This package provides an interface to the NoSQL database CouchDB (<http://couchdb.apache.org>). Methods are provided for managing databases within CouchDB', including creating/deleting/updating/transferring, and managing documents within databases. One can connect with a local CouchDB instance, or a remote CouchDB databases such as Cloudant'. Documents can be inserted directly from vectors, lists, data.frames, and JSON'. Targeted at CouchDB v2 or greater.

Returns a data frame with the names of the input data points and hex colors (or CIELab coordinates). Data can be mapped to colors for use in data visualization. It optimally maps data points into a polygon that represents the CIELab colour space. Since Euclidean distance approximates relative perceptual differences in CIELab color space, the result is a color encoding that aims to capture much of the structure of the original data.

Create an interactive Shiny-based graphical user interface for exploring data stored in SummarizedExperiment objects, including row- and column-level metadata. The interface supports transmission of selections between plots and tables, code tracking, interactive tours, interactive or programmatic initialization, preservation of app state, and extensibility to new panel types via S4 classes. Special attention is given to single-cell data in a SingleCellExperiment object with visualization of dimensionality reduction results.

Mappable vector library provides convenient way to access large datasets. Use all of your data at once, with few limits. Memory mapped data can be shared between multiple R processes. Access speed depends on storage medium, so solid state drive is recommended, preferably with PCI Express (or M.2 nvme) interface or a fast network file system. The data is memory mapped into R and then accessed using usual R list and array subscription operators. Convenience functions are provided for merging, grouping and indexing large vectors and data.frames. The layout of underlying MVL files is optimized for large datasets. The vectors are stored to guarantee alignment for vector intrinsics after memory map. The package is built on top of libMVL, which can be used as a standalone C library. libMVL has simple C API making it easy to interchange datasets with outside programs. Large MVL datasets are distributed via Academic Torrents <https://academictorrents.com/collection/mvl-datasets>.

The SCDE package implements a set of statistical methods for analyzing single-cell RNA-seq data. SCDE fits individual error models for single-cell RNA-seq measurements. These models can then be used for assessment of differential expression between groups of cells, as well as other types of analysis. The SCDE package also contains the pagoda framework which applies pathway and gene set overdispersion analysis to identify aspects of transcriptional heterogeneity among single cells.

This package offers an implementation of the Abnormal blood profile score (ABPS). The ABPS is a part of the Athlete biological passport program of the World anti-doping agency, which combines several blood parameters into a single score in order to detect blood doping. The package also contains functions to calculate other scores used in anti-doping programs, such as the ratio of hemoglobin to reticulocytes (OFF-score), as well as example data.

This package implements maximum likelihood methods for evaluating the durability of vaccine efficacy in a randomized, placebo-controlled clinical trial with staggered enrollment of participants and potential crossover of placebo recipients before the end of the trial. Lin, D. Y., Zeng, D., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab226> and Lin, D. Y., Gu, Y., Zeng, D., Janes, H. E., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab630>.

Returns the noncentrality parameter of the noncentral F distribution if probability of type I and type II error, degrees of freedom of the numerator and the denominator are given. It may be useful for computing minimal detectable differences for general ANOVA models. This program is documented in the paper of A. Baharev, S. Kemeny, On the computation of the noncentral F and noncentral beta distribution; Statistics and Computing, 2008, 18 (3), 333-340.

Application of multi-site models for daily precipitation and temperature data. This package is designed for an application to 105 precipitation and 26 temperature gauges located in Switzerland. It applies fitting procedures and provides weather generators described in the following references: - Evin, G., A.-C. Favre, and B. Hingray. (2018) <doi:10.5194/hess-22-655-2018>. - Evin, G., A.-C. Favre, and B. Hingray. (2018) <doi:10.1007/s00704-018-2404-x>.

Builds and optimizes Hopfield artificial neural networks (Hopfield, 1982, <doi:10.1073/pnas.79.8.2554>). One-layer and three-layer models are implemented. The energy of the Hopfield network is minimized with formula from Krotov and Hopfield (2016, <doi:10.48550/ARXIV.1606.01164>). Optimization (supervised learning) is done through a gradient-based method. Classification is done with S3 methods predict(). Parallelization with OpenMP is used if available during compilation.

The Harmonised Index of Consumer Prices (HICP) is the key economic figure to measure inflation in the euro area. The methodology underlying the HICP is documented in the HICP Methodological Manual (<https://ec.europa.eu/eurostat/web/products-manuals-and-guidelines/w/ks-gq-24-003>). Based on the manual, this package provides functions to access and work with HICP data from Eurostat's public database (<https://ec.europa.eu/eurostat/data/database>).

Calculate nine types of coefficients of determination (R-squared) based on the classification by Kvalseth (1985) <doi:10.1080/00031305.1985.10479448>. This package is designed for educational purposes to demonstrate how R-squared values can fluctuate depending on the choice of formula, particularly in power regression models or linear models without an intercept. By providing a comprehensive list of definitions, it helps users understand the mathematical sensitivity of goodness-of-fit indices.

