Computes 26 financial risk measures for any continuous distribution. The 26 financial risk measures include value at risk, expected shortfall due to Artzner et al. (1999) <DOI:10.1007/s10957-011-9968-2>, tail conditional median due to Kou et al. (2013) <DOI:10.1287/moor.1120.0577>, expectiles due to Newey and Powell (1987) <DOI:10.2307/1911031>, beyond value at risk due to Longin (2001) <DOI:10.3905/jod.2001.319161>, expected proportional shortfall due to Belzunce et al. (2012) <DOI:10.1016/j.insmatheco.2012.05.003>, elementary risk measure due to Ahmadi-Javid (2012) <DOI:10.1007/s10957-011-9968-2>, omega due to Shadwick and Keating (2002), sortino ratio due to Rollinger and Hoffman (2013), kappa due to Kaplan and Knowles (2004), Wang (1998)'s <DOI:10.1080/10920277.1998.10595708> risk measures, Stone (1973)'s <DOI:10.2307/2978638> risk measures, Luce (1980)'s <DOI:10.1007/BF00135033> risk measures, Sarin (1987)'s <DOI:10.1007/BF00126387> risk measures, Bronshtein and Kurelenkova (2009)'s risk measures.

The adapted pair correlation function transfers the concept of the pair correlation function from point patterns to patterns of objects of finite size and irregular shape (e.g. lakes within a country). The pair correlation function describes the spatial distribution of objects, e.g. random, aggregated or regularly spaced. This is a reimplementation of the method suggested by Nuske et al. (2009) <doi:10.1016/j.foreco.2009.09.050> using the library GEOS <doi:10.5281/zenodo.11396894>.

This package provides Bayesian methods for comparing groups on multiple binary outcomes. Includes basic tests using multivariate Bernoulli distributions, subgroup analysis via generalized linear models, and multilevel models for clustered data. For statistical underpinnings, see Kavelaars, Mulder, and Kaptein (2020) <doi:10.1177/0962280220922256>, Kavelaars, Mulder, and Kaptein (2024) <doi:10.1080/00273171.2024.2337340>, and Kavelaars, Mulder, and Kaptein (2023) <doi:10.1186/s12874-023-02034-z>. An interactive shiny app to perform sample size computations is available.

Measuring cellular energetics is essential to understanding a matrixâ s (e.g. cell, tissue or biofluid) metabolic state. The Agilent Seahorse machine is a common method to measure real-time cellular energetics, but existing analysis tools are highly manual or lack functionality. The Cellular Energetics Analysis Software (ceas) R package fills this analytical gap by providing modular and automated Seahorse data analysis and visualization using the methods described by Mookerjee et al. (2017) <doi:10.1074/jbc.m116.774471>.

This package provides a uniform statistical inferential tool in making individualized treatment decisions, which implements the methods of Ma et al. (2017)<DOI:10.1177/0962280214541724> and Guo et al. (2021)<DOI:10.1080/01621459.2020.1865167>. It uses a flexible semiparametric modeling strategy for heterogeneous treatment effect estimation in high-dimensional settings and can gave valid confidence bands. Based on it, one can find the subgroups of patients that benefit from each treatment, thereby making individualized treatment selection.

R interface for the Google Cloud Services Document AI API <https://cloud.google.com/document-ai> with additional tools for output file parsing and text reconstruction. Document AI is a powerful server-based OCR service that extracts text and tables from images and PDF files with high accuracy. daiR gives R users programmatic access to this service and additional tools to handle and visualize the output. See the package website <https://dair.info/> for more information and examples.

Basic time series functionalities such as listing of missing values, application of arbitrary aggregation as well as rolling (asymmetric) window functions and automatic detection of periodicity. As it is mainly based on data.table', it is fast and (in combination with the R6 package) offers reference semantics. In addition to its native R6 interface, it provides an S3 interface for those who prefer the latter. Finally yet importantly, its functional approach allows for incorporating functionalities from many other packages.

