Analyse prescription drug deliveries to calculate several indicators of polypharmacy corresponding to the various definitions found in the literature. Bjerrum, L., Rosholm, J. U., Hallas, J., & Kragstrup, J. (1997) <doi:10.1007/s002280050329>. Chan, D.-C., Hao, Y.-T., & Wu, S.-C. (2009a) <doi:10.1002/pds.1712>. Fincke, B. G., Snyder, K., Cantillon, C., Gaehde, S., Standring, P., Fiore, L., ... Gagnon, D.R. (2005) <doi:10.1002/pds.966>. Hovstadius, B., Astrand, B., & Petersson, G. (2009) <doi:10.1186/1472-6904-9-11>. Hovstadius, B., Astrand, B., & Petersson, G. (2010) <doi:10.1002/pds.1921>. Kennerfalk, A., Ruigómez, A., Wallander, M.-A., Wilhelmsen, L., & Johansson, S. (2002) <doi:10.1345/aph.1A226>. Masnoon, N., Shakib, S., Kalisch-Ellett, L., & Caughey, G. E. (2017) <doi:10.1186/s12877-017-0621-2>. Narayan, S. W., & Nishtala, P. S. (2015) <doi:10.1007/s40801-015-0020-y>. Nishtala, P. S., & Salahudeen, M. S. (2015) <doi:10.1159/000368191>. Park, H. Y., Ryu, H. N., Shim, M. K., Sohn, H. S., & Kwon, J. W. (2016) <doi:10.5414/cp202484>. Veehof, L., Stewart, R., Haaijer-Ruskamp, F., & Jong, B. M. (2000) <doi:10.1093/fampra/17.3.261>.

Calculates a comprehensive list of features from profile hidden Markov models (HMMs) of proteins. Adapts and ports features for use with HMMs instead of Position Specific Scoring Matrices, in order to take advantage of more accurate multiple sequence alignment by programs such as HHBlits Remmert et al. (2012) <DOI:10.1038/nmeth.1818> and HMMer Eddy (2011) <DOI:10.1371/journal.pcbi.1002195>. Features calculated by this package can be used for protein fold classification, protein structural class prediction, sub-cellular localization and protein-protein interaction, among other tasks. Some examples of features extracted are found in Song et al. (2018) <DOI:10.3390/app8010089>, Jin & Zhu (2021) <DOI:10.1155/2021/8629776>, Lyons et al. (2015) <DOI:10.1109/tnb.2015.2457906> and Saini et al. (2015) <DOI:10.1016/j.jtbi.2015.05.030>.

This package provides a toolbox for making R functions and capabilities more accessible to students and professionals from Epidemiology and Public Health related disciplines. Includes a function to report coefficients and confidence intervals from models using robust standard errors (when available), functions that expand ggplot2 plots and functions relevant for introductory papers in Epidemiology or Public Health. Please note that use of the provided data sets is for educational purposes only.

This package provides an interface to the GenderAPI.io Phone Number Validation & Formatter API (<https://www.genderapi.io>) for validating international phone numbers, detecting number type (mobile, landline, Voice over Internet Protocol (VoIP)), retrieving region and country metadata, and formatting numbers to E.164 or national format. Designed to simplify integration into R workflows for data validation, Customer Relationship Management (CRM) data cleaning, and analytics tasks. Full documentation is available at <https://www.genderapi.io/docs-phone-validation-formatter-api>.

R Interface to Pullword Service for natural language processing in Chinese. It enables users to extract valuable words from text by deep learning models. For more details please visit the official site (in Chinese) <http://www.pullword.com/>.

Computes probability-scale residuals and residual correlations for continuous, ordinal, binary, count, and time-to-event data Qi Liu, Bryan Shepherd, Chun Li (2020) <doi:10.18637/jss.v094.i12>.

Useful functions and workflows for proteomics quality control and data analysis of both limited proteolysis-coupled mass spectrometry (LiP-MS) (Feng et. al. (2014) <doi:10.1038/nbt.2999>) and regular bottom-up proteomics experiments. Data generated with search tools such as Spectronaut', MaxQuant and Proteome Discover can be easily used due to flexibility of functions.

