This package provides a collection of pancreatic Cancer transcriptomic datasets that are part of the MetaGxData package compendium. This package contains multiple pancreas cancer datasets that have been downloaded from various resources and turned into SummarizedExperiment objects. The details of how the authors normalized the data can be found in the experiment data section of the objects. Additionally, the location the data was obtained from can be found in the url variables of the experiment data portion of each SE.

Reads chromatograms from binary formats into R objects. Currently supports conversion of Agilent ChemStation', Agilent MassHunter', Agilent OpenLab', Shimadzu LabSolutions', ThermoRaw', Varian Workstation', and Waters Empower files as well as various other formats. In addition to its internal parsers, chromConverter contains bindings to parsers in external libraries, such as Aston <https://github.com/bovee/aston>, Entab <https://github.com/bovee/entab>, rainbow <https://rainbow-api.readthedocs.io/>, and ThermoRawFileParser <https://github.com/compomics/ThermoRawFileParser>.

This package provides an interface to the GenderAPI.io Phone Number Validation & Formatter API (<https://www.genderapi.io>) for validating international phone numbers, detecting number type (mobile, landline, Voice over Internet Protocol (VoIP)), retrieving region and country metadata, and formatting numbers to E.164 or national format. Designed to simplify integration into R workflows for data validation, Customer Relationship Management (CRM) data cleaning, and analytics tasks. Full documentation is available at <https://www.genderapi.io/docs-phone-validation-formatter-api>.

Add a searchbar widget to your Shiny application. The widget quickly integrates with any existing element containing text to highlight matches. Highlighting is done with the JavaScript library mark.js'. The widget includes buttons to cycle through multiple instances of the match and automatically scroll to the matches in an overflow element (or window). The widget also displays the total number of matches and which match is currently being cycled through. The widget is structured as a Bootstrap 3 input group.

The function SurvRegCens() of this package allows estimation of a Weibull Regression for a right-censored endpoint, one interval-censored covariate, and an arbitrary number of non-censored covariates. Additional functions allow to switch between different parametrizations of Weibull regression used by different R functions, inference for the mean difference of two arbitrarily censored Normal samples, and estimation of canonical parameters from censored samples for several distributional assumptions. Hubeaux, S. and Rufibach, K. (2014) <doi:10.48550/arXiv.1402.0432>.

This package provides functions for estimating natural direct and indirect effects for mediation analysis. It uses weighting where the weights are functions of estimates of the probability of exposure or treatment assignment (Hong, G (2010). <https://cepa.stanford.edu/sites/default/files/workshops/GH_JSM%20Proceedings%202010.pdf> Huber, M. (2014). <doi:10.1002/jae.2341>). Estimation of probabilities can use generalized boosting or logistic regression. Additional functions provide diagnostics of the model fit and weights. The vignette provides details and examples.

Elasticsearch is an open-source, distributed, document-based datastore (<https://www.elastic.co/products/elasticsearch>). It provides an HTTP API for querying the database and extracting datasets, but that API was not designed for common data science workflows like pulling large batches of records and normalizing those documents into a data frame that can be used as a training dataset for statistical models. uptasticsearch provides an interface for Elasticsearch that is explicitly designed to make these data science workflows easy and fun.

This package is designed for typesetting the programmable elements in digital hardware, i.e., registers. Such registers typically have many fields and can be quite wide; they are thus a challenge to typeset in a consistent manner. Register is similar in some aspects to the bytefield and bitpattern packages. Anyone doing hardware documentation using LaTeX should examine those packages. An example Perl module and script are provided, to convert the register specifications into structures suitable for, say, a pre-silicon test environment.

This package provides tools to study sorting patterns in matching markets and to estimate the affinity matrix of both the bipartite one-to-one matching model without frictions and with Transferable Utility by Dupuy and Galichon (2014) <doi:10.1086/677191> and its unipartite variant by Ciscato', Galichon and Gousse (2020) <doi:10.1086/704611>. It also contains all the necessary tools to implement the saliency analysis, to run rank tests of the affinity matrix and to build tables and plots summarizing the findings.

Test for cluster tendency (clusterability) of a data set. The methods implemented - reducing the data set to a single dimension using principal component analysis or computing pairwise distances, and performing a multimodality test like the Dip Test or Silverman's Critical Bandwidth Test - are described in Adolfsson, Ackerman, and Brownstein (2019) <doi:10.1016/j.patcog.2018.10.026> and Laborde et al. (2023) <doi: 10.1186/s12859-023-05210-6>. Such methods can inform whether clustering algorithms are appropriate for a data set.

Various statistical methods for survival analysis in comparing survival curves between two groups, including overall hypothesis tests described in Li et al. (2015) <doi:10.1371/journal.pone.0116774> and Huang et al. (2020) <doi:10.1080/03610918.2020.1753075>, fixed-point tests in Klein et al. (2007) <doi:10.1002/sim.2864>, short-term tests, and long-term tests in Logan et al. (2008) <doi:10.1111/j.1541-0420.2007.00975.x>. Some commonly used descriptive statistics and plots are also included.

Implementations of classical and machine learning models for survival analysis, including deep neural networks via keras and tensorflow'. Each model includes a separated fit and predict interface with consistent prediction types for predicting risk or survival probabilities. Models are either implemented from Python via reticulate <https://CRAN.R-project.org/package=reticulate>, from code in GitHub packages, or novel implementations using Rcpp <https://CRAN.R-project.org/package=Rcpp>. Neural networks are implemented from the Python package pycox <https://github.com/havakv/pycox>.

