Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) <doi:10.1002/sim.7689> for details.

Creation of interactive tables, listings and figures ('TLFs') and associated report for exploratory analysis of data in a clinical trial, e.g. for clinical oversight activities. Interactive figures include sunburst, treemap, scatterplot, line plot and barplot of counts data. Interactive tables include table of summary statistics (as counts of adverse events, enrollment table) and listings. Possibility to compare data (summary table or listing) across two data batches/sets. A clinical data review report is created via study-specific configuration files and template R Markdown reports contained in the package.

Design parameters of the optimal two-period multiarm platform design (controlling for either family-wise error rate or pair-wise error rate) can be calculated using this package, allowing pre-planned deferred arms to be added during the trial. More details about the design method can be found in the paper: Pan, H., Yuan, X. and Ye, J. (2022) "An optimal two-period multiarm platform design with new experimental arms added during the trial". Manuscript submitted for publication. For additional references: Dunnett, C. W. (1955) <doi:10.2307/2281208>.

TaskJuggler (tj3) is a project management tool for project planning and tracking using a domain specific language; projects are plain text files written using your favourite text editor. It includes reporting in HTML, CSV or iCalendar format and an email based status tracking system to send and receive time sheets from collaborators.

It covers the complete spectrum of project management tasks from the first idea to the completion of the project. It assists you during project scoping, resource assignment, cost and revenue planning, risk and communication management, status tracking and reporting.

This package provides a comprehensive package for comparing multiple Structural Equation Models (SEM). Supports both nested and non-nested model comparisons, chi-square difference tests, and extraction of multiple fit indices including AIC (Akaike Information Criterion), BIC (Bayesian Information Criterion), CFI (Comparative Fit Index), TLI (Tucker-Lewis Index), RMSEA (Root Mean Square Error of Approximation), and SRMR (Standardized Root Mean Square Residual). Built on top of the lavaan package for seamless SEM model comparison workflows. The Vuong test (Vuong, 1989) for non-nested models is used as the statistical test.

LaBB-CAT is a web-based language corpus management system developed by the New Zealand Institute of Language, Brain and Behaviour (NZILBB) - see <https://labbcat.canterbury.ac.nz>. This package defines functions for accessing corpus data in a LaBB-CAT instance. You must have at least version 20230818.1400 of LaBB-CAT to use this package. For more information about LaBB-CAT', see Robert Fromont and Jennifer Hay (2008) <doi:10.3366/E1749503208000142> or Robert Fromont (2017) <doi:10.1016/j.csl.2017.01.004>.

Estimate and understand individual-level variation in transmission. Implements density and cumulative compound Poisson discrete distribution functions (Kremer et al. (2021) <doi:10.1038/s41598-021-93578-x>), as well as functions to calculate infectious disease outbreak statistics given epidemiological parameters on individual-level transmission; including the probability of an outbreak becoming an epidemic/extinct (Kucharski et al. (2020) <doi:10.1016/S1473-3099(20)30144-4>), or the cluster size statistics, e.g. what proportion of cases cause X\% of transmission (Lloyd-Smith et al. (2005) <doi:10.1038/nature04153>).

It makes the creation of networks from sequences of RNA, with this is done the abstraction of characteristics of these networks with a methodology of maximum entropy for the purpose of making a classification between the classes of the sequences. There are two data present in the BASiNET package, "mRNA", and "ncRNA" with 10 sequences. These sequences were taken from the data set used in the article (LI, Aimin; ZHANG, Junying; ZHOU, Zhongyin, 2014) <doi:10.1186/1471-2105-15-311>, these sequences are used to run examples.

This package provides tools for sensitivity analysis of LSD simulation models. Reads object-oriented data produced by LSD simulation models and performs screening and global sensitivity analysis (Sobol decomposition method, Saltelli et al. (2008) ISBN:9780470725177). A Kriging or polynomial meta-model (Kleijnen (2009) <doi:10.1016/j.ejor.2007.10.013>) is estimated using the simulation data to provide the data required by the Sobol decomposition. LSD (Laboratory for Simulation Development) is free software developed by Marco Valente and Marcelo C. Pereira (documentation and downloads available at <https://www.labsimdev.org/>).