This package provides access to the PlanScore Application Programming Interface (<https://github.com/PlanScore/PlanScore/blob/main/API.md>) for scoring redistricting plans. Allows for upload of plans from block assignment files and shape files. For shapes in memory, such as from sf or redist', it processes them to save and upload. Includes tools for tidying responses and saving output from the website.

Access the data of the Catalogue of the Timber Forest Species of the Peruvian Amazon Vásquez Martà nez, R., & Rojas Gonzáles, R.D.P.(2022)<doi:10.21704/rfp.v37i3.1956>.

This package provides a collection of methods for commonly undertaken analytical tasks, primarily developed for Public Health Scotland (PHS) analysts, but the package is also generally useful to others working in the healthcare space, particularly since it has functions for working with Community Health Index (CHI) numbers. The package can help to make data manipulation and analysis more efficient and reproducible.

Fast and memory-less computation of the partial distance correlation for vectors and matrices. Permutation-based and asymptotic hypothesis testing for zero partial distance correlation are also performed. References include: Szekely G. J. and Rizzo M. L. (2014). "Partial distance correlation with methods for dissimilarities". The Annals Statistics, 42(6): 2382--2412. <doi:10.1214/14-AOS1255>. Shen C., Panda S. and Vogelstein J. T. (2022). "The Chi-Square Test of Distance Correlation". Journal of Computational and Graphical Statistics, 31(1): 254--262. <doi:10.1080/10618600.2021.1938585>. Szekely G. J. and Rizzo M. L. (2023). "The Energy of Data and Distance Correlation". Chapman and Hall/CRC. <ISBN:9781482242744>. Kontemeniotis N., Vargiakakis R. and Tsagris M. (2025). On independence testing using the (partial) distance correlation. <doi:10.48550/arXiv.2506.15659>.

NOTE: PARAMLINK HAS BEEN SUPERSEDED BY THE PEDSUITE PACKAGES (<https://magnusdv.github.io/pedsuite/>). PARAMLINK IS MAINTAINED ONLY FOR LEGACY PURPOSES AND SHOULD NOT BE USED IN NEW PROJECTS. A suite of tools for analysing pedigrees with marker data, including parametric linkage analysis, forensic computations, relatedness analysis and marker simulations. The core of the package is an implementation of the Elston-Stewart algorithm for pedigree likelihoods, extended to allow mutations as well as complex inbreeding. Features for linkage analysis include singlepoint LOD scores, power analysis, and multipoint analysis (the latter through a wrapper to the MERLIN software). Forensic applications include exclusion probabilities, genotype distributions and conditional simulations. Data from the Familias software can be imported and analysed in paramlink'. Finally, paramlink offers many utility functions for creating, manipulating and plotting pedigrees with or without marker data (the actual plotting is done by the kinship2 package).

For a given graph containing vertices, edges, and a signal associated with the vertices, the PathwaySpace package performs a convolution operation, which involves a weighted combination of neighboring vertices and their associated signals. The package uses a decay function to project these signals, creating geodesic paths on a 2D-image space. PathwaySpace has various applications, such as visualizing network data in a graphical format that highlights the relationships and signal strengths between vertices. By combining graph theory, signal processing, and visualization, PathwaySpace provides a way of representing graph data on a continuous projection space. Based on methods introduced in Tercan et al. (2025) <doi:10.1016/j.xpro.2025.103681> and Ellrott et al. (2025) <doi:10.1016/j.ccell.2024.12.002>.

This package provides a collection of miscellaneous functions for passive acoustics. Much of the content here is adapted to R from code written by other people. If you have any ideas of functions to add, please contact Taiki Sakai.

Download economic and financial time series from public sources, including the St Louis Fed's FRED system, Yahoo Finance, the US Bureau of Labor Statistics, the US Energy Information Administration, the World Bank, Eurostat, the European Central Bank, the Bank of England, the UK's Office of National Statistics, Deutsche Bundesbank, and INSEE.

This package provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.

