The goal of pak is to make package installation faster and more reliable. In particular, it performs all HTTP operations in parallel, so metadata resolution and package downloads are fast. Metadata and package files are cached on the local disk as well. pak has a dependency solver, so it finds version conflicts before performing the installation. This version of pak supports CRAN, Bioconductor and GitHub packages as well.

Transforms datetime data into a format ready for analysis. It offers two core functionalities; aggregating data to a higher level interval (thicken) and imputing records where observations were absent (pad).

This package implements projected sparse Gaussian process Kriging ('Ingram et. al.', 2008, <doi:10.1007/s00477-007-0163-9>) as an additional method for the intamap package. More details on implementation ('Barillec et. al.', 2010, <doi:10.1016/j.cageo.2010.05.008>).

Computes the minimum sample size required for the external validation of an existing multivariable prediction model using the criteria proposed by Archer (2020) <doi:10.1002/sim.8766> and Riley (2021) <doi:10.1002/sim.9025>.

Simulate via Markov chain Monte Carlo (hit-and-run algorithm) a Dirichlet distribution conditioned to satisfy a finite set of linear equality and inequality constraints (hence to lie in a convex polytope that is a subset of the unit simplex).

Calculate parametric mortality and Fertility models, following packages BaSTA in Colchero, Jones and Rebke (2012) <doi:10.1111/j.2041-210X.2012.00186.x> and BaFTA <https://github.com/fercol/BaFTA>, summary statistics (e.g. ageing rates, life expectancy, lifespan equality, etc.), life table and product limit estimators from census data.

Distributes data from the Polarization in Comparative Attitudes Project. Helper functions enable data retrieval in wide and tidy formats for user-defined countries and years. Provides support for case-insensitive country names in many languages. Mehlhaff (2022) <https://imehlhaff.net/files/Polarization%20and%20Democracy.pdf>.

This package provides a suite of diagnostic tools for univariate point processes. This includes tools for simulating and fitting both common and more complex temporal point processes. We also include functions to visualise these point processes and collect existing diagnostic tools of Brown et al. (2002) <doi:10.1162/08997660252741149> and Wu et al. (2021) <doi:10.1002/9781119821588.ch7>, which can be used to assess the fit of a chosen point process model.

Displays provenance graphically for provenance collected by the rdt or rdtLite packages, or other tools providing compatible PROV JSON output. The exact format of the JSON created by rdt and rdtLite is described in <https://github.com/End-to-end-provenance/ExtendedProvJson>. More information about rdtLite and associated tools is available at <https://github.com/End-to-end-provenance/> and Barbara Lerner, Emery Boose, and Luis Perez (2018), Using Introspection to Collect Provenance in R, Informatics, <doi: 10.3390/informatics5010012>.

An implementation of Bayesian single-arm phase II design methods for binary outcome based on posterior probability (Thall and Simon (1994) <doi:10.2307/2533377>) and predictive probability (Lee and Liu (2008) <doi:10.1177/1740774508089279>).

Generates predicted stage change days for an insect, based on daily temperatures and development rate parameters, as developed by Pollard (2014) <http://mural.maynoothuniversity.ie/view/ethesisauthor/Pollard=3ACiaran_P=2E=3A=3A.html>. A few example datasets are included and implemented for P. vulgatissima, the blue willow beetle, but the approach can be readily applied to other species that display similar behaviour.

Cluster analysis via nonparametric density estimation is performed. Operationally, the kernel method is used throughout to estimate the density. Diagnostics methods for evaluating the quality of the clustering are available. The package includes also a routine to estimate the probability density function obtained by the kernel method, given a set of data with arbitrary dimensions.

Given a vector of Taylor series coefficients of sufficient length as input, the function returns the numerator and denominator coefficients for the Padé approximant of appropriate order (Baker, 1975) <ISBN:9780120748556>.

This package provides functions to create confidence intervals for ratios of Poisson rates under misclassification using double sampling. Implementations of the methods described in Kahle, D., P. Young, B. Greer, and D. Young (2016). "Confidence Intervals for the Ratio of Two Poisson Rates Under One-Way Differential Misclassification Using Double Sampling." Computational Statistics & Data Analysis, 95:122â 132.

Fit a time-series model to a crop phenology data, such as time-series rice canopy height. This package returns the model parameters as the summary statistics of crop phenology, and these parameters will be useful to characterize the growth pattern of each cultivar and predict manually-measured traits, such as days to heading and biomass. Please see Taniguchi et al. (2022) <doi:10.3389/fpls.2022.998803> and Taniguchi et al. (2025) <doi: 10.3389/frai.2024.1477637> for detail. This package has been designed for scientific use. Use for commercial purposes shall not be allowed.

