This package provides a test for the existence of a subgroup with enhanced treatment effect. And, a sample size calculation procedure for the subgroup detection test.

Simulation methods to study the effect of management policies on efforts to restore populations back to their original genetic composition. Allows for single-scenario simulation and for optimization of specific chosen scenarios. Further information can be found in Hernandez, Janzen and Lavretsky (2023) <doi:10.1111/1755-0998.13892>.

This package provides a novel semi-supervised machine learning algorithm to predict phenotype event times using Electronic Health Record (EHR) data.

An efficient sensitivity analysis for stochastic models based on Monte Carlo samples. Provides weights on simulated scenarios from a stochastic model, such that stressed random variables fulfil given probabilistic constraints (e.g. specified values for risk measures), under the new scenario weights. Scenario weights are selected by constrained minimisation of the relative entropy to the baseline model. The SWIM package is based on Pesenti S.M., Millossovich P., Tsanakas A. (2019) "Reverse Sensitivity Testing: What does it take to break the model" <openaccess.city.ac.uk/id/eprint/18896/> and Pesenti S.M. (2021) "Reverse Sensitivity Analysis for Risk Modelling" <https://www.ssrn.com/abstract=3878879>.

Uses parametric and nonparametric methods to quantify the proportion of the estimated selection bias (SB) explained by each observed confounder when estimating propensity score weighted treatment effects. Parast, L and Griffin, BA (2020). "Quantifying the Bias due to Observed Individual Confounders in Causal Treatment Effect Estimates". Statistics in Medicine, 39(18): 2447- 2476 <doi: 10.1002/sim.8549>.

This package provides a framework to generating random variates from arbitrary multivariate copulae, while concentrating on (bivariate) extreme value copulae. Particularly useful if the multivariate copulae are not available in closed form. Detailed discussion of the methodologies used can be found in Tajvidi and Turlach (2018) <doi:10.1111/anzs.12209>.

This package provides three types of datetime pickers for usage in a Shiny UI. A datetime picker is an input field for selecting both a date and a time.

Easily use Blueprint', the popular React library from Palantir, in your Shiny app. Blueprint provides a rich set of UI components for creating visually appealing applications and is optimized for building complex, data-dense web interfaces. This package provides most components from the underlying library, as well as special wrappers for some components to make it easy to use them in R without writing JavaScript code.

Enables small area estimation (SAE) of health and demographic indicators in low- and middle-income countries (LMICs). It powers an R shiny application for generating subnational estimates and prevalence maps of 150+ binary indicators from Demographic and Health Surveys (DHS). It builds on the SAE analysis workflow from the surveyPrev package. For documentation, visit <https://sae4health.stat.uw.edu/>. Methodological details can be found at Wu et al. (2025) <doi:10.48550/arXiv.2505.01467>.

Interact with the Smartsheet platform through the Smartsheet API 2.0. <https://smartsheet.redoc.ly/>. API is an acronym for application programming interface; the Smartsheet API allows users to interact with Smartsheet sheets directly within R.

Enables the ability to change or flash the title of the browser window during a shiny session.

This package creates static / animated / interactive visualisations embeddable in R Markdown documents. It implements an R-to-JavaScript transpiler and enables users to write JavaScript applications using the syntax of R.

In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package Surrogate allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's Seventh Framework Programme for research, technological development and demonstration (Grant Agreement no 602552), the Special Research Fund (BOF) of Hasselt University (BOF-number: BOF2OCPO3), GlaxoSmithKline Biologicals, Baekeland Mandaat (HBC.2022.0145), and Johnson & Johnson Innovative Medicine.

