This package implements atom-based regression models (ABRM) for analyzing spatially misaligned data. Provides functions for simulating misaligned spatial data, preparing NIMBLE model inputs, running MCMC diagnostics, and comparing different spatial analysis methods including dasymetric mapping. All main functions return S3 objects with print(), summary(), and plot() methods for intuitive result exploration. Methods are described in Nethery et al. (2023) <doi:10.1101/2023.01.10.23284410>. Further methodological details and software implementation are described in Qian et al. (in review).

CukeModeler facilitates modeling a test suite that is written in Gherkin (e.g. Cucumber, SpecFlow, Lettuce, etc.). It does this by providing an abstraction layer on top of the Abstract Syntax Tree (AST) that the cucumber-gherkin generates when parsing features, as well as providing models for feature files and directories in order to be able to have a fully traversable model tree of a test suite's structure. These models can then be analyzed or manipulated more easily than the underlying AST layer.

This package provides tools for integrated sensitivity analysis of evidence factors in observational studies. When an observational study allows for multiple independent or nearly independent inferences which, if vulnerable, are vulnerable to different biases, we have multiple evidence factors. This package provides methods that respect type I error rate control. Examples are provided of integrated evidence factors analysis in a longitudinal study with continuous outcome and in a case-control study. Karmakar, B., French, B., and Small, D. S. (2019)<DOI:10.1093/biomet/asz003>.

This library is a collection of pseudo random number generators.

While Common Lisp does provide a RANDOM function, it does not allow the user to pass an explicit SEED, nor to portably exchange the random state between implementations. This can be a headache in cases like games, where a controlled seeding process can be very useful.

For both curiosity and convenience, this library offers multiple algorithms to generate random numbers, as well as a bunch of generally useful methods to produce desired ranges.

Estimation and goodness-of-fit functions for copula-based models of bivariate data with arbitrary distributions (discrete, continuous, mixture of both types). The copula families considered here are the Gaussian, Student, Clayton, Frank, Gumbel, Joe, Plackett, BB1, BB6, BB7,BB8, together with the following non-central squared copula families in Nasri (2020) <doi:10.1016/j.spl.2020.108704>: ncs-gaussian, ncs-clayton, ncs-gumbel, ncs-frank, ncs-joe, and ncs-plackett. For theoretical details, see, e.g., Nasri and Remillard (2023) <arXiv:2301.13408>.

RStudio as of recently offers the option to define addins and assign shortcuts to them. This package contains addins for a few most frequently used functions in a data scientist's (at least mine) daily work (like str(), example(), plot(), head(), view(), Desc()). Most of these functions will use the current selection in the editor window and send the specific command to the console while instantly executing it. Assigning shortcuts to these addins will save you quite a few keystrokes.

This package provides implementations of some of the most important outlier detection algorithms. Includes a tutorial mode option that shows a description of each algorithm and provides a step-by-step execution explanation of how it identifies outliers from the given data with the specified input parameters. References include the works of Azzedine Boukerche, Lining Zheng, and Omar Alfandi (2020) <doi:10.1145/3381028>, Abir Smiti (2020) <doi:10.1016/j.cosrev.2020.100306>, and Xiaogang Su, Chih-Ling Tsai (2011) <doi:10.1002/widm.19>.

This package implements a framework for creating boxplots where the whisker lengths are determined by formal multiple testing procedures, making them adaptive to sample size and data characteristics. The function bh_boxplot() generates boxplots that control the False Discovery Rate (FDR) via the Benjamini-Hochberg procedure, and the function holm_boxplot() generates boxplots that control the Family-Wise Error Rate (FWER) via the Holm procedure. The methods are based on the framework in Gang, Lin, and Tong (2025) <doi:10.48550/arXiv.2510.20259>.

This package provides the heuristics miner algorithm for process discovery as proposed by Weijters et al. (2011) <doi:10.1109/CIDM.2011.5949453>. The algorithm builds a causal net from an event log created with the bupaR package. Event logs are a set of ordered sequences of events for which bupaR provides the S3 class eventlog(). The discovered causal nets can be visualised as htmlwidgets and it is possible to annotate them with the occurrence frequency or processing and waiting time of process activities.

