Currently fully supports Enrichr, JASPAR, miEAA, PANTHER, Reactome, STRING, and UniProt! The goal of rbioapi is to provide a user-friendly and consistent interface to biological databases and services. In a way that insulates the user from the technicalities of using web services API and creates a unified and easy-to-use interface to biological and medical web services. This is an ongoing project; New databases and services will be added periodically. Feel free to suggest any databases or services you often use.

This package implements various Riemannian metrics for symmetric positive definite matrices, including AIRM (Affine Invariant Riemannian Metric, <doi:10.1007/s11263-005-3222-z>), Log-Euclidean (<doi:10.1002/mrm.20965>), Euclidean, Log-Cholesky (<doi:10.1137/18M1221084>), and Bures-Wasserstein metrics (<doi:10.1016/j.exmath.2018.01.002>). Provides functions for computing logarithmic and exponential maps, vectorization, and statistical operations on the manifold of positive definite matrices.

Implementations of several robust nonparametric two-sample tests for location or scale differences. The test statistics are based on robust location and scale estimators, e.g. the sample median or the Hodges-Lehmann estimators as described in Fried & Dehling (2011) <doi:10.1007/s10260-011-0164-1>. The p-values can be computed via the permutation principle, the randomization principle, or by using the asymptotic distributions of the test statistics under the null hypothesis, which ensures (approximate) distribution independence of the test decision. To test for a difference in scale, we apply the tests for location difference to transformed observations; see Fried (2012) <doi:10.1016/j.csda.2011.02.012>. Random noise on a small range can be added to the original observations in order to hold the significance level on data from discrete distributions. The location tests assume homoscedasticity and the scale tests require the location parameters to be zero.

Tests linear regressions for significance reversal through leave-one(multiple)-out.

This package implements the hierarchical Bayesian analysis of populations structure (hierBAPS) algorithm of Cheng et al. (2013) <doi:10.1093/molbev/mst028> for clustering DNA sequences from multiple sequence alignments in FASTA format. The implementation includes improved defaults and plotting capabilities and unlike the original MATLAB version removes singleton SNPs by default.

Retrieve, map and summarize data from the VertNet.org archives (<https://vertnet.org/>). Functions allow searching by many parameters, including taxonomic names, places, and dates. In addition, there is an interface for conducting spatially delimited searches, and another for requesting large datasets via email.

Bayesian geostatistical modeling of Gaussian processes using a reparameterized and marginalized posterior sampling (RAMPS) algorithm designed to lower autocorrelation in MCMC samples. Package performance is tuned for large spatial datasets.

An implementation of the RaCE-NMA (Rank-Clustered Estimation for Network Meta-Analysis) model for post-hoc clustering of treatments or interventions by rank in network meta-analysis data. Functions for model estimation, assessment, and displaying results are provided. For more details, see Pearce and Zhou (2025) <doi:10.1017/rsm.2025.10049>.

Manually bin data using weight of evidence and information value. Includes other binning methods such as equal length, quantile and winsorized. Options for combining levels of categorical data are also available. Dummy variables can be generated based on the bins created using any of the available binning methods. References: Siddiqi, N. (2006) <doi:10.1002/9781119201731.biblio>.

This package provides functions for fitting a linear regression model with ARIMA errors using a filtered tau-estimate. The methodology is described in Maronna et al (2017, ISBN:9781119214687).

An R implementation of ChASM (Chromosomal Aneuploidy Screening Methodology): a statistically rigorous Bayesian approach for screening data sets for autosomal and sex chromosomal aneuploidies. This package takes as input the number of (deduplicated) reads mapping to chromosomes 1-22 and the X and Y chromosomes, and models these using a Dirichlet-multinomial distribution. From this, This package returns posterior probabilities of sex chromosomal karyotypes (XX, XY, XXY, XYY, XXX and X) and full autosomal aneuploidies (trisomy 13, trisomy 18 and trisomy 21). This package also returns two diagnostic statistics: (i) a posterior probability addressing whether contamination between XX and XY may explain the observed sex chromosomal aneuploidy, and (ii) a chi-squared statistic measuring whether the observed read counts are too divergent from the underlying distribution (and may represent abnormal sequencing/quality issues).