DNA methylation is essential for human, and environment can change the DNA methylation and affect body status. Epigenome-Wide Mediation Analysis Study (EMAS) can find potential mediator CpG sites between exposure (x) and outcome (y) in epigenome-wide. For more information on the methods we used, please see the following references: Tingley, D. (2014) <doi:10.18637/jss.v059.i05>, Turner, S. D. (2018) <doi:10.21105/joss.00731>, Rosseel, D. (2012) <doi:10.18637/jss.v048.i02>.

The R package proposes extreme value index estimators for heavy tailed models by mean of order p <DOI:10.1016/j.csda.2012.07.019>, peaks over random threshold <DOI:10.57805/revstat.v4i3.37> and a bias-reduced estimator <DOI:10.1080/00949655.2010.547196>. The package also computes moment, generalised Hill <DOI:10.2307/3318416> and mixed moment estimates for the extreme value index. High quantiles and value at risk estimators based on these estimators are implemented.

Gaussian mixture graphical models include Bayesian networks and dynamic Bayesian networks (their temporal extension) whose local probability distributions are described by Gaussian mixture models. They are powerful tools for graphically and quantitatively representing nonlinear dependencies between continuous variables. This package provides a complete framework to create, manipulate, learn the structure and the parameters, and perform inference in these models. Most of the algorithms are described in the PhD thesis of Roos (2018) <https://theses.hal.science/tel-01943718>.

Inference of chromosome-length haplotypes using a few haploid gametes of an individual. The gamete genotype data may be generated from various platforms including genotyping arrays and sequencing even with low-coverage. Hapi simply takes genotype data of known hetSNPs in single gamete cells as input and report the high-resolution haplotypes as well as confidence of each phased hetSNPs. The package also includes a module allowing downstream analyses and visualization of identified crossovers in the gametes.

This package provides a collection of functions and data sets that support teaching a quantitative finance MS level course on Portfolio Construction and Risk Analysis, and the writing of a textbook for such a course. The package provides several real-world data sets for problem assignments and student projects, including cross-sections of stock data from the Center for Research on Security Prices, LLC (CRSP), corresponding factor exposures from S&P Global, and several S&P 500 data sets.

This package provides a SAS interface, through SASPy'(<https://sassoftware.github.io/saspy/>) and reticulate'(<https://rstudio.github.io/reticulate/>). This package helps you create SAS sessions, execute SAS code in remote SAS servers, retrieve execution results and log, and exchange datasets between SAS and R'. It also helps you to install SASPy and create a configuration file for the connection. Please review the SASPy license file as instructed so that you comply with its separate and independent license.

This package provides tools for predicting ICU length of stay and assessing ICU efficiency. It is based on the methodologies proposed by Peres et al. (2022, 2023), which utilize data-driven approaches for modeling and validation, offering insights into ICU performance and patient outcomes. References: Peres et al. (2022)<https://pubmed.ncbi.nlm.nih.gov/35988701/>, Peres et al. (2023)<https://pubmed.ncbi.nlm.nih.gov/37922007/>. More information: <https://github.com/igor-peres/ICU-Length-of-Stay-Prediction>.

Inferring causation from time series data through empirical dynamic modeling (EDM), with methods such as convergent cross mapping from Sugihara et al. (2012) <doi:10.1126/science.1227079>, partial cross mapping introduced by Leng et al. (2020) <doi:10.1038/s41467-020-16238-0>, and cross mapping cardinality described in Tao et al. (2023) <doi:10.1016/j.fmre.2023.01.007>, following a systematic description proposed in Lyu et al. (2026) <doi:10.1016/j.compenvurbsys.2026.102435>.

The output gap indicates the percentage difference between the actual output of an economy and its potential. Since potential output is a latent process, the estimation of the output gap poses a challenge and numerous filtering techniques have been proposed. RGAP facilitates the estimation of a Cobb-Douglas production function type output gap, as suggested by the European Commission (Havik et al. 2014) <https://ideas.repec.org/p/euf/ecopap/0535.html>. To that end, the non-accelerating wage rate of unemployment (NAWRU) and the trend of total factor productivity (TFP) can be estimated in two bivariate unobserved component models by means of Kalman filtering and smoothing. RGAP features a flexible modeling framework for the appropriate state-space models and offers frequentist as well as Bayesian estimation techniques. Additional functionalities include direct access to the AMECO <https://economy-finance.ec.europa.eu/economic-research-and-databases/economic-databases/ameco-database_en> database and automated model selection procedures. See the paper by Streicher (2022) <http://hdl.handle.net/20.500.11850/552089> for details.

