Estimates the proportion of treatment effect on a censored primary outcome that is explained by the treatment effect on a censored surrogate outcome/event. All methods are described in detail in Parast, et al (2020) "Assessing the Value of a Censored Surrogate Outcome" <doi:10.1007/s10985-019-09473-1> and Wang et al (2025) "Model-free Approach to Evaluate a Censored Intermediate Outcome as a Surrogate for Overall Survival" <doi:10.1002/sim.70268>. A tutorial for this package can be found at <https://www.laylaparast.com/surrogateoutcome>.

This package provides a toolbox for programming Clinical Data Standards Interchange Consortium (CDISC) compliant Analysis Data Model (ADaM) datasets in R. ADaM datasets are a mandatory part of any New Drug or Biologics License Application submitted to the United States Food and Drug Administration (FDA). Analysis derivations are implemented in accordance with the "Analysis Data Model Implementation Guide" (CDISC Analysis Data Model Team, 2021, <https://www.cdisc.org/standards/foundational/adam>). The package is an extension package of the admiral package focusing on the metabolism therapeutic area.

Analysis and plotting tools for snow profile data produced from manual snowpack observations and physical snowpack models. The functions in this package support snowpack and avalanche research by reading various formats of data (including CAAML, SMET, generic csv, and outputs from the snow cover model SNOWPACK), manipulate the data, and produce graphics such as stratigraphy and time series profiles. Package developed by the Simon Fraser University Avalanche Research Program <http://www.avalancheresearch.ca>. Graphics apply visualization concepts from Horton, Nowak, and Haegeli (2020, <doi:10.5194/nhess-20-1557-2020>).

This package creates an interactive graphics interface to visualize backtest results of different financial instruments, such as equities, futures, and credit default swaps. The package does not run backtests on the given data set but displays a graphical explanation of the backtest results. Users can look at backtest graphics for different instruments, investment strategies, and portfolios. Summary statistics of different portfolio holdings are shown in the left panel, and interactive plots of profit and loss (P&L), net market value (NMV) and gross market value (GMV) are displayed in the right panel.

PathExpander helps pre-process command-line arguments expanding directories into their constituent files. It further helps by providing additional mechanisms to make specifying subsets easier with path subtraction and allowing for command-line arguments to be saved in a file.

NOTE: this is NOT an options processor. It is a path processor (basically everything else besides options). It does provide a mechanism for pre-filtering cmdline options, but not with the intent of actually processing them in PathExpander. Use OptionParser to deal with options either before or after passing ARGV through PathExpander.

This package provides a comprehensive educational package combining clustering algorithms with detailed step-by-step explanations. Provides implementations of both traditional (hierarchical, k-means) and modern (Density-Based Spatial Clustering of Applications with Noise (DBSCAN), Gaussian Mixture Models (GMM), genetic k-means) clustering methods as described in Ezugwu et. al., (2022) <doi:10.1016/j.engappai.2022.104743>. Includes educational datasets highlighting different clustering challenges, based on scikit-learn examples (Pedregosa et al., 2011) <https://jmlr.csail.mit.edu/papers/v12/pedregosa11a.html>. Features detailed algorithm explanations, visualizations, and weighted distance calculations for enhanced learning.

It is well known that the distribution of a Gaussian ratio does not follow a Gaussian distribution. The lack of awareness among users of vegetation indices about this non-Gaussian nature could lead to incorrect statistical modeling and interpretation. This package provides tools to accurately handle and analyse such ratios: density function, parameter estimation, simulation. An example on the study of chlorophyll fluorescence can be found in A. El Ghaziri et al. (2023) <doi:10.3390/rs15020528> and another method for parameter estimation is given in Bouhlel et al. (2023) <doi:10.23919/EUSIPCO58844.2023.10290111>.

Select balanced and spatially balanced probability samples in multi-dimensional spaces with any prescribed inclusion probabilities. It contains fast (C++ via Rcpp) implementations of the included sampling methods. The local pivotal method by Grafström, Lundström and Schelin (2012) <doi:10.1111/j.1541-0420.2011.01699.x> and spatially correlated Poisson sampling by Grafström (2012) <doi:10.1016/j.jspi.2011.07.003> are included. Also the cube method (for balanced sampling) and the local cube method (for doubly balanced sampling) are included, see Grafström and Tillé (2013) <doi:10.1002/env.2194>.

