This package implements the template ICA (independent components analysis) model proposed in Mejia et al. (2020) <doi:10.1080/01621459.2019.1679638> and the spatial template ICA model proposed in Mejia et al. (2022) <doi:10.1080/10618600.2022.2104289>. Both models estimate subject-level brain as deviations from known population-level networks, which are estimated using standard ICA algorithms. Both models employ an expectation-maximization algorithm for estimation of the latent brain networks and unknown model parameters. Includes direct support for CIFTI', GIFTI', and NIFTI neuroimaging file formats. Note, this package has been deprecated and superseded by BayesBrainMap', which includes model improvements and new names for the core functions.

This package performs Bayesian unit root testing for time series models with maintained polynomial trend components as proposed by Chaturvedi and Kumar (2005) <doi:10.1016/j.spl.2005.04.044>. The package BayesURTrend computes posterior odds ratios, Bayes factors, and posterior probabilities for unit root hypotheses against stationary alternatives in autoregressive models augmented with polynomial trends. Methodological foundations for Bayesian unit root testing under structural breaks and maintained trends are drawn from Schotman and van Dijk (1991) <doi:10.1016/0304-4076(91)90038-F>, Phillips and Perron (1988) <doi:10.1093/biomet/75.2.335>, and Ouliaris et al. (1988) <doi:10.1007/978-94-009-2953-1_10>.

This package provides a program for reconstructing local fire histories from high-resolution, continuously sampled lake-sediment charcoal records. CharAnalysis decomposes a charcoal record into low- and high-frequency components and uses locally defined thresholds to separate fire signal from noise, following the approach of Higuera et al. (2009) <doi:10.1890/07-2019.1>, with underlying assumptions and rationale described in Higuera et al. (2010) <doi:10.1071/WF09134>. The package is designed for macroscopic charcoal records with contiguous sampling fine enough to resolve individual fire events, and is not appropriate for low-resolution or discontinuously sampled records. See the package URL for the User's Guide and application examples.

This package performs demographic, bifurcation and evolutionary analysis of physiologically structured population models, which is a class of models that consistently translates continuous-time models of individual life history to the population level. A model of individual life history has to be implemented specifying the individual-level functions that determine the life history, such as development and mortality rates and fecundity. M.A. Kirkilionis, O. Diekmann, B. Lisser, M. Nool, B. Sommeijer & A.M. de Roos (2001) <doi:10.1142/S0218202501001264>. O.Diekmann, M.Gyllenberg & J.A.J.Metz (2003) <doi:10.1016/S0040-5809(02)00058-8>. A.M. de Roos (2008) <doi:10.1111/j.1461-0248.2007.01121.x>.

Calculates the community four moments (mean, variance, skewness, and kurtosis) of a given trait based on the moments described in Wieczynski et al. (2019) <doi:10.1073/pnas.1813723116>. These functional metrics are extremely useful in characterizing the distribution of traits in a plant community. It also provides tidyverse-friendly wrappers to seamlessly calculate advanced functional diversity indices (e.g., FDis, Rao's Q) using fundiversity (Grenie et al. 2023 <doi:10.1111/ecog.06585>) and functional rarity indices using funrar (Grenie et al. 2017 <doi:10.1111/ddi.12629>). Evaluating these community-weighted moments and diversity metrics allows researchers to evaluate shifts in optimal phenotypes and understand ecological filtering with exactness.

Aimed at applying the Harvest classification tree algorithm, modified algorithm of classic classification tree.The harvested tree has advantage of deleting redundant rules in trees, leading to a simplify and more efficient tree model.It was firstly used in drug discovery field, but it also performs well in other kinds of data, especially when the region of a class is disconnected. This package also improves the basic harvest classification tree algorithm by extending the field of data of algorithm to both continuous and categorical variables. To learn more about the harvest classification tree algorithm, you can go to http://www.stat.ubc.ca/Research/TechReports/techreports/220.pdf for more information.

High throughput toxicokinetics ("HTTK") is the combination of 1) chemical-specific in vitro measurements or in silico predictions and 2) generic mathematical models, to predict absorption, distribution, metabolism, and excretion by the body. HTTK methods have been described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>). Here we provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.

Use stem analysis data to reconstructing tree growth and carbon accumulation. Users can independently or in combination perform a number of standard tasks for any tree species. (i) Age class determination. (ii) The cumulative growth, mean annual increment, and current annual increment of diameter at breast height (DBH) with bark, tree height, and stem volume with bark are estimated. (iii) Tree biomass and carbon storage estimation from volume and allometric models are calculated. (iv) Height-diameter relationship is fitted with nonlinear models, if diameter at breast height (DBH) or tree height are available, which can be used to retrieve tree height and diameter at breast height (DBH). <https://github.com/forestscientist/StemAnalysis>.

