently has functions for linear regression: all_lm(), logistic and Poisson regression: all_glm(), and Cox proportional hazards regression: all_cox().

Identifies and visualizes document overlap in any number of bibliographic datasets. This package implements the identification of overlapping documents through the exact match of a unique identifier (e.g. Digital Object Identifier - DOI) and, for records where the identifier is absent, through a score calculated from a set of fields commonly found in bibliographic datasets (Title, Source, Authors and Publication Year). Additionally, it provides functions to visualize the results of the document matching through a Venn diagram and/or UpSet plot, as well as a summary of the matching procedure.

This package performs cryptographic randomness tests on a sequence of random integers or bits. Included tests are greatest common divisor, birthday spacings, book stack, adaptive chi-square, topological binary, and three random walk tests (Ryabko and Monarev, 2005) <doi:10.1016/j.jspi.2004.02.010>. Tests except greatest common divisor and birthday spacings are not covered by standard test suites. In addition to the chi-square goodness-of-fit test, results of Anderson-Darling, Kolmogorov-Smirnov, and Jarque-Bera tests are also generated by some of the cryptographic randomness tests.

This package provides tools to support systematic and reproducible workflows for both stationary and nonstationary flood frequency analysis, with applications extending to other hydroclimate extremes, such as precipitation frequency analysis. This package implements the FFA framework proposed by Vidrio- Sahagún et al. (2024) <doi:10.1016/j.envsoft.2024.105940>, originally developed in MATLAB', now adapted for the R environment. This work was funded by the Flood Hazard Identification and Mapping Program of Environment and Climate Change Canada, as well as the Canada Research Chair (Tier 1) awarded to Dr. Pietroniro.

The intent here is to enable the simulation of plays/drives and evaluate game-play strategies in the National Football League (NFL). Built-in strategies include going for it on fourth down and varying the proportion of passing/rushing plays during a drive. The user should be familiar with nflscrapR data before trying to write his/her own strategies. This work is inspired by a blog post by Mike Lopez, currently the Director of Data and Analytics at the NFL, Lopez (2019) <https://statsbylopez.netlify.app/post/resampling-nfl-drives/>.

Fits sparse linear varying coefficient models (VCMs), which assert a linear relationship between an outcome and several covariates that is allowed to change as functions of additional variables known as effect modifiers. Designed for high-dimensional settings where the number of covariates (i.e., number of slopes) is comparable to or larger than the number of observations. Approximates the coefficient functions using a version of Bayesian Additive Regression Trees that can perform global-local shrinkage. For more details see Ghosh, Bhogale, and Deshpande (2026+) <doi:10.48550/arXiv.2510.08204>.

Fitting a smooth path to a given set of noisy spherical data observed at known time points. It implements a piecewise geodesic curve fitting method on the unit sphere based on a velocity-based penalization scheme. The proposed approach is implemented using the Riemannian block coordinate descent algorithm. To understand the method and algorithm, one can refer to Bak, K. Y., Shin, J. K., & Koo, J. Y. (2023) <doi:10.1080/02664763.2022.2054962> for the case of order 1. Additionally, this package includes various functions necessary for handling spherical data.

This package provides functions that provide point and interval estimations of optimum thresholds for continuous diagnostic tests. The methodology used is based on minimizing an overall cost function in the two- and three-state settings. We also provide functions for sample size determination and estimation of diagnostic accuracy measures. We also include graphical tools. The statistical methodology used here can be found in Perez-Jaume et al (2017) <doi:10.18637/jss.v082.i04> and in Skaltsa et al (2010, 2012) <doi:10.1002/bimj.200900294>, <doi:10.1002/sim.4369>.

The package lets you change page layout parameters in small steps over a range of values using options. It can set \textwidth appropriately for the main fount, and ensure that the text fits inside the printable area of a printer. An rmpage-formatted document can be typeset identically without rmpage after a single cut and paste operation. Local configuration can set defaults: for all documents; and by class, by printer, and by paper size. The geometry package is better if you want to set page layout parameters to particular measurements.

This package provides functions for planning clinical trials subject to a delayed treatment effect using assurance-based methods. Includes two shiny applications for interactive exploration, simulation, and visualisation of trial designs and outcomes. The methodology is described in: Salsbury JA, Oakley JE, Julious SA, Hampson LV (2024) "Assurance methods for designing a clinical trial with a delayed treatment effect" <doi:10.1002/sim.10136>, Salsbury JA, Oakley JE, Julious SA, Hampson LV (2024) "Adaptive clinical trial design with delayed treatment effects using elicited prior distributions" <doi:10.48550/arXiv.2509.07602>.

Use multi-state splitting to apply Adaptive-Dynamic PCA (ADPCA) to data generated from a continuous-time multivariate industrial or natural process. Employ PCA-based dimension reduction to extract linear combinations of relevant features, reducing computational burdens. For a description of ADPCA, see <doi:10.1007/s00477-016-1246-2>, the 2016 paper from Kazor et al. The multi-state application of ADPCA is from a manuscript under current revision entitled "Multi-State Multivariate Statistical Process Control" by Odom, Newhart, Cath, and Hering, and is expected to appear in Q1 of 2018.

