Basic time series functionalities such as listing of missing values, application of arbitrary aggregation as well as rolling (asymmetric) window functions and automatic detection of periodicity. As it is mainly based on data.table', it is fast and (in combination with the R6 package) offers reference semantics. In addition to its native R6 interface, it provides an S3 interface for those who prefer the latter. Finally yet importantly, its functional approach allows for incorporating functionalities from many other packages.

R interface for the Google Cloud Services Document AI API <https://cloud.google.com/document-ai/> with additional tools for output file parsing and text reconstruction. Document AI is a powerful server-based OCR service that extracts text and tables from images and PDF files with high accuracy. daiR gives R users programmatic access to this service and additional tools to handle and visualize the output. See the package website <https://dair.info/> for more information and examples.

The R package proposes extreme value index estimators for heavy tailed models by mean of order p <DOI:10.1016/j.csda.2012.07.019>, peaks over random threshold <DOI:10.57805/revstat.v4i3.37> and a bias-reduced estimator <DOI:10.1080/00949655.2010.547196>. The package also computes moment, generalised Hill <DOI:10.2307/3318416> and mixed moment estimates for the extreme value index. High quantiles and value at risk estimators based on these estimators are implemented.

DNA methylation is essential for human, and environment can change the DNA methylation and affect body status. Epigenome-Wide Mediation Analysis Study (EMAS) can find potential mediator CpG sites between exposure (x) and outcome (y) in epigenome-wide. For more information on the methods we used, please see the following references: Tingley, D. (2014) <doi:10.18637/jss.v059.i05>, Turner, S. D. (2018) <doi:10.21105/joss.00731>, Rosseel, D. (2012) <doi:10.18637/jss.v048.i02>.

The Fill-Mask Association Test ('FMAT') <doi:10.1037/pspa0000396> is an integrative and probability-based method using Masked Language Models to measure conceptual associations (e.g., attitudes, biases, stereotypes, social norms, cultural values) as propositions in natural language. Supported language models include BERT <doi:10.48550/arXiv.1810.04805> and its variants available at Hugging Face <https://huggingface.co/models?pipeline_tag=fill-mask>. Methodological references and installation guidance are provided at <https://psychbruce.github.io/FMAT/>.

Inference of chromosome-length haplotypes using a few haploid gametes of an individual. The gamete genotype data may be generated from various platforms including genotyping arrays and sequencing even with low-coverage. Hapi simply takes genotype data of known hetSNPs in single gamete cells as input and report the high-resolution haplotypes as well as confidence of each phased hetSNPs. The package also includes a module allowing downstream analyses and visualization of identified crossovers in the gametes.

Generalized low-rank models for mixed and incomplete data frames. The main function may be used for dimensionality reduction of imputation of numeric, binary and count data (simultaneously). Main effects such as column means, group effects, or effects of row-column side information (e.g. user/item attributes in recommendation system) may also be modelled in addition to the low-rank model. Geneviève Robin, Olga Klopp, Julie Josse, à ric Moulines, Robert Tibshirani (2018) <arXiv:1806.09734>.

This package provides tools for predicting ICU length of stay and assessing ICU efficiency. It is based on the methodologies proposed by Peres et al. (2022, 2023), which utilize data-driven approaches for modeling and validation, offering insights into ICU performance and patient outcomes. References: Peres et al. (2022)<https://pubmed.ncbi.nlm.nih.gov/35988701/>, Peres et al. (2023)<https://pubmed.ncbi.nlm.nih.gov/37922007/>. More information: <https://github.com/igor-peres/ICU-Length-of-Stay-Prediction>.

This package provides a SAS interface, through SASPy'(<https://sassoftware.github.io/saspy/>) and reticulate'(<https://rstudio.github.io/reticulate/>). This package helps you create SAS sessions, execute SAS code in remote SAS servers, retrieve execution results and log, and exchange datasets between SAS and R'. It also helps you to install SASPy and create a configuration file for the connection. Please review the SASPy license file as instructed so that you comply with its separate and independent license.

The output gap indicates the percentage difference between the actual output of an economy and its potential. Since potential output is a latent process, the estimation of the output gap poses a challenge and numerous filtering techniques have been proposed. RGAP facilitates the estimation of a Cobb-Douglas production function type output gap, as suggested by the European Commission (Havik et al. 2014) <https://ideas.repec.org/p/euf/ecopap/0535.html>. To that end, the non-accelerating wage rate of unemployment (NAWRU) and the trend of total factor productivity (TFP) can be estimated in two bivariate unobserved component models by means of Kalman filtering and smoothing. RGAP features a flexible modeling framework for the appropriate state-space models and offers frequentist as well as Bayesian estimation techniques. Additional functionalities include direct access to the AMECO <https://economy-finance.ec.europa.eu/economic-research-and-databases/economic-databases/ameco-database_en> database and automated model selection procedures. See the paper by Streicher (2022) <http://hdl.handle.net/20.500.11850/552089> for details.

Query the four endpoints of the Air and Water Database (AWDB) REST API maintained by the National Water and Climate Center (NWCC) at the United States Department of Agriculture (USDA). Endpoints include data, forecast, reference-data, and metadata. The package is extremely light weight, with Rust via extendr doing most of the heavy lifting to deserialize and flatten deeply nested JSON responses. The AWDB can be found at <https://wcc.sc.egov.usda.gov/awdbRestApi/swagger-ui/index.html>.

This package implements the Improved Expectation Maximisation EM* and the traditional EM algorithm for clustering big data (gaussian mixture models for both multivariate and univariate datasets). This version implements the faster alternative-EM* that expedites convergence via structure based data segregation. The implementation supports both random and K-means++ based initialization. Reference: Parichit Sharma, Hasan Kurban, Mehmet Dalkilic (2022) <doi:10.1016/j.softx.2021.100944>. Hasan Kurban, Mark Jenne, Mehmet Dalkilic (2016) <doi:10.1007/s41060-017-0062-1>.