This package provides tools to extract, label, and read microdata from the 2022 National Census of Population, Households and Dwellings of Argentina stored in REDATAM databases officially distributed by INDEC. Implements a complete province-by-province extraction pipeline with efficient memory management, reconstruction of hierarchical identifiers, automatic variable labeling from official INDEC dictionaries, and integrity verification against published totals. Allows working with census data directly in R without knowledge of REDATAM syntax, and supports export to multiple formats including Parquet, CSV, SPSS and SAS. Census data must be downloaded directly from the official INDEC portal (<https://www.indec.gob.ar>). This package does not distribute census data. Duran (2026) <doi:10.5281/zenodo.19560728>.

Google offers public access to global search volumes from its search engine through the Google Trends portal. The package downloads these search volumes provided by Google Trends and uses them to measure and analyze the distribution of search scores across countries or within countries. The package allows researchers and analysts to use these search scores to investigate global trends based on patterns within these scores. This offers insights such as degree of internationalization of firms and organizations or dissemination of political, social, or technological trends across the globe or within single countries. An outline of the package's methodological foundations and potential applications is available as a working paper: <doi:10.2139/ssrn.3969013>.

Multivariate data analysis is the simultaneous observation of more than one characteristic. In contrast to the analysis of univariate data, in this approach not only a single variable or the relation between two variables can be investigated, but the relations between many attributes can be considered. For the statistical analysis of chemical data one has to take into account the special structure of this type of data. This package contains about 30 functions, mostly for regression, classification and model evaluation and includes some data sets used in the R help examples. It was designed as a R companion to the book "Introduction to Multivariate Statistical Analysis in Chemometrics" written by K. Varmuza and P. Filzmoser (2009).

Non-parametric hypothesis testing for populations of brain networks represented as graphs, following the L1-distance ANOVA framework of Fraiman and Fraiman (2018) <doi:10.1038/s41598-018-23152-5>. The package builds on this nonparametric graph-comparison framework, extending it with procedures for edge-level inference and identification of the specific connections driving group differences. In particular, it provides utilities to compute central (mean) graphs, pairwise Manhattan distances between adjacency matrices, the group test statistic T and its permutation p-value, and a fast permutation procedure to identify the critical edges that drive between-group differences. Helper functions to generate synthetic community-structured graphs and to visualise brain networks with communities are also included.

Identify the most relative data points by dividing a numeric data set into three classes A, B, and C, where class A items are the "import few", class C items are the "trivial many" with class B items being something in between, resembling the idea of the Pareto principle. This ABC classification is done using an ABC curve, which plots cumulative "Yield" against "Effort", similar to a Lorenz curve. Class borders are then precisely mathematically defined on that curve, aiding in interpretation. Based on: Ultsch A, Lotsch J (2015) "Computed ABC Analysis for rational Selection of most informative Variables in multivariate Data". PLoS ONE 10(6): e0129767. <doi:10.1371/journal.pone.0129767>.

This package provides functions for identification and transportation of causal effects. Provides a conditional causal effect identification algorithm (IDC) by Shpitser, I. and Pearl, J. (2006) <http://ftp.cs.ucla.edu/pub/stat_ser/r329-uai.pdf>, an algorithm for transportability from multiple domains with limited experiments by Bareinboim, E. and Pearl, J. (2014) <http://ftp.cs.ucla.edu/pub/stat_ser/r443.pdf>, and a selection bias recovery algorithm by Bareinboim, E. and Tian, J. (2015) <http://ftp.cs.ucla.edu/pub/stat_ser/r445.pdf>. All of the previously mentioned algorithms are based on a causal effect identification algorithm by Tian , J. (2002) <http://ftp.cs.ucla.edu/pub/stat_ser/r309.pdf>.

Relatively easy access is provided to 2023 version of the Maddison project data downloaded 2025-08-28. This project collates all the credible data on population and GDP for 169 countries, with some dating back to the year 1 of the current era. One function makes it easy to find the leaders for each year, allowing users to delete countries like OPEC with narrow economies to focus on technology leaders. Another function makes it easy to plot data for only selected countries or years. Another function makes it relatively easy to obtain references to the original sources, which must be cited per the copyright rules of the Maddison Project for different uses of their data.

adverSCarial is an R Package designed for generating and analyzing the vulnerability of scRNA-seq classifiers to adversarial attacks. The package is versatile and provides a format for integrating any type of classifier. It offers functions for studying and generating two types of attacks, single gene attack and max change attack. The single-gene attack involves making a small modification to the input to alter the classification. The max-change attack involves making a large modification to the input without changing its classification. The CGD attack is based on an estimated gradient descent. against adversarial attacks. The package provides a comprehensive solution for evaluating the robustness of scRNA-seq classifiers against adversarial attacks.

