In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. This package provides the setup and calculations needed to run a dose-finding trial with non-binary endpoints and performs simulations to assess designâ s operating characteristics under various scenarios. Three dose finding designs are included in this package: unified phase I design (Ivanova et al. (2009) <doi:10.1111/j.1541-0420.2008.01045.x>), Quasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007) <doi:10.1111/j.1541-0420.2006.00666.x>, Pan et al. (2014) <doi:10.1371/journal.pone.0098147>) and generalized BOIN design (Mu et al. (2018) <doi:10.1111/rssc.12263>). The toxicity endpoints can be handled with these functions including equivalent toxicity score (ETS), total toxicity burden (TTB), general continuous toxicity endpoints, with incorporating ordinal grade toxicity information into dose-finding procedure. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous toxicity score, and incorporate safety and/or stopping rules.

This package provides a tool to define the rare biosphere. ulrb solves the problem of the definition of rarity by replacing arbitrary thresholds with an unsupervised machine learning algorithm (partitioning around medoids, or k-medoids). This algorithm works for any type of microbiome data, provided there is an abundance table. This method also works for non-microbiome data.

By gaining the property of emergence through self-organization, the enhancement of SOMs(self organizing maps) is called Emergent SOM (ESOM). The result of the projection by ESOM is a grid of neurons which can be visualised as a three dimensional landscape in form of the Umatrix. Further details can be found in the referenced publications (see url). This package offers tools for calculating and visualising the ESOM as well as Umatrix, Pmatrix and UStarMatrix. All the functionality is also available through graphical user interfaces implemented in shiny'. Based on the recognized data structures, the method can be used to generate new data.

Uniform sampling on various geometric shapes, such as spheres, ellipsoids, simplices.

Fit a univariate-guided sparse regression (lasso), by a two-stage procedure. The first stage fits p separate univariate models to the response. The second stage gives more weight to the more important univariate features, and preserves their signs. Conveniently, it returns an objects that inherits from class glmnet', so that all of the methods for glmnet are available. See Chatterjee, Hastie and Tibshirani (2025) <doi:10.1162/99608f92.c79ff6db> for details.

Extracts coordinates of an event location from text based on dictionaries of landmarks, roads, and areas. Only returns the location of an event of interest and ignores other location references; for example, if determining the location of a road traffic crash from the text "crash near [location 1] heading towards [location 2]", only the coordinates of "location 1" would be returned. Moreover, accounts for differences in spelling between how a user references a location and how a location is captured in location dictionaries.

This package implements functions to derive uncertainty intervals for (i) regression (linear and probit) parameters when outcome is missing not at random (non-ignorable missingness) introduced in Genbaeck, M., Stanghellini, E., de Luna, X. (2015) <doi:10.1007/s00362-014-0610-x> and Genbaeck, M., Ng, N., Stanghellini, E., de Luna, X. (2018) <doi:10.1007/s10433-017-0448-x>; and (ii) double robust and outcome regression estimators of average causal effects (on the treated) with possibly unobserved confounding introduced in Genbaeck, M., de Luna, X. (2018) <doi:10.1111/biom.13001>.

Comprehensive analysis and forecasting of univariate time series using automatic time series models of many kinds. Harvey AC (1989) <doi:10.1017/CBO9781107049994>. Pedregal DJ and Young PC (2002) <doi:10.1002/9780470996430>. Durbin J and Koopman SJ (2012) <doi:10.1093/acprof:oso/9780199641178.001.0001>. Hyndman RJ, Koehler AB, Ord JK, and Snyder RD (2008) <doi:10.1007/978-3-540-71918-2>. Gómez V, Maravall A (2000) <doi:10.1002/9781118032978>. Pedregal DJ, Trapero JR and Holgado E (2024) <doi:10.1016/j.ijforecast.2023.09.004>.

Reconstructs all possible raw data that could have led to reported summary statistics. Provides a wrapper for the Rust implementation of the CLOSURE algorithm.

Allows users to access live UK energy market information via various APIs.

