Analysis of treatment effects in clinical trials with time-to-event outcomes is complicated by intercurrent events. This package implements methods for estimating and inferring the cumulative incidence functions for time-to-event (TTE) outcomes with intercurrent events (ICE) under the five strategies outlined in the ICH E9 (R1) addendum, see Deng (2025) <doi:10.1002/sim.70091>. This package can be used for analyzing data from both randomized controlled trials and observational studies. In general, the data involve a primary outcome event and, potentially, an intercurrent event. Two data structures are allowed: competing risks, where only the time to the first event is recorded, and semicompeting risks, where the times to both the primary outcome event and intercurrent event (or censoring) are recorded. For estimation methods, users can choose nonparametric estimation (which does not use covariates) and semiparametrically efficient estimation.

Carries out analyses of two-way tables with one observation per cell, together with graphical displays for an additive fit and a diagnostic plot for removable non-additivity via a power transformation of the response. It implements Tukey's Exploratory Data Analysis (1973) <ISBN: 978-0201076165> methods, including a 1-degree-of-freedom test for row*column non-additivity', linear in the row and column effects.

This package provides various commonly-used response time trimming methods, including the recursive / moving-criterion methods reported by Van Selst and Jolicoeur (1994). By passing trimming functions raw data files, the package will return trimmed data ready for inferential testing.

Estimates time varying regression effects under Cox type models in survival data using classification and regression tree. The codes in this package were originally written in S-Plus for the paper "Survival Analysis with Time-Varying Regression Effects Using a Tree-Based Approach," by Xu, R. and Adak, S. (2002) <doi:10.1111/j.0006-341X.2002.00305.x>, Biometrics, 58: 305-315. Development of this package was supported by NIH grants AG053983 and AG057707, and by the UCSD Altman Translational Research Institute, NIH grant UL1TR001442. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The example data are from the Honolulu Heart Program/Honolulu Asia Aging Study (HHP/HAAS).

Measures the degree of balance for a given phylogenetic tree by calculating the Total Cophenetic Index. Reference: A. Mir, F. Rossello, L. A. Rotger (2013). A new balance index for phylogenetic trees. Math. Biosci. 241, 125-136 <doi:10.1016/j.mbs.2012.10.005>.

Here we provide tools for the computation and factorization of high-dimensional tensor products that are formed by smaller matrices. The methods are based on properties of Kronecker products (Searle 1982, p. 265, ISBN-10: 0470009616). We evaluated this methodology by benchmark testing and illustrated its use in Gaussian Linear Models ('Lopez-Cruz et al., 2024') <doi:10.1093/g3journal/jkae001>.

This package provides a collection of functions and routines for inputting thermal image video files, plotting and converting binary raw data into estimates of temperature. First published 2015-03-26. Written primarily for research purposes in biological applications of thermal images. v1 included the base calculations for converting thermal image binary values to temperatures. v2 included additional equations for providing heat transfer calculations and an import function for thermal image files (v2.2.3 fixed error importing thermal image to windows OS). v3. Added numerous functions for converting thermal image, videos, rewriting and exporting. v3.1. Added new functions to convert files. v3.2. Fixed the various functions related to finding frame times. v4.0. fixed an error in atmospheric attenuation constants, affecting raw2temp and temp2raw functions. Recommend update for use with long distance calculations. v.4.1.3 changed to frameLocates to reflect change to as.character() to format().

This package provides functions for preparing and analyzing animal tracking data, with the intention of identifying areas which are potentially important at the population level and therefore of conservation interest. Areas identified using this package may be checked against global or regionally-defined criteria, such as those set by the Key Biodiversity Area program. The method published herein is described in full in Beal et al. 2021 <doi:10.1111/2041-210X.13713>.

Analyse data from longitudinal studies to characterise changes in values of semi-quantitative outcome variables within individual subjects, using high performance C++ code to enable rapid processing of large datasets. A flexible methodology is available for codifying these state transitions.

Perform test to detect differences in structure between families of trees. The method is based on cophenetic distances and aggregated Student's tests.

R implementation of the software tools developed in the H-CUP (Healthcare Cost and Utilization Project) <https://hcup-us.ahrq.gov> and AHRQ (Agency for Healthcare Research and Quality) <https://www.ahrq.gov>. It currently contains functions for mapping ICD-9 codes to the AHRQ comorbidity measures and translating ICD-9 (resp. ICD-10) codes to ICD-10 (resp. ICD-9) codes based on GEM (General Equivalence Mappings) from CMS (Centers for Medicare and Medicaid Services).

This package provides a wrapper for The Cancer Imaging Archive's REST API. The Cancer Imaging Archive (TCIA) hosts de-identified medical images of cancer available for public download, as well as rich metadata for each image series. TCIA provides a REST API for programmatic access to the data. This package provides simple functions to access each API endpoint. For more information, see <https://github.com/pamelarussell/TCIApathfinder> and TCIA's website.