This package provides functions to calculate weights, estimates of changes and corresponding variance estimates for panel data with non-response. Partially overlapping samples are handled. Initially, weights are calculated by linear calibration. By default, the survey package is used for this purpose. It is also possible to use ReGenesees', which can be installed from <https://github.com/DiegoZardetto/ReGenesees>. Variances of linear combinations (changes and averages) and ratios are calculated from a covariance matrix based on residuals according to the calibration model. The methodology was presented at the conference, The Use of R in Official Statistics, and is described in Langsrud (2016) <http://www.revistadestatistica.ro/wp-content/uploads/2016/06/RRS2_2016_A021.pdf>.

This package provides tools for crop breeding analysis including Genetic Coefficient of Variation (GCV), Phenotypic Coefficient of Variation (PCV), heritability, genetic advance calculations, stability analysis using the Eberhart-Russell model, two-way ANOVA for genotype-environment interactions, and Additive Main Effects and Multiplicative Interaction (AMMI) analysis. These tools are developed for crop breeding research and stability evaluation under various environmental conditions. The methods are based on established statistical and biometrical principles. Refer to Eberhart and Russell (1966) <doi:10.2135/cropsci1966.0011183X000600010011x> for stability parameters, Fisher (1935) "The Design of Experiments" <ISBN:9780198522294>, Falconer (1996) "Introduction to Quantitative Genetics" <ISBN:9780582243026>, and Singh and Chaudhary (1985) "Biometrical Methods in Quantitative Genetic Analysis" <ISBN:9788122433764> for foundational methodologies.

This package provides functions to perform comparative causal mediation analysis to compare the mediation effects of different treatments via a common mediator. Results contain the estimates and confidence intervals for the two comparative causal mediation analysis estimands, as well as the ATE and ACME for each treatment. Functions provided in the package will automatically assess the comparative causal mediation analysis scope conditions (i.e. for each comparative causal mediation estimand, a numerator and denominator that are both estimated with the desired statistical significance and of the same sign). Results will be returned for each comparative causal mediation estimand only if scope conditions are met for it. See details in Bansak(2020)<doi:10.1017/pan.2019.31>.

Create a skeleton shiny application with create_template() that is reproducible, can be saved and meets academic standards for attribution. Forked from wallace'. Code is split into modules that are loaded and linked together automatically and each call one function. Guidance pages explain modules to users and flexible logging informs them of any errors. Options enable asynchronous operations, viewing of source code, interactive maps and data tables. Use to create complex analytical applications, following best practices in open science and software development. Includes functions for automating repetitive development tasks and an example application at run_shinyscholar() that requires install.packages("shinyscholar", dependencies = TRUE). A guide to developing applications can be found on the package website.

This package provides a comprehensive suite of functions to design and annotate CRISPR guide RNA (gRNAs) sequences. This includes on- and off-target search, on-target efficiency scoring, off-target scoring, full gene and TSS contextual annotations, and SNP annotation (human only). It currently support five types of CRISPR modalities (modes of perturbations): CRISPR knockout, CRISPR activation, CRISPR inhibition, CRISPR base editing, and CRISPR knockdown. All types of CRISPR nucleases are supported, including DNA- and RNA-target nucleases such as Cas9, Cas12a, and Cas13d. All types of base editors are also supported. gRNA design can be performed on reference genomes, transcriptomes, and custom DNA and RNA sequences. Both unpaired and paired gRNA designs are enabled.

This package provides a likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.

This package provides functions to access data from public RESTful APIs including FINDIC API', World Bank API', and Nager.Date', retrieving real-time or historical data related to Chile such as financial indicators, holidays, and more. Additionally, the package includes curated datasets related to Chile, covering topics such as human rights violations during the Pinochet regime, electoral data, census samples, health surveys, seismic events, territorial codes, and environmental measurements. The package supports research and analysis focused on Chile by integrating open APIs with high-quality datasets from multiple domains. For more information on the APIs, see: FINDIC <https://findic.cl/>, World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, and Nager.Date <https://date.nager.at/Api>.

Empirical Bayes thresholding using the methods developed by I. M. Johnstone and B. W. Silverman. The basic problem is to estimate a mean vector given a vector of observations of the mean vector plus white noise, taking advantage of possible sparsity in the mean vector. Within a Bayesian formulation, the elements of the mean vector are modelled as having, independently, a distribution that is a mixture of an atom of probability at zero and a suitable heavy-tailed distribution. The mixing parameter can be estimated by a marginal maximum likelihood approach. This leads to an adaptive thresholding approach on the original data. Extensions of the basic method, in particular to wavelet thresholding, are also implemented within the package.