Rcpp reimplementation of the the Bayesian non-parametric Dirichlet Process Regression model for penalized regression first published in Zeng and Zhou (2017) <doi:10.1038/s41467-017-00470-2>. A full Bayesian version is implemented with Gibbs sampling, as well as a faster but less accurate variational Bayes approximation.

Streamlined statistical reporting in Rmarkdown environments. Facilitates the automated reporting of descriptive statistics, multiple univariate models, multivariable models and tables combining these outputs. Plotting functions include customisable survival curves, forest plots from logistic and ordinal regression and bivariate comparison plots.

Earth Engine <https://earthengine.google.com/> client library for R. All of the Earth Engine API classes, modules, and functions are made available. Additional functions implemented include importing (exporting) of Earth Engine spatial objects, extraction of time series, interactive map display, assets management interface, and metadata display. See <https://r-spatial.github.io/rgee/> for further details.

Loads Blackrock <https://blackrockneurotech.com> neural signal data files into the memory, provides utility tools to extract the data into common formats such as plain-text tsv and HDF5'.

Interface to the flsgen neutral landscape generator <https://github.com/dimitri-justeau/flsgen>. It allows to - Generate fractal terrain; - Generate landscape structures satisfying user targets over landscape indices; - Generate landscape raster from landscape structures.

Queries data from WHOIS servers.

This package provides algorithms to locate multiple distributional change-points in piecewise stationary time series. The algorithms are provably consistent, even in the presence of long-range dependencies. Knowledge of the number of change-points is not required. The code is written in Go and interfaced with R.

This package provides a programmatic interface to the Web Service methods provided by the Global Biodiversity Information Facility (GBIF; <https://www.gbif.org/developer/summary>). GBIF is a database of species occurrence records from sources all over the globe. rgbif includes functions for searching for taxonomic names, retrieving information on data providers, getting species occurrence records, getting counts of occurrence records, and using the GBIF tile map service to make rasters summarizing huge amounts of data.

Recursive lists in the form of R objects, JSON', and XML', for use in teaching and examples. Examples include color palettes, Game of Thrones characters, GitHub users and repositories, music collections, and entities from the Star Wars universe. Data from the gapminder package is also included, as a simple data frame and in nested and split forms.

This package provides methods for ranking responses of a single response question or a multiple response question are described in the two papers: 1. Wang, H. (2008). Ranking Responses in Multiple-Choice Questions. Journal of Applied Statistics, 35, 465-474. <DOI:10.1080/02664760801924533> 2. Wang, H. and Huang, W. H. (2014). Bayesian Ranking Responses in Multiple Response Questions. Journal of the Royal Statistical Society: Series A (Statistics in Society), 177, 191-208. <DOI:10.1111/rssa.12009>.

Efficiently parses, filters, and writes binary ITCH files (Version 5.0) containing detailed financial transactions as distributed by NASDAQ to a data.table. Includes functions to interact with NASDAQ data services at <https://emi.nasdaq.com/ITCH/> and <https://emi.nasdaq.com/ITCH/Stock_Locate_Codes/>.

The implemented R6 class SCM aims to simplify working with structural causal models. The missing data mechanism can be defined as a part of the structural model. The class contains methods for 1) defining a structural causal model via functions, text or conditional probability tables, 2) printing basic information on the model, 3) plotting the graph for the model using packages igraph or qgraph', 4) simulating data from the model, 5) applying an intervention, 6) checking the identifiability of a query using the R packages causaleffect and dosearch', 7) defining the missing data mechanism, 8) simulating incomplete data from the model according to the specified missing data mechanism and 9) checking the identifiability in a missing data problem using the R package dosearch'. In addition, there are functions for running experiments and doing counterfactual inference using simulation.

We implement full-ranked, rank-penalized, and adaptive nuclear norm penalized estimation methods using multivariate mixture models proposed by Kang, Chen, and Yao (2022+).