This package provides methods for valuation of life insurance premiums and reserves (including variable-benefit and fractional coverage) based on "Actuarial Mathematics" by Bowers, H.U. Gerber, J.C. Hickman, D.A. Jones and C.J. Nesbitt (1997, ISBN: 978-0938959465), "Actuarial Mathematics for Life Contingent Risks" by Dickson, David C. M., Hardy, Mary R. and Waters, Howard R (2009) <doi:10.1017/CBO9780511800146> and "Life Contingencies" by Jordan, C. W (1952) <doi:10.1017/S002026810005410X>. It also contains functions for equivalent interest and discount rate calculation, present and future values of annuities, and loan amortization schedule.

H(x) is the h-index for the past x years. Here, the h(x) of a scientist/department/etc. can be calculated using the exported excel file from a Web of Science citation report of a search. Also calculated is the year of first publication, total number of publications, and sum of times cited for the specified period. Therefore, for h-10: the date of first publication, total number of publications, and sum of times cited in the past 10 years are calculated. Note: the excel file has to first be saved in a .csv format.

The number of studies involving correlated traits and the availability of tools to handle this type of data has increased considerably in the last decade. With such a demand, we need tools for testing hypotheses related to single and multi-trait (correlated) phenotypes based on many genetic settings. Thus, we implemented various options for simulation of pleiotropy and Linkage Disequilibrium under additive, dominance and epistatic models. The simulation currently takes a marker data set as an input and then uses it for simulating multiple traits as described in Fernandes and Lipka (2020) <doi:10.1186/s12859-020-03804-y>.

For high-dimensional data whose main feature is a large number, p, of variables but a small sample size, the null hypothesis that the marginal distributions of p variables are the same for two groups is tested. We propose a test statistic motivated by the simple idea of comparing, for each of the p variables, the empirical characteristic functions computed from the two samples. If one rejects this global null hypothesis of no differences in distributions between the two groups, a set of permutation p-values is reported to identify which variables are not equally distributed in both groups.

Romande ADF is a serif font family with oldstyle figures, designed as a substitute for Times, Tiffany or Caslon. The family currently includes upright, italic and small-caps shapes in each of regular and demi-bold weights and an italic script in regular. The support package renames the fonts according to the Karl Berry font name scheme and defines four families. Two of these primarily provide access to the ``standard'' or default characters while the ``alternate'' families support alternate characters, additional ligatures and the long ``s''. The included package files provide access to these features in LaTeX as explained in the documentation.

Intra-miR-ExploreR, an integrative miRNA target prediction bioinformatics tool, identifies targets combining expression and biophysical interactions of a given microRNA (miR). Using the tool, we have identified targets for 92 intragenic miRs in D. melanogaster, using available microarray expression data, from Affymetrix 1 and Affymetrix2 microarray array platforms, providing a global perspective of intragenic miR targets in Drosophila. Predicted targets are grouped according to biological functions using the DAVID Gene Ontology tool and are ranked based on a biologically relevant scoring system, enabling the user to identify functionally relevant targets for a given miR.

Diversification is one of the most important concepts in portfolio management. This framework offers scholars, practitioners and policymakers a useful toolbox to measure diversification. Specifically, this framework provides recent diversification measures from the recent literature. These diversification measures are based on the works of Rudin and Morgan (2006) <doi:10.3905/jpm.2006.611807>, Choueifaty and Coignard (2008) <doi:10.3905/JPM.2008.35.1.40>, Vermorken et al. (2012) <doi:10.3905/jpm.2012.39.1.067>, Flores et al. (2017) <doi:10.3905/jpm.2017.43.4.112>, Calvet et al. (2007) <doi:10.1086/524204>, and Candelon, Fuerst and Hasse (2020).

This app provides some useful tools for Offering an accessible GUI for generalised blockmodeling of single-relation, one-mode networks. The user can execute blockmodeling without having to write a line code by using the app's visual helps. Moreover, there are several ways to visualisations networks and their partitions. Finally, the results can be exported as if they were produced by writing code. The development of this package is financially supported by the Slovenian Research Agency (www.arrs.gov.si) within the research project J5-2557 (Comparison and evaluation of different approaches to blockmodeling dynamic networks by simulations with application to Slovenian co-authorship networks).

Adds variable-selection functions for Beta regression models (both mean and phi submodels) so they can be used within the SelectBoost algorithm. Includes stepwise AIC, BIC, and corrected AIC on betareg() fits, gamlss'-based LASSO/Elastic-Net, a pure glmnet iterative re-weighted least squares-based selector with an optional standardization speedup, and C++ helpers for iterative re-weighted least squares working steps and precision updates. Also provides a fastboost_interval() variant for interval responses, comparison helpers, and a flexible simulator simulation_DATA.beta() for interval-valued data. For more details see Bertrand and Maumy (2023) <doi:10.7490/f1000research.1119552.1>.