Sample size requirements calculation using three different Bayesian criteria in the context of designing an experiment to estimate a normal mean or the difference between two normal means. Functions for calculation of required sample sizes for the Average Length Criterion, the Average Coverage Criterion and the Worst Outcome Criterion in the context of normal means are provided. Functions for both the fully Bayesian and the mixed Bayesian/likelihood approaches are provided. For reference see Joseph L. and Bélisle P. (1997) <https://www.jstor.org/stable/2988525>.

This package provides a set of tools and methods for making and manipulating transcript centric annotations. With these tools the user can easily download the genomic locations of the transcripts, exons and cds of a given organism, from either the UCSC Genome Browser or a BioMart database (more sources will be supported in the future). This information is then stored in a local database that keeps track of the relationship between transcripts, exons, cds and genes. Flexible methods are provided for extracting the desired features in a convenient format.

Efficient simulation-based power and sample size calculations are supported for a broad class of late-stage clinical trials. The following modules are included in the package: Adaptive designs with data-driven sample size or event count re-estimation, Adaptive designs with data-driven treatment selection, Adaptive designs with data-driven population selection, Optimal selection of a futility stopping rule, Event prediction in event-driven trials, Adaptive trials with response-adaptive randomization (experimental module), Traditional trials with multiple objectives (experimental module). Traditional trials with cluster-randomized designs (experimental module).

Managing and exploring parameter estimation results derived from Maximum Likelihood Estimation (MLE) using the likelihood package. It provides functions for organizing, visualizing, and summarizing MLE outcomes, streamlining statistical analysis workflows. By improving interpretation and facilitating model evaluation, it helps users gain deeper insights into parameter estimation and model fitting, making MLE result exploration more efficient and accessible. See Goffe et al. (1994) <doi:10.1016/0304-4076(94)90038-8> for details on MLE, and Canham and Uriarte (2006) <doi:10.1890/04-0657> for application of MLE using likelihood'.

The multispatial convergent cross mapping algorithm can be used as a test for causal associations between pairs of processes represented by time series. This is a combination of convergent cross mapping (CCM), described in Sugihara et al., 2012, Science, 338, 496-500, and dew-drop regression, described in Hsieh et al., 2008, American Naturalist, 171, 71â 80. The algorithm allows CCM to be implemented on data that are not from a single long time series. Instead, data can come from many short time series, which are stitched together using bootstrapping.

This package implements methods for inference on potential waning of vaccine efficacy and for estimation of vaccine efficacy at a user-specified time after vaccination based on data from a randomized, double-blind, placebo-controlled vaccine trial in which participants may be unblinded and placebo subjects may be crossed over to the study vaccine. The methods also for variant stratification and allow adjustment for possible confounding via inverse probability weighting through specification of models for the trial entry process, unblinding mechanisms, and the probability an unblinded placebo participant accepts study vaccine.

This package aggregateBioVar contains tools to summarize single cell gene expression profiles at the level of subject for single cell RNA-seq data collected from more than one subject (e.g. biological sample or technical replicates). A SingleCellExperiment object is taken as input and converted to a list of SummarizedExperiment objects, where each list element corresponds to an assigned cell type. The SummarizedExperiment objects contain aggregate gene-by-subject count matrices and inter-subject column metadata for individual subjects that can be processed using downstream bulk RNA-seq tools.

This package provides generic data structures and algorithms for use with forest mensuration data in a consistent framework. The functions and objects included are a collection of broadly applicable tools. More specialized applications should be implemented in separate packages that build on this foundation. Documentation about ForestElementsR is provided by three vignettes included in this package. For an introduction to the field of forest mensuration, refer to the textbooks by Kershaw et al. (2017) <doi:10.1002/9781118902028>, and van Laar and Akca (2007) <doi:10.1007/978-1-4020-5991-9>.