Combines information from two independent surveys using a model-assisted projection method. Designed for survey sampling scenarios where a large sample collects only auxiliary information (Survey 1) and a smaller sample provides data on both variables of interest and auxiliary variables (Survey 2). Implements a working model to generate synthetic values of the variable of interest by fitting the model to Survey 2 data and predicting values for Survey 1 based on its auxiliary variables (Kim & Rao, 2012) <doi:10.1093/biomet/asr063>.

This package provides a developed and benchmarked reproducible machine learning framework for microbiome-based colorectal cancer (CRC) screening. By systematically evaluating normalization strategies, taxonomic resolutions, and class imbalance handling. This R package allows users to apply the full pipeline or selectively run specific components depending on their analytical needs. It establishes a scalable foundation for developing interpretable microbiome-based screening tools to support early CRC detection. This approach could be easily implemented in a national screening programme, to improve early detection rates for this disease.

The package curatedPCaData offers a selection of annotated prostate cancer datasets featuring multiple omics, manually curated metadata, and derived downstream variables. The studies are offered as MultiAssayExperiment (MAE) objects via ExperimentHub, and comprise of clinical characteristics tied to gene expression, copy number alteration and somatic mutation data. Further, downstream features computed from these multi-omics data are offered. Multiple vignettes help grasp characteristics of the various studies and provide example exploratory and meta-analysis of leveraging the multiple studies provided here-in.

This library is a collection of pseudo random number generators.

While Common Lisp does provide a RANDOM function, it does not allow the user to pass an explicit SEED, nor to portably exchange the random state between implementations. This can be a headache in cases like games, where a controlled seeding process can be very useful.

For both curiosity and convenience, this library offers multiple algorithms to generate random numbers, as well as a bunch of generally useful methods to produce desired ranges.

TrainFastImputation() uses training data to describe a multivariate normal distribution that the data approximates or can be transformed into approximating and stores this information as an object of class FastImputationPatterns'. FastImputation() function uses this FastImputationPatterns object to impute (make a good guess at) missing data in a single line or a whole data frame of data. This approximates the process used by Amelia <https://gking.harvard.edu/amelia> but is much faster when filling in values for a single line of data.

This package provides a synthetic, longitudinal athletic dataset generated through a transparent, rule-based simulation engine. Captures individual activity sessions across multiple athletes, environmental conditions, and physiological responses. Specifically designed as an alternative to legacy teaching datasets by introducing realistic hierarchical repeated measures, complex two-way covariate interactions, and a deliberate Missing Not At Random (MNAR) tracking mechanism suitable for advanced imputation workflows. Methodologies implemented are based on van Buuren (2018) <doi:10.1201/9780429492259> and Bates et al. (2015) <doi:10.18637/jss.v067.i01>.

Estimates unit-level and population-level parameters from a hierarchical model in marketing applications. The package includes: Hierarchical Linear Models with a mixture of normals prior and covariates, Hierarchical Multinomial Logits with a mixture of normals prior and covariates, Hierarchical Multinomial Logits with a Dirichlet Process prior and covariates. For more details, see Bumbaca, F. (Rico), Misra, S., & Rossi, P. E. (2020) <doi:10.1177/0022243720952410> "Scalable Target Marketing: Distributed Markov Chain Monte Carlo for Bayesian Hierarchical Models". Journal of Marketing Research, 57(6), 999-1018.

This package provides an algebra over probability distributions enabling composition, sampling, and automatic simplification to closed forms. Supports normal, exponential, gamma, Weibull, chi-squared, uniform, beta, log-normal, Poisson, multivariate normal, empirical, and mixture distributions with algebraic operators (addition, subtraction, multiplication, division, power, exp, log, min, max) that automatically simplify when mathematical identities apply. Includes closed-form MVN conditioning (Schur complement), affine transformations, mixture marginals/conditionals (Bayes rule), and limiting distribution builders (CLT, LLN, delta method). Uses S3 classes for distributions and R6 for support objects.

Maintenance has been discontinued for this package. It has been superseded by GeneralizedHyperbolic'. GeneralizedHyperbolic includes all the functionality of HyperbolicDist and more and is based on a more rational design. HyperbolicDist provides functions for the hyperbolic and related distributions. Density, distribution and quantile functions and random number generation are provided for the hyperbolic distribution, the generalized hyperbolic distribution, the generalized inverse Gaussian distribution and the skew-Laplace distribution. Additional functionality is provided for the hyperbolic distribution, including fitting of the hyperbolic to data.

Estimation of different quantile models, at the moment only Conditional autoregressive value at risk (CAViaR) proposed by Engle & Manganelli (2004) <doi:10.1198/073500104000000370> with also the specification proposed in Huang et al. (2009) <doi:10.1016/j.eneco.2008.12.006> and it's multivariate extension, Multi-variate multi-quantile CAViaR (MVMQ-CAViaR) proposed by White et al. (2015) <doi:10.1016/j.jeconom.2015.02.004> are available, however, in further updates, other models and extensions will be included.

The package provides access to the copy of the Synaptic proteome database. It was designed as an accompaniment for Synaptome.DB package. Database provides information for specific synaptic genes and allows building the protein-protein interaction graph for gene sets, synaptic compartments, and brain regions. In the current update we added 6 more synaptic proteome studies, which resulted in total of 64 studies. We introduced Synaptic Vesicle as a separate compartment. We also added coding mutations for Autistic Spectral disorder and Epilepsy collected from publicly available databases.

This package provides a set of tools for processing and analyzing in vitro toxicokinetic measurements in a standardized and reproducible pipeline. The package was developed to perform frequentist and Bayesian estimation on a variety of in vitro toxicokinetic measurements including -- but not limited to -- chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The methods provided by the package were described in Wambaugh et al. (2019) <doi:10.1093/toxsci/kfz205>.