Provide estimation for particular cases of the power series cure rate model <doi:10.1080/03610918.2011.639971>. For the distribution of the concurrent causes the alternative models are the Poisson, logarithmic, negative binomial and Bernoulli (which are includes in the original work), the polylogarithm model <doi:10.1080/00949655.2018.1451850> and the Flory-Schulz <doi:10.3390/math10244643>. The estimation procedure is based on the EM algorithm discussed in <doi:10.1080/03610918.2016.1202276>. For the distribution of the time-to-event the alternative models are slash half-normal, Weibull, gamma and Birnbaum-Saunders distributions.

Allows the comparison of data cohorts (DC) against a Counter Factual Model (CFM) and measures the difference in terms of an efficacy parameter. Allows the application of Personalised Synthetic Controls.

Computation of predictive information criteria (PIC) from select model object classes for model selection in predictive contexts. In contrast to the more widely used Akaike Information Criterion (AIC), which are derived under the assumption that target(s) of prediction (i.e. validation data) are independently and identically distributed to the fitting data, the PIC are derived under less restrictive assumptions and thus generalize AIC to the more practically relevant case of training/validation data heterogeneity. The methodology featured in this package is based on Flores (2021) <https://iro.uiowa.edu/esploro/outputs/doctoral/A-new-class-of-information-criteria/9984097169902771?institution=01IOWA_INST> "A new class of information criteria for improved prediction in the presence of training/validation data heterogeneity".

Generates design matrix for analysing real paired comparisons and derived paired comparison data (Likert type items/ratings or rankings) using a loglinear approach. Fits loglinear Bradley-Terry model (LLBT) exploiting an eliminate feature. Computes pattern models for paired comparisons, rankings, and ratings. Some treatment of missing values (MCAR and MNAR). Fits latent class (mixture) models for paired comparison, rating and ranking patterns using a non-parametric ML approach.

This package provides a scalable and accurate tool for Killer-cell Immunoglobulin-like Receptor (KIR) genotype imputation directly from SNP array data using supervised machine learning models trained across five continental ancestry groups. Uses attribute bagging and an ensemble classifier method with haplotype inference for SNPs and KIR types. Models are built from global populations in the 1000 Genomes Project and validated across diverse biobank cohorts. Methods are based on Zheng et al. (2014) <doi:10.1016/j.ajhg.2013.12.015> and Sadeeq et al. (2026) <https://github.com/NormanLabUCD/PONG2>.

Partial Least Squares Path Modeling (PLS-PM), Tenenhaus, Esposito Vinzi, Chatelin, Lauro (2005) <doi:10.1016/j.csda.2004.03.005>, analysis for both metric and non-metric data, as well as REBUS analysis, Esposito Vinzi, Trinchera, Squillacciotti, and Tenenhaus (2008) <doi:10.1002/asmb.728>.

Reads the provenance collected by the rdtLite or rdt packages, or other tools providing compatible PROV JSON output, created by the execution of a script or a console session, and provides a human-readable summary identifying the input and output files, the scripts used (if any), errors and warnings produced, and the environment in which it was executed. It can also optionally package all the files into a zip file. The exact format of the PROV JSON file created by rdtLite and rdt is described in <https://github.com/End-to-end-provenance/ExtendedProvJson>. More information about rdtLite and associated tools is available at <https://github.com/End-to-end-provenance/> and Lerner, Boose, and Perez (2018), Using Introspection to Collect Provenance in R, Informatics, <doi: 10.3390/informatics5010012>.

Calculates the Probability Plot Correlation Coefficient (PPCC) between a continuous variable X and a specified distribution. The corresponding composite hypothesis test that was first introduced by Filliben (1975) <doi: 10.1080/00401706.1975.10489279> can be performed to test whether the sample X is element of either the Normal, log-Normal, Exponential, Uniform, Cauchy, Logistic, Generalized Logistic, Gumbel (GEVI), Weibull, Generalized Extreme Value, Pearson III (Gamma 2), Mielke's Kappa, Rayleigh or Generalized Logistic Distribution. The PPCC test is performed with a fast Monte-Carlo simulation.