Conditioned Latin hypercube sampling, as published by Minasny and McBratney (2006) <DOI:10.1016/j.cageo.2005.12.009>. This method proposes to stratify sampling in presence of ancillary data. An extension of this method, which propose to associate a cost to each individual and take it into account during the optimisation process, is also proposed (Roudier et al., 2012, <DOI:10.1201/b12728>).

This package provides a comprehensive framework for time series omics analysis, integrating changepoint detection, smooth and shape-constrained trends, and uncertainty quantification. It supports gene- and transcript-level inferences, p-value aggregation for improved power, and both case-only and case-control designs. It includes an interactive shiny interface. The methods are described in Yates et al. (2024) <doi:10.1101/2024.12.22.630003>.

This package provides an implementation of a mixture of hidden Markov models (HMMs) for discrete sequence data in the Discrete Bayesian HMM Clustering (DBHC) algorithm. The DBHC algorithm is an HMM Clustering algorithm that finds a mixture of discrete-output HMMs while using heuristics based on Bayesian Information Criterion (BIC) to search for the optimal number of HMM states and the optimal number of clusters.

This package provides implementations of computationally efficient maximum likelihood parameter estimation algorithms for models representing linear dynamical systems. Currently, two such algorithms (one offline and one online) are implemented for the single-output cumulative structural equation model with an additive-noise output measurement equation and assumptions of normality and independence. The corresponding scientific papers are referenced in the descriptions of the functions implementing these algorithms.

This package provides functions of five estimation method for ED50 (50 percent effective dose) are provided, and they are respectively Dixon-Mood method (1948) <doi:10.2307/2280071>, Choi's original turning point method (1990) <doi:10.2307/2531453> and it's modified version given by us, as well as logistic regression and isotonic regression. Besides, the package also supports comparison between two estimation results.

This package provides a simple wrapper around the ical.js library executing Javascript code via V8 (the Javascript engine driving the Chrome browser and Node.js and accessible via the V8 R package). This package enables users to parse iCalendar files ('.ics', .ifb', .iCal', .iFBf') into lists and data.frames to ultimately do statistics on events, meetings, schedules, birthdays, and the like.

This package contains a set of functions to create data libraries, generate data dictionaries, and simulate a data step. The libname() function will load a directory of data into a library in one line of code. The dictionary() function will generate data dictionaries for individual data frames or an entire library. And the datestep() function will perform row-by-row data processing.

Due to lack of proper inference procedure and software, the ordinary linear regression model is seldom used in practice for the analysis of right censored data. This paper presents an S-Plus/R program that implements a recently developed inference procedure (Jin, Lin and Ying, 2006) <doi:10.1093/biomet/93.1.147> for the accelerated failure time model based on the least-squares principle.

Classification method obtained through linear programming. It is advantageous with respect to the classical developments when the distribution of the variables involved is unknown or when the number of variables is much greater than the number of individuals. Mathematical details behind the method are published in Nueda, et al. (2022) "LPDA: A new classification method based on linear programming". <doi:10.1371/journal.pone.0270403>.

This package performs Bayesian linear regression and forecasting in astronomy. The method accounts for heteroscedastic errors in both the independent and the dependent variables, intrinsic scatters (in both variables) and scatter correlation, time evolution of slopes, normalization, scatters, Malmquist and Eddington bias, upper limits and break of linearity. The posterior distribution of the regression parameters is sampled with a Gibbs method exploiting the JAGS library.

This package provides new functions info(), warn() and error(), similar to message(), warning() and stop() respectively. However, the new functions can have a level associated with them, so that when executed the global level option determines whether they are shown or not. This allows debug modes, outputting more information. The can also output all messages to a log file.

Ordered homogeneity pursuit lasso (OHPL) algorithm for group variable selection proposed in Lin et al. (2017) <DOI:10.1016/j.chemolab.2017.07.004>. The OHPL method exploits the homogeneity structure in high-dimensional data and enjoys the grouping effect to select groups of important variables automatically. This feature makes it particularly useful for high-dimensional datasets with strongly correlated variables, such as spectroscopic data.

This package provides a system for fast, accurate, and flexible whole genome bisulfite sequencing (WGBS) data analysis of two-condition comparisons. Principal Component BiSulfite, PCBS', assigns methylated loci eigenvector values from the treatment-delineating principal component in lieu of running millions of pairwise statistical tests, which dramatically increases analysis flexibility and reduces computational requirements. Methods: <https://katlande.github.io/PCBS/articles/Differential_Methylation.html>.

