This package offers an implementation of the Abnormal blood profile score (ABPS). The ABPS is a part of the Athlete biological passport program of the World anti-doping agency, which combines several blood parameters into a single score in order to detect blood doping. The package also contains functions to calculate other scores used in anti-doping programs, such as the ratio of hemoglobin to reticulocytes (OFF-score), as well as example data.

High-throughput extensible toolkit for processing FASTQ data. The goal of this package is to empower users to quickly build out small programmatic kernels to define any FASTQ processing task they may need. Builds on Intel TBB’s flow graph to orchestrate concurrent I/O and data processing; throughput can be as fast as compression and disk speed allows. The package also ships with a suite of predefined kernels for common FASTQ tasks.

This package implements maximum likelihood methods for evaluating the durability of vaccine efficacy in a randomized, placebo-controlled clinical trial with staggered enrollment of participants and potential crossover of placebo recipients before the end of the trial. Lin, D. Y., Zeng, D., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab226> and Lin, D. Y., Gu, Y., Zeng, D., Janes, H. E., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab630>.

Supports global health data analysis, including a publication-ready ggplot2 theme, a flextable defaults helper, a thin pie chart wrapper, built-in regional country-code datasets with a WHO region lookup helper, a geometric mean function for indicator aggregation, and convenience clients for the World Health Organization Global Health Observatory (GHO) OData API <https://ghoapi.azureedge.net/api/> and the United Nations Sustainable Development Goals (SDG) API <https://unstats.un.org/SDGAPI/swagger/>.

Returns the noncentrality parameter of the noncentral F distribution if probability of type I and type II error, degrees of freedom of the numerator and the denominator are given. It may be useful for computing minimal detectable differences for general ANOVA models. This program is documented in the paper of A. Baharev, S. Kemeny, On the computation of the noncentral F and noncentral beta distribution; Statistics and Computing, 2008, 18 (3), 333-340.

Application of multi-site models for daily precipitation and temperature data. This package is designed for an application to 105 precipitation and 26 temperature gauges located in Switzerland. It applies fitting procedures and provides weather generators described in the following references: - Evin, G., A.-C. Favre, and B. Hingray. (2018) <doi:10.5194/hess-22-655-2018>. - Evin, G., A.-C. Favre, and B. Hingray. (2018) <doi:10.1007/s00704-018-2404-x>.

The Harmonised Index of Consumer Prices (HICP) is the key economic figure to measure inflation in the euro area. The methodology underlying the HICP is documented in the HICP Methodological Manual (<https://ec.europa.eu/eurostat/web/products-manuals-and-guidelines/w/ks-gq-24-003>). Based on the manual, this package provides functions to access and work with HICP data from Eurostat's public database (<https://ec.europa.eu/eurostat/data/database>).

Builds and optimizes Hopfield artificial neural networks (Hopfield, 1982, <doi:10.1073/pnas.79.8.2554>). One-layer and three-layer models are implemented. The energy of the Hopfield network is minimized with formula from Krotov and Hopfield (2016, <doi:10.48550/ARXIV.1606.01164>). Optimization (supervised learning) is done through a gradient-based method. Classification is done with S3 methods predict(). Parallelization with OpenMP is used if available during compilation.

Calculate nine types of coefficients of determination (R-squared) based on the classification by Kvalseth (1985) <doi:10.1080/00031305.1985.10479448>. This package is designed for educational purposes to demonstrate how R-squared values can fluctuate depending on the choice of formula, particularly in power regression models or linear models without an intercept. By providing a comprehensive list of definitions, it helps users understand the mathematical sensitivity of goodness-of-fit indices.

This package implements the Kidney Failure Risk Equation (KFRE; Tangri and colleagues (2011) <doi:10.1001/jama.2011.451>; Tangri and colleagues (2016) <doi:10.1001/jama.2015.18202>) to compute 2- and 5-year kidney failure risk using 4-, 6-, and 8-variable models. Includes helpers to append risk columns to data frames, classify chronic kidney disease (CKD) stages and end-stage renal disease (ESRD) outcomes, and evaluate and plot model performance.

Accompanies the book "Nonparametric Statistical Methods Using R, 2nd Edition" by Kloke and McKean (2024, ISBN:9780367651350). Includes methods, datasets, and random number generation useful for the study of robust and/or nonparametric statistics. Emphasizes classical nonparametric methods for a variety of designs --- especially one-sample and two-sample problems. Includes methods for general scores, including estimation and testing for the two-sample location problem as well as Hogg's adaptive method.

Estimates principal causal effects under principal stratification using a margin-free, conditional odds ratio sensitivity parameter. This framework unifies the monotonicity assumption and the counterfactual intermediate independence assumption, allowing for robust analysis when monotonicity may not hold. Computes point estimates, standard errors, and confidence intervals for conditionally doubly robust and debiased machine learning estimators. The methodological details are described in Tong, Kahan, Harhay, and Li (2025) <doi:10.48550/arXiv.2501.17514>.

