This package provides a collection of classes and methods for working with indexed rectangular data. The index values can be calendar (timeSeries class) or numeric (signalSeries class). Methods are included for aggregation, alignment, merging, and summaries. The code was originally available in S-PLUS'.

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

Given a list of substance compositions, a list of substances involved in a process, and a list of constraints in addition to mass conservation of elementary constituents, the package contains functions to build the substance composition matrix, to analyze the uniqueness of process stoichiometry, and to calculate stoichiometric coefficients if process stoichiometry is unique. (See Reichert, P. and Schuwirth, N., A generic framework for deriving process stoichiometry in enviromental models, Environmental Modelling and Software 25, 1241-1251, 2010 for more details.).

This package provides tools for retrieving, organizing, and analyzing environmental data from the System Wide Monitoring Program of the National Estuarine Research Reserve System <https://cdmo.baruch.sc.edu/>. These tools address common challenges associated with continuous time series data for environmental decision making.

This package provides a simple interface to developing complex data pipelines which can be executed in a single call. sewage makes it easy to test, debug, and share data pipelines through it's interface and visualizations.

This package provides a spatial covariate-augmented overdispersed Poisson factor model is proposed to perform efficient latent representation learning method for high-dimensional large-scale spatial count data with additional covariates.

This package provides tools for reading, visualising and processing Magnetic Resonance Spectroscopy data. The package includes methods for spectral fitting: Wilson (2021) <DOI:10.1002/mrm.28385>, Wilson (2025) <DOI:10.1002/mrm.30462> and spectral alignment: Wilson (2018) <DOI:10.1002/mrm.27605>.

This package provides tools to decompose (transformed) spatial connectivity matrices and perform supervised or unsupervised semiparametric spatial filtering in a regression framework. The package supports unsupervised spatial filtering in standard linear as well as some generalized linear regression models.

Computes the sBIC for various singular model collections including: binomial mixtures, factor analysis models, Gaussian mixtures, latent forests, latent class analyses, and reduced rank regressions.

To meet the needs of statistical power calculation for stepped wedge cluster randomized trials, we developed this software. Different parameters can be specified by users for different scenarios, including: cross-sectional and cohort designs, binary and continuous outcomes, marginal (GEE) and conditional models (mixed effects model), three link functions (identity, log, logit links), with and without time effects (the default specification assumes no-time-effect) under exchangeable, nested exchangeable and block exchangeable correlation structures. Unequal numbers of clusters per sequence are also allowed. The methods included in this package: Zhou et al. (2020) <doi:10.1093/biostatistics/kxy031>, Li et al. (2018) <doi:10.1111/biom.12918>. Supplementary documents can be found at: <https://ysph.yale.edu/cmips/research/software/study-design-power-calculation/swdpwr/>. The Shiny app for swdpwr can be accessed at: <https://jiachenchen322.shinyapps.io/swdpwr_shinyapp/>. The package also includes functions that perform calculations for the intra-cluster correlation coefficients based on the random effects variances as input variables for continuous and binary outcomes, respectively.

Sonification (or audification) is the process of representing data by sounds in the audible range. This package provides the R function sonify() that transforms univariate data, sampled at regular or irregular intervals, into a continuous sound with time-varying frequency. The ups and downs in frequency represent the ups and downs in the data. Sonify provides a substitute for R's plot function to simplify data analysis for the visually impaired.

Simulates data sets in order to explore modeling techniques or better understand data generating processes. The user specifies a set of relationships between covariates, and generates data based on these specifications. The final data sets can represent data from randomized control trials, repeated measure (longitudinal) designs, and cluster randomized trials. Missingness can be generated using various mechanisms (MCAR, MAR, NMAR).

This package provides a tool for computing network representations of attitudes, extracted from tabular data such as sociological surveys. Development of surveygraph software and training materials was initially funded by the European Union under the ERC Proof-of-concept programme (ERC, Attitude-Maps-4-All, project number: 101069264). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

Perform a probabilistic linkage of two data files using a scaling procedure using the methods described in Goldstein, H., Harron, K. and Cortina-Borja, M. (2017) <doi:10.1002/sim.7287>.

