Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software. Some features are 1) CDISC SDTM terms 2) Automatic slope selection with the same criterion of WinNonlin(R) 3) Supporting both linear-up linear-down and linear-up log-down method 4) Interval(partial) AUCs with linear or log interpolation method * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

Access a variety of PubMed data through a single, user-friendly interface, including abstracts, bibliometrics from iCite', pubtations from PubTator3', and full-text records from PMC'.

This package performs partial principal component analysis of a large sparse matrix. The matrix may be stored as a list of matrices to be concatenated (implicitly) horizontally. Useful application includes cases where the number of total nonzero entries exceed the capacity of 32 bit integers (e.g., with large Single Nucleotide Polymorphism data).

Graphical methods testing multivariate normality assumption. Methods including assessing score function, and moment generating functions,independent transformations and linear transformations. For more details see Tran (2024),"Contributions to Multivariate Data Science: Assessment and Identification of Multivariate Distributions and Supervised Learning for Groups of Objects." , PhD thesis, <https://our.oakland.edu/items/c8942577-2562-4d2f-8677-cb8ec0bf6234>.

This package performs partial verification bias (PVB) correction for binary diagnostic tests, where PVB arises from selective patient verification in diagnostic accuracy studies. Supports correction of important accuracy measures -- sensitivity, specificity, positive predictive values and negative predictive value -- under missing-at-random and missing-not-at-random missing data mechanisms. Available methods and references are "Begg and Greenes methods" in Alonzo & Pepe (2005) <doi:10.1111/j.1467-9876.2005.00477.x> and deGroot et al. (2011) <doi:10.1016/j.annepidem.2010.10.004>; "Multiple imputation" in Harel & Zhou (2006) <doi:10.1002/sim.2494>, "EM-based logistic regression" in Kosinski & Barnhart (2003) <doi:10.1111/1541-0420.00019>; "Inverse probability weighting" in Alonzo & Pepe (2005) <doi:10.1111/j.1467-9876.2005.00477.x>; "Inverse probability bootstrap sampling" in Nahorniak et al. (2015) <doi:10.1371/journal.pone.0131765> and Arifin & Yusof (2022) <doi:10.3390/diagnostics12112839>; "Scaled inverse probability resampling methods" in Arifin & Yusof (2025) <doi:10.1371/journal.pone.0321440>.

Psychometric mixture models based on flexmix infrastructure. At the moment Rasch mixture models with different parameterizations of the score distribution (saturated vs. mean/variance specification), Bradley-Terry mixture models, and MPT mixture models are implemented. These mixture models can be estimated with or without concomitant variables. See Frick et al. (2012) <doi:10.18637/jss.v048.i07> and Frick et al. (2015) <doi:10.1177/0013164414536183> for details on the Rasch mixture models.

Fits penalized generalized estimating equations to longitudinal data with high-dimensional covariates.

Compute detailed and aggregated performance spectrum for event data. The detailed performance spectrum describes the event data in terms of segments, where the performance of each segment is measured and plotted for any occurrences of this segment over time and can be classified, e.g., regarding the overall population. The aggregated performance spectrum visualises the amount of cases of particular performance over time. Denisov, V., Fahland, D., & van der Aalst, W. M. P. (2018) <doi:10.1007/978-3-319-98648-7_9>.

R API for Pathling', a tool for querying and transforming electronic health record data that is represented using the Fast Healthcare Interoperability Resources (FHIR) standard - see <https://pathling.csiro.au/docs>.

High-quality real-world data can be transformed into scientific real-world evidence for regulatory and healthcare decision-making using proven analytical methods and techniques. For example, propensity score (PS) methodology can be applied to select a subset of real-world data containing patients that are similar to those in the current clinical study in terms of baseline covariates, and to stratify the selected patients together with those in the current study into more homogeneous strata. Then, statistical methods such as the power prior approach or composite likelihood approach can be applied in each stratum to draw inference for the parameters of interest. This package provides functions that implement the PS-integrated real-world evidence analysis methods such as Wang et al. (2019) <doi:10.1080/10543406.2019.1657133>, Wang et al. (2020) <doi:10.1080/10543406.2019.1684309>, and Chen et al. (2020) <doi:10.1080/10543406.2020.1730877>.

Implementations of several methods for principal component analysis using the L1 norm. The package depends on COIN-OR Clp version >= 1.17.4. The methods implemented are PCA-L1 (Kwak 2008) <DOI:10.1109/TPAMI.2008.114>, L1-PCA (Ke and Kanade 2003, 2005) <DOI:10.1109/CVPR.2005.309>, L1-PCA* (Brooks, Dula, and Boone 2013) <DOI:10.1016/j.csda.2012.11.007>, L1-PCAhp (Visentin, Prestwich and Armagan 2016) <DOI:10.1007/978-3-319-46227-1_37>, wPCA (Park and Klabjan 2016) <DOI: 10.1109/ICDM.2016.0054>, awPCA (Park and Klabjan 2016) <DOI: 10.1109/ICDM.2016.0054>, PCA-Lp (Kwak 2014) <DOI:10.1109/TCYB.2013.2262936>, and SharpEl1-PCA (Brooks and Dula, submitted).

