The Moving Epidemic Method, created by T Vega and JE Lozano (2012, 2015) <doi:10.1111/j.1750-2659.2012.00422.x>, <doi:10.1111/irv.12330>, allows the weekly assessment of the epidemic and intensity status to help in routine respiratory infections surveillance in health systems. Allows the comparison of different epidemic indicators, timing and shape with past epidemics and across different regions or countries with different surveillance systems. Also, it gives a measure of the performance of the method in terms of sensitivity and specificity of the alert week.

Package for moving grid adjustment in plant breeding field trials.

This package performs multivariate meta-analysis for high-dimensional data to integrate and collectively analyse individual-level data from multiple studies, as well as to combine summary estimates. This approach accounts for correlation between outcomes, incorporates within- and between-study variability, handles missing values, and uses shrinkage estimation to accommodate high dimensionality. The MetaHD R package provides access to our multivariate meta-analysis approach, along with a comprehensive suite of existing meta-analysis methods, including fixed-effects and random-effects models, Fisher's method, Stouffer's method, the weighted Z method, Lancaster's method, the weighted Fisher's method, and vote-counting approach. Visualisation tools are provided for interpreting and comparing results across methods, including Venn diagrams, UpSet plots, and ROC curves, heatmaps of pooled effect sizes and correlations among outcomes. A detailed vignette with example datasets and code for data preparation and analysis is available at <https://alyshadelivera.github.io/MetaHD_vignette/>.

Pooling estimates reported in meta-analyses (literature-based, LB) and estimates based on individual participant data (IPD) is not straight-forward as the details of the LB nonlinear function estimate are not usually reported. This package pools the nonlinear IPD dose-response estimates based on a natural cubic spline from lm or glm with the pointwise LB estimates and their estimated variances. Details will be presented in Härkänen, Tapanainen, Sares-Jäske, Männistö, Kaartinen and Paalanen (2026) "Novel pooling method for nonlinear cohort analysis and meta-analysis estimates: Predicting health outcomes based on climate-friendly diets" Epidemiology <doi:10.1097/EDE.0000000000001932>.

Routines to generate fully randomized moodle quizzes. It also contains 15 examples and a shiny app.

This package provides tools for privacy-preserving meta-analysis of function-valued quantities across heterogeneous studies. Implements the MetaHunt pipeline, including the denoised functional Successive Projection Algorithm (d-fSPA) for basis hunting, constrained weight estimation, Dirichlet regression of weights on study-level covariates, target prediction, and split/cross conformal prediction intervals. Operates on aggregate-level function evaluations, so individual-level data from source studies are not required. Methodology described in Shi, Imai, and Zhang (2026) <doi:10.48550/arXiv.2604.23847>.

Plotting functions for mutational signatures and mutational spectra, including single base substitutions (SBS), doublet base substitutions (DBS), and small insertions and deletions (indels). Generates plots similar to those used previously in Alexandrov et al. (2020)<doi:10.1038/s41586-020-1943-3> and Rozen et al. (2026)<doi:10.5281/zenodo.18451842>.

Random Forest Spatial Interpolation (RFSI, SekuliÄ et al. (2020) <doi:10.3390/rs12101687>) and spatio-temporal geostatistical (spatio-temporal regression Kriging (STRK)) interpolation for meteorological (Kilibarda et al. (2014) <doi:10.1002/2013JD020803>, SekuliÄ et al. (2020) <doi:10.1007/s00704-019-03077-3>) and other environmental variables. Contains global spatio-temporal models calculated using publicly available data.

Three algorithms for estimating a Markov random field structure.Two of them are an exact version and a simulated annealing version of a penalized maximum conditional likelihood method similar to the Bayesian Information Criterion. These algorithm are described in Frondana (2016) <doi:10.11606/T.45.2018.tde-02022018-151123>.The third one is a greedy algorithm, described in Bresler (2015) <doi:10.1145/2746539.2746631).

The detection of worrying approximate collinearity in a multiple linear regression model is a problem addressed in all existing statistical packages. However, we have detected deficits regarding to the incorrect treatment of qualitative independent variables and the role of the intercept of the model. The objective of this package is to correct these deficits. In this package will be available detection and treatment techniques traditionally used as the recently developed.

The model.matrix() function in R is convenient for transforming training dataset for modeling. But it does not save any parameter used in transformation, so it is hard to apply the same transformation to test dataset or new dataset. This package is created to solve the problem.

This package provides a complete toolkit to process the Munich ChronoType Questionnaire (MCTQ) for its three versions (standard, micro, and shift). MCTQ is a quantitative and validated tool to assess chronotypes using peoples sleep behavior, originally presented by Till Roenneberg, Anna Wirz-Justice, and Martha Merrow (2003, <doi:10.1177/0748730402239679>).

