This package provides McFly replaces your default ctrl-r shell history search with an intelligent search engine that takes into account your working directory and the context of recently executed commands. McFly's suggestions are prioritized in real time with a small neural network.

Psych is a YAML parser and emitter. Psych leverages libyaml[https://pyyaml.org/wiki/LibYAML] for its YAML parsing and emitting capabilities. In addition to wrapping libyaml, Psych also knows how to serialize and de-serialize most Ruby objects to and from the YAML format.

This package provides configurable progress bars. They may include percentage, elapsed time, and/or the estimated completion time. They work in terminals, in Emacs ESS, RStudio, Windows Rgui, and the macOS R.app. The package also provides a C++ API, that works with or without Rcpp.

This package provides tools that allow you to recreate the parsing, evaluation and display of R code, with enough information that you can accurately recreate what happens at the command line. The tools can easily be adapted for other output formats, such as HTML or LaTeX.

This package provides R bindings to the uchardet encoding detector library from Mozilla. It takes a sequence of bytes in an unknown character encoding without any additional information, and attempts to get the encoding of the text. All return names of the encodings are iconv-compatible.

cl-ratify is a collection of utilities to perform validation checks and parsing. The main intention of usage for this is in web-applications in order to check form inputs for correctness and automatically parse them into their proper representations or return meaningful errors.

RNA-Seq is currently used routinely, and it provides accurate information on gene transcription. However, the method cannot accurately estimate duplicated genes expression. Several strategies have been previously used, but all of them provide biased results. With Rmmquant, if a read maps at different positions, the tool detects that the corresponding genes are duplicated; it merges the genes and creates a merged gene. The counts of ambiguous reads is then based on the input genes and the merged genes. Rmmquant is a drop-in replacement of the widely used tools findOverlaps and featureCounts that handles multi-mapping reads in an unabiased way.

Ritornello is a ChIP-seq peak calling algorithm based on signal processing that can accurately call binding events without the need to do a pair total DNA input or IgG control sample. It has been tested for use with narrow binding events such as transcription factor ChIP-seq.

This package provides an estimation and inference methods for models of conditional quantiles: linear and nonlinear parametric and non-parametric models for conditional quantiles of a univariate response and several methods for handling censored survival data. Portfolio selection methods based on expected shortfall risk are also included.

This package constructs basis functions of B-splines, M-splines, I-splines, convex splines (C-splines), periodic splines, natural cubic splines, generalized Bernstein polynomials, their derivatives, and integrals (except C-splines) by closed-form recursive formulas. It also contains a C++ head-only library integrated with Rcpp.

This package performs projection predictive feature selection for generalized linear models and generalized linear and additive multilevel models. The package is compatible with the rstanarm and brms packages, but other reference models can also be used. See the package vignette for more information and examples.

Comprehensive and flexible logging library written in Ruby for use in Ruby programs. It features a hierarchical logging system of any number of levels, custom level names, logger inheritance, multiple output destinations per log event, execution tracing, custom formatting, thread safteyness, XML and YAML configuration, and more.

Subtypes are defined as groups of samples that have distinct molecular and clinical features. Genomic data can be analyzed for discovering patient subtypes, associated with clinical data, especially for survival information. This package is aimed to identify subtypes that are both clinically relevant and biologically meaningful.

Splatter is a package for the simulation of single-cell RNA sequencing count data. It provides a simple interface for creating complex simulations that are reproducible and well-documented. Parameters can be estimated from real data and functions are provided for comparing real and simulated datasets.

rocALUTION is a sparse linear algebra library that can be used to explore fine-grained parallelism on top of the ROCm platform runtime and toolchains. Based on C++ and HIP, rocALUTION provides a portable, generic, and flexible design that allows seamless integration with other scientific software packages.

MaAsLin2 is comprehensive R package for efficiently determining multivariable association between clinical metadata and microbial meta'omic features. This package relies on general linear models to accommodate most modern epidemiological study designs, including cross-sectional and longitudinal, and offers a variety of data exploration, normalization, and transformation methods.

This package implements functions for simulation-based inference. In particular, it implements functions to perform likelihood inference from data summaries whose distributions are simulated. The package implements more advanced methods than the ones first described in: Rousset, Gouy, Almoyna and Courtiol (2017) <doi:10.1111/1755-0998.12627>.

This package can be used to normalize cytometry samples when a control sample is taken along in each of the batches. This is done by first identifying multiple clusters/cell types, learning the batch effects from the control samples and applying quantile normalization on all markers of interest.

This is a package for random number generation for the truncated multivariate normal and Student t distribution. It computes probabilities, quantiles and densities, including one-dimensional and bivariate marginal densities. It computes first and second moments (i.e. mean and covariance matrix) for the double-truncated multinormal case.

The topdownr package allows automatic and systemic investigation of fragment conditions. It creates Thermo Orbitrap Fusion Lumos method files to test hundreds of fragmentation conditions. Additionally it provides functions to analyse and process the generated MS data and determine the best conditions to maximise overall fragment coverage.

This package provides a enhanced visualization of single-cell data based on gene-weighted density estimation. Nebulosa recovers the signal from dropped-out features and allows the inspection of the joint expression from multiple features (e.g. genes). Seurat and SingleCellExperiment objects can be used within Nebulosa.

MultiBaC is a strategy to correct batch effects from multiomic datasets distributed across different labs or data acquisition events. MultiBaC is able to remove batch effects across different omics generated within separate batches provided that at least one common omic data type is included in all the batches considered.

The fishpond package contains methods for differential transcript and gene expression analysis of RNA-seq data using inferential replicates for uncertainty of abundance quantification, as generated by Gibbs sampling or bootstrap sampling. Also the package contains a number of utilities for working with Salmon and Alevin quantification files.

This package provides extra themes and scales for ggplot2 that replicate the look of plots by Edward Tufte and Stephen Few in Fivethirtyeight, The Economist, Stata, Excel, and The Wall Street Journal, among others. This package also provides geoms for Tufte's box plot and range frame.