Conduct post-selection inference for regression coefficients in linear models after they have been selected by adjusted R squared. The p-values and confidence intervals are valid after model selection with the same data. This allows the user to use all data for both model selection and inference without losing control over the type I error rate. The provided tests are more powerful than data splitting, which bases inference on less data since it discards all information used for selection.

Accurate classification of breast cancer tumors based on gene expression data is not a trivial task, and it lacks standard practices.The PAM50 classifier, which uses 50 gene centroid correlation distances to classify tumors, faces challenges with balancing estrogen receptor (ER) status and gene centering. The PCAPAM50 package leverages principal component analysis and iterative PAM50 calls to create a gene expression-based ER-balanced subset for gene centering, avoiding the use of protein expression-based ER data resulting into an enhanced Breast Cancer subtyping. The PCA-PAM50 method is described in Raj-Kumar et al. (2019) <https://www.nature.com/articles/s41598-019-44339-4> and the package implementation is described in Raj-Kumar et al. (2026) <https://www.nature.com/articles/s41598-025-30752-5>.

Use phenotype risk scores based on linked clinical and genetic data to study Mendelian disease and rare genetic variants. See Bastarache et al. 2018 <doi:10.1126/science.aal4043>.

This package provides function declarations and inline function definitions that facilitate cleaning strings in C++ code before passing them to R.

Providing functions to diagnose and make inferences from various linear models, such as those obtained from aov', lm', glm', gls', lme', lmer', glmmTMB and semireg'. Inferences include predicted means and standard errors, contrasts, multiple comparisons, permutation tests, adjusted R-square and graphs.

This package provides functions for obtaining the density, random deviates and maximum likelihood estimates of the Poisson lognormal distribution and the bivariate Poisson lognormal distribution.

Data sets for statistical inference modeling related to People Analytics. Contains various data sets from the book Handbook of Regression Modeling in People Analytics by Keith McNulty (2026).

Easy function for text-mining the PubMed repository based on defined sets of terms. The relationship between fix-terms (related to your research topic) and pub-terms (terms which pivot around your research focus) is calculated using the pointwise mutual information algorithm ('PMI'). Church, Kenneth Ward and Hanks, Patrick (1990) <https://www.aclweb.org/anthology/J90-1003/> A text file is generated with the PMI'-scores for each fix-term. Then for each collocation pairs (a fix-term + a pub-term), a text file is generated with related article titles and publishing years. Additional Author section will follow in the next version updates.

Given a data matrix with rows representing data vectors and columns representing variables, produces a directed polytree for the underlying causal structure. Based on the algorithm developed in Chatterjee and Vidyasagar (2022) <arxiv:2209.07028>. The method is fully nonparametric, making no use of linearity assumptions, and especially useful when the number of variables is large.

This package provides tools for Natural Language Processing in French and texts from Marcel Proust's collection "A La Recherche Du Temps Perdu". The novels contained in this collection are "Du cote de chez Swann ", "A l'ombre des jeunes filles en fleurs","Le Cote de Guermantes", "Sodome et Gomorrhe I et II", "La Prisonniere", "Albertine disparue", and "Le Temps retrouve".

Analyse common types of plant phenotyping data, provide a simplified interface to longitudinal growth modeling and select Bayesian statistics, and streamline use of PlantCV output. Several Bayesian methods and reporting guidelines for Bayesian methods are described in Kruschke (2018) <doi:10.1177/2515245918771304>, Kruschke (2013) <doi:10.1037/a0029146>, and Kruschke (2021) <doi:10.1038/s41562-021-01177-7>.

This package provides tools for processing, analyzing, and visualizing spectral data collected from 3D laser-based scanning systems. Supports applications in agriculture, forestry, environmental monitoring, industrial quality control, and biomedical research. Enables evaluation of plant growth, productivity, resource efficiency, disease management, and pest monitoring. Includes statistical methods for extracting insights from multispectral and hyperspectral data and generating publication-ready visualizations. See Zieschank & Junker (2023) <doi:10.3389/fpls.2023.1141554> and Saric et al. (2022) <doi:10.1016/J.TPLANTS.2021.12.003> for related work.

This package provides a C++ backend for multivariate phylogenetic comparative models implemented in the R-package PCMBase'. Can be used in combination with PCMBase to enable fast and parallel likelihood calculation. Implements the pruning likelihood calculation algorithm described in Mitov et al. (2020) <doi:10.1016/j.tpb.2019.11.005>. Uses the SPLITT C++ library for parallel tree traversal described in Mitov and Stadler (2018) <doi:10.1111/2041-210X.13136>.

Drop-in replacements for standard base graphics functions. The replacements are prettier versions of the originals.

This package contains functions for data preparation, prediction of transition probabilities, estimating semi-parametric regression models and for implementing nonparametric estimators for other quantities. See Meira-Machado and Roca-Pardiñas (2011) <doi:10.18637/jss.v038.i03>.

Estimate False Discovery Rates (FDRs) for importance metrics from random forest runs.

Allows the comparison of data cohorts (DC) against a Counter Factual Model (CFM) and measures the difference in terms of an efficacy parameter. Allows the application of Personalised Synthetic Controls.

Implementation of the Pearson distribution system, including full support for the (d,p,q,r)-family of functions for probability distributions and fitting via method of moments and maximum likelihood method.

Power and sample size calculation for testing fixed effect coefficients in multilevel linear mixed effect models with one or more than one independent populations. Laird, Nan M. and Ware, James H. (1982) <doi:10.2307/2529876>.

Fits and evaluates three-state partitioned survival analyses (PartSAs) and Markov models (clock forward or clock reset) to progression and overall survival data typically collected in oncology clinical trials. These model structures are typically considered in cost-effectiveness modeling in advanced/metastatic cancer indications. Muston (2024). "Informing structural assumptions for three state oncology cost-effectiveness models through model efficiency and fit". Applied Health Economics and Health Policy.

This package provides a set of Analysis Data Model (ADaM) datasets constructed by modifying the ADaM datasets in the pharmaverseadam package to meet J&J Innovative Medicine's standard data structure for Clinical and Statistical Programming.

The constructs used to study the human psychology have many definitions and corresponding instructions for eliciting and coding qualitative data pertaining to constructs content and for measuring the constructs. This plethora of definitions and instructions necessitates unequivocal reference to specific definitions and instructions in empirical and secondary research. This package implements a human- and machine-readable standard for specifying construct definitions and instructions for measurement and qualitative research based on YAML'. This standard facilitates systematic unequivocal reference to specific construct definitions and corresponding instructions in a decentralized manner (i.e. without requiring central curation; Peters (2020) <doi:10.31234/osf.io/xebhn>).

PHATE is a tool for visualizing high dimensional single-cell data with natural progressions or trajectories. PHATE uses a novel conceptual framework for learning and visualizing the manifold inherent to biological systems in which smooth transitions mark the progressions of cells from one state to another. To see how PHATE can be applied to single-cell RNA-seq datasets from hematopoietic stem cells, human embryonic stem cells, and bone marrow samples, check out our publication in Nature Biotechnology at <doi:10.1038/s41587-019-0336-3>.

An implementation of the pediatric complex chronic conditions (CCC) classification system using R and C++.