This package performs pathway enrichment analysis using a voting-based framework that integrates CpGâ gene regulatory information from expression quantitative trait methylation (eQTM) data. For a grid of top-ranked CpGs and filtering thresholds, gene sets are generated and refined using an entropy-based pruning strategy that balances information richness, stability, and probe bias correction. In particular, gene lists dominated by genes with disproportionately high numbers of CpG mappings are penalized to mitigate active probe biasâ a common artifact in methylation data analysis. Enrichment results across parameter combinations are then aggregated using a voting scheme, prioritizing pathways that are consistently recovered under diverse settings and robust to parameter perturbations.

R package to compute Incoming Solar Radiation (insolation) for palaeoclimate studies. Features three solutions: Berger (1978), Berger and Loutre (1991) and Laskar et al. (2004). Computes daily-mean, season-averaged and annual means and for all latitudes, and polar night dates.

Pharmacometric tools for common data analytical tasks; closed-form solutions for calculating concentrations at given times after dosing based on compartmental PK models (1-compartment, 2-compartment and 3-compartment, covering infusions, zero- and first-order absorption, and lag times, after single doses and at steady state, per Bertrand & Mentre (2008) <https://www.facm.ucl.ac.be/cooperation/Vietnam/WBI-Vietnam-October-2011/Modelling/Monolix32_PKPD_library.pdf>); parametric simulation from NONMEM-generated parameter estimates and other output; and parsing, tabulating and plotting results generated by Perl-speaks-NONMEM (PsN).

Levels and changes of productivity and profitability are measured with various indices. The package contains the multiplicatively complete Färe-Primont, Fisher, Hicks-Moorsteen, Laspeyres, Lowe, and Paasche indices, as well as the classic Malmquist productivity index. Färe-Primont and Lowe indices verify the transitivity property and can therefore be used for multilateral or multitemporal comparison. Fisher, Hicks-Moorsteen, Laspeyres, Malmquist, and Paasche indices are not transitive and are only to be used for binary comparison. All indices can also be decomposed into different components, providing insightful information on the sources of productivity and profitability changes. In the use of Malmquist productivity index, the technological change index can be further decomposed into bias technological change components. The package also allows to prohibit technological regression (negative technological change). In the case of the Fisher, Hicks-Moorsteen, Laspeyres, Paasche and the transitive Färe-Primont and Lowe indices, it is furthermore possible to rule out technological change. Deflated shadow prices can also be obtained. Besides, the package allows parallel computing as an option, depending on the user's computer configuration. All computations are carried out with the nonparametric Data Envelopment Analysis (DEA), and several assumptions regarding returns to scale are available. All DEA linear programs are implemented using lp_solve'.

This package provides functions to aid in micro and macro economic analysis and handling of price and currency data. Includes extraction of relevant inflation and exchange rate data from World Bank API, data cleaning/parsing, and standardisation. Inflation adjustment calculations as found in Principles of Macroeconomics by Gregory Mankiw et al (2014). Current and historical end of day exchange rates for 171 currencies from the European Central Bank Statistical Data Warehouse (2020).

This package implements (1) panel cointegration rank tests, (2) estimators for panel vector autoregressive (VAR) models, and (3) identification methods for panel structural vector autoregressive (SVAR) models as described in the accompanying vignette. The implemented functions allow to account for cross-sectional dependence and for structural breaks in the deterministic terms of the VAR processes. Among the large set of functions, particularly noteworthy are those that implement (1) the correlation-augmented inverse normal test on the cointegration rank by Arsova and Oersal (2021, <doi:10.1016/j.ecosta.2020.05.002>), (2) the two-step estimator for pooled cointegrating vectors by Breitung (2005, <doi:10.1081/ETC-200067895>), and (3) the pooled identification based on independent component analysis by Herwartz and Wang (2024, <doi:10.1002/jae.3044>).

In ancient Roman mythology, Pluto was the ruler of the underworld and presides over the afterlife. Pluto was frequently conflated with Plutus', the god of wealth, because mineral wealth was found underground. When plotting with R, you try once, twice, practice again and again, and finally you get a pretty figure you want. It's a plot tour', a tour about repetition and reward. Hope plutor helps you on the tour!

This package contains functions to run propensity-biased allocation to balance covariate distributions in sequential trials and propensity-constrained randomization to balance covariate distributions in trials with known baseline covariates at time of randomization. Currently only supports trials comparing two groups.

Implementation of Probabilistic Regression Trees (PRTree), providing functions for model fitting and prediction, with specific adaptations to handle missing values. The main computations are implemented in Fortran for high efficiency. The package is based on the PRTree methodology described in Alkhoury et al. (2020), "Smooth and Consistent Probabilistic Regression Trees" <https://proceedings.neurips.cc/paper_files/paper/2020/file/8289889263db4a40463e3f358bb7c7a1-Paper.pdf>. Details on the treatment of missing data and implementation aspects are presented in Prass, T.S.; Neimaier, A.S.; Pumi, G. (2025), "Handling Missing Data in Probabilistic Regression Trees: Methods and Implementation in R" <doi:10.48550/arXiv.2510.03634>.

