Instead of nesting function calls, annotate and transform functions using "#." comments.

This package provides a bioinformatics tool for the estimation of the tumor purity from sequencing data. It uses the set of putative clonal somatic single nucleotide variants within copy number neutral segments to call tumor cellularity.

We provide a tidy grammar of population genetics, facilitating the manipulation and analysis of data on biallelic single nucleotide polymorphisms (SNPs). tidypopgen scales to very large genetic datasets by storing genotypes on disk, and performing operations on them in chunks, without ever loading all data in memory. The full functionalities of the package are described in Carter et al. (2025) <doi:10.1111/2041-210x.70204>.

Computation of stopping boundaries for a single-arm trial using a Bayesian criterion; i.e., for each m<=n (n= total patient number of the trial) the smallest number of observed toxicities is calculated leading to the termination of the trial/accrual according to the specified criteria. The probabilities of stopping the trial/accrual at and up until (resp.) the m-th patient (m<=n) is also calculated. This design is more conservative than the frequentist approach (using Clopper Pearson CIs) which might be preferred as it concerns safety.See also Aamot et.al.(2010) "Continuous monitoring of toxicity in clinical trials - simulating the risk of stopping prematurely" <doi:10.5414/cpp48476>.

Interactively gate points on a scatter plot. Interactively drawn gates are recorded and can be applied programmatically to reproduce results exactly. Programmatic gating is based on the package gatepoints by Wajid Jawaid.

Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.

This package provides a collection of functions for visualizing,exploring and annotating genetic association results.Association results from multiple traits can be viewed simultaneously along with gene annotation, over the entire genome (Manhattan plot) or in the more detailed regional view.

This package provides functions for the analysis of time series using copula models. The package is based on methodology described in the following references. McNeil, A.J. (2021) <doi:10.3390/risks9010014>, Bladt, M., & McNeil, A.J. (2021) <doi:10.1016/j.ecosta.2021.07.004>, Bladt, M., & McNeil, A.J. (2022) <doi:10.1515/demo-2022-0105>.

Interfaces with the Hugging Face tokenizers library to provide implementations of today's most used tokenizers such as the Byte-Pair Encoding algorithm <https://huggingface.co/docs/tokenizers/index>. It's extremely fast for both training new vocabularies and tokenizing texts.

Regression models for temporal process responses with time-varying coefficient.

This package provides functions such as str_crush(), add_missing_column(), coalesce_data() and drop_na_all() that complement tidyverse functionality or functions that provide alternative behaviors such as if_else2() and str_detect2().

Interface to TensorFlow <https://www.tensorflow.org/>, an open source software library for numerical computation using data flow graphs. Nodes in the graph represent mathematical operations, while the graph edges represent the multidimensional data arrays (tensors) communicated between them. The flexible architecture allows you to deploy computation to one or more CPUs or GPUs in a desktop, server, or mobile device with a single API'. TensorFlow was originally developed by researchers and engineers working on the Google Brain Team within Google's Machine Intelligence research organization for the purposes of conducting machine learning and deep neural networks research, but the system is general enough to be applicable in a wide variety of other domains as well.

This package provides various commonly-used response time trimming methods, including the recursive / moving-criterion methods reported by Van Selst and Jolicoeur (1994). By passing trimming functions raw data files, the package will return trimmed data ready for inferential testing.

Matrix factorization for multivariate time series with both low rank and temporal structures. The procedure is the one proposed by Alquier, P. and Marie, N. "Matrix factorization for multivariate time series analysis." Electronic Journal of Statistics, 13(2), 4346-4366 (2019).

