This package provides a statistical learning method to simultaneously predict a range of target phenotypes using codified and natural language processing (NLP)-derived Electronic Health Record (EHR) data. See Ahuja et al (2020) JAMIA <doi:10.1093/jamia/ocaa079> for details.

Select the most suitable shape to describe the relationship between the exposure and the outcome among increasing, decreasing, convex, and concave shapes (Yin et al. (2021) <DOI:10.1007/s13571-020-00246-7>); estimate the direct and indirect effects with prior knowledge on the relationship between the mediator and the outcome with binary exposure (Yin et al. (2024) <DOI:10.1007/s13571-024-00336-w>); estimate the direct and indirect effects using linear regression-based approach (VanderWeele (2015, ISBN:9780199325870)).

This package provides a comprehensive toolkit for extracting latent signals from panel data through multivariate time series analysis. Implements spectral decomposition methods including wavelet multiresolution analysis via maximal overlap discrete wavelet transform, Percival and Walden (2000) <doi:10.1017/CBO9780511841040>, empirical mode decomposition for non-stationary signals, Huang et al. (1998) <doi:10.1098/rspa.1998.0193>, and Bayesian trend extraction via the Grant-Chan embedded Hodrick-Prescott filter, Grant and Chan (2017) <doi:10.1016/j.jedc.2016.12.007>. Features Bayesian variable selection through regularized Horseshoe priors, Piironen and Vehtari (2017) <doi:10.1214/17-EJS1337SI>, for identifying structurally relevant predictors from high-dimensional candidate sets. Includes dynamic factor model estimation, principal component analysis with bootstrap significance testing, and automated technical interpretation of signal morphology and variance topology.

This package provides a framework for modeling cellular metabolic states and continuous metabolic trajectories from single-cell RNA-seq data using pathway-level scoring. Enables lineage-restricted metabolic analysis, metabolic pseudotime inference, module-level trend analysis, and visualization of metabolic state transitions.

Estimates a covariance matrix using Stein's isotonized covariance estimator, or a related estimator suggested by Haff.

Bayesian regression tree ensembles for survival analysis and causal inference. Implements BART, DART, Bayesian Causal Forests (BCF), and Horseshoe Forests models. Supports right-censored survival outcomes via accelerated failure time (AFT) formulations. Designed for high-dimensional prediction and heterogeneous treatment effect estimation in causal inference.

SqueezeMeta is a versatile pipeline for the automated analysis of metagenomics/metatranscriptomics data (<https://github.com/jtamames/SqueezeMeta>). This package provides functions loading SqueezeMeta results into R, filtering them based on different criteria, and visualizing the results using basic plots. The SqueezeMeta project (and any subsets of it generated by the different filtering functions) is parsed into a single object, whose different components (e.g. tables with the taxonomic or functional composition across samples, contig/gene abundance profiles) can be easily analyzed using other R packages such as vegan or DESeq2'. The methods in this package are further described in Puente-Sánchez et al., (2020) <doi:10.1186/s12859-020-03703-2>.

This package provides a variety of functions to estimate time-dependent true/false positive rates and AUC curves from a set of censored survival data.

Data simulator including genotype, phenotype, pedigree, selection and reproduction in R. It simulates most of reproduction process of animals or plants and provides data for GS (Genomic Selection), GWAS (Genome-Wide Association Study), and Breeding. For ADI model, please see Kao C and Zeng Z (2002) <doi:10.1093/genetics/160.3.1243>. For build.cov, please see B. D. Ripley (1987) <ISBN:9780470009604>.

Use of Knock Out and Round Robin Techniques in preparing tournament fixtures as discussed in the Book Health and Physical Education by Dr. V K Sharma'(2018,ISBN:978-93-5272-134-4).

This package provides you with easy, programmatic access to SRDP data.

This package provides a fast implementation of the SWAG algorithm for Generalized Linear Models which allows to perform a meta-learning procedure that combines screening and wrapper methods to find a set of extremely low-dimensional attribute combinations. The package then performs test on the network of selected models to identify the variables that are highly predictive by using entropy-based network measures.