Analyzing soil food webs or any food web measured at equilibrium. The package calculates carbon and nitrogen fluxes and stability properties using methods described by Hunt et al. (1987) <doi:10.1007/BF00260580>, de Ruiter et al. (1995) <doi:10.1126/science.269.5228.1257>, Holtkamp et al. (2011) <doi:10.1016/j.soilbio.2010.10.004>, and Buchkowski and Lindo (2021) <doi:10.1111/1365-2435.13706>. The package can also manipulate the structure of the food web as well as simulate food webs away from equilibrium and run decomposition experiments.

This package provides infrastructure to store and manage all aspects related to a complete proteomics or metabolomics mass spectrometry (MS) experiment. The MsExperiment package provides light-weight and flexible containers for MS experiments building on the new MS infrastructure provided by the Spectra, QFeatures and related packages. Along with raw data representations, links to original data files and sample annotations, additional metadata or annotations can also be stored within the MsExperiment container. To guarantee maximum flexibility only minimal constraints are put on the type and content of the data within the containers.

MSstatsShiny is an R-Shiny graphical user interface (GUI) integrated with the R packages MSstats, MSstatsTMT, and MSstatsPTM. It provides a point and click end-to-end analysis pipeline applicable to a wide variety of experimental designs. These include data-dependedent acquisitions (DDA) which are label-free or tandem mass tag (TMT)-based, as well as DIA, SRM, and PRM acquisitions and those targeting post-translational modifications (PTMs). The application automatically saves users selections and builds an R script that recreates their analysis, supporting reproducible data analysis.

This package provides tools for estimating censored Almost Ideal (AI) and Quadratic Almost Ideal (QUAI) demand systems using Maximum Likelihood Estimation (MLE). It includes functions for calculating demand share equations and the truncated log-likelihood function for a system of equations, incorporating demographic variables. The package is designed to handle censored data, where some observations may be zero due to non-purchase of certain goods. Package also contains a procedure to approximate demand elasticities numerically and estimate standard errors via Delta Method. It is particularly useful for applied researchers analyzing household consumption data.

Genotyping the population using next generation sequencing data is essentially important for the rare variant detection. In order to distinguish the genomic structural variation from sequencing error, we propose a statistical model which involves the genotype effect through a latent variable to depict the distribution of non-reference allele frequency data among different samples and different genome loci, while decomposing the sequencing error into sample effect and positional effect. An ECM algorithm is implemented to estimate the model parameters, and then the genotypes and SNPs are inferred based on the empirical Bayes method.

Robust estimation methods for the mean vector, scatter matrix, and covariance matrix (if it exists) from data (possibly containing NAs) under multivariate heavy-tailed distributions such as angular Gaussian (via Tyler's method), Cauchy, and Student's t distributions. Additionally, a factor model structure can be specified for the covariance matrix. The latest revision also includes the multivariate skewed t distribution. The package is based on the papers: Sun, Babu, and Palomar (2014); Sun, Babu, and Palomar (2015); Liu and Rubin (1995); Zhou, Liu, Kumar, and Palomar (2019); Pascal, Ollila, and Palomar (2021).

Neural networks are applied to create a density value function which approximates density values for a data source. The trained neural network is analyzed for different levels. For each level metric subspaces with density values above a level are determined. The obtained set of metric subspaces and the trained neural network are assembled into a data model. A prerequisite is the definition of a data source, the generation of generative data and the calculation of density values. These tasks are executed using package ganGenerativeData <https://cran.r-project.org/package=ganGenerativeData>.

This function predicts item response probabilities and item responses using the item-focused tree model. The item-focused tree model combines logistic regression with recursive partitioning to detect Differential Item Functioning in dichotomous items. The model applies partitioning rules to the data, splitting it into homogeneous subgroups, and uses logistic regression within each subgroup to explain the data. Differential Item Functioning detection is achieved by examining potential group differences in item response patterns. This method is useful for understanding how different predictors, such as demographic or psychological factors, influence item responses across subgroups.

Implemented are the one-sided and two-sided multiple-direction logrank test for two-sample right censored data. In addition to the statistics p-values are calculated: 1. For the one-sided testing problem one p-value based on a wild bootstrap approach is determined. 2. In the two-sided case one p-value based on a chi-squared approximation and a second p-values based on a permutation approach are calculated. Ditzhaus, M. and Friedrich, S. (2018) <arXiv:1807.05504>. Ditzhaus, M. and Pauly, M. (2018) <arXiv:1808.05627>.

Facilitate the evaluation of forecasts in a convenient framework based on data.table. It allows user to to check their forecasts and diagnose issues, to visualise forecasts and missing data, to transform data before scoring, to handle missing forecasts, to aggregate scores, and to visualise the results of the evaluation. The package mostly focuses on the evaluation of probabilistic forecasts and allows evaluating several different forecast types and input formats. Find more information about the package in the Vignettes as well as in the accompanying paper, <doi:10.48550/arXiv.2205.07090>.