This package provides tools for analyzing data generated from conjoint survey experiments, a method widely used in the social sciences for studying multidimensional preferences. The package implements estimation of marginal means (MMs) and average marginal component effects (AMCEs), with corrections for measurement error. Methods include profile-level and choice-level estimators, bias correction using intra-respondent reliability (IRR), and visualization utilities. For details on the methodology, see Clayton, Horiuchi, Kaufman, King, and Komisarchik (2025) <https://gking.harvard.edu/conjointE>.

This package provides functionality for the prior and posterior projected Polya tree for the analysis of circular data (Nieto-Barajas and Nunez-Antonio (2019) <arXiv:1902.06020>).

This package provides functionality for quality control processing and statistical analysis of mass spectrometry (MS) omics data, in particular proteomic (either at the peptide or the protein level), lipidomic, and metabolomic data, as well as RNA-seq based count data and nuclear magnetic resonance (NMR) data. This includes data transformation, specification of groups that are to be compared against each other, filtering of features and/or samples, data normalization, data summarization (correlation, PCA), and statistical comparisons between defined groups. Implements methods described in: Webb-Robertson et al. (2014) <doi:10.1074/mcp.M113.030932>. Webb-Robertson et al. (2011) <doi:10.1002/pmic.201100078>. Matzke et al. (2011) <doi:10.1093/bioinformatics/btr479>. Matzke et al. (2013) <doi:10.1002/pmic.201200269>. Polpitiya et al. (2008) <doi:10.1093/bioinformatics/btn217>. Webb-Robertson et al. (2010) <doi:10.1021/pr1005247>.

This package provides a set of Study Data Tabulation Model (SDTM) datasets constructed by modifying the pharmaversesdtm package to meet J&J Innovative Medicine's standard data structure for Clinical and Statistical Programming.

Simulating particle movement in 2D space has many application. The particles package implements a particle simulator based on the ideas behind the d3-force JavaScript library. particles implements all forces defined in d3-force as well as others such as vector fields, traps, and attractors.

It creates a lattice plot to visualize panel or longitudinal data. The observed values are plotted as dots and the fitted values as lines, both against time. The plot is customizable and easy to edit, even if you do not know how to construct a lattice plot from scratch.

Computation of predictive information criteria (PIC) from select model object classes for model selection in predictive contexts. In contrast to the more widely used Akaike Information Criterion (AIC), which are derived under the assumption that target(s) of prediction (i.e. validation data) are independently and identically distributed to the fitting data, the PIC are derived under less restrictive assumptions and thus generalize AIC to the more practically relevant case of training/validation data heterogeneity. The methodology featured in this package is based on Flores (2021) <https://iro.uiowa.edu/esploro/outputs/doctoral/A-new-class-of-information-criteria/9984097169902771?institution=01IOWA_INST> "A new class of information criteria for improved prediction in the presence of training/validation data heterogeneity".

Density, distribution function, quantile function, and random generation function based on Kittipong Klinjan,Tipat Sottiwan and Sirinapa Aryuyuen (2024)<DOI:10.28919/cmbn/8833>.

This package provides a simple function to bind a piped object to a placeholder symbol to enable complex function evaluation with the base R |> pipe.

Different regularization approaches for Cox Frailty Models by penalization methods are provided. see Groll et al. (2017) <doi:10.1111/biom.12637> for effects selection. See also Groll and Hohberg (2024) <doi:10.1002/bimj.202300020> for classical LASSO approach.

This package provides a modeling tool dedicated to biological network modeling (Bertrand and others 2020, <doi:10.1093/bioinformatics/btaa855>). It allows for single or joint modeling of, for instance, genes and proteins. It starts with the selection of the actors that will be the used in the reverse engineering upcoming step. An actor can be included in that selection based on its differential measurement (for instance gene expression or protein abundance) or on its time course profile. Wrappers for actors clustering functions and cluster analysis are provided. It also allows reverse engineering of biological networks taking into account the observed time course patterns of the actors. Many inference functions are provided and dedicated to get specific features for the inferred network such as sparsity, robust links, high confidence links or stable through resampling links. Some simulation and prediction tools are also available for cascade networks (Jung and others 2014, <doi:10.1093/bioinformatics/btt705>). Example of use with microarray or RNA-Seq data are provided.