This package provides functions to aid in the design and analysis of agronomic and agricultural experiments through easy access to documentation and helper functions, especially for users who are learning these concepts. While not required for most functionality, this package enhances the `asreml` package which provides a computationally efficient algorithm for fitting mixed models using Residual Maximum Likelihood. It is a commercial package that can be purchased as ASReml-R from VSNi <https://vsni.co.uk/>, who will supply a zip file for local installation/updating (see <https://asreml.kb.vsni.co.uk/>).

Identifies clinically relevant concepts in Observational Medical Outcomes Partnership Common Data Model cohorts using an enrichment-based workflow. Defines target and control cohorts and extracts medical interventions that are over-represented in the target cohort during the observation period. Users can tune filtering and selection thresholds. The workflow includes chi-squared tests for two proportions with Yates continuity correction, logistic tests, and hierarchy and correlation mappings for relevant concepts. The results can be optionally explored using the bundled graphical user interface. For workflow details and examples, see <https://healthinformaticsut.github.io/CohortContrast/>.

This package provides functions for converting time series of spatial abundance or density data in raster format to vector fields of population movement using the digital image correlation technique. More specifically, the functions in the package compute cross-covariance using discrete fast Fourier transforms for computational efficiency. Vectors in vector fields point in the direction of highest two dimensional cross-covariance. The package has a novel implementation of the digital image correlation algorithm that is designed to detect persistent directional movement when image time series extend beyond a sequence of two raster images.

Provide the safe color set for color blindness, the simulator of protanopia, deuteranopia. The color sets are collected from: Wong, B. (2011) <doi:10.1038/nmeth.1618>, and <http://mkweb.bcgsc.ca/biovis2012/>. The simulations of the appearance of the colors to color-deficient viewers were based on algorithms in Vienot, F., Brettel, H. and Mollon, J.D. (1999) <doi:10.1002/(SICI)1520-6378(199908)24:4%3C243::AID-COL5%3E3.0.CO;2-3>. The cvdPlot() function to generate ggplot grobs of simulations were modified from <https://github.com/clauswilke/colorblindr>.

This package performs analysis of popular experimental designs used in the field of biological research. The designs covered are completely randomized design, randomized complete block design, factorial completely randomized design, factorial randomized complete block design, split plot design, strip plot design and latin square design. The analysis include analysis of variance, coefficient of determination, normality test of residuals, standard error of mean, standard error of difference and multiple comparison test of means. The package has functions for transformation of data and yield data conversion. Some datasets are also added in order to facilitate examples.

Reproduces classic Rasch psychometric analysis features using Bayesian item response theory models fitted with brms following Bürkner (2021) <doi:10.18637/jss.v100.i05> and Bürkner (2020) <doi:10.3390/jintelligence8010005>. Supports both dichotomous and polytomous Rasch models. Features include posterior predictive item fit, conditional infit, item-restscore associations, person fit, differential item functioning, local dependence assessment via Q3 residual correlations, dimensionality assessment with residual principal components analysis, person-item targeting plots, item category probability curves, and reliability using relative measurement uncertainty following Bignardi et al. (2025) <doi:10.31234/osf.io/h54k8_v1>.

This package provides functions and necessary JavaScript bindings to quickly transfer spatial data from R memory or remote URLs to the browser for use in interactive HTML widgets created with the htmlwidgets R package. Leverages GeoArrow (<https://geoarrow.org/>) data representation for data stored in local R memory which is generally faster than traditional GeoJSON by minimising the amount of copy, serialization and deserialization steps necessary for the data transfer. Furthermore, provides functionality and JavaScript bindings to consume GeoParquet (<https://geoparquet.org/>) files from remote URLs in the browser.

Aids in the analysis of genes influencing cancer survival by including a principal function, calculator(), which calculates the P-value for each provided gene under the optimal cutoff in cancer survival studies. Grounded in methodologies from significant works, this package references Therneau's survival package (Therneau, 2024; <https://CRAN.R-project.org/package=survival>) and the survival analysis extensions by Therneau and Grambsch (2000, ISBN 0-387-98784-3). It also integrates the survminer package by Kassambara et al. (2021; <https://CRAN.R-project.org/package=survminer>), enhancing survival curve visualizations with ggplot2'.