This package provides a collection of functions to simulate, estimate and forecast a wide range of regression based dynamic models for positive time series. This package implements the results presented in Prass, T.S.; Pumi, G.; Taufemback, C.G. and Carlos, J.H. (2025). "Positive time series regression models: theoretical and computational aspects". Computational Statistics 40, 1185â 1215. <doi:10.1007/s00180-024-01531-z>.

We present a penalized log-density estimation method using Legendre polynomials with lasso penalty to adjust estimate's smoothness. Re-expressing the logarithm of the density estimator via a linear combination of Legendre polynomials, we can estimate parameters by maximizing the penalized log-likelihood function. Besides, we proposed an implementation strategy that builds on the coordinate decent algorithm, together with the Bayesian information criterion (BIC).

This package implements recently developed projection pursuit algorithms for finding optimal linear cluster separators. The clustering algorithms use optimal hyperplane separators based on minimum density, Pavlidis et. al (2016) <http://jmlr.org/papers/volume17/15-307/15-307.pdf>; minimum normalised cut, Hofmeyr (2017) <doi:10.1109/TPAMI.2016.2609929>; and maximum variance ratio clusterability, Hofmeyr and Pavlidis (2015) <doi:10.1109/SSCI.2015.116>.

Spatial Stochastic Frontier Analysis (SSFA) is an original method for controlling the spatial heterogeneity in Stochastic Frontier Analysis (SFA) models, for cross-sectional data, by splitting the inefficiency term into three terms: the first one related to spatial peculiarities of the territory in which each single unit operates, the second one related to the specific production features and the third one representing the error term.

We provide a flexible Zero-inflated Poisson-Gamma Model (ZIPG) by connecting both the mean abundance and the variability to different covariates, and build valid statistical inference procedures for both parameter estimation and hypothesis testing. These functions can be used to analyze microbiome count data with zero-inflation and overdispersion. The model is discussed in Jiang et al (2023) <doi:10.1080/01621459.2022.2151447>.

Parameter estimation for zero-inflated discrete Weibull (ZIDW) regression models, the univariate setting, distribution functions, functions to generate randomized quantile residuals a pseudo R2, and plotting of rootograms. For more details, see Kalktawi (2017) <https://bura.brunel.ac.uk/handle/2438/14476>, Taconeli and Rodrigues de Lara (2022) <doi:10.1080/00949655.2021.2005597>, and Yeh and Young (2025) <doi:10.1080/03610918.2025.2464076>.

The curl() and curl_download() functions provide highly configurable drop-in replacements for base url() and download.file() with better performance, support for encryption, gzip compression, authentication, and other libcurl goodies. The core of the package implements a framework for performing fully customized requests where data can be processed either in memory, on disk, or streaming via the callback or connection interfaces.

Logging functions in RcppSpdlog provide access to the logging functionality from the spdlog C++ library. This package offers shorter convenience wrappers for the R functions which match the C++ functions, namely via, say, spdl::debug() at the debug level. The actual formatting is done by the fmt::format() function from the fmtlib library (that is also std::format() in C++20 or later).

qsea (quantitative sequencing enrichment analysis) was developed as the successor of the MEDIPS package for analyzing data derived from methylated DNA immunoprecipitation (MeDIP) experiments followed by sequencing (MeDIP-seq). However, qsea provides several functionalities for the analysis of other kinds of quantitative sequencing data (e.g. ChIP-seq, MBD-seq, CMS-seq and others) including calculation of differential enrichment between groups of samples.

Single linkage clustering and connected component analyses are often performed on biological images. Bioi provides a set of functions for performing these tasks. This functionality is implemented in several key functions that can extend to from 1 to many dimensions. The single linkage clustering method implemented here can be used on n-dimensional data sets, while connected component analyses are limited to 3 or fewer dimensions.

This package provides a tool to use a principal component analysis on radially averaged two dimensional Fourier spectra to characterize image texture. The method within the context of ecology was first described by Couteron et al. (2005) <doi:10.1111/j.1365-2664.2005.01097.x> and expanded upon by Solorzano et al. (2018) <doi:10.1117/1.JRS.12.036006> using a moving window approach.