Creation and selection of PARAllel FACtor Analysis (PARAFAC) models of longitudinal microbiome data. You can import your own data with our import functions or use one of the example datasets to create your own PARAFAC models. Selection of the optimal number of components can be done using assessModelQuality() and assessModelStability(). The selected model can then be plotted using plotPARAFACmodel(). The Parallel Factor Analysis method was originally described by Caroll and Chang (1970) <doi:10.1007/BF02310791> and Harshman (1970) <https://www.psychology.uwo.ca/faculty/harshman/wpppfac0.pdf>.

Supports the creation of burndown charts and gantt diagrams.

Village potential statistics (PODES) collects various information on village potential and challenges faced by villages in Indonesia. Information related to village potential includes economy, security, health, employment, communication and information, sports, entertainment, development, community empowerment, education, socio-culture, transportation in the village. Information related to challenges includes natural disasters, public health, environmental pollution, social problems and security disturbances that occur in the village.

The pwrss R package provides flexible and comprehensive functions for statistical power and minimum required sample size calculations across a wide range of commonly used hypothesis tests in psychological, biomedical, and social sciences.

This package provides methods for reducing the number of features within a data set. See Bauer JO (2021) <doi:10.1145/3475827.3475832> and Bauer JO, Drabant B (2021) <doi:10.1016/j.jmva.2021.104754> for more information on principal loading analysis.

This package provides tools to print a compact, readable directory tree for a folder or project. The package can automatically detect common project roots (e.g., RStudio .Rproj files) and formats output for quick inspection of code and data organization. It supports typical tree customizations such as limiting depth, excluding files using ignore patterns, and producing clean, aligned text output suitable for console use, reports, and reproducible documentation. A snapshot helper can also render the tree output to a PNG image for sharing in issues, teaching material, or project documentation.

This package implements fast, safe, and customizable assertions routines, which can be used in place of base::stopifnot().

This function obtains a Random Number Generator (RNG) or collection of RNGs that replicate the required parameter(s) of a distribution for a time series of data. Consider the case of reproducing a time series data set of size 20 that uses an autoregressive (AR) model with phi = 0.8 and standard deviation equal to 1. When one checks the arima.sin() function's estimated parameters, it's possible that after a single trial or a few more, one won't find the precise parameters. This enables one to look for the ideal RNG setting for a simulation that will accurately duplicate the desired parameters.

Implementation of the automatic shift detection method for Brownian Motion (BM) or Ornsteinâ Uhlenbeck (OU) models of trait evolution on phylogenies. Some tools to handle equivalent shifts configurations are also available. See Bastide et al. (2017) <doi:10.1111/rssb.12206> and Bastide et al. (2018) <doi:10.1093/sysbio/syy005>.

Matches cases to controls based on genotype principal components (PC). In order to produce better results, matches are based on the weighted distance of PCs where the weights are equal to the % variance explained by that PC. A weighted Mahalanobis distance metric (Kidd et al. (1987) <DOI:10.1016/0031-3203(87)90066-5>) is used to determine matches.

Based on different statistical definitions of discrimination, several methods have been proposed to detect and mitigate social inequality in machine learning models. This package aims to provide an alternative to fairness treatment in predictive models. The ROC method implemented in this package is described by Kamiran, Karim and Zhang (2012) <https://ieeexplore.ieee.org/document/6413831/>.

Statistical methods for estimating preferential attachment and node fitness generative mechanisms in temporal complex networks are provided. Thong Pham et al. (2015) <doi:10.1371/journal.pone.0137796>. Thong Pham et al. (2016) <doi:10.1038/srep32558>. Thong Pham et al. (2020) <doi:10.18637/jss.v092.i03>. Thong Pham et al. (2021) <doi:10.1093/comnet/cnab024>.

Calculate common types of tables for weighted survey data. Options include topline and (2-way and 3-way) crosstab tables of categorical or ordinal data as well as summary tables of weighted numeric variables. Optionally, include the margin of error at selected confidence intervals including the design effect. The design effect is calculated as described by Kish (1965) <doi:10.1002/bimj.19680100122> beginning on page 257. Output takes the form of tibbles (simple data frames). This package conveniently handles labelled data, such as that commonly used by Stata and SPSS. Complex survey design is not supported at this time.

This package contains a function to categorize accelerometer readings collected in free-living (e.g., for 24 hours/day for 7 days), preprocessed and compressed as counts (unit-less value) in a specified time period termed epoch (e.g., 1 minute) as either bedrest (sleep) or active. The input is a matrix with a timestamp column and a column with number of counts per epoch. The output is the same dataframe with an additional column termed bedrest. In the bedrest column each line (epoch) contains a function-generated classification br or a denoting bedrest/sleep and activity, respectively. The package is designed to be used after wear/nonwear marking function in the PhysicalActivity package. Version 1.1 adds preschool thresholds and corrects for possible errors in algorithm implementation.

Combine probabilistic forecasts using CRPS learning algorithms proposed in Berrisch, Ziel (2021) <doi:10.48550/arXiv.2102.00968> <doi:10.1016/j.jeconom.2021.11.008>. The package implements multiple online learning algorithms like Bernstein online aggregation; see Wintenberger (2014) <doi:10.48550/arXiv.1404.1356>. Quantile regression is also implemented for comparison purposes. Model parameters can be tuned automatically with respect to the loss of the forecast combination. Methods like predict(), update(), plot() and print() are available for convenience. This package utilizes the optim C++ library for numeric optimization <https://github.com/kthohr/optim>.