This software is useful for loading .fasta or .gbk files, and for retrieving sequences from GenBank dataset <https://www.ncbi.nlm.nih.gov/genbank/>. This package allows to detect differences or asymmetries based on nucleotide composition by using local linear kernel smoothers. Also, it is possible to draw inference about critical points (i. e. maximum or minimum points) related with the derivative curves. Additionally, bootstrap methods have been used for estimating confidence intervals and speed computational techniques (binning techniques) have been implemented in seq2R'.

Collection (syllogi in greek) of real and fictitious data sets for teaching purposes. The datasets were manually entered by the author from the respective references as listed in the individual dataset documentation. The fictions datasets are the creation of the author, that he has found useful for teaching statistics.

Identifying outcome relevant subgroups has now become as simple as possible! The formerly lengthy and tedious search for the needle in a haystack will be replaced by a single, comprehensive and coherent presentation. The central result of a subgroup screening is a diagram in which each single dot stands for a subgroup. The diagram may show thousands of them. The position of the dot in the diagram is determined by the sample size of the subgroup and the statistical measure of the treatment effect in that subgroup. The sample size is shown on the horizontal axis while the treatment effect is displayed on the vertical axis. Furthermore, the diagram shows the line of no effect and the overall study results. For small subgroups, which are found on the left side of the plot, larger random deviations from the mean study effect are expected, while for larger subgroups only small deviations from the study mean can be expected to be chance findings. So for a study with no conspicuous subgroup effects, the dots in the figure are expected to form a kind of funnel. Any deviations from this funnel shape hint to conspicuous subgroups.

This package provides facilities to implement and run population models of stage-structured species...

Create a scatter plot matrix, using `htmlwidgets` package and `d3.js`.

The focus is on simulating and modeling families with founders drawn from a structured population (for example, with different ancestries or other potentially non-family relatedness), in contrast to traditional pedigree analysis that treats all founders as equally unrelated. Main function simulates a random pedigree for many generations, avoiding close relatives, pairing closest individuals according to a 1D geography and their randomly-drawn sex, and with variable children sizes to result in a target population size per generation. Auxiliary functions calculate kinship matrices, admixture matrices, and draw random genotypes across arbitrary pedigree structures starting from the corresponding founder values. The code is built around the plink FAM table format for pedigrees. Described in Yao and Ochoa (2022) <doi:10.1101/2022.03.25.485885>.

This package implements Surprisal analysis for gene expression data such as RNA-seq or microarray experiments. Surprisal analysis is an information-theoretic method that decomposes gene expression data into a baseline state and constraint-associated deviations, capturing coordinated gene expression patterns under different biological conditions. References: Kravchenko-Balasha N. et al. (2014) <doi:10.1371/journal.pone.0108549>. Zadran S. et al. (2014) <doi:10.1073/pnas.1414714111>. Su Y. et al. (2019) <doi:10.1371/journal.pcbi.1007034>. Bogaert K. A. et al. (2018) <doi:10.1371/journal.pone.0195142>.

Testing for Spatial Dependence of Qualitative Data in Cross Section. The list of functions includes join-count tests, Q test, spatial scan test, similarity test and spatial runs test. The methodology of these models can be found in <doi:10.1007/s10109-009-0100-1> and <doi:10.1080/13658816.2011.586327>.

Copula based Cox proportional hazards models for survival data subject to dependent censoring. This approach does not assume that the parameter defining the copula is known. The dependency parameter is estimated with other finite model parameters by maximizing a Pseudo likelihood function. The cumulative hazard function is estimated via estimating equations derived based on martingale ideas. Available copula functions include Frank, Gumbel and Normal copulas. Only Weibull and lognormal models are allowed for the censoring model, even though any parametric model that satisfies certain identifiability conditions could be used. Implemented methods are described in the article "Copula based Cox proportional hazards models for dependent censoring" by Deresa and Van Keilegom (2024) <doi:10.1080/01621459.2022.2161387>.

This package provides a user-friendly wrapper for web automation, using either chromote or selenium'. Provides a simple and consistent API to make web scraping and testing scripts easy to write and understand. Elements are lazy, and automatically wait for the website to be valid, resulting in reliable and reproducible code, with no visible impact on the experience of the programmer.