Machine learning hierarchical risk clustering portfolio allocation strategies. The implemented methods are: Hierarchical risk parity (De Prado, 2016) <DOI: 10.3905/jpm.2016.42.4.059>. Hierarchical clustering-based asset allocation (Raffinot, 2017) <DOI: 10.3905/jpm.2018.44.2.089>. Hierarchical equal risk contribution portfolio (Raffinot, 2018) <DOI: 10.2139/ssrn.3237540>. A Constrained Hierarchical Risk Parity Algorithm with Cluster-based Capital Allocation (Pfitzingera and Katzke, 2019) <https://www.ekon.sun.ac.za/wpapers/2019/wp142019/wp142019.pdf>.

The proportion of cancer cells in solid tumor sample, known as the tumor purity, has adverse impact on a variety of data analyses if not properly accounted for. We develop InfiniumPurify', which is a comprehensive R package for estimating and accounting for tumor purity based on DNA methylation Infinium 450k array data. InfiniumPurify provides functionalities for tumor purity estimation. In addition, it can perform differential methylation detection and tumor sample clustering with the consideration of tumor purities.

The function SurvRegCens() of this package allows estimation of a Weibull Regression for a right-censored endpoint, one interval-censored covariate, and an arbitrary number of non-censored covariates. Additional functions allow to switch between different parametrizations of Weibull regression used by different R functions, inference for the mean difference of two arbitrarily censored Normal samples, and estimation of canonical parameters from censored samples for several distributional assumptions. Hubeaux, S. and Rufibach, K. (2014) <arXiv:1402.0432>.

Second version of RareVariantVis package aims to provide comprehensive information about rare variants for your genome data. It annotates, filters and presents genomic variants (especially rare ones) in a global, per chromosome way. For discovered rare variants CRISPR guide RNAs are designed, so the user can plan further functional studies. Large structural variants, including copy number variants are also supported. Package accepts variants directly from variant caller - for example GATK or Speedseq. Output of package are lists of variants together with adequate visualization. Visualization of variants is performed in two ways - standard that outputs png figures and interactive that uses JavaScript d3 package. Interactive visualization allows to analyze trio/family data, for example in search for causative variants in rare Mendelian diseases, in point-and-click interface. The package includes homozygous region caller and allows to analyse whole human genomes in less than 30 minutes on a desktop computer. RareVariantVis disclosed novel causes of several rare monogenic disorders, including one with non-coding causative variant - keratolythic winter erythema.

This package implements a methodology for using cell volume distributions to estimate cell growth rates and division times that is described in the paper entitled, "Cell Volume Distributions Reveal Cell Growth Rates and Division Times", by Michael Halter, John T. Elliott, Joseph B. Hubbard, Alessandro Tona and Anne L. Plant, which is in press in the Journal of Theoretical Biology. In order to reproduce the analysis used to obtain Table 1 in the paper, execute the command "example(fitVolDist)".

Implementations of most of the existing proximity-based methods of link prediction in graphs. Among the 20 implemented methods are e.g.: Adamic L. and Adar E. (2003) <doi:10.1016/S0378-8733(03)00009-1>, Leicht E., Holme P., Newman M. (2006) <doi:10.1103/PhysRevE.73.026120>, Zhou T. and Zhang Y (2009) <doi:10.1140/epjb/e2009-00335-8>, and Fouss F., Pirotte A., Renders J., and Saerens M. (2007) <doi:10.1109/TKDE.2007.46>.

This package provides functions are provided for the density function, distribution function, quantiles and random number generation for the skew hyperbolic t-distribution. There are also functions that fit the distribution to data. There are functions for the mean, variance, skewness, kurtosis and mode of a given distribution and to calculate moments of any order about any centre. To assess goodness of fit, there are functions to generate a Q-Q plot, a P-P plot and a tail plot.

Allow users to obtain clean and tidy football (soccer) game, team and player data. Data is collected from a number of popular sites, including FBref', transfer and valuations data from Transfermarkt'<https://www.transfermarkt.com/> and shooting location and other match stats data from Understat'<https://understat.com/> and fotmob'<https://www.fotmob.com/>. It gives users the ability to access data more efficiently, rather than having to export data tables to files before being able to complete their analysis.

This package provides a hierarchy of classes and methods for manipulating matrices formed implicitly from the sums of the inverses of other matrices, a situation commonly encountered in spatial statistics and related fields. Enables easy use of the Woodbury matrix identity and the matrix determinant lemma to allow computation (e.g., solving linear systems) without having to form the actual matrix. More information on the underlying linear algebra can be found in Harville, D. A. (1997) <doi:10.1007/b98818>.

The package includes DNA methylation data for the primary Chronic Lymphocytic Leukemia samples included in the Primary Blood Cancer Encyclopedia (PACE) project. Raw data from the 450k DNA methylation arrays is stored in the European Genome-Phenome Archive (EGA) under accession number EGAS0000100174. For more information concerning the project please refer to the paper "Drug-perturbation-based stratification of blood cancer" by Dietrich S, Oles M, Lu J et al., J. Clin. Invest. (2018) and R/Bioconductor package BloodCancerMultiOmics2017.

Estimation of reliability coefficients for ability estimates and sum scores from item response theory models as defined in Cheng, Y., Yuan, K.-H. and Liu, C. (2012) <doi:10.1177/0013164411407315> and Kim, S. and Feldt, L. S. (2010) <doi:10.1007/s12564-009-9062-8>. The package supports the 3-PL and generalized partial credit models and includes estimates of the standard errors of the reliability coefficient estimators, derived in Andersson, B. and Xin, T. (2018) <doi:10.1177/0013164417713570>.