Unit testing is a solid component of automated CI/CD pipelines. tinytest - a lightweight, zero-dependency alternative to testthat was developed. To be able to integrate tinytests results into common CI/CD systems the test results from tinytest need to be caputred and converted to JUnit XML format. tinytest2JUnit enables this conversion while staying also lightweight and only have tinytest as its dependency.

Trusted Timestamps (tts) are created by incorporating a hash of a file or dataset into a transaction on the decentralized blockchain (Stellar network). The package makes use of a free service provided by <https://stellarapi.io>.

Interactive laboratory of Time Series based in Box-Jenkins methodology.

Execution of various time series models and choosing the best one either by a specific error metric or by picking the best one by majority vote. The models are based on the "forecast" package, written by Prof. Rob Hyndman.

This package implements target trial emulation methods to apply randomized clinical trial design and analysis in an observational setting. Using marginal structural models, it can estimate intention-to-treat and per-protocol effects in emulated trials using electronic health records. A description and application of the method can be found in Danaei et al (2013) <doi:10.1177/0962280211403603>.

This package provides a two-stage regression method that can be used when various input data types are correlated, for example gene expression and methylation in drug response prediction. In the first stage it uses the upstream features (such as methylation) to predict the response variable (such as drug response), and in the second stage it uses the downstream features (such as gene expression) to predict the residuals of the first stage. In our manuscript (Aben et al., 2016, <doi:10.1093/bioinformatics/btw449>), we show that using TANDEM prevents the model from being dominated by gene expression and that the features selected by TANDEM are more interpretable.

The tsgc package provides comprehensive tools for the analysis and forecasting of epidemic trajectories. It is designed to model the progression of an epidemic over time while accounting for the various uncertainties inherent in real-time data. Underpinned by a dynamic Gompertz model, the package adopts a state space approach, using the Kalman filter for flexible and robust estimation of the non-linear growth pattern commonly observed in epidemic data. The reinitialization feature enhances the modelâ s ability to adapt to the emergence of new waves. The forecasts generated by the package are of value to public health officials and researchers who need to understand and predict the course of an epidemic to inform decision-making. Beyond its application in public health, the package is also a useful resource for researchers and practitioners in fields where the trajectories of interest resemble those of epidemics, such as innovation diffusion. The package includes functionalities for data preprocessing, model fitting, and forecast visualization, as well as tools for evaluating forecast accuracy. The core methodologies implemented in tsgc are based on well-established statistical techniques as described in Harvey and Kattuman (2020) <doi:10.1162/99608f92.828f40de>, Harvey and Kattuman (2021) <doi:10.1098/rsif.2021.0179>, and Ashby, Harvey, Kattuman, and Thamotheram (2024) <https://www.jbs.cam.ac.uk/wp-content/uploads/2024/03/cchle-tsgc-paper-2024.pdf>.

This package provides a simple Natural Language Processing (NLP) toolkit focused on search-centric workflows with minimal dependencies. The package offers key features for web scraping, text processing, corpus search, and text embedding generation via the HuggingFace API <https://huggingface.co/docs/api-inference/index>.

Gives the required 2^n treatment combinations in a 2^n symmetric factorial experiment in their respective standard order.

Autoregressive distributed lag (A[R]DL) models (and their reparameterized equivalent, the Generalized Error-Correction Model [GECM]) are the workhorse models in uncovering dynamic inferences. ADL models are simple to estimate; this is what makes them attractive. Once these models are estimated, what is less clear is how to uncover a rich set of dynamic inferences from these models. We provide tools for recovering those inferences. These tools apply to traditional time-series quantities of interest: especially instantaneous effects for any period and cumulative effects for any period (including the long-run effect). They also allow for a variety of shock histories to be applied to the independent variable (beyond just a one-time, one-unit increase) as well as the recovery of inferences in levels for shocks applies to (in)dependent variables in differences (what we call the Generalized Dynamic Response Function). These effects are also available for the general conditional dynamic model advocated by Warner, Vande Kamp, and Jordan (2026 <doi:10.1017/psrm.2026.10087>). We also provide the actual formulae for these effects.

Write modelling results into a database for tigreBrowser', a web-based tool for browsing figures and summary data of independent model fits, such as Gaussian process models fitted for each gene or other genomic element. The browser is available at <https://github.com/PROBIC/tigreBrowser>.

The t-Digest construction algorithm, by Dunning et al., (2019) <doi:10.48550/arXiv.1902.04023>, uses a variant of 1-dimensional k-means clustering to produce a very compact data structure that allows accurate estimation of quantiles. This t-Digest data structure can be used to estimate quantiles, compute other rank statistics or even to estimate related measures like trimmed means. The advantage of the t-Digest over previous digests for this purpose is that the t-Digest handles data with full floating point resolution. The accuracy of quantile estimates produced by t-Digests can be orders of magnitude more accurate than those produced by previous digest algorithms. Methods are provided to create and update t-Digests and retrieve quantiles from the accumulated distributions.