Surface Protein abundance Estimation using CKmeans-based clustered thresholding ('SPECK') is an unsupervised learning-based method that performs receptor abundance estimation for single cell RNA-sequencing data based on reduced rank reconstruction (RRR) and a clustered thresholding mechanism. Seurat's normalization method is described in: Hao et al., (2021) <doi:10.1016/j.cell.2021.04.048>, Stuart et al., (2019) <doi:10.1016/j.cell.2019.05.031>, Butler et al., (2018) <doi:10.1038/nbt.4096> and Satija et al., (2015) <doi:10.1038/nbt.3192>. Method for the RRR is further detailed in: Erichson et al., (2019) <doi:10.18637/jss.v089.i11> and Halko et al., (2009) <doi:10.48550/arXiv.0909.4061>. Clustering method is outlined in: Song et al., (2020) <doi:10.1093/bioinformatics/btaa613> and Wang et al., (2011) <doi:10.32614/RJ-2011-015>.

This package provides a set of basic functions for creating Moodle XML output files suited for importing questions in Moodle (a learning management system, see <https://moodle.org/> for more information).

This package provides a set of tools for determining the necessary sample size in order to identify the optimal dynamic treatment regime in a sequential, multiple assignment, randomized trial (SMART). Utilizes multiple comparisons with the best methodology to adjust for multiple comparisons. Designed for an arbitrary SMART design. Please see Artman (2018) <doi:10.1093/biostatistics/kxy064> for more details.

An interface to access data from Substack publications via API. Users can fetch the latest, top, search for specific posts, or retrieve a single post by its slug. This functionality is useful for developers and researchers looking to analyze Substack content or integrate it into their applications. For more information, visit the API documentation at <https://substackapi.dev/introduction>.

This package provides a collection of data processing, visualization, and export functions to support soil survey operations. Many of the functions build on the `SoilProfileCollection` S4 class provided by the aqp package, extending baseline visualization to more elaborate depictions in the context of spatial and taxonomic data. While this package is primarily developed by and for the USDA-NRCS, in support of the National Cooperative Soil Survey, the authors strive for generalization sufficient to support any soil survey operation. Many of the included functions are used by the SoilWeb suite of websites and movile applications. These functions are provided here, with additional documentation, to enable others to replicate high quality versions of these figures for their own purposes.

This package provides methods for fitting bivariate lines in allometry using the major axis (MA) or standardised major axis (SMA), and for making inferences about such lines. The available methods of inference include confidence intervals and one-sample tests for slope and elevation, testing for a common slope or elevation amongst several allometric lines, constructing a confidence interval for a common slope or elevation, and testing for no shift along a common axis, amongst several samples. See Warton et al. 2012 <doi:10.1111/j.2041-210X.2011.00153.x> for methods description.

Perform association test within linear mixed model framework using score test integrated with Empirical Bayes for genome-wide association study. Firstly, score test was conducted for each marker under linear mixed model framework, taking into account the genetic relatedness and population structure. And then all the potentially associated markers were selected with a less stringent criterion. Finally, all the selected markers were placed into a multi-locus model to identify the true quantitative trait nucleotide.

Implementations of stochastic, limited-memory quasi-Newton optimizers, similar in spirit to the LBFGS (Limited-memory Broyden-Fletcher-Goldfarb-Shanno) algorithm, for smooth stochastic optimization. Implements the following methods: oLBFGS (online LBFGS) (Schraudolph, N.N., Yu, J. and Guenter, S., 2007 <http://proceedings.mlr.press/v2/schraudolph07a.html>), SQN (stochastic quasi-Newton) (Byrd, R.H., Hansen, S.L., Nocedal, J. and Singer, Y., 2016 <arXiv:1401.7020>), adaQN (adaptive quasi-Newton) (Keskar, N.S., Berahas, A.S., 2016, <arXiv:1511.01169>). Provides functions for easily creating R objects with partial_fit/predict methods from some given objective/gradient/predict functions. Includes an example stochastic logistic regression using these optimizers. Provides header files and registered C routines for using it directly from C/C++.

Estimation and inference for parameters in a Gaussian copula model, treating the univariate marginal distributions as nuisance parameters as described in Hoff (2007) <doi:10.1214/07-AOAS107>. This package also provides a semiparametric imputation procedure for missing multivariate data.

This package implements shrinkage principal fitted components for sufficient dimension reduction in high-dimensional regression and classification. Provides regularised covariance estimation using Oracle Approximating Shrinkage and Maximum Entropy Covariance, structural-dimension selection using conventional and information-complexity criteria, response-guided feature screening, reduced-space prediction, and simulation utilities. Methodological foundations include Cook and Forzani (2008) <doi:10.1214/08-STS275>, Chen et al. (2010) <doi:10.1109/TSP.2010.2053029>, Bozdogan (2000) <doi:10.1006/jmps.1999.1277>, and Olorede and Yahya (2019) <doi:10.48550/arXiv.1909.13017>.