With the development of high-throughput techniques, more and more gene expression analysis tend to replace hybridization-based microarrays with the revolutionary technology.The novel method encodes the category again by employing the rank of samples for each gene in each class. We then consider the correlation coefficient of gene and class with rank of sample and new rank of category. The highest correlation coefficient genes are considered as the feature genes which are most effective to classify the samples.

The edge package implements methods for carrying out differential expression analyses of genome-wide gene expression studies. Significance testing using the optimal discovery procedure and generalized likelihood ratio tests (equivalent to F-tests and t-tests) are implemented for general study designs. Special functions are available to facilitate the analysis of common study designs, including time course experiments. Other packages such as sva and qvalue are integrated in edge to provide a wide range of tools for gene expression analysis.

An integrated pipeline to predict the potential synthetic lethality partners (SLPs) of tumour mutations, based on gene expression, mutation profiling and cell line genetic screens data. It has builtd-in support for data from cBioPortal. The primary SLPs correlating with muations in WT and compensating for the loss of function of mutations are predicted by random forest based methods (GENIE3) and Rank Products, respectively. Genetic screens are employed to identfy consensus SLPs leads to reduced cell viability when perturbed.

Query the four endpoints of the Air and Water Database (AWDB) REST API maintained by the National Water and Climate Center (NWCC) at the United States Department of Agriculture (USDA). Endpoints include data, forecast, reference-data, and metadata. The package is extremely light weight, with Rust via extendr doing most of the heavy lifting to deserialize and flatten deeply nested JSON responses. The AWDB can be found at <https://wcc.sc.egov.usda.gov/awdbRestApi/swagger-ui/index.html>.

Compute expected shortfall (ES) and Value at Risk (VaR) from a quantile function, distribution function, random number generator, probability density function, or data. ES is also known as Conditional Value at Risk (CVaR). Virtually any continuous distribution can be specified. The functions are vectorized over the arguments. The computations are done directly from the definitions, see e.g. Acerbi and Tasche (2002) <doi:10.1111/1468-0300.00091>. Some support for GARCH models is provided, as well.

This package implements the Improved Expectation Maximisation EM* and the traditional EM algorithm for clustering big data (gaussian mixture models for both multivariate and univariate datasets). This version implements the faster alternative-EM* that expedites convergence via structure based data segregation. The implementation supports both random and K-means++ based initialization. Reference: Parichit Sharma, Hasan Kurban, Mehmet Dalkilic (2022) <doi:10.1016/j.softx.2021.100944>. Hasan Kurban, Mark Jenne, Mehmet Dalkilic (2016) <doi:10.1007/s41060-017-0062-1>.

Cross-validated eigenvalues are estimated by splitting a graph into two parts, the training and the test graph. The training graph is used to estimate eigenvectors, and the test graph is used to evaluate the correlation between the training eigenvectors and the eigenvectors of the test graph. The correlations follow a simple central limit theorem that can be used to estimate graph dimension via hypothesis testing, see Chen et al. (2021) <doi:10.48550/arXiv.2108.03336> for details.

Multidimensional nonparametric spatial (spatio-temporal) geostatistics. S3 classes and methods for multidimensional: linear binning, local polynomial kernel regression (spatial trend estimation), density and variogram estimation. Nonparametric methods for simultaneous inference on both spatial trend and variogram functions (for spatial processes). Nonparametric residual kriging (spatial prediction). For details on these methods see, for example, Fernandez-Casal and Francisco-Fernandez (2014) <doi:10.1007/s00477-013-0817-8> or Castillo-Paez et al. (2019) <doi:10.1016/j.csda.2019.01.017>.