This package provides a system for submitting multiple IP information queries to IP2Location.io'â s IP Geolocation API and storing the resulting data in a dataframe. You provide a vector of IP addresses and your IP2Location.io API key. The package returns a dataframe with one row per IP address and a column for each available data field (data fields not included in your API plan will contain NAs). This is the second submission of the package to CRAN.

Displays percentage changes by height and absolute changes by area for up to three nested or non-nested levels. The plots visualise changes in indices and markets, showing how the changes for sectors or for individual components contribute to the overall change. Data can be classified by up to three levels of grouping variables in a layered, hierarchical plot. Each level can be ordered in several ways including by baseline, by percentage change, and by absolute change. The vignettes give examples.

The float package provides commands to define new floats of various styles (plain, boxed, ruled, and userdefined ones); the rotating package provides new environments (sidewaysfigure and sidewaystable) which are rotated by 90 or 270 degrees. But what about new rotated floats, e.g., a rotated ruled one? This package makes this possible; it builds a bridge between the two packages and extends the commands from the float package to define rotated versions of the new floats, too.

Add a searchbar widget to your Shiny application. The widget quickly integrates with any existing element containing text to highlight matches. Highlighting is done with the JavaScript library mark.js'. The widget includes buttons to cycle through multiple instances of the match and automatically scroll to the matches in an overflow element (or window). The widget also displays the total number of matches and which match is currently being cycled through. The widget is structured as a Bootstrap 3 input group.

This package provides functions for estimating natural direct and indirect effects for mediation analysis. It uses weighting where the weights are functions of estimates of the probability of exposure or treatment assignment (Hong, G (2010). <https://cepa.stanford.edu/sites/default/files/workshops/GH_JSM%20Proceedings%202010.pdf> Huber, M. (2014). <doi:10.1002/jae.2341>). Estimation of probabilities can use generalized boosting or logistic regression. Additional functions provide diagnostics of the model fit and weights. The vignette provides details and examples.

Elasticsearch is an open-source, distributed, document-based datastore (<https://www.elastic.co/products/elasticsearch>). It provides an HTTP API for querying the database and extracting datasets, but that API was not designed for common data science workflows like pulling large batches of records and normalizing those documents into a data frame that can be used as a training dataset for statistical models. uptasticsearch provides an interface for Elasticsearch that is explicitly designed to make these data science workflows easy and fun.

This package provides a collection of pancreatic Cancer transcriptomic datasets that are part of the MetaGxData package compendium. This package contains multiple pancreas cancer datasets that have been downloaded from various resources and turned into SummarizedExperiment objects. The details of how the authors normalized the data can be found in the experiment data section of the objects. Additionally, the location the data was obtained from can be found in the url variables of the experiment data portion of each SE.

The MouseAgingData package provides analysis-ready data resources from different studies focused on aging and rejuvenation in mice. The package currently provides two 10x Genomics single-cell RNA-seq datasets. The first study profiled the aging mouse brain measured across 37,089 cells (Ximerakis et al., 2019). The second study investigated parabiosis by profiling a total of 105,329 cells (Ximerakis & Holton et al., 2023). The datasets are provided as SingleCellExperiment objects and provide raw UMI counts and cell metadata.

This package implements two functions:

• pairwise.adonis is a wrapper function for multilevel pairwise comparison using adonis2 from package vegan. The function returns adjusted p-values using p.adjust(). It does not accept interaction between factors neither strata.

• pairwise.adonis2 accepts a model formula like in adonis from vegan. You can use interactions between factors and define strata to constrain permutations. For pairwise comparison a list of unique pairwise combination of factors is produced.

This package provides tools to study sorting patterns in matching markets and to estimate the affinity matrix of both the bipartite one-to-one matching model without frictions and with Transferable Utility by Dupuy and Galichon (2014) <doi:10.1086/677191> and its unipartite variant by Ciscato', Galichon and Gousse (2020) <doi:10.1086/704611>. It also contains all the necessary tools to implement the saliency analysis, to run rank tests of the affinity matrix and to build tables and plots summarizing the findings.

Various statistical methods for survival analysis in comparing survival curves between two groups, including overall hypothesis tests described in Li et al. (2015) <doi:10.1371/journal.pone.0116774> and Huang et al. (2020) <doi:10.1080/03610918.2020.1753075>, fixed-point tests in Klein et al. (2007) <doi:10.1002/sim.2864>, short-term tests, and long-term tests in Logan et al. (2008) <doi:10.1111/j.1541-0420.2007.00975.x>. Some commonly used descriptive statistics and plots are also included.

Combines information from two independent surveys using a model-assisted projection method. Designed for survey sampling scenarios where a large sample collects only auxiliary information (Survey 1) and a smaller sample provides data on both variables of interest and auxiliary variables (Survey 2). Implements a working model to generate synthetic values of the variable of interest by fitting the model to Survey 2 data and predicting values for Survey 1 based on its auxiliary variables (Kim & Rao, 2012) <doi:10.1093/biomet/asr063>.

Implementations of classical and machine learning models for survival analysis, including deep neural networks via keras and tensorflow'. Each model includes a separated fit and predict interface with consistent prediction types for predicting risk or survival probabilities. Models are either implemented from Python via reticulate <https://CRAN.R-project.org/package=reticulate>, from code in GitHub packages, or novel implementations using Rcpp <https://CRAN.R-project.org/package=Rcpp>. Neural networks are implemented from the Python package pycox <https://github.com/havakv/pycox>.