Gaussian mixture graphical models include Bayesian networks and dynamic Bayesian networks (their temporal extension) whose local probability distributions are described by Gaussian mixture models. They are powerful tools for graphically and quantitatively representing nonlinear dependencies between continuous variables. This package provides a complete framework to create, manipulate, learn the structure and the parameters, and perform inference in these models. Most of the algorithms are described in the PhD thesis of Roos (2018) <https://tel.archives-ouvertes.fr/tel-01943718>.

Multidimensional nonparametric spatial (spatio-temporal) geostatistics. S3 classes and methods for multidimensional: linear binning, local polynomial kernel regression (spatial trend estimation), density and variogram estimation. Nonparametric methods for simultaneous inference on both spatial trend and variogram functions (for spatial processes). Nonparametric residual kriging (spatial prediction). For details on these methods see, for example, Fernandez-Casal and Francisco-Fernandez (2014) <doi:10.1007/s00477-013-0817-8> or Castillo-Paez et al. (2019) <doi:10.1016/j.csda.2019.01.017>.

Calculate the ratio of iron oxides, hematite and goethite, in soil using the diffuse reflectance technique. The Kubelka-Munk theory, second derivative analysis, and spectral region amplitudes related to hematite and goethite content are used for quantification (Torrent, J., & Barron, V. (2008) <doi:10.2136/sssabookser5.5.c13>). Additionally, the package calculates soil color in the visible spectrum using Munsell and RGB color spaces, based on color theory (Viscarra et al. (2006) <doi:10.1016/j.geoderma.2005.07.017>).

Stagewise techniques implemented with Generalized Estimating Equations to handle individual, group, bi-level, and interaction selection. Stagewise approaches start with an empty model and slowly build the model over several iterations, which yields a path of candidate models from which model selection can be performed. This slow brewing approach gives stagewise techniques a unique flexibility that allows simple incorporation of Generalized Estimating Equations; see Vaughan, G., Aseltine, R., Chen, K., Yan, J., (2017) <doi:10.1111/biom.12669> for details.

Many of the models encountered in applications of point process methods to the study of spatio-temporal phenomena are covered in stpp'. This package provides statistical tools for analyzing the global and local second-order properties of spatio-temporal point processes, including estimators of the space-time inhomogeneous K-function and pair correlation function. It also includes tools to get static and dynamic display of spatio-temporal point patterns. See Gabriel et al (2013) <doi:10.18637/jss.v053.i02>.

Computes the optimal sample size for various 2-group designs (e.g., when comparing the means of two groups assuming equal variances, unequal variances, or comparing proportions) when the aim is to maximize the rewards over the full decision procedure of a) running a trial (with the computed sample size), and b) subsequently administering the winning treatment to the remaining N-n units in the population. Sample sizes and expected rewards for standard t- and z- tests are also provided.

Simulation of reconstructed phylogenetic trees under tree-wide time-heterogeneous birth-death processes and estimation of diversification parameters under the same model. Speciation and extinction rates can be any function of time and mass-extinction events at specific times can be provided. Trees can be simulated either conditioned on the number of species, the time of the process, or both. Additionally, the likelihood equations are implemented for convenience and can be used for Maximum Likelihood (ML) estimation and Bayesian inference.

Penalized weighted least-squares estimate for variable selection on correlated multiply imputed data and penalized estimating equations for generalized linear models with multiple imputation. Reference: Li, Y., Yang, H., Yu, H., Huang, H., Shen, Y*. (2023) "Penalized estimating equations for generalized linear models with multiple imputation", <doi:10.1214/22-AOAS1721>. Li, Y., Yang, H., Yu, H., Huang, H., Shen, Y*. (2023) "Penalized weighted least-squares estimate for variable selection on correlated multiply imputed data", <doi:10.1093/jrsssc/qlad028>.

With the development of high-throughput techniques, more and more gene expression analysis tend to replace hybridization-based microarrays with the revolutionary technology.The novel method encodes the category again by employing the rank of samples for each gene in each class. We then consider the correlation coefficient of gene and class with rank of sample and new rank of category. The highest correlation coefficient genes are considered as the feature genes which are most effective to classify the samples.

The edge package implements methods for carrying out differential expression analyses of genome-wide gene expression studies. Significance testing using the optimal discovery procedure and generalized likelihood ratio tests (equivalent to F-tests and t-tests) are implemented for general study designs. Special functions are available to facilitate the analysis of common study designs, including time course experiments. Other packages such as sva and qvalue are integrated in edge to provide a wide range of tools for gene expression analysis.

An integrated pipeline to predict the potential synthetic lethality partners (SLPs) of tumour mutations, based on gene expression, mutation profiling and cell line genetic screens data. It has builtd-in support for data from cBioPortal. The primary SLPs correlating with muations in WT and compensating for the loss of function of mutations are predicted by random forest based methods (GENIE3) and Rank Products, respectively. Genetic screens are employed to identfy consensus SLPs leads to reduced cell viability when perturbed.

This is an implementation of design methods for binomial reliability demonstration tests (BRDTs) with failure count data. The acceptance decision uncertainty of BRDT has been quantified and the impacts of the uncertainty on related reliability assurance activities such as reliability growth (RG) and warranty services (WS) are evaluated. This package is associated with the work from the published paper "Optimal Binomial Reliability Demonstration Tests Design under Acceptance Decision Uncertainty" by Suiyao Chen et al. (2020) <doi:10.1080/08982112.2020.1757703>.