This package implements functionality for exploratory data analysis and nonparametric analysis of spatial data, mainly spatial point patterns, in the spatstat family of packages. Methods include quadrat counts, K-functions and their simulation envelopes, nearest neighbour distance and empty space statistics, Fry plots, pair correlation function, kernel smoothed intensity, relative risk estimation with cross-validated bandwidth selection, mark correlation functions, segregation indices, mark dependence diagnostics, and kernel estimates of covariate effects. Formal hypothesis tests of random pattern (chi-squared, Kolmogorov-Smirnov, Monte Carlo, Diggle-Cressie-Loosmore-Ford, Dao-Genton, two-stage Monte Carlo) and tests for covariate effects (Cox-Berman-Waller-Lawson, Kolmogorov-Smirnov, ANOVA) are also supported.

This package provides a well known identifiability issue in factor analytic models is the invariance with respect to orthogonal transformations. This problem burdens the inference under a Bayesian setup, where Markov chain Monte Carlo (MCMC) methods are used to generate samples from the posterior distribution. The package applies a series of rotation, sign and permutation transformations (Papastamoulis and Ntzoufras (2022) <DOI:10.1007/s11222-022-10084-4>) into raw MCMC samples of factor loadings, which are provided by the user. The post-processed output is identifiable and can be used for MCMC inference on any parametric function of factor loadings. Comparison of multiple MCMC chains is also possible.

This package provides a statistical disclosure control tool to protect tables by suppression using the Gaussian elimination secondary suppression algorithm (Langsrud, 2024) <doi:10.1007/978-3-031-69651-0_6>. A suggestion is to start by working with functions SuppressSmallCounts() and SuppressDominantCells(). These functions use primary suppression functions for the minimum frequency rule and the dominance rule, respectively. Novel functionality for suppression of disclosive cells is also included. General primary suppression functions can be supplied as input to the general working horse function, GaussSuppressionFromData(). Suppressed frequencies can be replaced by synthetic decimal numbers as described in Langsrud (2019) <doi:10.1007/s11222-018-9848-9>.

Derive instances of Arbitrary for QuickCheck, with various options to customize implementations.

Automating the arbitrary boilerplate also ensures that when a type changes to have more or fewer constructors, then the generator either fixes itself to generate that new case (when using the uniform distribution) or causes a compilation error so you remember to fix it (when using an explicit distribution).

This package also offers a simple (optional) strategy to ensure termination for recursive types: make Test.QuickCheck.Gen's size parameter decrease at every recursive call; when it reaches zero, sample directly from a trivially terminating generator given explicitly (genericArbitraryRec and withBaseCase) or implicitly (genericArbitrary').

This package provides functions to be used in conjunction with the Sequential package that allows for planning of observational database studies that will be analyzed with exact sequential analysis. This package supports Poisson- and binomial-based data. The primary function, seq_wrapper(...), accepts parameters for simulation of a simple exposure pattern and for the Sequential package setup and analysis functions. The exposure matrix is used to simulate the true and false positive and negative populations (Green (1983) <doi:10.1093/oxfordjournals.aje.a113521>, Brenner (1993) <doi:10.1093/oxfordjournals.aje.a116805>). Functions are then run from the Sequential package on these populations, which allows for the exploration of outcome misclassification in data.

DuplexDiscovereR is a package designed for analyzing data from RNA cross-linking and proximity ligation protocols such as SPLASH, PARIS, LIGR-seq, and others. DuplexDiscovereR accepts input in the form of chimerically or split-aligned reads. It includes procedures for alignment classification, filtering, and efficient clustering of individual chimeric reads into duplex groups (DGs). Once DGs are identified, the package predicts RNA duplex formation and their hybridization energies. Additional metrics, such as p-values for random ligation hypothesis or mean DG alignment scores, can be calculated to rank final set of RNA duplexes. Data from multiple experiments or replicates can be processed separately and further compared to check the reproducibility of the experimental method.

For any spending function specified by the user, this package provides corresponding boundaries for interim testing using the adaptively weighted log-rank test developed by Yang and Prentice (2010 <doi:10.1111/j.1541-0420.2009.01243.x>). The package uses a re-sampling method to obtain stopping boundaries at the interim looks.The output consists of stopping boundaries and observed values of the test statistics at the interim looks, along with nominal p-values defined as the probability of the test exceeding the specific observed test statistic value or critical value, regardless of the test behavior at other looks. The asymptotic validity of the stopping boundaries is established in Yang (2018 <doi:10.1002/sim.7958>).