The sinaplot is a data visualization chart suitable for plotting any single variable in a multiclass data set. It is an enhanced jitter strip chart, where the width of the jitter is controlled by the density distribution of the data within each class.

Structurally guided sampling (SGS) approaches for airborne laser scanning (ALS; LIDAR). Primary functions provide means to generate data-driven stratifications & methods for allocating samples. Intermediate functions for calculating and extracting important information about input covariates and samples are also included. Processing outcomes are intended to help forest and environmental management practitioners better optimize field sample placement as well as assess and augment existing sample networks in the context of data distributions and conditions. ALS data is the primary intended use case, however any rasterized remote sensing data can be used, enabling data-driven stratifications and sampling approaches.

This package provides a consistently well behaved method of interpolation based on piecewise rational functions using Stineman's algorithm.

Static analysis for R scientific data analysis code. Flags patterns that often correspond to hidden scientific commitments -- silent error swallowing, smuggled defaults, label leakage in selection-stage code, magic-eps floors in BIC formulas, and shadow-overwrite of sourced helpers. Designed for agentic coding workflows; high recall over precision; structured ANALYSIS_OK waivers as the audit trail.

Fits symmetric soft windowing to linear and non-linear models by assigning exponential weights over time around specified modes; bandwidth and sharpness of the windows are chosen by a grid search and comparison diagnostics (Hamed Haselimashhadi et al (2019) <doi:10.1093/bioinformatics/btz744>).

This package provides a novel spatial topic model to integrate both cell type and spatial information to identify the complex spatial tissue architecture on multiplexed tissue images without human intervention. The Package implements a collapsed Gibbs sampling algorithm for inference. The method is highly scalable to large-scale image datasets without extracting neighborhood information for every single cell. The package supports spatially resolved cell-level data analysis, topic inference, visualization, and downstream biological interpretation of tissue microenvironments.

This package provides a simple progress bar to use for basic and advanced users that suits all those who prefer procedural programming. It is especially useful for integration into markdown files thanks to the progress bar's customisable appearance.

Generate simulated datasets from an initial underlying distribution and apply transformations to obtain realistic data. Implements the NORTA (Normal-to-anything) approach from Cario and Nelson (1997) and other data generating mechanisms. Simple network visualization tools are provided to facilitate communicating the simulation setup.

Calculates ratings for two-player or multi-player challenges. Methods included in package such as are able to estimate ratings (players strengths) and their evolution in time, also able to predict output of challenge. Algorithms are based on Bayesian Approximation Method, and they don't involve any matrix inversions nor likelihood estimation. Parameters are updated sequentially, and computation doesn't require any additional RAM to make estimation feasible. Additionally, base of the package is written in C++ what makes sport computation even faster. Methods used in the package refer to Mark E. Glickman (1999) <https://www.glicko.net/research/glicko.pdf>; Mark E. Glickman (2001) <doi:10.1080/02664760120059219>; Ruby C. Weng, Chih-Jen Lin (2011) <https://www.jmlr.org/papers/volume12/weng11a/weng11a.pdf>; W. Penny, Stephen J. Roberts (1999) <doi:10.1109/IJCNN.1999.832603>.

Generate common data forms for complex data suitable for conversions and transmission by decomposition as paths or primitives. Paths are sequentially-linked records, primitives are basic atomic elements and both can model many forms and be grouped into hierarchical structures. The universal models SC0 (structural) and SC (labelled, relational) are composed of edges and can represent any hierarchical form. Specialist models PATH', ARC and TRI provide the most common intermediate forms used for converting from one form to another. The methods are inspired by the simplicial complex <https://en.wikipedia.org/wiki/Simplicial_complex> and provide intermediate forms that relate spatial data structures to this mathematical construct.

The sparse vector field consensus (SparseVFC) algorithm (Ma et al., 2013 <doi:10.1016/j.patcog.2013.05.017>) for robust vector field learning. Largely translated from the Matlab functions in <https://github.com/jiayi-ma/VFC>.

This package provides a system that provides a streamlined way of generating publication ready plots for known Single-Cell transcriptomics data in a â publication readyâ format. This is, the goal is to automatically generate plots with the highest quality possible, that can be used right away or with minimal modifications for a research article.

This package provides a database-independent JDBC interface.

This package contains methods for simulation and for evaluating the pdf, cdf, and quantile functions for symmetric stable, symmetric classical tempered stable, and symmetric power tempered stable distributions.