Reports markers list, differentially expressed genes, associated pathways, cell-type annotations, does batch correction and other related single cell analyses all wrapped within Seurat'.

Sample surveys use scientific methods to draw inferences about population parameters by observing a representative part of the population, called sample. The SRSWOR (Simple Random Sampling Without Replacement) is one of the most widely used probability sampling designs, wherein every unit has an equal chance of being selected and units are not repeated.This function draws multiple SRSWOR samples from a finite population and estimates the population parameter i.e. total of HT, Ratio, and Regression estimators. Repeated simulations (e.g., 500 times) are used to assess and compare estimators using metrics such as percent relative bias (%RB), percent relative root means square error (%RRMSE).For details on sampling methodology, see, Cochran (1977) "Sampling Techniques" <https://archive.org/details/samplingtechniqu0000coch_t4x6>.

This package contains space filling based tools for machine learning and data mining. Some functions offer several computational techniques and deal with the out of memory for large big data by using the ff package.

The goal of SIHR is to provide inference procedures in the high-dimensional generalized linear regression setting for: (1) linear functionals <doi:10.48550/arXiv.1904.12891> <doi:10.48550/arXiv.2012.07133>, (2) conditional average treatment effects, (3) quadratic functionals <doi:10.48550/arXiv.1909.01503>, (4) inner product, (5) distance.

This package implements the discrete nonlinear filter (DNF) of Kitagawa (1987) <doi:10.1080/01621459.1987.10478534> to a wide class of stochastic volatility (SV) models with return and volatility jumps following the work of Bégin and Boudreault (2021) <doi:10.1080/10618600.2020.1840995> to obtain likelihood evaluations and maximum likelihood parameter estimates. Offers several built-in SV models and a flexible framework for users to create customized models by specifying drift and diffusion functions along with an arrival distribution for the return and volatility jumps. Allows for the estimation of factor models with stochastic volatility (e.g., heteroskedastic volatility CAPM) by incorporating expected return predictors. Also includes functions to compute filtering and prediction distribution estimates, to simulate data from built-in and custom SV models with jumps, and to forecast future returns and volatility values using Monte Carlo simulation from a given SV model.

Uses simulation to create prediction intervals for post-policy outcomes in interrupted time series (ITS) designs, following Miratrix (2020) <arXiv:2002.05746>. This package provides methods for fitting ITS models with lagged outcomes and variables to account for temporal dependencies. It then conducts inference via simulation, simulating a set of plausible counterfactual post-policy series to compare to the observed post-policy series. This package also provides methods to visualize such data, and also to incorporate seasonality models and smoothing and aggregation/summarization. This work partially funded by Arnold Ventures in collaboration with MDRC.

Data from statistical agencies and other institutions are mostly confidential. This package, introduced in Templ, Kowarik and Meindl (2017) <doi:10.18637/jss.v067.i04>, can be used for the generation of anonymized (micro)data, i.e. for the creation of public- and scientific-use files. The theoretical basis for the methods implemented can be found in Templ (2017) <doi:10.1007/978-3-319-50272-4>. Various risk estimation and anonymization methods are included. Note that the package includes a graphical user interface published in Meindl and Templ (2019) <doi:10.3390/a12090191> that allows to use various methods of this package.

This package provides the spatial sign correlation and the two-stage spatial sign correlation as well as a one-sample test for the correlation coefficient.

An implementation of split-population duration regression models. Unlike regular duration models, split-population duration models are mixture models that accommodate the presence of a sub-population that is not at risk for failure, e.g. cancer patients who have been cured by treatment. This package implements Weibull and Loglogistic forms for the duration component, and focuses on data with time-varying covariates. These models were originally formulated in Boag (1949) and Berkson and Gage (1952), and extended in Schmidt and Witte (1989).

This package provides most of the data files used in the textbook "Scientific Research and Methodology" by Dunn (2025, ISBN: 9781032496726).

Visualization and analysis of spatially resolved transcriptomics data. The spatialGE R package provides methods for visualizing and analyzing spatially resolved transcriptomics data, such as 10X Visium, CosMx, or csv/tsv gene expression matrices. It includes tools for spatial interpolation, autocorrelation analysis, tissue domain detection, gene set enrichment, and differential expression analysis using spatial mixed models.

