Implementation of the GTE (Group Technical Effects) model for single-cell data. GTE is a quantitative metric to assess batch effects for individual genes in single-cell data. For a single-cell dataset, the user can calculate the GTE value for individual features (such as genes), and then identify the highly batch-sensitive features. Removing these highly batch-sensitive features results in datasets with low batch effects.

Help to the occasional R user for synthesis and enhanced graphical visualization of redundancy analysis (RDA) and principal component analysis (PCA) methods and objects. Inputs are : data frame, RDA (package vegan') and PCA (package FactoMineR') objects. Outputs are : synthesized results of RDA, displayed in console and saved in tables ; displayed and saved objects of PCA graphic visualization of individuals and variables projections with multiple graphic parameters.

Penalised likelihood estimation of a covariance matrix via the ridge-regularised covglasso estimator described in Cibinel et al. (2024) <doi:10.48550/arXiv.2410.02403>. Based on the C++ code of the R package covglasso (by Michael Fop, <https://orcid.org/0000-0003-3936-2757>) and the R code of icf (by Mathias Drton, <https://orcid.org/0000-0001-5614-3025>) within the R package ggm'.

The haversine is a function used to calculate the distance between a pair of latitude and longitude points while accounting for the assumption that the points are on a spherical globe. This package provides a fast, dataframe compatible, haversine function. For the first publication on the haversine calculation see Joseph de Mendoza y RÃ os (1795) <https://books.google.cat/books?id=030t0OqlX2AC> (In Spanish).

Miscellaneous functions for classification and visualization, e.g. regularized discriminant analysis, sknn() kernel-density naive Bayes, an interface to svmlight and stepclass() wrapper variable selection for supervised classification, partimat() visualization of classification rules and shardsplot() of cluster results as well as kmodes() clustering for categorical data, corclust() variable clustering, variable extraction from different variable clustering models and weight of evidence preprocessing.

Density evaluation and random number generation for the Matrix-Normal Inverse-Wishart (MNIW) distribution, as well as the the Matrix-Normal, Matrix-T, Wishart, and Inverse-Wishart distributions. Core calculations are implemented in a portable (header-only) C++ library, with matrix manipulations using the Eigen library for linear algebra. Also provided is a Gibbs sampler for Bayesian inference on a random-effects model with multivariate normal observations.

Test whether equality and order constraints hold for all individuals simultaneously by comparing Bayesian mixed models through Bayes factors. A tutorial style vignette and a quickstart guide are available, via vignette("manual", "quid"), and vignette("quickstart", "quid") respectively. See Haaf and Rouder (2017) <doi:10.1037/met0000156>; Haaf, Klaassen and Rouder (2019) <doi:10.31234/osf.io/a4xu9>; and Rouder & Haaf (2021) <doi:10.5334/joc.131>.

Markov chain Monte Carlo samplers for posterior simulations of conjugate Bayesian nonparametric mixture models. Functionality is provided for Gibbs sampling as in Algorithm 3 of Neal (2000) <DOI:10.1080/10618600.2000.10474879>, restricted Gibbs merge-split sampling as described in Jain & Neal (2004) <DOI:10.1198/1061860043001>, and sequentially-allocated merge-split sampling <DOI:10.1080/00949655.2021.1998502>, as well as summary and utility functions.

This package creates stratum orthogonal arrays (also known as strong orthogonal arrays). These are arrays with more levels per column than the typical orthogonal array, and whose low order projections behave like orthogonal arrays, when collapsing levels to coarser strata. Details are described in Groemping (2022) "A unifying implementation of stratum (aka strong) orthogonal arrays" <http://www1.bht-berlin.de/FB_II/reports/Report-2022-002.pdf>.

We utilize approximate Bayesian machinery to fit two-level conjugate hierarchical models on overdispersed Gaussian, Poisson, and Binomial data and evaluates whether the resulting approximate Bayesian interval estimates for random effects meet the nominal confidence levels via frequency coverage evaluation. The data that Rgbp assumes comprise observed sufficient statistic for each random effect, such as an average or a proportion of each group, without population-level data. The approximate Bayesian tool equipped with the adjustment for density maximization produces approximate point and interval estimates for model parameters including second-level variance component, regression coefficients, and random effect. For the Binomial data, the package provides an option to produce posterior samples of all the model parameters via the acceptance-rejection method. The package provides a quick way to evaluate coverage rates of the resultant Bayesian interval estimates for random effects via a parametric bootstrapping, which we call frequency method checking.

Rapidly create a GUI for a function you created by automatically creating widgets for arguments of the function. This package automatically parses help routines for context-sensitive help to these arguments. The interface is essentially a wrapper to some Tcl/Tk routines to both simplify and facilitate GUI creation. More advanced Tcl/Tk routines/GUI objects can be incorporated into the interface for greater customization for the more experienced.

