This package provides tools to read, write, visualize Protein Data Bank (PDB) files and perform some structural manipulations.

Decimal rounding is non-trivial in binary arithmetic. ISO standard round to even is more rare than typically assumed as most decimal fractions are not exactly representable in binary. Our roundX() versions explore differences between current and potential future versions of round() in R. Further, provides (some partly related) C99 math lib functions not in base R.

Annotate text with entities and the relations between them. Annotate areas of interest in images with your labels. Providing htmlwidgets bindings to the recogito <https://github.com/recogito/recogito-js> and annotorious <https://github.com/recogito/annotorious> libraries.

This package contains several useful navigation helper functions, including easily building folder paths, quick viewing dataframes in Excel', creating date vectors and changing the console prompt to reflect time.

Mathematical and statistical tools for computational biology in drug discovery. Functions are designed for high performance. Implements the hierarchical fuzzy multi-linkage partitioning method proposed by Huang et al. (2007) <doi:10.1186/gb-2007-8-9-r183>.

Test for effects of both individual factors and their interaction on replicated spatial patterns in a two factorial design, as explained in Ramon et al. (2016) <doi:10.1111/ecog.01848>.

HydroBudget is a spatially distributed groundwater recharge model that computes a superficial water budget on grid cells with outputs aggregated into monthly time steps. It was developed as an accessible and computationally affordable model to simulate groundwater recharge over large areas (thousands of km2, regional-scale watersheds) and for long time periods (decades), in cold and humid climates. Model algorithms are based on the research of Dubois, E. et al. (2021a) <doi:10.5683/SP3/EUDV3H> and Dubois, E. et al. (2021b) <doi:10.5194/hess-25-6567-2021>.

Fast C++ agglomerative hierarchical clustering algorithm packaged into easily callable R functions, designed to help cluster biological terms based on how similar of genes are expressed in their activation.

An interface to the Open Tree of Life API to retrieve phylogenetic trees, information about studies used to assemble the synthetic tree, and utilities to match taxonomic names to Open Tree identifiers'. The Open Tree of Life aims at assembling a comprehensive phylogenetic tree for all named species.

This package provides tools for regression-based Boolean rule inference in artificial intelligence studies. The package fits ridge regression models on conjunction expansions and composes interpretable rule sets. Parallel execution is supported for multi-CPU environments.

The Linear Programming via Regularized Least Squares (LPPinv) is a two-stage estimation method that reformulates linear programs as structured least-squares problems. Based on the Convex Least Squares Programming (CLSP) framework, LPPinv solves linear inequality, equality, and bound constraints by (1) constructing a canonical constraint system and computing a pseudoinverse projection, followed by (2) a convex-programming correction stage to refine the solution under additional regularization (e.g., Lasso, Ridge, or Elastic Net). LPPinv is intended for underdetermined and ill-posed linear problems, for which standard solvers fail.

Validates estimates of (conditional) average treatment effects obtained using observational data by a) making it easy to obtain and visualize estimates derived using a large variety of methods (G-computation, inverse propensity score weighting, etc.), and b) ensuring that estimates are easily compared to a gold standard (i.e., estimates derived from randomized controlled trials). RCTrep offers a generic protocol for treatment effect validation based on four simple steps, namely, set-selection, estimation, diagnosis, and validation. RCTrep provides a simple dashboard to review the obtained results. The validation approach is introduced by Shen, L., Geleijnse, G. and Kaptein, M. (2023) <doi:10.21203/rs.3.rs-2559287/v2>.

Robust (outlier-resistant) estimators of finite population characteristics like of means, totals, ratios, regression, etc. Available methods are M- and GM-estimators of regression, weight reduction, trimming, and winsorization. The package extends the survey <https://CRAN.R-project.org/package=survey> package.

The R commander plug-in for robust principal component analysis. The Graphical User Interface for Principal Component Analysis (PCA) with Hubert Algorithm method.

This package provides functions to convert Rd to roxygen documentation. It can parse an Rd file to a list, create the roxygen documentation and update the original R script (e.g. the one containing the definition of the function) accordingly. This package also provides utilities that can help developers build packages using roxygen more easily. The formatR package can be used to reformat the R code in the examples sections so that the code will be more readable.