This package provides a subgroup identification method for precision medicine based on quantitative objectives. This method can handle continuous, binary and survival endpoint for both prognostic and predictive case. For the predictive case, the method aims at identifying a subgroup for which treatment is better than control by at least a pre-specified or auto-selected constant. For the prognostic case, the method aims at identifying a subgroup that is at least better than a pre-specified/auto-selected constant. The derived signature is a linear combination of predictors, and the selected subgroup are subjects with the signature > 0. The false discover rate when no true subgroup exists is controlled at a user-specified level.

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

An efficient tool for fitting nested mixture models based on a shared set of atoms via Markov Chain Monte Carlo and variational inference algorithms. Specifically, the package implements the common atoms model (Denti et al., 2023), its finite version (similar to D'Angelo et al., 2023), and a hybrid finite-infinite model (D'Angelo and Denti, 2024). All models implement univariate nested mixtures with Gaussian kernels equipped with a normal-inverse gamma prior distribution on the parameters. Additional functions are provided to help analyze the results of the fitting procedure. References: Denti, Camerlenghi, Guindani, Mira (2023) <doi:10.1080/01621459.2021.1933499>, Dâ Angelo, Canale, Yu, Guindani (2023) <doi:10.1111/biom.13626>, Dâ Angelo, Denti (2024) <doi:10.1214/24-BA1458>.

This package provides functions for constructing mathematical models of dynamical systems from measured input-output data.

This package provides inference based on the survey package for the wide range of parametric models in the VGAM package.

Perform sensitivity analysis in structural equation modeling using meta-heuristic optimization methods (e.g., ant colony optimization and others). The references for the proposed methods are: (1) Leite, W., & Shen, Z., Marcoulides, K., Fish, C., & Harring, J. (2022). <doi:10.1080/10705511.2021.1881786> (2) Harring, J. R., McNeish, D. M., & Hancock, G. R. (2017) <doi:10.1080/10705511.2018.1506925>; (3) Fisk, C., Harring, J., Shen, Z., Leite, W., Suen, K., & Marcoulides, K. (2022). <doi:10.1177/00131644211073121>; (4) Socha, K., & Dorigo, M. (2008) <doi:10.1016/j.ejor.2006.06.046>. We also thank Dr. Krzysztof Socha for sharing his research on ant colony optimization algorithm with continuous domains and associated R code, which provided the base for the development of this package.

This package provides SAS'-style IF/ELSE chains, independent IF rules, and DELETE logic for data.table', enabling clinical programmers to express Study Data Tabulation Model (SDTM) and Analysis Data Model (ADaM)-style derivations in familiar SAS-like syntax. Methods are informed by clinical data standards described in CDISC SDTM and ADaM implementation guides. See <https://www.cdisc.org/standards/foundational/sdtm> and <https://www.cdisc.org/standards/foundational/adam>.

Validate data.frames against schemas to ensure that data matches expectations. Define schemas using tidyselect and predicate functions for type consistency, nullability, and more. Schema failure messages can be tailored for non-technical users and are ideal for user-facing applications such as in shiny or plumber'.

It can be useful to temporarily hide some text or other HTML elements in Shiny applications. Building on Spoiler-Alert.js', it is possible to select the elements to hide at startup, to partially reveal them by hovering them, and to completely show them when clicking on them.

This package provides tools for designing spatially explicit capture-recapture studies of animal populations. This is primarily a simulation manager for package secr'. Extensions in version 2.5.0 include costing and evaluation of detector spacing.

Various functions for creating spherical coordinate system plots via extensions to rgl.

This is a graph database in SQLite'. It is inspired by Denis Papathanasiou's Python simple-graph project on GitHub'.

Sonification (or audification) is the process of representing data by sounds in the audible range. This package provides the R function sonify() that transforms univariate data, sampled at regular or irregular intervals, into a continuous sound with time-varying frequency. The ups and downs in frequency represent the ups and downs in the data. Sonify provides a substitute for R's plot function to simplify data analysis for the visually impaired.