This package provides a robust and powerful approach is developed for replicability analysis of two Genome-wide association studies (GWASs) accounting for the linkage disequilibrium (LD) among genetic variants. The LD structure in two GWASs is captured by a four-state hidden Markov model (HMM). The unknowns involved in the HMM are estimated by an efficient expectation-maximization (EM) algorithm in combination with a non-parametric estimation of functions. By incorporating information from adjacent locations via the HMM, this approach identifies the entire clusters of genotype-phenotype associated signals, improving the power of replicability analysis while effectively controlling the false discovery rate.

The pscl is an R package providing classes and methods for:

1. Bayesian analysis of roll call data (item-response models);

2. elementary Bayesian statistics;

3. maximum likelihood estimation of zero-inflated and hurdle models for count data;

4. utility functions.

This package implements the Signaling Pathway Impact Analysis (SPIA) which uses the information form a list of differentially expressed genes and their log fold changes together with signaling pathways topology, in order to identify the pathways most relevant to the condition under the study.

Fits a discharge rating curve based on the power-law and the generalized power-law from data on paired stage and discharge measurements in a given river using a Bayesian hierarchical model as described in Hrafnkelsson et al. (2022) <doi:10.1002/env.2711>.

This package provides easy access to historical climate data in Canada from R. Search for weather stations and download raw hourly, daily or monthly weather data across Canada from 1840 to present. Implements public API access as detailed at <https://climate.weather.gc.ca>.

Generate point data for representing people within spatial data. This collects a suite of tools for creating simple dot density maps. Several functions from different spatial packages are standardized to take the same arguments so that they can be easily substituted for each other.

Identification of hub genes in a gene co-expression network from gene expression data. The differential network analysis for two contrasting conditions leads to the identification of various types of hubs like Housekeeping, Unique to stress (Disease) and Unique to control (Normal) hub genes.

An implementation of data analytic methods in R for analyses for data with ceiling/floor effects. The package currently includes functions for mean/variance estimation and mean comparison tests. Implemented methods are from Aitkin (1964) <doi:10.1007/BF02289723> and Liu & Wang (in prep).

Simulation and analysis of Fully-Latent Principal Stratification (FLPS) with measurement models. Lee, Adam, Kang, & Whittaker (2023). <doi:10.1007/978-3-031-27781-8_25>. This package is supported by the Institute of Education Sciences, U.S. Department of Education, through Grant R305D210036.

This package implements the Known Sub-Sequence Algorithm <doi:10.1016/j.aaf.2021.12.013>, which helps to automatically identify and validate the best method for missing data imputation in a time series. Supports the comparison of multiple state-of-the-art algorithms.

This package contains functions to help create log files. The package aims to overcome the difficulty of the base R sink() command. The log_print() function will print to both the console and the file log, without interfering in other write operations.

Difference scaling is a method for scaling perceived supra-threshold differences. The package contains functions that allow the user to design and run a difference scaling experiment, to fit the resulting data by maximum likelihood and test the internal validity of the estimated scale.

Fetch data from the National Oceanic and Atmospheric Administration Climate Data Online (NOAA CDO) <https://www.ncdc.noaa.gov/cdo-web/webservices/v2> API including daily, monthly, and yearly climate summaries, radar data, climatological averages, precipitation data, annual summaries, storm events, and agricultural meteorology.

This package provides functions to calculate the normalised Lineage-Through- Time (nLTT) statistic, given two phylogenetic trees. The nLTT statistic measures the difference between two Lineage-Through-Time curves, where each curve is normalised both in time and in number of lineages.

An interface between R and the OSRM API. OSRM is a routing service based on OpenStreetMap data. See <http://project-osrm.org/> for more information. This package enables the computation of routes, trips, isochrones and travel distances matrices (travel time and kilometric distance).

Alternative to using withCallingHandlers() in the simple case of catch and rethrow. The `%!%` operator evaluates the expression on its left hand side, and if an error occurs, the right hand side is used to construct a new error that embeds the original error.

Generates data from R or JAGS code for use in simulation studies. The data are returned as an nlist::nlists object and/or saved to file as individual .rds files. Parallelization is implemented using the future package. Progress is reported using the progressr package.

This package implements the Bayesian model selection method with suspected latent grouping factor methodology of Metzger and Franck (2020), <doi:10.1080/00401706.2020.1739561>. SLGF detects latent heteroscedasticity or group-based regression effects based on the levels of a user-specified categorical predictor.

The goal of stim is to provide a function for estimating the Stability Informed Model. The Stability Informed Model integrates stability information (how much a variable correlates with itself in the future) into cross-sectional estimates. Wysocki and Rhemtulla (2022) <https://psyarxiv.com/vg5as>.

This package provides a tufte'-alike style for rmarkdown'. A modern take on the Tufte design for pdf and html vignettes, building on the tufte package with additional contributions from the knitr and ggtufte package, and also acknowledging the key influence of envisioned css'.

We implement causal mediation analysis using the methods proposed by Hong (2010) and Hong, Deutsch & Hill (2015) <doi:10.3102/1076998615583902>. It allows the estimation and hypothesis testing of causal mediation effects through ratio of mediator probability weights (RMPW). This strategy conveniently relaxes the assumption of no treatment-by-mediator interaction while greatly simplifying the outcome model specification without invoking strong distributional assumptions. We also implement a sensitivity analysis by extending the RMPW method to assess potential bias in the presence of omitted pretreatment or posttreatment covariates. The sensitivity analysis strategy was proposed by Hong, Qin, and Yang (2018) <doi:10.3102/1076998617749561>.

Native R interface to TMB (Template Model Builder) so models can be written entirely in R rather than C++'. Automatic differentiation, to any order, is available for a rich subset of R features, including linear algebra for dense and sparse matrices, complex arithmetic, Fast Fourier Transform, probability distributions and special functions. RTMB provides easy access to model fitting and validation following the principles of Kristensen, K., Nielsen, A., Berg, C. W., Skaug, H., & Bell, B. M. (2016) <DOI:10.18637/jss.v070.i05> and Thygesen, U.H., Albertsen, C.M., Berg, C.W. et al. (2017) <DOI:10.1007/s10651-017-0372-4>.

This package provides tools for accessing the Botanical Information and Ecology Network (BIEN) database. The BIEN database contains cleaned and standardized botanical data including occurrence, trait, plot and taxonomic data. This package provides functions that query the BIEN database by constructing and executing optimized SQL queries.

The aim of httr is to provide a wrapper for RCurl customised to the demands of modern web APIs. It provides useful tools for working with HTTP organised by HTTP verbs (GET(), POST(), etc). Configuration functions make it easy to control additional request components.