Efficient estimation of the population-level causal effects of stochastic interventions on a continuous-valued exposure. Both one-step and targeted minimum loss estimators are implemented for the counterfactual mean value of an outcome of interest under an additive modified treatment policy, a stochastic intervention that may depend on the natural value of the exposure. To accommodate settings with outcome-dependent two-phase sampling, procedures incorporating inverse probability of censoring weighting are provided to facilitate the construction of inefficient and efficient one-step and targeted minimum loss estimators. The causal parameter and its estimation were first described by DÃ az and van der Laan (2013) <doi:10.1111/j.1541-0420.2011.01685.x>, while the multiply robust estimation procedure and its application to data from two-phase sampling designs is detailed in NS Hejazi, MJ van der Laan, HE Janes, PB Gilbert, and DC Benkeser (2020) <doi:10.1111/biom.13375>. The software package implementation is described in NS Hejazi and DC Benkeser (2020) <doi:10.21105/joss.02447>. Estimation of nuisance parameters may be enhanced through the Super Learner ensemble model in sl3', available for download from GitHub using remotes::install_github("tlverse/sl3")'.

This package implements measures of tree similarity, including information-based generalized Robinson-Foulds distances (Phylogenetic Information Distance, Clustering Information Distance, Matching Split Information Distance; Smith 2020) <doi:10.1093/bioinformatics/btaa614>; Jaccard-Robinson-Foulds distances (Bocker et al. 2013) <doi:10.1007/978-3-642-40453-5_13>, including the Nye et al. (2006) metric <doi:10.1093/bioinformatics/bti720>; the Matching Split Distance (Bogdanowicz & Giaro 2012) <doi:10.1109/TCBB.2011.48>; the Hierarchical Mutual Information (Perotti et al. 2015) <doi:10.1103/PhysRevE.92.062825>; Maximum Agreement Subtree distances; the Kendall-Colijn (2016) distance <doi:10.1093/molbev/msw124>, and the Nearest Neighbour Interchange (NNI) distance, approximated per Li et al. (1996) <doi:10.1007/3-540-61332-3_168>. Includes tools for visualizing mappings of tree space (Smith 2022) <doi:10.1093/sysbio/syab100>, for identifying islands of trees (Silva and Wilkinson 2021) <doi:10.1093/sysbio/syab015>, for calculating the median of sets of trees, and for computing the information content of trees and splits.

The Cancer Genome Atlas (TCGA) is a program aimed at improving our understanding of Cancer Biology. Several TCGA Datasets are available online. TCGAretriever helps accessing and downloading TCGA data hosted on cBioPortal via its Web Interface (see <https://www.cbioportal.org/> for more information).

Displays processing time in a clear and structured way. One function supports iterative workflows by predicting and showing the total time required, while another reports the time taken for individual steps within a process.

Parsing (R)Markdown files with numerous regular expressions can be fraught with peril, but it does not have to be this way. Converting (R)Markdown files to XML using the commonmark package allows in-memory editing via of markdown elements via XPath through the extensible R6 class called yarn'. These modified XML representations can be written to (R)Markdown documents via an xslt stylesheet which implements an extended version of GitHub'-flavoured markdown so that you can tinker to your hearts content.

Demonstration functions that can be used in a classroom to demonstrate statistical concepts, or on your own to better understand the concepts or the programming.

The companion package that provides all the datasets used in the book "Data Integration, Manipulation and Visualization of Phylogenetic Trees" by Guangchuang Yu (2022, ISBN:9781032233574).

Includes the results of general, local, and presidential elections held in Turkey between 1995 and 2024, broken down by provinces and overall national results. It facilitates easy processing of this data and the creation of visual representations based on these election results.

This package provides functions and example files to calculate the tRNA adaptation index, a measure of the level of co-adaptation between the set of tRNA genes and the codon usage bias of protein-coding genes in a given genome. The methodology is described in dos Reis, Wernisch and Savva (2003) <doi:10.1093/nar/gkg897>, and dos Reis, Savva and Wernisch (2004) <doi:10.1093/nar/gkh834>.

This package provides model specifications, tuning parameters for models in dann package. Models based on Hastie (1996) <https://web.stanford.edu/~hastie/Papers/dann_IEEE.pdf>.