The Ziggurat pseudo-random number generator (or PRNG) offers a lightweight and very fast PRNG for the normal, exponential, and uniform distributions. It is provided here in a small zero-dependency package. It can be used from R as well as from C/C++ code in other packages as is demonstrated by four included sample packages using four distinct methods to use the PRNG presented here in client package.

bnem combines the use of indirect measurements of Nested Effects Models (package mnem) with the Boolean networks of CellNOptR. Perturbation experiments of signalling nodes in cells are analysed for their effect on the global gene expression profile. Those profiles give evidence for the Boolean regulation of down-stream nodes in the network, e.g., whether two parents activate their child independently (OR-gate) or jointly (AND-gate).

Network meta-analyses using Bayesian framework following Dias et al. (2013) <DOI:10.1177/0272989X12458724>. Based on the data input, creates prior, model file, and initial values needed to run models in rjags'. Able to handle binomial, normal and multinomial arm-level data. Can handle multi-arm trials and includes methods to incorporate covariate and baseline risk effects. Includes standard diagnostics and visualization tools to evaluate the results.

This package provides a collection of functions for calculating the M2 model fit statistic for diagnostic classification models as described by Liu et al. (2016) <DOI:10.3102/1076998615621293>. These functions provide multiple sources of information for model fit according to the M2 statistic, including the M2 statistic, the *p* value for that M2 statistic, and the Root Mean Square Error of Approximation based on the M2 statistic.

An implementation by Chen, Li, and Zhang (2022) <doi: 10.1093/bioadv/vbac041> of the Depth Importance in Precision Medicine (DIPM) method in Chen and Zhang (2022) <doi:10.1093/biostatistics/kxaa021> and Chen and Zhang (2020) <doi:10.1007/978-3-030-46161-4_16>. The DIPM method is a classification tree that searches for subgroups with especially poor or strong performance in a given treatment group.

The automated clustering and quantification of the digital PCR data is based on the combination of DBSCAN (Hahsler et al. (2019) <doi:10.18637/jss.v091.i01>) and c-means (Bezdek et al. (1981) <doi:10.1007/978-1-4757-0450-1>) algorithms. The analysis is independent of multiplexing geometry, dPCR system, and input amount. The details about input data and parameters are available in the vignette.

An implementation of European Forestry Dynamics Model (EFDM) and an estimation algorithm for the transition probabilities. The EFDM is a large-scale forest model that simulates the development of the forest and estimates volume of wood harvested for any given forested area. This estimate can be broken down by, for example, species, site quality, management regime and ownership category. See Packalen et al. (2015) <doi:10.2788/153990>.

This package provides access to a range of functions for computing and visualizing the Full Bayesian Significance Test (FBST) and the e-value for testing a sharp hypothesis against its alternative, and the Full Bayesian Evidence Test (FBET) and the (generalized) Bayesian evidence value for testing a composite (or interval) hypothesis against its alternative. The methods are widely applicable as long as a posterior MCMC sample is available.

Two-step modeling with separation of sources of variation through analysis of variance and subsequent multivariate modeling through a range of unsupervised and supervised statistical methods. Separation can focus on removal of interfering effects or isolation of effects of interest. EF Mosleth et al. (2021) <doi:10.1038/s41598-021-82388-w> and EF Mosleth et al. (2020) <doi:10.1016/B978-0-12-409547-2.14882-6>.

This package provides the following types of models: Models for contingency tables (i.e. log-linear models) Graphical Gaussian models for multivariate normal data (i.e. covariance selection models) Mixed interaction models. Documentation about gRim is provided by vignettes included in this package and the book by Højsgaard, Edwards and Lauritzen (2012, <doi:10.1007/978-1-4614-2299-0>); see citation("gRim") for details.

Automated General-to-Specific (GETS) modelling of the mean and variance of a regression, and indicator saturation methods for detecting and testing for structural breaks in the mean, see Pretis, Reade and Sucarrat (2018) <doi:10.18637/jss.v086.i03> for an overview of the package. In advanced use, the estimator and diagnostics tests can be fully user-specified, see Sucarrat (2021) <doi:10.32614/RJ-2021-024>.

This package provides seamless access to the WEkEO Harmonised Data Access (HDA) API, enabling users to query, download, and process data efficiently from the HDA platform. With hdar', researchers and data scientists can integrate the extensive HDA datasets into their R workflows, enhancing their data analysis capabilities. Comprehensive information on the API functionality and usage is available at <https://gateway.prod.wekeo2.eu/hda-broker/docs>.

This package provides functions to implement a hierarchical approach which is designed to perform joint analysis of summary statistics using the framework of Mendelian Randomization or transcriptome analysis. Reference: Lai Jiang, Shujing Xu, Nicholas Mancuso, Paul J. Newcombe, David V. Conti (2020). "A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis." <bioRxiv><doi:10.1101/2020.02.03.924241>.