Extend the functionality of the mclust package for Gaussian finite mixture modeling by including: density estimation for data with bounded support (Scrucca, 2019 <doi:10.1002/bimj.201800174>); modal clustering using MEM (Modal EM) algorithm for Gaussian mixtures (Scrucca, 2021 <doi:10.1002/sam.11527>); entropy estimation via Gaussian mixture modeling (Robin & Scrucca, 2023 <doi:10.1016/j.csda.2022.107582>); Gaussian mixtures modeling of financial log-returns (Scrucca, 2024 <doi:10.3390/e26110907>).

This package provides functions to perform all steps of genome-wide association meta-analysis for studying Genotype x Environment interactions, from collecting the data to the manhattan plot. The procedure accounts for the potential correlation between studies. In addition to the Fixed and Random models, one can investigate the relationship between QTL effects and some qualitative or quantitative covariate via the test of contrast and the meta-regression, respectively. The methodology is available from: (De Walsche, A., et al. (2025) \doi10.1371/journal.pgen.1011553).

Compute the average of a sequence of random vectors in a moving expanding window using a fixed amount of memory.

This package provides functions to enhance the available statistical analysis procedures in R by providing simple functions to analysis and visualize the 16S rRNA data.Here we present a tutorial with minimum working examples to demonstrate usage and dependencies.

This package provides spatially survey balanced designs. Information about the package itself is given in Foster (2021) <doi:10.1111/2041-210X.13535>. Designs using MBHdesign can: 1) accommodate, without substantial detrimental effects on spatial balance, legacy sites (Foster et al., 2017 <doi:10.1111/2041-210X.12782>); 2) be based on points or transects (foster et al. 2020 <doi:10.1111/2041-210X.13321> and produce clustered samples (Foster et al. (in press). The base idea that these designs stem from is the quasi-random number method described Robinson et al. (2013) <doi:10.1111/biom.12059> and adjusted in Robinson et al. (2017) <doi:10.1016/j.spl.2017.05.004>.

Use multi-state splitting to apply Adaptive-Dynamic PCA (ADPCA) to data generated from a continuous-time multivariate industrial or natural process. Employ PCA-based dimension reduction to extract linear combinations of relevant features, reducing computational burdens. For a description of ADPCA, see <doi:10.1007/s00477-016-1246-2>, the 2016 paper from Kazor et al. The multi-state application of ADPCA is from a manuscript under current revision entitled "Multi-State Multivariate Statistical Process Control" by Odom, Newhart, Cath, and Hering, and is expected to appear in Q1 of 2018.

Matrix eQTL is designed for fast eQTL analysis on large datasets. Matrix eQTL can test for association between genotype and gene expression using linear regression with either additive or ANOVA genotype effects. The models can include covariates to account for factors as population stratification, gender, and clinical variables. It also supports models with heteroscedastic and/or correlated errors, false discovery rate estimation and separate treatment of local (cis) and distant (trans) eQTLs. For more details see Shabalin (2012) <doi:10.1093/bioinformatics/bts163>.

Do multilevel mediation analysis with generalized additive multilevel models. The analysis method is described in Yu and Li (2020), "Third-Variable Effect Analysis with Multilevel Additive Models", PLoS ONE 15(10): e0241072.

This package provides a streamlined toolkit specifically designed for genomic selection and quantitative genetics in animal breeding. It provides high-performance data manipulation backed by data.table', focusing on multi-breed and multi-trait nested grouping operations. Features include zero-copy data importing, automated cross-validation splitting, and robust tools to generate and batch-export formatted phenotypic files required by various breeding software (e.g., ASReml-R', HIBLUP', DMU'), heavily optimizing iterative variance component analysis and large-scale evaluation pipelines.

We introduce a generalized factor model designed to jointly analyze high-dimensional multi-modality data from multiple studies by extracting study-shared and specified factors. Our factor models account for heterogeneous noises and overdispersion among modality variables with augmented covariates. We propose an efficient and speedy variational estimation procedure for estimating model parameters, along with a novel criterion for selecting the optimal number of factors. More details can be referred to Liu et al. (2025) <doi:10.48550/arXiv.2507.09889>.

Computes dielectric response and optical cross-sections of metallic nanoparticles using Drude dielectric model and Rayleigh approximation.

This package provides density, distribution, quantile, and random generation functions for the Modified Half-Normal (MHN) distribution, along with moments, mode, and the Fox-Wright Psi function used as the normalizing constant. The MHN distribution arises as a conditional posterior in Bayesian MCMC and generalizes the half-normal, truncated normal, and square-root gamma distributions. Implements efficient sampling via the Sun, Kong & Pal (2023) <doi:10.1080/03610926.2021.1934700> algorithms and the Gao & Wang (2025) <doi:10.1080/03610918.2025.2524551> RTDR method.