This package implements the efficient algorithm by Ortmann and Brandes (2017) <doi:10.1007/s41109-017-0027-2> to compute the orbit-aware frequency distribution of induced and non-induced quads, i.e. subgraphs of size four. Given an edge matrix, data frame, or a graph object (e.g., igraph'), the orbit-aware counts are computed respective each of the edges and nodes.

This package provides new tools for analyzing discrete trait data integrating bio-ontologies and phylogenetics. It expands on the previous work of Tarasov et al. (2019) <doi:10.1093/isd/ixz009>. The PARAMO pipeline allows to reconstruct ancestral phenomes treating groups of morphological traits as a single complex character. The pipeline incorporates knowledge from ontologies during the amalgamation of individual character stochastic maps. Here we expand the current PARAMO functionality by adding new statistical methods for inferring evolutionary phenome dynamics using non-homogeneous Poisson process (NHPP). The new functionalities include: (1) reconstruction of evolutionary rate shifts of phenomes across lineages and time; (2) reconstruction of morphospace dynamics through time; and (3) estimation of rates of phenome evolution at different levels of anatomical hierarchy (e.g., entire body or specific regions only). The package also includes user-friendly tools for visualizing evolutionary rates of different anatomical regions using vector images of the organisms of interest.

Detection of overdispersion in count data for multiple regression analysis. Log-linear count data regression is one of the most popular techniques for predictive modeling where there is a non-negative discrete quantitative dependent variable. In order to ensure the inferences from the use of count data models are appropriate, researchers may choose between the estimation of a Poisson model and a negative binomial model, and the correct decision for prediction from a count data estimation is directly linked to the existence of overdispersion of the dependent variable, conditional to the explanatory variables. Based on the studies of Cameron and Trivedi (1990) <doi:10.1016/0304-4076(90)90014-K> and Cameron and Trivedi (2013, ISBN:978-1107667273), the overdisp() command is a contribution to researchers, providing a fast and secure solution for the detection of overdispersion in count data. Another advantage is that the installation of other packages is unnecessary, since the command runs in the basic R language.

For the problem of indirect treatment comparison with limited subject-level data, this package provides tools for model-based standardisation with several different computation approaches. See Remiroâ Azócar A, Heath A, Baio G (2022) ``Parametric Gâ computation for compatible indirect treatment comparisons with limited individual patient data'', Res. Synth. Methods, 1â 31. ISSN 1759-2879, <doi:10.1002/jrsm.1565>.

This package provides cohort pathway analysis for Observational Medical Outcomes Partnership (OMOP) Common Data Model databases, including both standard (post-index) and pre-index pathway analyses. The pre-index analysis identifies sequences of events occurring in a lookback window before the target cohort index date. Built on the CohortPathways analysis framework originally developed by Christopher Knoll and the Observational Health Data Sciences and Informatics community through WebAPI'. Methodological background and the originating implementation are described in <https://github.com/OHDSI/CohortPathways>.

Computes the routing distribution, the expectation of the number of broadcasts, transmissions and receptions considering an Opportunistic transport model. It provides theoretical results and also estimated values based on Monte Carlo simulations.

Estimates propensity scores by the outcome-adaptive lasso of Shortreed and Ertefaie (2017) <doi:10.1111/biom.12679> and the generalized outcome-adaptive lasso (GOAL) of Balde, Yang and Lefebvre (2023) <doi:10.1111/biom.13683>, using glmnet with an exact penalty-scale correction so that the published objectives and tuning grids are reproduced. Tuning is by the weighted absolute mean difference balance criterion. The resulting score is designed to be supplied directly to the matchit() function of MatchIt as a distance measure, to the weightit() function of WeightIt as a propensity score, or to the psave() function of psAve as an appended candidate.

This package performs robust cluster analysis allowing for outliers and noise that cannot be fitted by any cluster. The data are modelled by a mixture of Gaussian distributions and a noise component, which is an improper uniform distribution covering the whole Euclidean space. Parameters are estimated by (pseudo) maximum likelihood. This is fitted by a EM-type algorithm. See Coretto and Hennig (2016) <doi:10.1080/01621459.2015.1100996>, and Coretto and Hennig (2017) <https://jmlr.org/papers/v18/16-382.html>.

Create R plots visualising ontological terms and the relationships between them with various graphical options - Greene et al. 2017 <doi:10.1093/bioinformatics/btw763>.

This package provides tools for multivariate outlier detection based on geometric properties of multivariate data using random directional projections. Observation-level outlier scores are computed by jointly probing radial magnitude and angular alignment through repeated projections onto random directions, with optional robust centering and covariance adjustment. In addition to global outlier scoring, the method produces dimension-level contribution measures to support interpretation of detected anomalies. Visualization utilities are included to summarize directional contributions for extreme observations.

This package provides a framework for organizing R projects with a standardized structure. Most analyses consist of three main components: code, results, and data, each with different requirements such as version control, sharing, and encryption. This package provides tools to set up and manage project directories, handle file paths consistently across operating systems, organize results using date-based structures, source code from specified directories, and perform file operations safely. It ensures consistency across projects while accommodating different requirements for various types of content.

