There are four categories of Phase III clinical trials according to different research goals, including (1) Testing for equality, (2) Superiority trial, (3) Non-inferiority trial, and (4) Equivalence trial. This package aims to help researchers to calculate sample size when comparing means or proportions in Phase III clinical trials with different research goals.

This package provides a graphical user interface (GUI) for fitting Bayesian regression models using the package brms which in turn relies on Stan (<https://mc-stan.org/>). The shinybrms GUI is a shiny app.

This package provides a classification framework to use expression patterns of pathways as features to identify similarity between biological samples. It provides a new measure for quantifying similarity between expression patterns of pathways.

Blind source separation for multivariate spatial data based on simultaneous/joint diagonalization of (robust) local covariance matrices. This package is an implementation of the methods described in Bachoc, Genton, Nordhausen, Ruiz-Gazen and Virta (2020) <doi:10.1093/biomet/asz079>.

Efficient estimation of multivariate skew-normal distribution in closed form.

Estimates the population average controlled difference for a given outcome between levels of a binary treatment, exposure, or other group membership variable of interest for clustered, stratified survey samples where sample selection depends on the comparison group. Provides three methods for estimation, namely outcome modeling and two factorizations of inverse probability weighting. Under stronger assumptions, these methods estimate the causal population average treatment effect. Salerno et al., (2024) <doi:10.48550/arXiv.2406.19597>.

An implementation of feature selection, weighting and ranking via simultaneous perturbation stochastic approximation (SPSA). The SPSA-FSR algorithm searches for a locally optimal set of features that yield the best predictive performance using some error measures such as mean squared error (for regression problems) and accuracy rate (for classification problems).

Summary ellipses superimposed on a scatter plot contain all bi-variate summary statistics for regression analysis. Furthermore, the outer ellipse flags potential outliers. Multiple groups can be compared in terms of centers and spreads as illustrated in the examples.

Detection of outliers and influential errors using a latent variable model.

This package provides a set of functions that can be used to spatially thin species occurrence data. The resulting thinned data can be used in ecological modeling, such as ecological niche modeling.

Affords researchers the ability to draw stratified samples from the U.S. Department of Veteran's Affairs/Department of Defense Identity Repository (VADIR) database according to a variety of population characteristics. The VADIR database contains information for all veterans who were separated from the military after 1980. The central utility of the present package is to integrate data cleaning and formatting for the VADIR database with the stratification methods described by Mahto (2019) <https://CRAN.R-project.org/package=splitstackshape>. Data from VADIR are not provided as part of this package.

Generate common data forms for complex data suitable for conversions and transmission by decomposition as paths or primitives. Paths are sequentially-linked records, primitives are basic atomic elements and both can model many forms and be grouped into hierarchical structures. The universal models SC0 (structural) and SC (labelled, relational) are composed of edges and can represent any hierarchical form. Specialist models PATH', ARC and TRI provide the most common intermediate forms used for converting from one form to another. The methods are inspired by the simplicial complex <https://en.wikipedia.org/wiki/Simplicial_complex> and provide intermediate forms that relate spatial data structures to this mathematical construct.

Screen for and analyze non-linear sparse direct effects in the presence of unobserved confounding using the spectral deconfounding techniques (Ä evid, Bühlmann, and Meinshausen (2020)<jmlr.org/papers/v21/19-545.html>, Guo, Ä evid, and Bühlmann (2022) <doi:10.1214/21-AOS2152>). These methods have been shown to be a good estimate for the true direct effect if we observe many covariates, e.g., high-dimensional settings, and we have fairly dense confounding. Even if the assumptions are violated, it seems like there is not much to lose, and the deconfounded models will, in general, estimate a function closer to the true one than classical least squares optimization. SDModels provides functions SDAM() for Spectrally Deconfounded Additive Models (Scheidegger, Guo, and Bühlmann (2025) <doi:10.1145/3711116>) and SDForest() for Spectrally Deconfounded Random Forests (Ulmer, Scheidegger, and Bühlmann (2025) <doi:10.1080/10618600.2025.2569602>).

Data on standard load profiles from the German Association of Energy and Water Industries (BDEW Bundesverband der Energie- und Wasserwirtschaft e.V.) in a tidy format. The data and methodology are described in VDEW (1999), "Repräsentative VDEW-Lastprofile", <https://www.bdew.de/media/documents/1999_Repraesentative-VDEW-Lastprofile.pdf>. The package also offers an interface for generating a standard load profile over a user-defined period. For the algorithm, see VDEW (2000), "Anwendung der Repräsentativen VDEW-Lastprofile step-by-step", <https://www.bdew.de/media/documents/2000131_Anwendung-repraesentativen_Lastprofile-Step-by-step.pdf>.

The function syncSubsample subsamples temporal data of different entities so that the result only contains synchronal events. The function mci calculates the Movement Coordination Index (MCI, see reference on help page for function mci') of a data set created with the function syncSubsample'.

This package provides confidence intervals in least-squares regressions when the variable of interest has a shift-share structure, and in instrumental variables regressions when the instrument has a shift-share structure. The confidence intervals implement the AKM and AKM0 methods developed in Adão, Kolesár, and Morales (2019) <doi:10.1093/qje/qjz025>.

This package provides functionality for structural equation modeling for the social relations model (Kenny & La Voie, 1984; <doi:10.1016/S0065-2601(08)60144-6>; Warner, Kenny, & Soto, 1979, <doi:10.1037/0022-3514.37.10.1742>). Maximum likelihood estimation (Gill & Swartz, 2001, <doi:10.2307/3316080>; Nestler, 2018, <doi:10.3102/1076998617741106>) and least squares estimation is supported (Bond & Malloy, 2018, <doi:10.1016/B978-0-12-811967-9.00014-X>).

Allow sharing sensitive information, for example passwords, API keys, etc., in R packages, using public key cryptography.

This package provides an R interface for SSW (Striped Smith-Waterman) via its Python binding ssw-py'. SSW is a fast C and C++ implementation of the Smith-Waterman algorithm for pairwise sequence alignment using Single-Instruction-Multiple-Data (SIMD) instructions. SSW enhances the standard algorithm by efficiently returning alignment information and suboptimal alignment scores. The core SSW library offers performance improvements for various bioinformatics tasks, including protein database searches, short-read alignments, primary and split-read mapping, structural variant detection, and read-overlap graph generation. These features make SSW particularly useful for genomic applications. Zhao et al. (2013) <doi:10.1371/journal.pone.0082138> developed the original C and C++ implementation.

Fits Bayesian spatio-temporal models and makes predictions on stream networks using the approach by Santos-Fernandez, Edgar, et al. (2022)."Bayesian spatio-temporal models for stream networks". <arXiv:2103.03538>. In these models, spatial dependence is captured using stream distance and flow connectivity, while temporal autocorrelation is modelled using vector autoregression methods.

Load Avro Files into Apache Spark using sparklyr'. This allows to read files from Apache Avro <https://avro.apache.org/>.

Isolation forest is anomaly detection method introduced by the paper Isolation based Anomaly Detection (Liu, Ting and Zhou <doi:10.1145/2133360.2133363>).

This package produces various measures of expected treatment effect heterogeneity under an assumption of homogeneity across subgroups. Graphical presentations are created to compare these expected differences with the observed differences.

Statistical analysis methods for environmental data are implemented. There is a particular focus on robust methods, and on methods for compositional data. In addition, larger data sets from geochemistry are provided. The statistical methods are described in Reimann, Filzmoser, Garrett, Dutter (2008, ISBN:978-0-470-98581-6).