Derives prediction rule ensembles (PREs). Largely follows the procedure for deriving PREs as described in Friedman & Popescu (2008; <DOI:10.1214/07-AOAS148>), with adjustments and improvements described in Fokkema (2020; <DOI:10.18637/jss.v092.i12>) and Fokkema & Strobl (2020; <DOI:10.1037/met0000256>). The main function pre() derives prediction rule ensembles consisting of rules and/or linear terms for continuous, binary, count, multinomial, survival and multivariate continuous responses. Function gpe() derives generalized prediction ensembles, consisting of rules, hinge and linear functions of the predictor variables.

This package provides a suite of multivariate methods and data visualization tools to implement profile analysis and cross-validation techniques described in Davison & Davenport (2002) <DOI: 10.1037/1082-989X.7.4.468>, Bulut (2013), and other published and unpublished resources. The package includes routines to perform criterion-related profile analysis, profile analysis via multidimensional scaling, moderated profile analysis, profile analysis by group, and a within-person factor model to derive score profiles.

This package provides a general framework for constructing partial dependence (i.e., marginal effect) plots from various types machine learning models in R.

An implementation of an S3 class based on a double vector for storing and displaying precision teaching measures, representing a growing or a decaying (multiplicative) change between two frequencies. The main format method allows researchers to display measures (including data.frame) that respect the established conventions in the precision teaching community (i.e., prefixed multiplication or division symbol, displayed number <= 1). Basic multiplication and division methods are allowed and other useful functions are provided for creating, converting or inverting precision teaching measures. For more details, see Pennypacker, Gutierrez and Lindsley (2003, ISBN: 1-881317-13-7).

Automate pharmacokinetic/pharmacodynamic bioanalytical procedures based on best practices and regulatory recommendations. The package impose regulatory constrains and sanity checking for common bioanalytical procedures. Additionally, PKbioanalysis provides a relational infrastructure for plate management and injection sequence.

Propagation of uncertainty using higher-order Taylor expansion and Monte Carlo simulation. Calculations of propagated uncertainties are based on matrix calculus including covariance structure according to Arras 1998 <doi:10.3929/ethz-a-010113668> (first order), Wang & Iyer 2005 <doi:10.1088/0026-1394/42/5/011> (second order) and BIPM Supplement 1 (Monte Carlo) <doi:10.59161/JCGM101-2008>.

This package provides a comprehensive framework for model fitting and simulation of drug release kinetics, pharmacokinetics (PK), and pharmacodynamics (PD). The package implements widely used mechanistic and empirical models for in vitro drug release, including zero-order, first-order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell, and Weibull models. Pharmacokinetic functionality includes linear and nonlinear functions for one- and two-compartment models for intravenous bolus and oral administration, Michaelis-Menten kinetics, and non-compartmental analysis (NCA). Pharmacodynamic and dose-response modeling is supported through Emax-based models, including stimulatory (sigmoid Emax) and inhibitory (sigmoid Imax) Hill models, four- and five-parameter logistic models, as well as median toxic dose (TD50) and lethal dose (LD50) models. The package is intended to support parameter estimation, simulation, and model comparison in pharmaceutical research, drug development, and pharmacometrics education. For more details, see Gabrielsson & Weiner (2000) <ISBN:9186274929>, Holford & Sheiner (1981) <doi:10.2165/00003088-198106060-00002>, and Manlapaz (2025) <doi:10.32614/CRAN.package.adsoRptionCMF>.

This package provides a function for estimating the transition probabilities in an illness-death model. The transition probabilities can be estimated from the unsmoothed landmark estimators developed by de Una-Alvarez and Meira-Machado (2015) <doi:10.1111/biom.12288>. Presmoothed estimates can also be obtained through the use of a parametric family of binary regression curves, such as logit, probit or cauchit. The additive logistic regression model and nonparametric regression are also alternatives which have been implemented. The idea behind the presmoothed landmark estimators is to use the presmoothing techniques developed by Cao et al. (2005) <doi:10.1007/s00180-007-0076-6> in the landmark estimation of the transition probabilities.

An R implementation of methods employed in the field of pedometrics, soil science discipline dedicated to studying the spatial, temporal, and spatio-temporal variation of soil using statistical and computational methods. The methods found here include the calibration of linear regression models using covariate selection strategies, computation of summary validation statistics for predictions, generation of summary plots, evaluation of the local quality of a geostatistical model of uncertainty, and so on. Other functions simply extend the functionalities of or facilitate the usage of functions from other packages that are commonly used for the analysis of soil data. Formerly available versions of suggested packages no longer available from CRAN can be obtained from the CRAN archive <https://cran.r-project.org/src/contrib/Archive/>.

Bayesian clustering using a Dirichlet process mixture model. This model is an alternative to regression models, non-parametrically linking a response vector to covariate data through cluster membership. The package allows Bernoulli, Binomial, Poisson, Normal, survival and categorical response, as well as Normal and discrete covariates. It also allows for fixed effects in the response model, where a spatial CAR (conditional autoregressive) term can be also included. Additionally, predictions may be made for the response, and missing values for the covariates are handled. Several samplers and label switching moves are implemented along with diagnostic tools to assess convergence. A number of R functions for post-processing of the output are also provided. In addition to fitting mixtures, it may additionally be of interest to determine which covariates actively drive the mixture components. This is implemented in the package as variable selection. The main reference for the package is Liverani, Hastie, Azizi, Papathomas and Richardson (2015) <doi:10.18637/jss.v064.i07>.