Fits n-dimensional data by means of orthogonal nonlinear least-squares using Levenberg-Marquardt minimization and provides functionality for fit diagnostics and plotting. Delivers the same results as the ODRPACK Fortran implementation described in Boggs et al. (1989) <doi:10.1145/76909.76913>, but is implemented in pure R.

Transactions occurring for a UK-based and registered, non-store online retail between 01/12/2010 and 09/12/2011 (Chen et. al., 2012, <doi:10.1145/1835804.1835882>). This dataset is included in this package with the donor's permission, Dr. Daqing Chen.

Reconstructs plausible 2 by 2 contingency tables from published cohort-study summaries when the original cell counts are unavailable. Given group sample sizes and an odds ratio with partial confidence interval information, the package searches for compatible event counts, then derives corresponding relative risks and confidence intervals. It implements the methods described in Wang (2013) <doi:10.18637/jss.v055.i05> and includes summary and plotting methods for reviewing admissible scenarios.

Intended to create standard human-in-the-loop validity tests for typical automated content analysis such as topic modeling and dictionary-based methods. This package offers a standard workflow with functions to prepare, administer and evaluate a human-in-the-loop validity test. This package provides functions for validating topic models using word intrusion, topic intrusion (Chang et al. 2009, <https://papers.nips.cc/paper/3700-reading-tea-leaves-how-humans-interpret-topic-models>) and word set intrusion (Ying et al. 2021) <doi:10.1017/pan.2021.33> tests. This package also provides functions for generating gold-standard data which are useful for validating dictionary-based methods. The default settings of all generated tests match those suggested in Chang et al. (2009) and Song et al. (2020) <doi:10.1080/10584609.2020.1723752>.

This package implements the Univariate Bootstrap and the Traditional (Naive) Bootstrap for resampling multivariate data while preserving covariance structure. Also provides functions for DeFries-Fulker behavioral genetics models, including the Rodgers-Kohler formulation with robust standard errors.

Implementation of optimistic optimization methods for global optimization of deterministic or stochastic functions. The algorithms feature guarantees of the convergence to a global optimum. They require minimal assumptions on the (only local) smoothness, where the smoothness parameter does not need to be known. They are expected to be useful for the most difficult functions when we have no information on smoothness and the gradients are unknown or do not exist. Due to the weak assumptions, however, they can be mostly effective only in small dimensions, for example, for hyperparameter tuning.

Identifies an optimal transformation of a surrogate marker such that the proportion of treatment effect explained can be inferred based on the transformation of the surrogate and nonparametrically estimates two model-free quantities of this proportion. Details are described in Wang et al (2020) <doi:10.1093/biomet/asz065>.

This package provides functions for plotting Australia's coastline and state boundaries.

Outcome-dependent sampling (ODS) schemes are cost-effective ways to enhance study efficiency. In ODS designs, one observes the exposure/covariates with a probability that depends on the outcome variable. Popular ODS designs include case-control for binary outcome, case-cohort for time-to-event outcome, and continuous outcome ODS design (Zhou et al. 2002) <doi: 10.1111/j.0006-341X.2002.00413.x>. Because ODS data has biased sampling nature, standard statistical analysis such as linear regression will lead to biases estimates of the population parameters. This package implements four statistical methods related to ODS designs: (1) An empirical likelihood method analyzing the primary continuous outcome with respect to exposure variables in continuous ODS design (Zhou et al., 2002). (2) A partial linear model analyzing the primary outcome in continuous ODS design (Zhou, Qin and Longnecker, 2011) <doi: 10.1111/j.1541-0420.2010.01500.x>. (3) Analyze a secondary outcome in continuous ODS design (Pan et al. 2018) <doi: 10.1002/sim.7672>. (4) An estimated likelihood method analyzing a secondary outcome in case-cohort data (Pan et al. 2017) <doi: 10.1111/biom.12838>.

An interface between R and the OSRM API. OSRM is a routing service based on OpenStreetMap data. See <http://project-osrm.org/> for more information. This package enables the computation of routes, trips, isochrones and travel distances matrices (travel time and kilometric distance).

Implementation of a likelihood ratio test of differential onset of senescence between two groups. Given two groups with measures of age and of an individual trait likely to be subjected to senescence (e.g. body mass), OnAge provides an asymptotic p-value for the null hypothesis that senescence starts at the same age in both groups. The package implements the procedure used in Douhard et al. (2017) <doi:10.1111/oik.04421>.

Fits community site occupancy models to environmental DNA metabarcoding data collected using spatially-replicated survey design. Model fitting results can be used to evaluate and compare the effectiveness of species detection to find an efficient survey design. Reference: Fukaya et al. (2022) <doi:10.1111/2041-210X.13732>, Fukaya and Hasebe (2025) <doi:10.1002/1438-390X.12219>.

This package provides a comprehensive set of indexes and tests for social segregation analysis, as described in Tivadar (2019) - OasisR': An R Package to Bring Some Order to the World of Segregation Measurement <doi:10.18637/jss.v089.i07>. The package is the most complete existing tool and it clarifies many ambiguities and errors regarding the definition of segregation indices. Additionally, OasisR introduces several resampling methods that enable testing their statistical significance (randomization tests, bootstrapping, and jackknife methods).