Stress Response score (SRscore) is a stress responsiveness measure for transcriptome datasets and is based on the vote-counting method. The SRscore is determined to evaluate and score genes on the basis of the consistency of the direction of their regulation (Up-regulation, Down-regulation, or No change) under stress conditions across multiple analyzed research projects. This package is based on the HN-score (score based on the ratio of gene expression between hypoxic and normoxic conditions) proposed by Tamura and Bono (2022) <doi:10.3390/life12071079>, and can calculate both the original method and an extended calculation method described in Fukuda et al. (2025) <doi:10.1093/plphys/kiaf105>.

Spatial Stochastic Frontier Analysis (SSFA) is an original method for controlling the spatial heterogeneity in Stochastic Frontier Analysis (SFA) models, for cross-sectional data, by splitting the inefficiency term into three terms: the first one related to spatial peculiarities of the territory in which each single unit operates, the second one related to the specific production features and the third one representing the error term.

This package provides several methods to integrate functions over the unit sphere and ball in n-dimensional Euclidean space. Routines for converting to/from multivariate polar/spherical coordinates are also provided.

This package provides a dynamic programming solution to segmentation based on maximization of arbitrary similarity measures within segments. The general idea, theory and this implementation are described in Machne, Murray & Stadler (2017) <doi:10.1038/s41598-017-12401-8>. In addition to the core algorithm, the package provides time-series processing and clustering functions as described in the publication. These are generally applicable where a `k-means` clustering yields meaningful results, and have been specifically developed for clustering of the Discrete Fourier Transform of periodic gene expression data (`circadian or `yeast metabolic oscillations'). This clustering approach is outlined in the supplemental material of Machne & Murray (2012) <doi:10.1371/journal.pone.0037906>), and here is used as a basis of segment similarity measures. Notably, the time-series processing and clustering functions can also be used as stand-alone tools, independent of segmentation, e.g., for transcriptome data already mapped to genes.

It can be useful to temporarily hide some text or other HTML elements in Shiny applications. Building on Spoiler-Alert.js', it is possible to select the elements to hide at startup, to partially reveal them by hovering them, and to completely show them when clicking on them.

Preview spatial data as leaflet maps with minimal effort. smartmap is optimized for interactive use and distinguishes itself from similar packages because it does not need real spatial ('sp or sf') objects an input; instead, it tries to automatically coerce everything that looks like spatial data to sf objects or leaflet maps. It - for example - supports direct mapping of: a vector containing a single coordinate pair, a two column matrix, a data.frame with longitude and latitude columns, or the path or URL to a (possibly compressed) shapefile'.

Software that leverages the capabilities of Circos by manipulating data, preparing configuration files, and running the Perl-native Circos directly from the R environment with minimal user intervention. Circos is a novel software that addresses the challenges in visualizing genetic data by creating circular ideograms composed of tracks of heatmaps, scatter plots, line plots, histograms, links between common markers, glyphs, text, and etc. Please see <http://www.circos.ca>.

This package provides a system that computes metrics to assess the segmentation accuracy of geospatial data. These metrics calculate the discrepancy between segmented and reference objects, and indicate the segmentation accuracy. For more details on choosing evaluation metrics, we suggest seeing Costa et al. (2018) <doi:10.1016/j.rse.2017.11.024> and Jozdani et al. (2020) <doi:10.1016/j.isprsjprs.2020.01.002>.

S4 class wrappers for the ODBC and Pool DBI connection, also provides some utilities to paste small datasets to clipboard, rename columns. It is used by the package stacomiR for connections to the database. Development versions of stacomiR are available in R-forge.

This package provides a simple interface to recursively list files from a directory, filter them using a regular expression, read their contents, and extract lines that match a user-defined pattern. The package returns a dataframe containing the matched lines, their line numbers, file paths, and the corresponding matched substrings. Designed for quick code base exploration, log inspection, or any use case involving pattern-based file and line filtering.

Create carousels using the JavaScript library Swiper and the package htmlwidgets'. The carousels can be displayed in the RStudio viewer pane, in Shiny applications and in R markdown documents. The package also provides a RStudio addin allowing to choose image files and to display them in the viewer pane.