Define and use graphical elements of corporate design manuals in R. The unikn package provides color functions (by defining dedicated colors and color palettes, and commands for finding, changing, viewing, and using them) and styled text elements (e.g., for marking, underlining, or plotting colored titles). The pre-defined range of colors and text decoration functions is based on the corporate design of the University of Konstanz <https://www.uni-konstanz.de/>, but can be adapted and extended for other purposes or institutions.

Dataset contains select attributes for each match result since 1949-1950 season for UNC men's basketball team.

Calculates one-sample unbiased central moment estimates and two-sample pooled estimates up to 6th order, including estimates of powers and products of central moments. Provides the machinery for obtaining unbiased central moment estimators beyond 6th order by generating expressions for expectations of raw sample moments and their powers and products. Gerlovina and Hubbard (2019) <doi:10.1080/25742558.2019.1701917>.

Interface to easily access data via the United States Department of Agriculture (USDA)'s Livestock Mandatory Reporting ('LMR') Data API at <https://mpr.datamart.ams.usda.gov/>. The downloaded data can be saved for later off-line use. Also provide relevant information and metadata for each of the input variables needed for sending the data inquiry.

Maximum likelihood estimation of univariate Gaussian Mixture Autoregressive (GMAR), Student's t Mixture Autoregressive (StMAR), and Gaussian and Student's t Mixture Autoregressive (G-StMAR) models, quantile residual tests, graphical diagnostics, forecast and simulate from GMAR, StMAR and G-StMAR processes. Leena Kalliovirta, Mika Meitz, Pentti Saikkonen (2015) <doi:10.1111/jtsa.12108>, Mika Meitz, Daniel Preve, Pentti Saikkonen (2023) <doi:10.1080/03610926.2021.1916531>, Savi Virolainen (2022) <doi:10.1515/snde-2020-0060>.

S3 classes and methods for manipulation with georeferenced raster data: reading/writing, processing, multi-panel visualization.

Downloads data from the UK Police public data API, the full docs of which are available at <https://data.police.uk/docs/>. Includes data on police forces and police force areas, crime reports, and the use of stop-and-search powers.

The framework proposed in Jenul et al., (2022) <doi:10.1007/s10994-022-06221-9>, together with an interactive Shiny dashboard. UBayFS is an ensemble feature selection technique embedded in a Bayesian statistical framework. The method combines data and user knowledge, where the first is extracted via data-driven ensemble feature selection. The user can control the feature selection by assigning prior weights to features and penalizing specific feature combinations. UBayFS can be used for common feature selection as well as block feature selection.

This package provides a set of functions leading to multivariate response L1 regression. This includes functions on computing Euclidean inner products and norms, weighted least squares estimates on multivariate responses, function to compute fitted values and residuals. This package is a companion to the book "U-Statistics, M-estimation and Resampling", by Arup Bose and Snigdhansu Chatterjee, to appear in 2017 as part of the "Texts and Readings in Mathematics" (TRIM) series of Hindustan Book Agency and Springer-Verlag.

Code snippets to fit models using the tidymodels framework can be easily created for a given data set.

Analyzes the impact of external conditions on air quality using counterfactual approaches, featuring methods for data preparation, modeling, and visualization.

Verb-like functions to work with messy data, often derived from spreadsheets or parsed PDF tables. Includes functions for unwrapping values broken up across rows, relocating embedded grouping values, and to annotate meaningful formatting in spreadsheet files.

Elasticsearch is an open-source, distributed, document-based datastore (<https://www.elastic.co/products/elasticsearch>). It provides an HTTP API for querying the database and extracting datasets, but that API was not designed for common data science workflows like pulling large batches of records and normalizing those documents into a data frame that can be used as a training dataset for statistical models. uptasticsearch provides an interface for Elasticsearch that is explicitly designed to make these data science workflows easy and fun.

The Unmanned Aerial Vehicle Mission Planner provides an easy to use work flow for planning autonomous obstacle avoiding surveys of ready to fly unmanned aerial vehicles to retrieve aerial or spot related data. It creates either intermediate flight control files for the DJI-Litchi supported series or ready to upload control files for the pixhawk-based flight controller. Additionally it contains some useful tools for digitizing and data manipulation.