This package provides a scrolling chat interface with multiline input, suitable for creating chatbot apps based on Large Language Models (LLMs). Designed to work particularly well with the ellmer R package for calling LLMs.

Handling of behavioural data from the Ethoscope platform (Geissmann, Garcia Rodriguez, Beckwith, French, Jamasb and Gilestro (2017) <DOI:10.1371/journal.pbio.2003026>). Ethoscopes (<https://giorgiogilestro.notion.site/Ethoscope-User-Manual-a9739373ae9f4840aa45b277f2f0e3a7>) are an open source/open hardware framework made of interconnected raspberry pis (<https://www.raspberrypi.org>) designed to quantify the behaviour of multiple small animals in a distributed and real-time fashion. The default tracking algorithm records primary variables such as xy coordinates, dimensions and speed. This package is part of the rethomics framework <https://rethomics.github.io/>.

This package provides a tool for producing synthetic versions of microdata containing confidential information so that they are safe to be released to users for exploratory analysis. The key objective of generating synthetic data is to replace sensitive original values with synthetic ones causing minimal distortion of the statistical information contained in the data set. Variables, which can be categorical or continuous, are synthesised one-by-one using sequential modelling. Replacements are generated by drawing from conditional distributions fitted to the original data using parametric or classification and regression trees models. Data are synthesised via the function syn() which can be largely automated, if default settings are used, or with methods defined by the user. Optional parameters can be used to influence the disclosure risk and the analytical quality of the synthesised data. For a description of the implemented method see Nowok, Raab and Dibben (2016) <doi:10.18637/jss.v074.i11>. Functions to assess identity and attribute disclosure for the original and for the synthetic data are included in the package, and their use is illustrated in a vignette on disclosure (Practical Privacy Metrics for Synthetic Data).

This package provides a group of functions that support the sf package, focused primarily on repairing polygons that break when re-projected.

This package provides a workflow based on scTenifoldNet to perform in-silico knockout experiments using single-cell RNA sequencing (scRNA-seq) data from wild-type (WT) control samples as input. First, the package constructs a single-cell gene regulatory network (scGRN) and knocks out a target gene from the adjacency matrix of the WT scGRN by setting the geneâ s outdegree edges to zero. Then, it compares the knocked out scGRN with the WT scGRN to identify differentially regulated genes, called virtual-knockout perturbed genes, which are used to assess the impact of the gene knockout and reveal the geneâ s function in the analyzed cells.

Add-on for the scan package that creates plots from single-case data frames ('scdf'). It includes functions for styling single-case plots, adding phase-based lines to indicate various statistical parameters, and predefined themes for presentations and publications. More information and in depth examples can be found in the online book "Analyzing Single-Case Data with R and scan" Jürgen Wilbert (2026) <https://jazznbass.github.io/scan-Book/>.

This package provides R functions for calculating basic effect size indices for single-case designs, including several non-overlap measures and parametric effect size measures, and for estimating the gradual effects model developed by Swan and Pustejovsky (2018) <DOI:10.1080/00273171.2018.1466681>. Standard errors and confidence intervals (based on the assumption that the outcome measurements are mutually independent) are provided for the subset of effect sizes indices with known sampling distributions.

Pathway Analysis is statistically linking observations on the molecular level to biological processes or pathways on the systems(i.e., organism, organ, tissue, cell) level. Traditionally, pathway analysis methods regard pathways as collections of single genes and treat all genes in a pathway as equally informative. However, this can lead to identifying spurious pathways as statistically significant since components are often shared amongst pathways. SIGORA seeks to avoid this pitfall by focusing on genes or gene pairs that are (as a combination) specific to a single pathway. In relying on such pathway gene-pair signatures (Pathway-GPS), SIGORA inherently uses the status of other genes in the experimental context to identify the most relevant pathways. The current version allows for pathway analysis of human and mouse datasets. In addition, it contains pre-computed Pathway-GPS data for pathways in the KEGG and Reactome pathway repositories and mechanisms for extracting GPS for user-supplied repositories.

This package provides a non convex optimization package that optimizes any function under the criterion, combination of variables are on the surface of a unit sphere, as described in the paper : Das et al. (2019) <arXiv:1909.04024> .

Sparse redundancy analysis for high dimensional (biomedical) data. Directional multivariate analysis to express the maximum variance in the predicted data set by a linear combination of variables of the predictive data set. Implemented in a partial least squares framework, for more details see Csala et al. (2017) <doi:10.1093/bioinformatics/btx374>.

This package implements several functions that automates the cleaning and spell-checking of text data. Also converges, finalizes, removes plurals and continuous strings, and puts text data in binary format for semantic network analysis. Uses the SemNetDictionaries package to make the cleaning process more accurate, efficient, and reproducible.

Allows the user to animate shiny elements when scrolling to view them. The animations are activated using the scrollrevealjs library. See <https://scrollrevealjs.org/> for more information.

This package provides methods for fitting bivariate lines in allometry using the major axis (MA) or standardised major axis (SMA), and for making inferences about such lines. The available methods of inference include confidence intervals and one-sample tests for slope and elevation, testing for a common slope or elevation amongst several allometric lines, constructing a confidence interval for a common slope or elevation, and testing for no shift along a common axis, amongst several samples. See Warton et al. 2012 <doi:10.1111/j.2041-210X.2011.00153.x> for methods description.