Several person-fit statistics (PFSs; Meijer and Sijtsma, 2001, <doi:10.1177/01466210122031957>) are offered. These statistics allow assessing whether individual response patterns to tests or questionnaires are (im)plausible given the other respondents in the sample or given a specified item response theory model. Some PFSs apply to dichotomous data, such as the likelihood-based PFSs (lz, lz*) and the group-based PFSs (personal biserial correlation, caution index, (normed) number of Guttman errors, agreement/disagreement/dependability statistics, U3, ZU3, NCI, Ht). PFSs suitable to polytomous data include extensions of lz, U3, and (normed) number of Guttman errors.

This package provides functions for point process time series. Autocorrelation functions for spatial and temporal time series, and estimation of trend-plus-seasonality models for temporal and spatial time series. See Gervini (2025) <doi:10.1111/jtsa.70018> and Gervini and Kopischke (2026) <doi:10.48550/arXiv.2605.21884>.

This package provides a quadratic time dynamic programming algorithm can be used to compute an approximate solution to the problem of finding the most likely changepoints with respect to the Poisson likelihood, subject to a constraint on the number of segments, and the changes which must alternate: up, down, up, down, etc. For more info read <http://proceedings.mlr.press/v37/hocking15.html> "PeakSeg: constrained optimal segmentation and supervised penalty learning for peak detection in count data" by TD Hocking et al, proceedings of ICML2015.

Pool dilution is a isotope tracer technique wherein a biogeochemical pool is artifically enriched with its heavy isotopologue and the gross productive and consumptive fluxes of that pool are quantified by the change in pool size and isotopic composition over time. This package calculates gross production and consumption rates from closed-system isotopic pool dilution time series data. Pool size concentrations and heavy isotope (e.g., 15N) content are measured over time and the model optimizes production rate (P) and the first order rate constant (k) by minimizing error in the model-predicted total pool size, as well as the isotopic signature. The model optimizes rates by weighting information against the signal:noise ratio of concentration and heavy- isotope signatures using measurement precision as well as the magnitude of change over time. The calculations used here are based on von Fischer and Hedin (2002) <doi:10.1029/2001GB001448> with some modifications.

Sensitivity and power analysis, for calculating statistics describing pedigrees from wild populations, and for visualizing pedigrees. This is a reboot of the methods developed by Morrissey and Wilson (2010) <doi: 10.1111/j.1755-0998.2009.02817.x>.

This package provides a collection of color palettes inspired by the enormous diversity of skin colors in Neotropical poison frog species. Suitable for use with ggplot2 and base R graphics.

This package provides a fast and flexible framework for agglomerative partitioning. partition uses an approach called Direct-Measure-Reduce to create new variables that maintain the user-specified minimum level of information. Each reduced variable is also interpretable: the original variables map to one and only one variable in the reduced data set. partition is flexible, as well: how variables are selected to reduce, how information loss is measured, and the way data is reduced can all be customized. partition is based on the Partition framework discussed in Millstein et al. (2020) <doi:10.1093/bioinformatics/btz661>.

Create a project directory structure, along with typical files for that project. This allows projects to be quickly and easily created, as well as for them to be standardized. Designed specifically with scientists in mind (mainly bio-medical researchers, but likely applies to other fields).

Use probability theory under the Bayesian framework for calculating the risk of selecting candidates in a multi-environment context. Contained are functions used to fit a Bayesian multi-environment model (based on the available presets), extract posterior values and maximum posterior values, compute the variance components, check the modelâ s convergence, and calculate the probabilities. For both across and within-environments scopes, the package computes the probability of superior performance and the pairwise probability of superior performance. Furthermore, the probability of superior stability and the pairwise probability of superior stability across environments is estimated. A joint probability of superior performance and stability is also provided.

This package provides functions for graph-based multiple-sample testing and visualization of microbiome data, in particular data stored in phyloseq objects. The tests are based on those described in Friedman and Rafsky (1979) <http://www.jstor.org/stable/2958919>, and the tests are described in more detail in Callahan et al. (2016) <doi:10.12688/f1000research.8986.1>.

This package provides a collection of functions that can be used to estimate selection and complementarity effects, sensu Loreau & Hector (2001) <doi:10.1038/35083573>, even in cases where data are only available for a random subset of species (i.e. incomplete sample-level data). A full derivation and explanation of the statistical corrections used here is available in Clark et al. (2019) <doi:10.1111/2041-210X.13285>.

An implementation of reliability estimation methods described in the paper (Bosnic, Z., & Kononenko, I. (2008) <doi:10.1007/s10489-007-0084-9>), which allows you to test the reliability of a single predicted instance made by your model and prediction function. It also allows you to make a correlation test to estimate which reliability estimate is the most accurate for your model.

This package provides a collection of functions for modelling mutations in pedigrees with marker data, as used e.g. in likelihood computations with microsatellite data. Implemented models include equal, proportional and stepwise models, as well as random models for experimental work, and custom models allowing the user to apply any valid mutation matrix. Allele lumping is done following the lumpability criteria of Kemeny and Snell (1976), ISBN:0387901922.

PROMETHEE (Preference Ranking Organisation METHod for Enrichment of Evaluations) based method assesses alternatives to obtain partial and complete rankings. The package also provides the GLNF (Global Local Net Flow) sorting algorithm to classify alternatives into ordered categories, as well as an index function to measure the classification quality. Barrera, F., Segura, M., & Maroto, C. (2023) <doi:10.1111/itor.13288>. Brans, J.P.; De Smet, Y., (2016) <doi:10.1007/978-1-4939-3094-4_6>.