Drawing population pyramid using (1) data.frame or (2) vectors. The former is named as pyramid() and the latter pyramids(), as wrapper function of pyramid(). pyramidf() is the function to draw population pyramid within the specified frame.

Fast functions for dealing with prime numbers, such as testing whether a number is prime and generating a sequence prime numbers. Additional functions include finding prime factors and Ruth-Aaron pairs, finding next and previous prime numbers in the series, finding or estimating the nth prime, estimating the number of primes less than or equal to an arbitrary number, computing primorials, prime k-tuples (e.g., twin primes), finding the greatest common divisor and smallest (least) common multiple, testing whether two numbers are coprime, and computing Euler's totient function. Most functions are vectorized for speed and convenience.

This package provides functions and datasets to support Valliant, Dever, and Kreuter (2018), <doi:10.1007/978-3-319-93632-1>, "Practical Tools for Designing and Weighting Survey Samples". Contains functions for sample size calculation for survey samples using stratified or clustered one-, two-, and three-stage sample designs, and single-stage audit sample designs. Functions are included that will group geographic units accounting for distances apart and measures of size. Other functions compute variance components for multistage designs, sample sizes in two-phase designs, and a stopping rule for ending data collection. A number of example data sets are included.

This package implements statistical methods for estimating disease penetrance in family-based studies. Penetrance refers to the probability of disease§ manifestation in individuals carrying specific genetic variants. The package provides tools for age-specific penetrance estimation, handling missing data, and accounting for ascertainment bias in family studies. Cite as: Kubista, N., Braun, D. & Parmigiani, G. (2024) <doi:10.48550/arXiv.2411.18816>.

Implementation of PCMRS (Partial Credit Model with Response Styles) as proposed in by Tutz, Schauberger and Berger (2018) <doi:10.1177/0146621617748322> . PCMRS is an extension of the regular partial credit model. PCMRS allows for an additional person parameter that characterizes the response style of the person. By taking the response style into account, the estimates of the item parameters are less biased than in partial credit models.

This package provides Partial least squares Regression and various regular, sparse or kernel, techniques for fitting Cox models in high dimensional settings <doi:10.1093/bioinformatics/btu660>, Bastien, P., Bertrand, F., Meyer N., Maumy-Bertrand, M. (2015), Deviance residuals-based sparse PLS and sparse kernel PLS regression for censored data, Bioinformatics, 31(3):397-404. Cross validation criteria were studied in <doi:10.48550/arXiv.1810.02962>, Bertrand, F., Bastien, Ph. and Maumy-Bertrand, M. (2018), Cross validating extensions of kernel, sparse or regular partial least squares regression models to censored data.

Shiny app to interactively visualize hierarchical clustering with prototypes. For details on hierarchical clustering with prototypes, see Bien and Tibshirani (2011) <doi:10.1198/jasa.2011.tm10183>. This package currently launches the application.

This package provides methods for spatial predictive modeling, especially for spatial distribution models. This includes algorithms for model fitting and prediction, as well as methods for model evaluation.

This package provides the probability, distribution, and quantile functions and random number generator for the Poisson-Binomial distribution. This package relies on FFTW to implement the discrete Fourier transform, so that it is much faster than the existing implementation of the same algorithm in R.

This package provides tools for analyzing and optimizing PTSD (Post-Traumatic Stress Disorder) diagnostic criteria using PCL-5 (PTSD Checklist for DSM-5) data. Functions identify optimal subsets of PCL-5 items that maintain diagnostic accuracy while reducing assessment burden. Includes tools for both hierarchical (cluster-based) and non-hierarchical symptom combinations, calculation of diagnostic metrics, and comparison with standard DSM-5 criteria. Model validation is conducted using holdout and cross-validation methods to assess robustness and generalizability of the results. For more details see Weidmann et al. (2025) <doi:10.31219/osf.io/6rk72_v1>.

Periodic B Splines Basis.

Includes functions to wrap most endpoints of the PaleobioDB API and to visualize and process the obtained fossil data. The API documentation for the Paleobiology Database can be found at <https://paleobiodb.org/data1.2/>.

This package implements an efficient and powerful Bayesian approach for sparse high-dimensional linear regression. It uses minimal prior assumptions on the parameters through plug-in empirical Bayes estimates of hyperparameters. An efficient Parameter-Expanded Expectation-Conditional-Maximization (PX-ECM) algorithm estimates maximum a posteriori (MAP) values of regression parameters and variable selection probabilities. The PX-ECM results in a robust computationally efficient coordinate-wise optimization, which adjusts for the impact of other predictor variables. The E-step is motivated by the popular two-group approach to multiple testing. The result is a PaRtitiOned empirical Bayes Ecm (PROBE) algorithm applied to sparse high-dimensional linear regression, implemented using one-at-a-time or all-at-once type optimization. More information can be found in McLain, Zgodic, and Bondell (2022) <arXiv:2209.08139>.