This package implements the Quantile Autoregressive Distributed Lag (QADF) unit root test proposed by Koenker and Xiao (2004) <doi:10.1198/016214504000001114>. The test examines unit root behaviour across the conditional distribution of a time series using quantile regression, providing a richer characterisation of persistence than standard ADF tests. Critical values follow Hansen (1995) <doi:10.1017/S0266466600009713>. Lag order selection is supported via AIC, BIC, or the t-statistic sequential testing approach.

The qda() function from package MASS is extended to calculate a weighted linear (LDA) and quadratic discriminant analysis (QDA) by changing the group variances and group means based on cell-wise uncertainties. The uncertainties can be derived e.g. through relative errors for each individual measurement (cell), not only row-wise or column-wise uncertainties. The method can be applied compositional data (e.g. portions of substances, concentrations) and non-compositional data.

This package provides a multivariate weather generator for daily climate variables based on weather-states (Flecher et al. (2010) <doi:10.1029/2009WR008098>). It uses a Markov chain for modeling the succession of weather states. Conditionally to the weather states, the multivariate variables are modeled using the family of Complete Skew-Normal distributions. Parameters are estimated on measured series. Must include the variable Rain and can accept as many other variables as desired.

Perform fast functional enrichment on feature lists (like genes or proteins) using the hypergeometric distribution. Tailored for speed, this package is ideal for interactive platforms such as Shiny. It supports the retrieval of functional data from sources like GO, KEGG, Reactome, Bioplanet and WikiPathways. By downloading and preparing data first, it allows for rapid successive tests on various feature selections without the need for repetitive, time-consuming preparatory steps typical of other packages.

Compute the fixed effects dynamic panel threshold model suggested by Ramà rez-Rondán (2020) <doi:10.1080/07474938.2019.1624401>, and dynamic panel linear model suggested by Hsiao et al. (2002) <doi:10.1016/S0304-4076(01)00143-9>, where maximum likelihood type estimators are used. Multiple thresholds estimation based on Markov Chain Monte Carlo (MCMC) is allowed, and model selection of linear model, threshold model and multiple threshold model is also allowed.

This package implements an explicit exploration strategy for evolutionary algorithms in order to have a more effective search in solving optimization problems. Along with this exploration search strategy, a set of four different Estimation of Distribution Algorithms (EDAs) are also implemented for solving optimization problems in continuous domains. The implemented explicit exploration strategy in this package is described in Salinas-Gutiérrez and Muñoz Zavala (2023) <doi:10.1016/j.asoc.2023.110230>.

This package provides methods and tools for the analysis of Genome Wide Identity-by-Descent ('gwid') mapping data, focusing on testing whether there is a higher occurrence of Identity-By-Descent (IBD) segments around potential causal variants in cases compared to controls, which is crucial for identifying rare variants. To enhance its analytical power, gwid incorporates a Sliding Window Approach, allowing for the detection and analysis of signals from multiple Single Nucleotide Polymorphisms (SNPs).

Penalized regression for generalized linear models for measurement error problems (aka. errors-in-variables). The package contains a version of the lasso (L1-penalization) which corrects for measurement error (Sorensen et al. (2015) <doi:10.5705/ss.2013.180>). It also contains an implementation of the Generalized Matrix Uncertainty Selector, which is a version the (Generalized) Dantzig Selector for the case of measurement error (Sorensen et al. (2018) <doi:10.1080/10618600.2018.1425626>).

The Iterative Cumulative Sum of Squares (ICSS) algorithm by Inclan/Tiao (1994) <https://www.jstor.org/stable/2290916> detects multiple change points, i.e. structural break points, in the variance of a sequence of independent observations. For series of moderate size (i.e. 200 observations and beyond), the ICSS algorithm offers results comparable to those obtained by a Bayesian approach or by likelihood ration tests, without the heavy computational burden required by these approaches.

We connect the multi-class Neyman-Pearson classification (NP) problem to the cost-sensitive learning (CS) problem, and propose two algorithms (NPMC-CX and NPMC-ER) to solve the multi-class NP problem through cost-sensitive learning tools. Under certain conditions, the two algorithms are shown to satisfy multi-class NP properties. More details are available in the paper "Neyman-Pearson Multi-class Classification via Cost-sensitive Learning" (Ye Tian and Yang Feng, 2021).

This package provides functions to access and download data from various NASA APIs <https://api.nasa.gov/#browseAPI>, including: Astronomy Picture of the Day (APOD), Mars Rover Photos, Earth Polychromatic Imaging Camera (EPIC), Near Earth Object Web Service (NeoWs), Earth Observatory Natural Event Tracker (EONET), and NASA Earthdata CMR Search. Most endpoints require a NASA API key for access. Data is retrieved, cleaned for analysis, and returned in a dataframe-friendly format.

In Switzerland, the landscape of municipalities is changing rapidly mainly due to mergers. The Swiss Municipal Data Merger Tool automatically detects these mutations and maps municipalities over time, i.e. municipalities of an old state to municipalities of a new state. This functionality is helpful when working with datasets that are based on different spatial references. The package's idea and use case is discussed in the following article: <doi:10.1111/spsr.12487>.