Determining potential output and the output gap - two inherently unobservable variables - is a major challenge for macroeconomists. sectorgap features a flexible modeling and estimation framework for a multivariate Bayesian state space model identifying economic output fluctuations consistent with subsectors of the economy. The proposed model is able to capture various correlations between output and a set of aggregate as well as subsector indicators. Estimation of the latent states and parameters is achieved using a simple Gibbs sampling procedure and various plotting options facilitate the assessment of the results. For details on the methodology and an illustrative example, see Streicher (2024) <https://www.research-collection.ethz.ch/handle/20.500.11850/653682>.

Computes the probability of a set of species abundances of a single or multiple samples of individuals with one or more guilds under a mainland-island model. One must specify the mainland (metacommunity) model and the island (local) community model. It assumes that species fluctuate independently. The package also contains functions to simulate under this model. See Haegeman, B. & R.S. Etienne (2017). A general sampling formula for community structure data. Methods in Ecology & Evolution 8: 1506-1519 <doi:10.1111/2041-210X.12807>.

This package provides a supervised compression method that incorporates the response for reducing big data to a carefully selected subset. Please see Joseph and Mak (2021) <doi:10.1002/sam.11508>. This research is supported by a U.S. National Science Foundation (NSF) grant CMMI-1921646.

This package provides a suite of functions that allow a full, fast, and efficient Bayesian treatment of the Bradley--Terry model. Prior assumptions about the model parameters can be encoded through a multivariate normal prior distribution. Inference is performed using a latent variable representation of the model.

This package provides tools for reading, visualising and processing Magnetic Resonance Spectroscopy data. The package includes methods for spectral fitting: Wilson (2021) <DOI:10.1002/mrm.28385>, Wilson (2025) <DOI:10.1002/mrm.30462> and spectral alignment: Wilson (2018) <DOI:10.1002/mrm.27605>.

This package provides tools for the integration and exploration of data tables measured on the same set of observational units. The package includes methods to assess similarities among tables, extract common patterns across variable blocks, and create visual summaries that highlight shared structures in multiblock data.

The objective of these functions is to derive a species assemblage that satisfies a functional trait profile. Restoring resilient ecosystems requires a flexible framework for selecting assemblages that are based on the functional traits of species. However, current trait-based models have been limited to algorithms that can only select species by optimising specific trait values, and could not elegantly accommodate the common desire among restoration ecologists to produce functionally diverse assemblages. We have solved this problem by applying a non-linear optimisation algorithm that optimises Rao Q, a closed-form functional trait diversity index that incorporates species abundances, subject to other linear constraints. This framework generalises previous models that only optimised the entropy of the community, and can optimise both functional diversity and entropy simultaneously. This package can also be used to generate experimental assemblages to test the effects of community-level traits on community dynamics and ecosystem function. The method is based on theory discussed in Laughlin (2014, Ecology Letters) <doi:10.1111/ele.12288>.

There are several functions to implement the method for analysis in a randomized clinical trial with strata with following key features. A stratified Mann-Whitney estimator addresses the comparison between two randomized groups for a strictly ordinal response variable. The multivariate vector of such stratified Mann-Whitney estimators for multivariate response variables can be considered for one or more response variables such as in repeated measurements and these can have missing completely at random (MCAR) data. Non-parametric covariance adjustment is also considered with the minimal assumption of randomization. The p-value for hypothesis test and confidence interval are provided.

The sparse principal component regression is computed. The regularization parameters are optimized by cross-validation.

Interface to Sudachi <https://github.com/WorksApplications/Sudachi>, a Japanese morphological analyzer. This is a port of what is available in Python.

This package provides tools to compute and analyze the set of statistically-equivalent (Gaussian, linear) path models which generate the input precision or (partial) correlation matrix. This procedure is useful for understanding how statistical network models such as the Gaussian Graphical Model (GGM) perform as causal discovery tools. The statistical-equivalence set of a given GGM expresses the uncertainty we have about the sign, size and direction of directed relationships based on the weights matrix of the GGM alone. The derivation of the equivalence set and its use for understanding GGMs as causal discovery tools is described by Ryan, O., Bringmann, L.F., & Schuurman, N.K. (2022) <doi: 10.31234/osf.io/ryg69>.

By adding dependencies to the "Suggests" field of a package's DESCRIPTION file, and then declaring that they are needed within any dependent functionality, it is often possible to significantly reduce the number of "hard" dependencies required by a package. This package provides a minimal way to declare when a suggested package is needed.