This package implements the Kidney Failure Risk Equation (KFRE; Tangri and colleagues (2011) <doi:10.1001/jama.2011.451>; Tangri and colleagues (2016) <doi:10.1001/jama.2015.18202>) to compute 2- and 5-year kidney failure risk using 4-, 6-, and 8-variable models. Includes helpers to append risk columns to data frames, classify chronic kidney disease (CKD) stages and end-stage renal disease (ESRD) outcomes, and evaluate and plot model performance.

Accompanies the book "Nonparametric Statistical Methods Using R, 2nd Edition" by Kloke and McKean (2024, ISBN:9780367651350). Includes methods, datasets, and random number generation useful for the study of robust and/or nonparametric statistics. Emphasizes classical nonparametric methods for a variety of designs --- especially one-sample and two-sample problems. Includes methods for general scores, including estimation and testing for the two-sample location problem as well as Hogg's adaptive method.

Estimates principal causal effects under principal stratification using a margin-free, conditional odds ratio sensitivity parameter. This framework unifies the monotonicity assumption and the counterfactual intermediate independence assumption, allowing for robust analysis when monotonicity may not hold. Computes point estimates, standard errors, and confidence intervals for conditionally doubly robust and debiased machine learning estimators. The methodological details are described in Tong, Kahan, Harhay, and Li (2025) <doi:10.48550/arXiv.2501.17514>.

This package implements the Quantile Autoregressive Distributed Lag (QADF) unit root test proposed by Koenker and Xiao (2004) <doi:10.1198/016214504000001114>. The test examines unit root behaviour across the conditional distribution of a time series using quantile regression, providing a richer characterisation of persistence than standard ADF tests. Critical values follow Hansen (1995) <doi:10.1017/S0266466600009713>. Lag order selection is supported via AIC, BIC, or the t-statistic sequential testing approach.

The qda() function from package MASS is extended to calculate a weighted linear (LDA) and quadratic discriminant analysis (QDA) by changing the group variances and group means based on cell-wise uncertainties. The uncertainties can be derived e.g. through relative errors for each individual measurement (cell), not only row-wise or column-wise uncertainties. The method can be applied compositional data (e.g. portions of substances, concentrations) and non-compositional data.

This package provides a multivariate weather generator for daily climate variables based on weather-states (Flecher et al. (2010) <doi:10.1029/2009WR008098>). It uses a Markov chain for modeling the succession of weather states. Conditionally to the weather states, the multivariate variables are modeled using the family of Complete Skew-Normal distributions. Parameters are estimated on measured series. Must include the variable Rain and can accept as many other variables as desired.

Perform fast functional enrichment on feature lists (like genes or proteins) using the hypergeometric distribution. Tailored for speed, this package is ideal for interactive platforms such as Shiny. It supports the retrieval of functional data from sources like GO, KEGG, Reactome, Bioplanet and WikiPathways. By downloading and preparing data first, it allows for rapid successive tests on various feature selections without the need for repetitive, time-consuming preparatory steps typical of other packages.

Uncertainty quantification and inverse estimation by probabilistic generative models from the beginning of the data analysis. An example is a Fourier basis method for inverse estimation in scattering analysis of microscopy videos. It does not require specifying a certain range of Fourier bases and it substantially reduces computational cost via the generalized Schur algorithm. See the reference: Mengyang Gu, Yue He, Xubo Liu and Yimin Luo (2023), <doi:10.48550/arXiv.2309.02468>.

This package provides a collection of LaTeX styles using Beamer customization for pdf-based presentation slides in RMarkdown'. At present it contains RMarkdown adaptations of the LaTeX themes Metropolis (formerly mtheme') theme by Matthias Vogelgesang and others (now included in TeXLive'), the IQSS by Ista Zahn (which is included here), and the Monash theme by Rob J Hyndman. Additional (free) fonts may be needed: Metropolis prefers Fira', and IQSS requires Libertinus'.

Compute the fixed effects dynamic panel threshold model suggested by Ramà rez-Rondán (2020) <doi:10.1080/07474938.2019.1624401>, and dynamic panel linear model suggested by Hsiao et al. (2002) <doi:10.1016/S0304-4076(01)00143-9>, where maximum likelihood type estimators are used. Multiple thresholds estimation based on Markov Chain Monte Carlo (MCMC) is allowed, and model selection of linear model, threshold model and multiple threshold model is also allowed.

This package implements an explicit exploration strategy for evolutionary algorithms in order to have a more effective search in solving optimization problems. Along with this exploration search strategy, a set of four different Estimation of Distribution Algorithms (EDAs) are also implemented for solving optimization problems in continuous domains. The implemented explicit exploration strategy in this package is described in Salinas-Gutiérrez and Muñoz Zavala (2023) <doi:10.1016/j.asoc.2023.110230>.

This package provides methods and tools for the analysis of Genome Wide Identity-by-Descent ('gwid') mapping data, focusing on testing whether there is a higher occurrence of Identity-By-Descent (IBD) segments around potential causal variants in cases compared to controls, which is crucial for identifying rare variants. To enhance its analytical power, gwid incorporates a Sliding Window Approach, allowing for the detection and analysis of signals from multiple Single Nucleotide Polymorphisms (SNPs).