Tool for statistical simulations that have two components. One component generates the data and the other one analyzes the data. The main aims of the package are the reduction of the administrative source code (mainly loops and management code for the results) and a simple applicability of the package that allows the user to quickly learn how to work with it. Parallel computing is also supported. Finally, convenient functions are provided to summarize the simulation results.

Selection of spatially balanced samples. In particular, the implemented sampling designs allow to select probability samples well spread over the population of interest, in any dimension and using any distance function (e.g. Euclidean distance, Manhattan distance). For more details, Pantalone F, Benedetti R, and Piersimoni F (2022) <doi:10.18637/jss.v103.c02>, Benedetti R and Piersimoni F (2017) <doi:10.1002/bimj.201600194>, and Benedetti R and Piersimoni F (2017) <arXiv:1710.09116>. The implementation has been done in C++ through the use of Rcpp and RcppArmadillo'.

Regression-based ranking of pathogen strains with respect to their contributions to natural epidemics, using demographic and genetic data sampled in the curse of the epidemics. This package also includes the GMCPIC test.

This package contains functions to perform various models and methods for test equating (Kolen and Brennan, 2014 <doi:10.1007/978-1-4939-0317-7> ; Gonzalez and Wiberg, 2017 <doi:10.1007/978-3-319-51824-4> ; von Davier et. al, 2004 <doi:10.1007/b97446>). It currently implements the traditional mean, linear and equipercentile equating methods. Both IRT observed-score and true-score equating are also supported, as well as the mean-mean, mean-sigma, Haebara and Stocking-Lord IRT linking methods. It also supports newest methods such that local equating, kernel equating (using Gaussian, logistic, Epanechnikov, uniform and adaptive kernels) with presmoothing, and IRT parameter linking methods based on asymmetric item characteristic functions. Functions to obtain both standard error of equating (SEE) and standard error of equating differences between two equating functions (SEED) are also implemented for the kernel method of equating.

This package provides diagnostic tests for assessing the informativeness of survey weights in regression models. Implements difference-in-coefficients tests (Hausman 1978 <doi:10.2307/1913827>; Pfeffermann 1993 <doi:10.2307/1403631>), weight-association tests (DuMouchel and Duncan 1983 <doi:10.2307/2288185>; Pfeffermann and Sverchkov 1999 <https://www.jstor.org/stable/25051118>; Pfeffermann and Sverchkov 2003 <ISBN:9780470845672>; Wu and Fuller 2005 <https://www.jstor.org/stable/27590461>), estimating equations tests (Pfeffermann and Sverchkov 2003 <ISBN:9780470845672>), and non-parametric permutation tests. Includes simulation utilities replicating Wang et al. (2023 <doi:10.1111/insr.12509>) and extensions.

Stepwise regression is a statistical technique used for model selection. This package streamlines stepwise regression analysis by supporting multiple regression types(linear, Cox, logistic, Poisson, Gamma, and negative binomial), incorporating popular selection strategies(forward, backward, bidirectional, and subset), and offering essential metrics. It enables users to apply multiple selection strategies and metrics in a single function call, visualize variable selection processes, and export results in various formats. StepReg offers a data-splitting option to address potential issues with invalid statistical inference and a randomized forward selection option to avoid overfitting. We validated StepReg's accuracy using public datasets within the SAS software environment. For an interactive web interface, users can install the companion StepRegShiny package.

Sensitivity analysis for tests, confidence intervals and estimates in matched observational studies with one or more controls using weighted or unweighted Huber-Maritz M-tests (including the permutational t-test). The method is from Rosenbaum (2014) Weighted M-statistics with superior design sensitivity in matched observational studies with multiple controls JASA, 109(507), 1145-1158 <doi:10.1080/01621459.2013.879261>.

This statistical method uses the nearest neighbor algorithm to estimate absolute distances between single cells based on a chosen constellation of surface proteins, with these distances being a measure of the similarity between the two cells being compared. Based on Sen, N., Mukherjee, G., and Arvin, A.M. (2015) <DOI:10.1016/j.ymeth.2015.07.008>.

This package provides a framework for modeling cellular metabolic states and continuous metabolic trajectories from single-cell RNA-seq data using pathway-level scoring. Enables lineage-restricted metabolic analysis, metabolic pseudotime inference, module-level trend analysis, and visualization of metabolic state transitions.

Parameter inference methods for models defined implicitly using a random simulator. Inference is carried out using simulation-based estimates of the log-likelihood of the data. The inference methods implemented in this package are explained in Park, J. (2025) <doi:10.48550/arxiv.2311.09446>. These methods are built on a simulation metamodel which assumes that the estimates of the log-likelihood are approximately normally distributed with the mean function that is locally quadratic around its maximum. Parameter estimation and uncertainty quantification can be carried out using the ht() function (for hypothesis testing) and the ci() function (for constructing a confidence interval for one-dimensional parameters).

This package provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) <DOI:10.1111/1467-9876.00244> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM (Rotolo et al, 2017 <DOI:10.1177/0962280217718582>).