This package provides automated methods for generating initial parameter estimates in population pharmacokinetic modeling. The pipeline integrates adaptive single-point methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter sweeping across pharmacokinetic models. It estimates residual unexplained variability using either data-driven or fixed-fraction approaches and assigns pragmatic initial values for inter-individual variability. These strategies are designed to improve model robustness and convergence in nlmixr2 workflows. For more details see Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025) <doi:10.1007/s10928-025-10000-z>.

This package provides methods for analysis of compositional data including robust methods (<doi:10.1007/978-3-319-96422-5>), imputation of missing values (<doi:10.1016/j.csda.2009.11.023>), methods to replace rounded zeros (<doi:10.1080/02664763.2017.1410524>, <doi:10.1016/j.chemolab.2016.04.011>, <doi:10.1016/j.csda.2012.02.012>), count zeros (<doi:10.1177/1471082X14535524>), methods to deal with essential zeros (<doi:10.1080/02664763.2016.1182135>), (robust) outlier detection for compositional data, (robust) principal component analysis for compositional data, (robust) factor analysis for compositional data, (robust) discriminant analysis for compositional data (Fisher rule), robust regression with compositional predictors, functional data analysis (<doi:10.1016/j.csda.2015.07.007>) and p-splines (<doi:10.1016/j.csda.2015.07.007>), contingency (<doi:10.1080/03610926.2013.824980>) and compositional tables (<doi:10.1111/sjos.12326>, <doi:10.1111/sjos.12223>, <doi:10.1080/02664763.2013.856871>) and (robust) Anderson-Darling normality tests for compositional data as well as popular log-ratio transformations (addLR, cenLR, isomLR, and their inverse transformations). In addition, visualisation and diagnostic tools are implemented as well as high and low-level plot functions for the ternary diagram.

This package provides implementations of functions that can be used to test multivariate integration routines. The package covers six different integration domains (unit hypercube, unit ball, unit sphere, standard simplex, non-negative real numbers and R^n). For each domain several functions with different properties (smooth, non-differentiable, ...) are available. The functions are available in all dimensions n >= 1. For each function the exact value of the integral is known and implemented to allow testing the accuracy of multivariate integration routines. Details on the available test functions can be found at on the development website.

In population management, data come at more or less regular intervals over time in sampling batches (bouts) and decisions should be made with the minimum number of samples and as quickly as possible. This package provides tools to implement, produce charts with stop lines, summarize results and assess sequential analyses that test hypotheses about population sizes. Two approaches are included: the sequential test of Bayesian posterior probabilities (Rincon, D.F. et al. 2025 <doi:10.1111/2041-210X.70053>), and the sequential probability ratio test (Wald, A. 1945 <http://www.jstor.org/stable/2235829>).

The package uses collectbox to define variants of common box related macros which read the content as real box and not as macro argument. This enables the use of verbatim or other special material as part of this content. The provided macros have the same names as the original versions but start with an upper-case letter instead. The long-form macros, like \Makebox, can also be used as environments, but not the short-form macros, like \Mbox. However, normally the long form uses the short form anyway when no optional arguments are used.

Tests for block-diagonal structure in symmetric matrices (e.g. correlation matrices) under the null hypothesis of exchangeable off-diagonal elements. As described in Segal et al. (2019), these tests can be useful for construct validation either by themselves or as a complement to confirmatory factor analysis. Monte Carlo methods are used to approximate the permutation p-value with Hubert's Gamma (Hubert, 1976) and a t-statistic. This package also implements the chi-squared statistic described by Steiger (1980). Please see Segal, et al. (2019) <doi:10.1007/s11336-018-9647-4> for more information.

This package compares genomic positions and genomic ranges from multiple experiments to extract common regions. The size of the analyzed region is adjustable as well as the number of experiences in which a feature must be present in a potential region to tag this region as a consensus region. In genomic analysis where feature identification generates a position value surrounded by a genomic range, such as ChIP-Seq peaks and nucleosome positions, the replication of an experiment may result in slight differences between predicted values. This package enables the conciliation of the results into consensus regions.