This package implements IV-estimator and Bayesian estimator for linear-in-means Spatial Autoregressive (SAR) model (see LeSage, 1997 <doi:10.1177/016001769702000107>; Lee, 2004 <doi:10.1111/j.1468-0262.2004.00558.x>; Bramoullé et al., 2009 <doi:10.1016/j.jeconom.2008.12.021>), while assuming that only a partial information about the network structure is available. Examples are when the adjacency matrix is not fully observed or when only consistent estimation of the network formation model is available (see Boucher and Houndetoungan, 2025 <doi:10.48550/arXiv.2509.08145>).

Kappa statistics is one of the most used methods to evaluate the effectiveness of inpsections based on attribute assessments in industry. However, its estimation by available methods does not provide its "real" or "intrinstic" value. This package provides functions for the computation of the intrinsic kappa value as it is described in: Rafael Sanchez-Marquez, Frank Gerhorst and David Schindler (2023) "Effectiveness of quality inspections of attributive characteristics â A novel and practical method for estimating the â intrinsicâ value of kappa based on alpha and beta statistics." <doi:10.1016/j.cie.2023.109006>.

Download, cache, and manage social contact survey data from the social contact data community on Zenodo (<https://zenodo.org/communities/social_contact_data>) for use in infectious disease modelling. Provides functions to list available surveys, download survey files with automatic caching, and retrieve citations. Contact survey data describe who contacts whom in a population and are used to parameterise age-structured transmission models, for example via the socialmixr package. The surveys available include those from the POLYMOD study (Mossong et al. (2008) <doi:10.1371/journal.pmed.0050074>) and other social contact data shared on Zenodo.

Univariate stratification of survey populations with a generalization of the Lavallee-Hidiroglou method of stratum construction. The generalized method takes into account a discrepancy between the stratification variable and the survey variable. The determination of the optimal boundaries also incorporate, if desired, an anticipated non-response, a take-all stratum for large units, a take-none stratum for small units, and a certainty stratum to ensure that some specific units are in the sample. The well known cumulative root frequency rule of Dalenius and Hodges and the geometric rule of Gunning and Horgan are also implemented.

This package implements multi-armed bandit approaches for pricing experiments with an unknown demand curve, as developed in Weaver, Kumar, and Jain, "Nonparametric Pricing Bandits Leveraging Informational Externalities to Learn the Demand Curve" <doi:10.1287/mksc.2022.0247>. Includes Upper Confidence Bound (UCB) and Thompson Sampling (TS) baselines, Gaussian process variants ('GP-UCB', GP-TS'), monotonic Gaussian process variants that constrain demand to be weakly decreasing in price, and heterogeneous-noise extensions. The willingness-to-pay distribution is fully user-specified via a vector of consumer valuations, so any demand environment can be simulated or replayed.

This package provides a tool set for food information and dietary assessment. It uses food composition data from several reference databases, including: USDA (United States), CIQUAL (France), BEDCA (Spain), CNF (Canada) and STFCJ (Japan). NutrienTrackeR calculates the intake levels for both macronutrient and micronutrients, and compares them with the recommended dietary allowances (RDA). It includes a number of visualization tools, such as time series plots of nutrient intake, and pie-charts showing the main foods contributing to the intake level of a given nutrient. A shiny app exposing the main functionalities of the package is also provided.

This package implements Multivariate ANalysis Of VAriance (MANOVA) parameters inference and test with regularization for semicontinuous high-dimensional data. The method can be applied also in presence of low-dimensional data. The p-value can be obtained through asymptotic distribution or using a permutation procedure. The package gives also the possibility to simulate this type of data. Method is described in Elena Sabbioni, Claudio Agostinelli and Alessio Farcomeni (2025) A regularized MANOVA test for semicontinuous high-dimensional data. Biometrical Journal, 67:e70054. DOI <doi:10.1002/bimj.70054>, arXiv DOI <doi:10.48550/arXiv.2401.04036>.