This package contains utilities for the analysis of post-translational modifications (PTMs) in proteins, with particular emphasis on the sulfoxidation of methionine residues. Features include the ability to download, filter and analyze data from the sulfoxidation database MetOSite'. Utilities to search and characterize S-aromatic motifs in proteins are also provided. In addition, functions to analyze sequence environments around modifiable residues in proteins can be found. For instance, ptm allows to search for amino acids either overrepresented or avoided around the modifiable residues from the proteins of interest. Functions tailored to test statistical hypothesis related to these differential sequence environments are also implemented. Further and detailed information regarding the methods in this package can be found in (Aledo (2020) <https://metositeptm.com>).

This package implements a partial linear semiparametric mixed-effects model (PLSMM) featuring a random intercept and applies a lasso penalty to both the fixed effects and the coefficients associated with the nonlinear function. The model also accommodates interactions between the nonlinear function and a grouping variable, allowing for the capture of group-specific nonlinearities. Nonlinear functions are modeled using a set of bases functions. Estimation is conducted using a penalized Expectation-Maximization algorithm, and the package offers flexibility in choosing between various information criteria for model selection. Post-selection inference is carried out using a debiasing method, while inference on the nonlinear functions employs a bootstrap approach.

Phylogenetic Diversity (PD, Faith 1992), Evolutionary Distinctiveness (ED, Isaac et al. 2007), Phylogenetic Endemism (PE, Rosauer et al. 2009; Laffan et al. 2016), and Weighted Endemism (WE, Laffan et al. 2016) for presence-absence raster. Faith, D. P. (1992) <doi:10.1016/0006-3207(92)91201-3> Isaac, N. J. et al. (2007) <doi:10.1371/journal.pone.0000296> Laffan, S. W. et al. (2016) <doi:10.1111/2041-210X.12513> Rosauer, D. et al. (2009) <doi:10.1111/j.1365-294X.2009.04311.x>.

This toolkit is designed for manipulation and analysis of peptides. It provides functionalities to assist researchers in peptide engineering and proteomics. Users can manipulate peptides by adding amino acids at every position, count occurrences of each amino acid at each position, and transform amino acid counts based on probabilities. The package offers functionalities to select the best versus the worst peptides and analyze these peptides, which includes counting specific residues, reducing peptide sequences, extracting features through One Hot Encoding (OHE), and utilizing Quantitative Structure-Activity Relationship (QSAR) properties (based in the package Peptides by Osorio et al. (2015) <doi:10.32614/RJ-2015-001>). This package is intended for both researchers and bioinformatics enthusiasts working on peptide-based projects, especially for their use with machine learning.

Construct a principal surface that are two-dimensional surfaces that pass through the middle of a p-dimensional data set. They minimise the distance from the data points, and provide a nonlinear summary of data. The surfaces are nonparametric and their shape is suggested by the data. The formation of a surface is found using an iterative procedure which starts with a linear summary, typically with a principal component plane. Each successive iteration is a local average of the p-dimensional points, where an average is based on a projection of a point onto the nonlinear surface of the previous iteration. For more information on principal surfaces, see Ganey, R. (2019, "https://open.uct.ac.za/items/4e655d7d-d10c-481b-9ccc-801903aebfc8").

Simulation of models Poisson-Tweedie.

Offers a range of utilities and functions for everyday programming tasks. 1.Data Manipulation. Such as grouping and merging, column splitting, and character expansion. 2.File Handling. Read and convert files in popular formats. 3.Plotting Assistance. Helpful utilities for generating color palettes, validating color formats, and adding transparency. 4.Statistical Analysis. Includes functions for pairwise comparisons and multiple testing corrections, enabling perform statistical analyses with ease. 5.Graph Plotting, Provides efficient tools for creating doughnut plot and multi-layered doughnut plot; Venn diagrams, including traditional Venn diagrams, upset plots, and flower plots; Simplified functions for creating stacked bar plots, or a box plot with alphabets group for multiple comparison group.

In causal mediation analysis with multiple causally ordered mediators, a set of path-specific effects are identified under standard ignorability assumptions. This package implements an imputation approach to estimating these effects along with a set of bias formulas for conducting sensitivity analysis (Zhou and Yamamoto <doi:10.31235/osf.io/2rx6p>). It contains two main functions: paths() for estimating path-specific effects and sens() for conducting sensitivity analysis. Estimation uncertainty is quantified using the nonparametric bootstrap.

Permutation Distribution Clustering is a clustering method for time series. Dissimilarity of time series is formalized as the divergence between their permutation distributions. The permutation distribution was proposed as measure of the complexity of a time series.