Datasets and utility functions to support the book "R for Plant Disease Epidemiology" (R4PDE). It includes functions for quantifying disease, assessing spatial patterns, and modeling plant disease epidemics based on weather predictors. These tools are intended for teaching and research in plant disease epidemiology. Several functions are based on classical and contemporary methods, including those discussed in Laurence V. Madden, Gareth Hughes, and Frank van den Bosch (2007) <doi:10.1094/9780890545058>.

This package provides a modified implementation of stepwise regression that greedily searches the space of interactions among features in order to build polynomial regression models. Furthermore, the hypothesis tests conducted are valid-post model selection due to the use of a revisiting procedure that implements an alpha-investing rule. As a result, the set of rejected sequential hypotheses is proven to control the marginal false discover rate. When not searching for polynomials, the package provides a statistically valid algorithm to run and terminate stepwise regression. For more information, see Johnson, Stine, and Foster (2019) <arXiv:1510.06322>.

It streamlines the evaluation of regression model assumptions, enhancing result reliability. With integrated tools for assessing key aspects like linearity, homoscedasticity, and more. It's a valuable asset for researchers and analysts working with regression models.

We provide a toolbox to fit univariate and multivariate linear mixed models via data transforming augmentation. Users can also fit these models via typical data augmentation for a comparison. It returns either maximum likelihood estimates of unknown model parameters (hyper-parameters) via an EM algorithm or posterior samples of those parameters via MCMC. Also see Tak et al. (2019) <doi:10.1080/10618600.2019.1704295>.

This package provides a lightweight wrapper around the RSQLite package for streamlined loading of data from tabular files (i,e. text delimited files like Comma Separated Values and Tab Separated Values, Microsoft Excel, and Arrow Inter-process Communication files) in SQLite databases. Includes helper functions for inspecting the structure of the input files, and some functions to simplify activities on the SQLite tables.

This package provides estimation and inference procedures for boundary regression discontinuity (RD) designs using local polynomial methods, based on either bivariate coordinates or distance-based approaches. Methods are developed in Cattaneo, Titiunik, and Yu (2025) <https://mdcattaneo.github.io/papers/Cattaneo-Titiunik-Yu_2025_BoundaryRD.pdf>.

This package provides methods to scan RR interval data for Premature Ventricular Complexes (PVCs) and parameterise and plot the resulting Heart Rate Turbulence (HRT). The methodology of HRT analysis is based on the original publication by Schmidt et al. <doi:10.1016/S0140-6736(98)08428-1> and extended with suggestions from <doi:10.1088/1361-6579/ab98b3>.

This package provides methods for analysis of compositional data including robust methods (<doi:10.1007/978-3-319-96422-5>), imputation of missing values (<doi:10.1016/j.csda.2009.11.023>), methods to replace rounded zeros (<doi:10.1080/02664763.2017.1410524>, <doi:10.1016/j.chemolab.2016.04.011>, <doi:10.1016/j.csda.2012.02.012>), count zeros (<doi:10.1177/1471082X14535524>), methods to deal with essential zeros (<doi:10.1080/02664763.2016.1182135>), (robust) outlier detection for compositional data, (robust) principal component analysis for compositional data, (robust) factor analysis for compositional data, (robust) discriminant analysis for compositional data (Fisher rule), robust regression with compositional predictors, functional data analysis (<doi:10.1016/j.csda.2015.07.007>) and p-splines (<doi:10.1016/j.csda.2015.07.007>), contingency (<doi:10.1080/03610926.2013.824980>) and compositional tables (<doi:10.1111/sjos.12326>, <doi:10.1111/sjos.12223>, <doi:10.1080/02664763.2013.856871>) and (robust) Anderson-Darling normality tests for compositional data as well as popular log-ratio transformations (addLR, cenLR, isomLR, and their inverse transformations). In addition, visualisation and diagnostic tools are implemented as well as high and low-level plot functions for the ternary diagram.

STG is a method for feature selection in neural network. The procedure is based on probabilistic relaxation of the l0 norm of features, or the count of the number of selected features. The framework simultaneously learns either a nonlinear regression or classification function while selecting a small subset of features. Read more: Yamada et al. (2020) <https://proceedings.mlr.press/v119/yamada20a.html>.