Precise knowledge on the binding sites of an RNA-binding protein (RBP) is key to understand (post-) transcriptional regulatory processes. Here we present a workflow that describes how exact binding sites can be defined from iCLIP data. The package provides functions for binding site definition and result visualization. For details please see the vignette.

Consider autoregressive model of order p where the distribution function of innovation is unknown, but innovations are independent and symmetrically distributed. The package contains a function named ARMDE which takes X (vector of n observations) and p (order of the model) as input argument and returns minimum distance estimator of the parameters in the model.

Speeds up exploratory data analysis (EDA) by providing a succinct workflow and interactive visualization tools for understanding which features have relationships to target (response). Uses binary correlation analysis to determine relationship. Default correlation method is the Pearson method. Lian Duan, W Nick Street, Yanchi Liu, Songhua Xu, and Brook Wu (2014) <doi:10.1145/2637484>.

This package reads remote parquet files that have processed Bioconductor build report logs. Users may query the tables directly for specific information or use pre-defined helper functions for common queries. The logs processed are from https://bioconductor.org/checkResults/. In the future we will extend this package out to include processing of r-universe logs.

Estimate bivariate common mean vector under copula models with known correlation. In the current version, available copulas are the Clayton, Gumbel, Frank, Farlie-Gumbel-Morgenstern (FGM), and normal copulas. See Shih et al. (2019) <doi:10.1080/02331888.2019.1581782> and Shih et al. (2021) <under review> for details under the FGM and general copulas, respectively.

This package contains the prepared data that is needed for the shiny application examples in the canvasXpress package. This package also includes datasets used for automated testthat tests. Scotto L, Narayan G, Nandula SV, Arias-Pulido H et al. (2008) <doi:10.1002/gcc.20577>. Davis S, Meltzer PS (2007) <doi:10.1093/bioinformatics/btm254>.

This package provides SPSS- and SAS-like output for least squares multiple regression, logistic regression, and count variable regressions. Detailed output is also provided for OLS moderated regression, interaction plots, and Johnson-Neyman regions of significance. The output includes standardized coefficients, partial and semi-partial correlations, collinearity diagnostics, plots of residuals, and detailed information about simple slopes for interactions. The output for some functions includes Bayes Factors and, if requested, regression coefficients from Bayesian Markov Chain Monte Carlo analyses. There are numerous options for model plots. The REGIONS_OF_SIGNIFICANCE function also provides Johnson-Neyman regions of significance and plots of interactions for both lm and lme models. There is also a function for partial and semipartial correlations and a function for conducting Cohen's set correlation analyses.

This package provides a Shiny app including the Monaco editor. The Monaco editor is the code editor which powers VS Code'. It is particularly well developed for JavaScript'. In addition to the Monaco editor features, the app provides prettifiers and minifiers for multiple languages, SCSS and TypeScript compilers, code checking for C and C++ (requires cppcheck').

This package provides functions for graph-based multiple-sample testing and visualization of microbiome data, in particular data stored in phyloseq objects. The tests are based on those described in Friedman and Rafsky (1979) <http://www.jstor.org/stable/2958919>, and the tests are described in more detail in Callahan et al. (2016) <doi:10.12688/f1000research.8986.1>.

This package implements the algorithm introduced in Tian, Y., and Safikhani, A. (2024) <doi:10.5705/ss.202024.0182>, "Sequential Change Point Detection in High-dimensional Vector Auto-regressive Models". This package provides tools for detecting change points in the transition matrices of VAR models, effectively identifying shifts in temporal and cross-correlations within high-dimensional time series data.

MicrobiotaProcess is an R package for analysis, visualization and biomarker discovery of microbial datasets. It introduces MPSE class, this make it more interoperable with the existing computing ecosystem. Moreover, it introduces a tidy microbiome data structure paradigm and analysis grammar. It provides a wide variety of microbiome data analysis procedures under the unified and common framework (tidy-like framework).

This package provides tools for designing and analyzing Acceptance Sampling plans. Supports both Attributes Sampling (Binomial and Poisson distributions) and Variables Sampling (Normal and Beta distributions), enabling quality control for fractional and compositional data. Uses nonlinear programming for sampling plan optimization, minimizing sample size while controlling producer's and consumer's risks. Operating Characteristic curves are available for plan visualization.