This package provides a suite of Propensity Score Predictive Inference (PSPI) methods to generalize treatment effects in trials to target populations. The package includes an existing model Bayesian Causal Forest (BCF) and four PSPI models (BCF-PS, FullBART, SplineBART, DSplineBART). These methods leverage Bayesian Additive Regression Trees (BART) to adjust for high-dimensional covariates and nonlinear associations, while SplineBART and DSplineBART further use propensity score based splines to address covariate shift between trial data and target population.

This package provides a collection of easy-to-use tools for regression analysis of survival data with a cure fraction proposed in Su et al. (2022) <doi:10.1177/09622802221108579>. The modeling framework is based on the Cox proportional hazards mixture cure model and the bounded cumulative hazard (promotion time cure) model. The pseudo-observations approach is utilized to assess covariate effects and embedded in the variable selection procedure.

This package provides a shiny app that supports merging of PDF and/or image files with page selection, removal, or rotation options. It is a fast, free, and secure alternative to commercial software or various online websites which require users to sign-up, and it avoids any potential risks associated with uploading files elsewhere.

This package provides some easy-to-use functions for spatial analyses of (plant-) phenological data sets and satellite observations of vegetation.

This package provides functions to easily convert data to binary formats other programs/machines can understand.

This package provides functions for generating variants of curves: restricted cubic spline, periodic restricted cubic spline, periodic cubic spline. Periodic splines can be used to model data that has periodic nature / seasonality.

Offers tools to estimate and visualize levels of major pollutants (CO, NO2, SO2, Ozone, PM2.5 and PM10) across the conterminous United States for user-defined time ranges. Provides functions to retrieve pollutant data from the U.S. Environmental Protection Agencyâ s Air Quality System (AQS) API service <https://aqs.epa.gov/aqsweb/documents/data_api.html> for interactive visualization through a shiny application, allowing users to explore pollutant levels for a given location over time relative to the National Ambient Air Quality Standards (NAAQS).

This package provides a shiny application for visualizing high-dimensional data using non-linear dimensionality reduction (NLDR) techniques such as t-SNE and UMAP. It provides an interactive platform to explore high-dimensional datasets, diagnose the quality of the embeddings using the quollr package, and compare different NLDR methods.

This package provides a suite of likelihood ratio test based methods to use in pharmacovigilance. Contains various testing and post-processing functions.

Estimate coefficient of variation percent (CV%) for any arbitrary distribution, including some built-in estimates for commonly-used transformations in pharmacometrics. Methods are described in various sources, but applied here as summarized in: Prybylski, (2024) <doi:10.1007/s40262-023-01343-2>.

This package provides tools for processing, analyzing, and visualizing spectral data collected from 3D laser-based scanning systems. Supports applications in agriculture, forestry, environmental monitoring, industrial quality control, and biomedical research. Enables evaluation of plant growth, productivity, resource efficiency, disease management, and pest monitoring. Includes statistical methods for extracting insights from multispectral and hyperspectral data and generating publication-ready visualizations. See Zieschank & Junker (2023) <doi:10.3389/fpls.2023.1141554> and Saric et al. (2022) <doi:10.1016/J.TPLANTS.2021.12.003> for related work.

Estimation of pharmacokinetic parameters using non-compartmental theory.

This package provides functions to make board game graphics with the ggplot2', grid', rayrender', rayvertex', and rgl packages. Specializes in game diagrams, animations, and "Print & Play" layouts for the piecepack <https://www.ludism.org/ppwiki> but can make graphics for other board game systems. Includes configurations for several public domain game systems such as checkers, (double-18) dominoes, go, piecepack', playing cards, etc.