This package implements the cross-validation methodology from Pein and Shah (2021) <arXiv:2112.03220>. Can be customised by providing different cross-validation criteria, estimators for the change-point locations and local parameters, and freely chosen folds. Pre-implemented estimators and criteria are available. It also includes our own implementation of the COPPS procedure <doi:10.1214/19-AOS1814>.

This package implements a novel approach for measuring feature importance in k-means clustering. Importance of a feature is measured by the misclassification rate relative to the baseline cluster assignment due to a random permutation of feature values. An explanation of permutation feature importance in general can be found here: <https://christophm.github.io/interpretable-ml-book/feature-importance.html>.

Implementation of the algorithm introduced in Shah, R. D. (2016) <https://www.jmlr.org/papers/volume17/13-515/13-515.pdf>. Data with thousands of predictors can be handled. The algorithm performs sequential Lasso fits on design matrices containing increasing sets of candidate interactions. Previous fits are used to greatly speed up subsequent fits, so the algorithm is very efficient.

This package provides a bootstrap test which decides whether two dose response curves can be assumed as equal concerning their maximum absolute deviation. A plenty of choices for the model types are available, which can be found in the DoseFinding package, which is used for the fitting of the models. See <doi:10.1080/01621459.2017.1281813> for details.

Beta version of Bayesian Inference (BI) using python and BI. It aims to unify the modeling experience by providing an intuitive model-building syntax together with the flexibility of low-level abstraction coding. It also includes pre-built functions for high-level abstraction and supports hardware-accelerated computation for improved scalability, including parallelization, vectorization, and execution on CPU, GPU, or TPU.

High dimensional discriminant analysis with compositional data is performed. The compositional data are first transformed using the alpha-transformation of Tsagris M., Preston S. and Wood A.T.A. (2011) <doi:10.48550/arXiv.1106.1451>, and then the High Dimensional Discriminant Analysis (HDDA) algorithm of Bouveyron C. Girard S. and Schmid C. (2007) <doi:10.1080/03610920701271095> is applied.

An R DataBase Interface ('DBI') compatible interface to various database platforms ('PostgreSQL', Oracle', Microsoft SQL Server', Amazon Redshift', Microsoft Parallel Database Warehouse', IBM Netezza', Apache Impala', Google BigQuery', Snowflake', Spark', SQLite', and InterSystems IRIS'). Also includes support for fetching data as Andromeda objects. Uses either Java Database Connectivity ('JDBC') or other DBI drivers to connect to databases.

This package provides a curated dataset of Microarrays samples. The samples are MDI- induced pre-adipocytes (3T3-L1) at different time points/stage of differentiation under different types of genetic (knockdown/overexpression) and pharmacological (drug treatment) perturbations. The package documents the data collection and processing. In addition to the documentation, the package contains the scripts that was used to generated the data.

The EnrichmentBrowser package implements essential functionality for the enrichment analysis of gene expression data. The analysis combines the advantages of set-based and network-based enrichment analysis in order to derive high-confidence gene sets and biological pathways that are differentially regulated in the expression data under investigation. Besides, the package facilitates the visualization and exploration of such sets and pathways.

This package provides methods for neutrosophic analysis of variance (NANOVA) and neutrosophic analysis of covariance (NANCOVA) for interval-valued data arising from incomplete block design experiments. The package supports balanced incomplete block designs (BIBDs), partially balanced incomplete block designs (PBIBDs), and lattice designs. Functions are included for treatment comparisons, least significant difference (LSD) tests, and interval-based statistical inference under neutrosophic environments.

Evaluate the presence of disposition effect and others irrational investor's behaviors based solely on investor's transactions and financial market data. Experimental data can also be used to perform the analysis. Four different methodologies are implemented to account for the different nature of human behaviors on financial markets. Novel analyses such as portfolio driven and time series disposition effect are also allowed.

Evolutionary game theory applies game theory to evolving populations in biology, see e.g. one of the books by Weibull (1994, ISBN:978-0262731218) or by Sandholm (2010, ISBN:978-0262195874) for more details. A comprehensive set of tools to illustrate the core concepts of evolutionary game theory, such as evolutionary stability or various evolutionary dynamics, for teaching and academic research is provided.